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Organs that make blood cells
The haematopoietic system (spelled hematopoietic system in American English) is the system in the body involved in the creation of the cells of blood.
Haematopoietic_system
List of organ systems in the human body
reproductive system Male reproductive system Genitourinary system Haematopoietic system Immune system Innate immune system Adaptive immune system Mononuclear
List of systems of the human body
List_of_systems_of_the_human_body
Formation of blood cellular components
cellular components. All cellular blood components are derived from haematopoietic stem cells. In a healthy adult human, roughly ten billion (1010) to
Haematopoiesis
Mammalian protein found in Homo sapiens
"Granulocyte-macrophage colony-stimulating factor: not just another haematopoietic growth factor". Medical Oncology. 31 (1) 774. doi:10.1007/s12032-013-0774-6
Granulocyte-macrophage colony-stimulating factor
Granulocyte-macrophage_colony-stimulating_factor
Diminution or abatement of a disease over time, without formal treatment
improvements in cancer. Spontaneous remissions concern cancers of the haematopoietic system (blood cancer, e.g., leukemia), while spontaneous regressions concern
Spontaneous_remission
Mammalian protein found in Homo sapiens
micro-organism results in activation of the lectin pathway of the complement system. Another important function of MBL is that this molecule binds senescent
Mannan-binding_lectin
Blood disease of the fetus and newborn
pathways. The resulting anemia has multiple sequelae: The immature haematopoietic system of the fetus is taxed as the liver and spleen attempt to put immature
Rh_disease
Protein-coding gene in the species Homo sapiens
maintenance of the neuronal cholinergic phenotype in the central nervous system by BMP-9". Science. 289 (5477): 313–316. Bibcode:2000Sci...289..313L. doi:10
GDF2
Protein-coding gene in humans
proteins, therefore the gene activity of RUNX1 is highly active in the haematopoietic system. The protein RUNX1 is composed of 453 amino acids. As a transcription
RUNX1
Family of transport proteins
is expressed mainly in peripheral tissues such as those of the haematopoietic system, colon, placenta, lung and pancreas. The KCa3.1 channel in red blood
IK_channel
Stem cells that give rise to other blood cells
hdl:10230/36965. PMID 29727679. Ottersbach K (April 2019). "Endothelial-to-haematopoietic transition: an update on the process of making blood". Biochemical Society
Hematopoietic_stem_cell
Protein-coding gene in the species Homo sapiens
nerve muscle of thigh lymph node prefrontal cortex fallopian tube haematopoietic system Top expressed in embryo More reference expression data BioGPS More
OR52N2
Educational animated television series (1987–1988)
series featured a different organ or system within the human body (like the brain, the heart, the circulatory system, etc.).[citation needed] In addition
Once_Upon_a_Time..._Life
intestines, kidneys, and reproductive and nervous systems. It mainly affects the haematopoietic system. It also affects the sulfhydryl group containing
Animal_lead_poisoning
French molecular biologist, political advisor and activist
concluded it effected the liver, kidney, adrenal glands, heart, and haematopoietic system and recommended that safety experiments continue beyond 90 days
Gilles-Éric_Séralini
Protein-coding gene in the species Homo sapiens
Top expressed in kidney multicellular organism Top expressed in haematopoietic system thymus More reference expression data BioGPS More reference expression
OR4D9
Protein found in humans
cell gallbladder renal cortex cervix canal of the cervix mouth haematopoietic system Top expressed in left lobe of liver embryo sexually immature organism
Solute carrier organic anion transporter family member 1B1
Solute_carrier_organic_anion_transporter_family_member_1B1
Belgian-born pathologist and electron microscopist (1928–2019)
Incidence and Classification of Spontaneous Malignant Diseases of the Haematopoietic System in Swiss Mice". Ciba Foundation Symposium - Tumour Viruses of Murine
Étienne_de_Harven
Retracted study led by Gilles-Éric Séralini
or organ damage in the liver, kidney, adrenal glands, heart and haematopoietic system. The European Food Safety Authority (EFSA) concluded that all blood
Séralini_affair
in chick, mouse and human embryos. The very first adult definitive haematopoietic stem cells, capable of long-term multilineage repopulation of adult
Aorta-gonad-mesonephros
Chemical compound
Olden K (April 1999). "Swainsonine protects both murine and human haematopoietic systems from chemotherapeutic toxicity". British Journal of Cancer. 80 (1–2):
Swainsonine
Study of the form or morphology of fishes
lampreys and hagfishes. Even in these animals, there is a diffuse layer of haematopoietic tissue within the gut wall, which has a similar structure to red pulp
Fish_anatomy
Compounds that inhibit or block the activity of cannabinoid receptors
the periphery. CB2 receptors are mostly located in the immune and haematopoietic systems. Endocannabinoids are eicosanoids acting as agonists for cannabinoid
Cannabinoid receptor antagonist
Cannabinoid_receptor_antagonist
Development and formation of the human embryo
Different organs take part in the development of the many organ systems of the body. Haematopoietic stem cells that give rise to all the blood cells develop
Human_embryonic_development
Disorders of adaptive immune system
Wijk F, Boelens JJ, Kuball J, van Laar JM, Wulffraat NM (April 2017). "Haematopoietic stem cell transplantation for autoimmune diseases". Nature Reviews.
Autoimmune_disease
American cardiothoracic surgeon
vessels, and automated vascular anastomotic devices. Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium (2004) Bridge-to-transplant
Robert_C._Robbins
Neurological disorder
immunoglobin, and rituximab. Limited but encouraging therapeutic experience of haematopoietic stem cell transplantation exists for SPS. Stiff-person syndrome (SPS)
Stiff-person_syndrome
Tissue of bone marrow
associated with the innate immune system, in contrast to lymphoid, which is associated with the adaptive immune system. Similarly, myelogenous usually refers
Myeloid_tissue
Formation of granulocyte cells in the bone marrow
a haematopoietic stem cell. These are multipotent cells that reside in the bone marrow niche and have the ability to give rise to all haematopoietic cells
Granulopoiesis
Medical condition
amount of IL-1β and IFN-γ. The only known cure for CAEBV is allogeneic haematopoietic stem cell transplant (HSCT), with all other treatment options (rituximab
Chronic_active_EBV_infection
Medical procedure to replace blood or immune stem cells
Radbruch A (1 July 2016). "Resetting the immune system with immunoablation and autologous haematopoietic stem cell transplantation in autoimmune diseases"
Hematopoietic stem cell transplantation
Hematopoietic_stem_cell_transplantation
Group of autoimmune diseases resulting in abnormal growth of connective tissue
beta-glycan peptides, halofuginone, basiliximab, alemtuzumab, abatacept, and haematopoietic stem cell transplantation. As of 2012[update], the five-year survival
Scleroderma
Tumors that affect the blood, bone marrow, lymph, and lymphatic system
tumours of the haematopoietic and lymphoid tissues (British English) are tumors that affect the blood, bone marrow, lymph, and lymphatic system. Because these
Tumors of the hematopoietic and lymphoid tissues
Tumors_of_the_hematopoietic_and_lymphoid_tissues
Italian molecular and systems biologist
understanding the molecular wiring of transformed cells of the haematopoietic system, as well as studying the mode of action of targeted agents counteracting
Giulio_Superti-Furga
RNA molecule
bioinformatically and it was subsequently characterized as part of the haematopoietic system. Its gene resembles a myeloid gene and it could be driven by the
Mir-223
Medical condition
is also used to treat CMML. It involves the transplantation of donor haematopoietic stem cells into the recipient. Blood transfusion and erythropoietin
Chronic myelomonocytic leukemia
Chronic_myelomonocytic_leukemia
Rejection of host tissue by a transplanted organ's immune cells
destruction Activation of APC occurs in the first stage of GvHD. Before haematopoietic stem cell transplantation, radiation or chemotherapy results in damage
Graft-versus-host_disease
endothelial cells scattered within blood vessels that can differentiate into haematopoietic cells. The development of hematopoietic cells in the embryo proceeds
Hemogenic_endothelium
Australian haematologist
devised the 2008 WHO classification of tumours of the lymphoid haematopoietic systems. She has translated two editions of an Italian work on the morphology
Barbara_J._Bain
Medical hypothesis on development of immunity
malaria skews globin gene expression balance in in-vitro haematopoietic stem cell culture system: Its implications in malaria associated anemia". Exp. Parasitol
Hygiene_hypothesis
Enzyme found in humans
causes a progressive loss of haematopoietic stem cells and bone marrow cellularity during aging. The sensitivity of haematopoietic stem cells to lig4 deficiency
DNA_ligase_4
Deterioration of function with age
et al. (2007). "Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age". Nature. 447 (7145): 725–9. Bibcode:2007Natur.447
Senescence
Cancer of the lymphatic system
2020-02-01. Steven H Swerdlow (2008). WHO classification of tumours of haematopoietic and lymphoid tissues. World Health Organization classification of tumours
Burkitt_lymphoma
Type of blood cancer
Jaffe ES, Pileri SA, eds. (2008). WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Lyon: IARC. ISBN 978-92-832-2431-0. Goldman L
Diffuse_large_B-cell_lymphoma
Exocrine glands that produce saliva through a system of ducts
Mashima Y, Oguchi Y, Ikeda Y, Tsubota K (October 1999). "Dry eye after haematopoietic stem cell transplantation". The British Journal of Ophthalmology. 83
Salivary_gland
Protein-coding gene in the species Homo sapiens
cells, and endothelial cells. It possesses metabolic, physiological, haematopoietic activities, and plays one of the central roles in the regulation of
Interleukin_1-alpha
Vertebrate organ involved in metabolism
up again. Unlike eutherian mammals, in marsupials the liver remains haematopoietic well after birth. The various functions of the liver are carried out
Liver
Type of blood cancer
World Health Organization classification of neoplastic diseases of the haematopoietic and lymphoid tissues: Report of the Clinical Advisory Committee Meeting
Waldenström_macroglobulinemia
Form of radiotherapy
radiotherapy used primarily as part of the preparative regimen for haematopoietic stem cell (or bone marrow) transplantation. As the name implies, TBI
Total_body_irradiation
Autoimmune disease affecting the peripheral nervous system
Andreas; Hägglund, Hans; Askmark, Håkan (2018-02-01). "Autologous haematopoietic stem cell transplantation for neurological diseases". Journal of Neurology
Chronic inflammatory demyelinating polyneuropathy
Chronic_inflammatory_demyelinating_polyneuropathy
Indian biotechnology company
rich source of haematopoietic stem cells (HSCs), which are primarily responsible for replenishing blood and regenerating the immune system. Lifecell announced
LifeCell_International
Human disease
DMT's. Being eligible for immunoablative therapy followed by autologous haematopoietic stem cell transplantation (aHSCT) because of a) the failure of conventional
Inflammatory demyelinating diseases of the central nervous system
Inflammatory_demyelinating_diseases_of_the_central_nervous_system
Indian-American physician, writer b. 1970
microenvironment ("niche") of stem cells, particularly on blood-forming (haematopoietic) stem cells. Blood-forming stem cells are present in the bone marrow
Siddhartha_Mukherjee
Cancer of plasma cells
treatment or prophylaxis for acute or chronic graft-versus-host disease in haematopoietic stem cell transplant (HSCT) recipients with a haematological condition"
Multiple_myeloma
Type of blood and immune-system cancer
Swerdlow SH (18 September 2017). WHO classification of tumours of haematopoietic and lymphoid tissues (Revised 4th ed.). Lyon: International Agency for
Hodgkin_lymphoma
Rare medical conditions that result in easy blistering of the skin and mucous membranes
with Hurler's syndrome transplanted from either related or unrelated haematopoietic stem cell sources". Bone Marrow Transplantation. 31 (12): 1105–17. doi:10
Epidermolysis_bullosa
Cell that differentiates into one or a few cell types
infection on the immune system. Inflammatory cytokines and other factors released during infections will activate haematopoietic progenitor cells to differentiate
Progenitor_cell
Family of inherited blood disorders
Retrieved 6 December 2024. Olson TS, Walters MC (October 2023). "Allogeneic haematopoietic stem-cell transplantation versus gene therapy for haemoglobinopathies"
Thalassemia
Cancer of the myeloid line of blood cells
The revised fourth edition of the WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues was released in 2016. This classification, based
Acute_myeloid_leukemia
Hematologic cancer that affects lymphocytes
Thiele, J., & Vardiman, J. W. (2008). WHO classification of tumours of haematopoietic and lymphoid tissues (Vol. 2, p. 439). S. H. Swerdlow (Ed.). Lyon, France:
Lymphoma
Drug made from biological source
activator) Hormones (insulin, glucagon, growth hormone, gonadotrophins) Haematopoietic growth factors (Erythropoietin, colony-stimulating factors) Interferons
Biopharmaceutical
Red blood cells separated for blood transfusion
with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem cell support". The Cochrane Database of Systematic Reviews. 5 (5)
Packed_red_blood_cells
Bone marrow cancer in which lymphocytes are overproduced
S2CID 73483725. Swerdlow SH (2017). WHO classification of tumours of haematopoietic and lymphoid tissues (Revised 4th ed.). Lyon: World Health Organization
Chronic_lymphocytic_leukemia
Hereditary blood disorder causing anemia
Retrieved 27 January 2025. "Clinical commissioning policy: allogeneic haematopoietic stem cell transplantation (Allo-HSCT) for adult transfusion dependent
Beta_thalassemia
Alternative medical procedure
versus alternative treatment for chronic graft-versus-host disease after haematopoietic stem cell transplantation in children and adolescents". The Cochrane
Blood_irradiation_therapy
Autoimmune disease resulting in skeletal muscle weakness
Burman J, Tolf A, Hägglund H, Askmark H (February 2018). "Autologous haematopoietic stem cell transplantation for neurological diseases". Journal of Neurology
Myasthenia_gravis
Biological term
PMC 12189941. PMID 40561015. Orkin SH (2000). "Diversification of haematopoietic stem cells to specific lineages". Nat. Rev. Genet. 1 (1): 57–64. doi:10
Hematopoietic_stem_cell_niche
Chemical compound
products, as reduced intensity conditioning treatment prior to allogeneic haematopoietic stem cell transplantation in malignant haematological diseases in adults
Melphalan
Old Stone Age ''Homo sapiens''
populations showed clustering in functional groups related to immune and haematopoietic pathways, while European populations showed clustering in functional
Early_modern_human
Kim J.; Weissman, Irving L. (April 2024). "Depleting myeloid-biased haematopoietic stem cells rejuvenates aged immunity". Nature. 628 (8006): 162–170.
2024_in_science
Acute inflammation diseases of the optic nerve and spinal cord
Burman J, Tolf A, Hägglund H, Askmark H (February 2018). "Autologous haematopoietic stem cell transplantation for neurological diseases". Journal of Neurology
Neuromyelitis optica spectrum disorder
Neuromyelitis_optica_spectrum_disorder
Genetic study of ancient Neanderthal DNA
populations showed clustering in functional groups related to complement and haematopoietic pathways, while Europeans showed clustering in functional groups related
Neanderthal_genetics
Blood production outside of the bone marrow
2017). "The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors". Nature. 544 (7648): 105–109. Bibcode:2017Natur.544..105L
Extramedullary_hematopoiesis
Type of cancer
bone marrow, and causes large numbers of abnormal blood cells "5.13 Haematopoietic and lymphoid malignancies". World Cancer Report 2014. World Health Organization
Leukemia
Obstruction of small blood vessels in the liver
review of its use in severe hepatic veno-occlusive disease following haematopoietic stem cell transplantation". Clinical Drug Investigation. 34 (12): 895–904
Hepatic veno-occlusive disease
Hepatic_veno-occlusive_disease
Blood in the placenta and umbilical cord after birth
clinical studies show that one year after the transplant of UM171 (a haematopoietic stem cell self-renewal agonist), transplant-related mortality was 5%
Cord_blood
Pharmaceutical drug
2016). "New perspectives on the use of mTOR inhibitors in allogeneic haematopoietic stem cell transplantation and graft-versus-host disease". British Journal
Sirolimus
Gene editing method
et al. (November 2016). "CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells". Nature. 539 (7629): 384–389. Bibcode:2016Natur.539..384D
CRISPR_gene_editing
Inherited blood disorder causing anemia
Retrieved 27 January 2025. "Clinical commissioning policy: allogeneic haematopoietic stem cell transplantation (Allo-HSCT) for adult transfusion dependent
Alpha-thalassemia
Species of crustacean
susceptibility to white spot syndrome, Taura syndrome, infectious hypodermal and haematopoietic necrosis, baculoviral midgut gland necrosis, and Vibrio infections.
Whiteleg_shrimp
Blood cancer characterized by overproduction of lymphoblasts
treatment or prophylaxis for acute or chronic graft-versus-host disease in haematopoietic stem cell transplant (HSCT) recipients with a haematological condition"
Acute_lymphoblastic_leukemia
Peptide hormone in animals
Caron KM, Frenette PS (January 2021). "Nociceptive nerves regulate haematopoietic stem cell mobilization". Nature. 589 (7843): 591–596. Bibcode:2021Natur
Calcitonin gene-related peptide
Calcitonin_gene-related_peptide
Medication
minimal direct in vivo or in vitro effects on the production of other haematopoietic cell types. Neupogen (filgrastim) is the name for recombinant methionyl
Filgrastim
Medical condition
adults receiving high-dose melphalan-based cancer treatment prior to haematopoietic stem cell transplantation, although there is uncertainty regarding the
Mucositis
Space surrounding blood vessels
PMID 8434012. Morrison, S. J; Scadden, D. T (2014). "The bone marrow niche for haematopoietic stem cells". Nature. 505 (7483): 327–334. Bibcode:2014Natur.505..327M
Perivascular_space
South Korean medical drama television series
registered applicants who wanted to donate organs, human tissues, and haematopoietic stem cells, which was 147,761 in 2019, decreased by 17,417 (11.8%) to
Hospital_Playlist
Extinct group of saber-toothed therapsids from the Permian
the Early Permian amphibians Seymouria and Discosauriscus likely had haematopoietic (red blood cell-producing) bone marrow in their limbs. Gorgonopsians
Gorgonopsia
Harald Stein; J.W. Vardiman (2001). Pathology and genetics of tumours of haematopoietic and lymphoid tissues. World Health Organization Classification of Tumors
List of hematologic conditions
List_of_hematologic_conditions
Medical treatment
levels of antibodies in the blood in people before or after allogeneic haematopoietic stem cell transplantation (a procedure where the patient's bone marrow
Immunoglobulin_therapy
Medical condition
treatments, require further research to determine their effectiveness. Haematopoietic stem cells (HSC) are cells in the bone marrow that can develop into
Sickle_cell_disease
Protein-coding gene in the species Homo sapiens
of normal chromosome stability that regulates the differentiation of haematopoietic stem cells into mature blood cells. Mutations involving the FANCA gene
Fanconi anemia group A protein
Fanconi_anemia_group_A_protein
Genetically inherited cancer of certain nerve tissues
van Dalen EC (October 2015). "High-dose chemotherapy and autologous haematopoietic stem cell rescue for children with high-risk neuroblastoma". The Cochrane
Neuroblastoma
Medical condition
Knol C, van Biezen A, Bresters D, et al. (October 2018). "Outcome of haematopoietic stem cell transplantation in dyskeratosis congenita". British Journal
Dyskeratosis_congenita
Hereditary disease group
TJ, et al. (April 2009). "Unrelated donor and HLA-identical sibling haematopoietic stem cell transplantation cure chronic granulomatous disease with good
Chronic_granulomatous_disease
Protein found in humans
cells, macrophages, basophils, NK cells, B lymphocytes, as well as non-haematopoietic cells (smooth muscle cells, endothelial cells, and epithelial cells)
CD154
Israeli psychoneuroimmunologist
Irving L.; de Lecea, Luis (2015-10-14). "Sleep disruption impairs haematopoietic stem cell transplantation in mice". Nature Communications. 6 (1): 8516
Asya_Rolls
Medication given to people before they have a bone marrow transplant
is indicated as part of conditioning treatment prior to allogeneic haematopoietic stem cell transplantation in adults with malignant and non malignant
Treosulfan
Component of blood aiding in coagulation
2017). "The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors". Nature. 544 (7648): 105–9. Bibcode:2017Natur.544..105L
Platelet
Medical technology
et al. (November 2016). "CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells". Nature. 539 (7629): 384–389. Bibcode:2016Natur.539..384D
Gene_therapy
American pathologist
Health Organization (WHO) publication, WHO Classification of Tumours of Haematopoietic and Lymphoid Tissue, that is part of a series on histological and genetic
Thomas_Grogan
HAEMATOPOIETIC SYSTEM
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