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Pharmaceutical drug
Hyftor (sirolimus gel) was authorized for topical treatment of facial angiofibroma in the European Union in May 2023. In the US, sirolimus, as Rapamune
Sirolimus
Drug that inhibits activity of immune system
Everolimus is an analog of sirolimus and also is an mTOR inhibitor. Zotarolimus is a semi-synthetic derivative of sirolimus used in drug-eluting stents
Immunosuppressive_drug
Corticosteroid medication
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Methylprednisolone
Drug interactions with grapefruit juice
ratio remained unchanged. Quetiapine (Seroquel) Repaglinide (Prandin) Sirolimus (Rapamycin, Rapamune) Tamoxifen (Nolvadex): Tamoxifen is metabolized by
Grapefruit–drug_interactions
Chemical compound
needed] It is the 40-O-(2-hydroxyethyl) derivative of sirolimus and works similarly to sirolimus as an inhibitor of mammalian target of rapamycin (mTOR)
Everolimus
Immunosuppressive drug
immunosuppressants discovered, preceded by the discovery of rapamycin (sirolimus) on Rapa Nui (Easter Island) in 1975. It is produced by a soil bacterium
Tacrolimus
Skin disease characterized by red, raised, and itchy bumps
medications (dapsone, sulfasalazine), immunosuppressants (cyclosporin, sirolimus) or other medications like omalizumab can be used. These options are explained
Hives
Type of drug-eluting stent
provide a "scaffold" to open the artery. An anti-rejection-type medication, sirolimus, helps to limit the overgrowth of normal cells while the artery heals
Cypher_stent
Medical implant to treat narrowed arteries
and the US Food and Drug Administration (FDA) were sirolimus-eluting stents (SES), releasing sirolimus, a natural immunosuppressant drug. SES were shown
Drug-eluting_stent
Progressive cystic lung disease
(mTORC1) led to successful use of rapamycin analog sirolimus in clinical trials and FDA approval of sirolimus for treatment of LAM. TSC1 and TSC2 form a tumor
Lymphangioleiomyomatosis
Rejection of host tissue by a transplanted organ's immune cells
substances that have been studied for GvHD treatment include, for example: sirolimus, pentostatin, etanercept, and alemtuzumab. In August 2017, the US FDA
Graft-versus-host_disease
Chemical compound
immunosuppressant, a macrocyclic lactone, a highly lipophilic derivative of sirolimus. This drug is proprietary to Biosensors International, which uses it in
Umirolimus
Chemical compound
Medicines Agency (EMA) in November 2007. It is a derivative and prodrug of sirolimus. Temsirolimus is a specific inhibitor of mTOR and interferes with the
Temsirolimus
Class of pharmaceutical drugs
sites for mTOR and FKBP12. The bacterial natural product rapamycin or sirolimus, a cytostatic agent, has been used in combination therapy with corticosteroids
MTOR_inhibitors
Benign nerve-sheath tumor in the peripheral nervous system
Sirolimus, a compound that inhibits mTOR signalling, is being studied to treat plexiform neurofibromas. The combination of erlotinib with sirolimus was
Neurofibroma
Malformations of the lymphatic system characterized by lesions that are thin-walled cysts
by damaging the endothelial lining of the abnormal lymphatic vessels. Sirolimus (rapamycin): An mTOR inhibitor that has emerged as an important medical
Lymphatic_malformations
Antibiotic derived from Penicillin
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Flucloxacillin
Excessive production of lymphocytes by the immune system
usually caused by the prolonged use of T cell suppressant drugs, such as sirolimus, tacrolimus, or ciclosporin. The Epstein-Barr virus, which infects >90%
Lymphoproliferative_disorders
Medical study concerned with the kidneys
cyclophosphamide, ciclosporin, tacrolimus, everolimus, thymoglobulin and sirolimus. Newer, so-called "biologic drugs" or monoclonal antibodies, are also
Nephrology
Antibiotic medication
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Rifaximin
Medical condition
after transplantation and on detection of CAV. Medications including sirolimus and everolimus can slow disease progression. A repeat heart transplantation
Cardiac allograft vasculopathy
Cardiac_allograft_vasculopathy
Rare genetic medical disorder with abnormal lymphocyte survival
drugs; however, sirolimus requires therapeutic drug monitoring and can cause mucositis. The goal serum trough is 5–15 ng/ml with Sirolimus and PCP prophylaxis
Autoimmune lymphoproliferative syndrome
Autoimmune_lymphoproliferative_syndrome
Antibiotic medication
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Rifampicin
Group of autoimmune diseases resulting in abnormal growth of connective tissue
cyclophosphamide, mycophenolate, intravenous immunoglobulin, rituximab, sirolimus, alefacept, and the tyrosine kinase inhibitors, imatinib, nilotinib, and
Scleroderma
Species of bacterium
natalensis) are antifungals isolated from Streptomyces.[citation needed] Sirolimus (Rapamycin), ascomycin, and tacrolimus were isolated from Streptomyces
Streptomyces_isolates
Antiretroviral medication
disopyramide, immunosuppressants such as tacrolimus, voclosporin and sirolimus, neuroleptics like lurasidone and pimozide, as well as some chemotherapeutic
Ritonavir
Indian-Canadian-American Scientist
scientist most widely known for his discovery and development of Rapamycin (Sirolimus), a immunosuppressant drug widely used in organ transplantation. Rapamycin
Surendra_Nath_Sehgal
Multinational medical technology manufacturer
platform features a unique abluminal groove-filled design that delivers sirolimus using a biodegradable polymer, with a lower drug and polymer load compared
MicroPort
Medical condition
chemicals. DIP has also been associated with certain drugs like marijuana, sirolimus, macrolides, nitrofurantoin, tocainide, and sulfasalazine. Disorders,
Desquamative interstitial pneumonia
Desquamative_interstitial_pneumonia
Condition in which a male has abnormally low semen volume
of scientific evidence are still insufficient (with the exception of Sirolimus, Sulfasalazine, exogenous testosterone, Finasteride and Cyproterone acetate
Hypospermia
Species of bacterium
hygroscopicus can be used to produce several chemical compounds or enzymes. Sirolimus (also known as rapamycin) is an antifungal and immunosuppressant that
Streptomyces_hygroscopicus
Spanish cardiologist (born 1943)
Jose; Fuster, Valentin (2002). "Viewpoint Overcoming restenosis with sirolimus: From alphabet soup to clinical reality". The Lancet. 359 (9306): 619–622
Valentín_Fuster
Italian American surgeon
long-term trial of tacrolimus/sirolimus versus tacrolimus/mycophenolate mofetil versus cyclosporine (NEORAL)/sirolimus in renal transplantation. Ii. Survival
Gaetano_Ciancio
Medical condition
after, in particular, high-dose therapy. Immunosuppressive drugs, such as sirolimus, mycophenolate mofetil, tacrolimus, ciclosporin, leflunomide and TNF inhibitors
Leukopenia
Opioid medication
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Fentanyl
Island in the southeastern Pacific
island View of Rano Kau and Pacific Ocean The immunosuppressant drug sirolimus was first discovered in the bacterium Streptomyces hygroscopicus in a
Easter_Island
American multinational pharmaceutical and biotechnology corporation
acquired by Pfizer in 2009, alleging that the company illegally marketed sirolimus (Rapamune) for off-label uses, targeted specific doctors and medical facilities
Pfizer
Transference of pancreatic islets
(Zenapax), sirolimus (Rapamune) and tacrolimus (Prograf). Daclizumab is given intravenously right after the transplant and then discontinued. Sirolimus and tacrolimus
Islet_cell_transplantation
Israeli biotech company
Alternariol, Alternariol methyl ether Immunomodulators: Tacrolimus, Sirolimus, Ascomycin, Myriocin Ionophores: Valinomycin, Nonactin, Ionomycin Special
Fermentek
Medication to treat gastroesophageal reflux disease and other conditions
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Omeprazole
Antibiotic
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Tetracycline
Surgical procedure in which a patient's diseased lungs are partially or totally replaced
in the US demonstrated significantly improved long-term survival using sirolimus + tacrolimus (median survival 8.9 years) instead of mycophenolate mofetil
Lung_transplantation
Medication against high blood pressure
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Amlodipine
Medical condition
cryoablation may offer an effective control of pain in FAVA lesions. Sirolimus has been effective in improving the quality of life in some people with
Fibro-adipose vascular anomaly
Fibro-adipose_vascular_anomaly
Medication of the barbiturate type
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Phenobarbital
Medical condition
vincristine, propranolol, octreotide, aminocaproic acid, bevacizumab, and/or sirolimus are available. Skin lesion List of cutaneous conditions Rapini, Ronald
Multifocal lymphangioendotheliomatosis
Multifocal_lymphangioendotheliomatosis
Triazole antifungical drug
Voriconazole should not be used in conjunction with many drugs (including sirolimus, rifampicin, rifabutin, carbamazepine, quinidine and ergot alkaloids)
Voriconazole
Chemical compound
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Cafestol
Chemical compound
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Clotrimazole
Medical intervention
drug-eluting stents to be utilized were the paclitaxel-eluting stent and the sirolimus-eluting stent, both of which have received approval from the U.S. Food
Percutaneous coronary intervention
Percutaneous_coronary_intervention
antibody coating of the Genous Stent with antiproliferative sirolimus elution. The sirolimus drug reduces the risk of stent restenosis through inhibiting
Dual_therapy_stent
doxorubicin, paclitaxel, docetaxel, etoposide, dactinomycin, carfilzomib, sirolimus (rapamycin), imatinib (Gleevec), sunitinib, trifluridine, and aminolevulinic
GT198
Swelling of gums due to side effect of medications
Phenytoin Sodium valproate Immunoregulating drugs Ciclosporine Tacrolimus Sirolimus Calcium channel blockers Nifedipine Verapamil Diltiazem Amlodipine Felodipine
Drug-induced gingival enlargement
Drug-induced_gingival_enlargement
Protein-coding gene in humans
isomerase that binds to the immunosuppressants tacrolimus (FK506) and sirolimus (rapamycin). It is thought to mediate calcineurin inhibition. It also
FKBP5
Typical antipsychotic medication
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Chlorpromazine
Atypical antidepressant
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Tianeptine
Natural organic compounds derived from a [C(O)–CH2] chain
The immunosuppressants tacrolimus (FK506) (a calcineurin inhibitor) and sirolimus (rapamycin) (a mTOR inhibitor) Radicicol and the pochonin family (HSP90
Polyketide
Antibiotic
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Clindamycin
Cypriot-American chemist (born 1946)
(1982) Amphoteronolide B and Amphotericin B (1987) Calicheamicin γ1 (1992) Sirolimus (1993) Taxol (1994) Zaragozic acid A (1994) Brevetoxin B (1995) Vancomycin
Kyriacos_Costa_Nicolaou
Pharmaceutical compound
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Indinavir
Medical condition
cyclosporine and tacrolimus, and least with mTOR inhibitors, such as sirolimus and everolimus. The antimetabolites azathioprine and mycophenolic acid
Cutaneous squamous-cell carcinoma
Cutaneous_squamous-cell_carcinoma
Chemical stimulant produced by some plants
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Nicotine
Chemical compound
is running a clinical trial to research the effects of auranofin and sirolimus on squamous, ras mutated lung adenocarcinoma, and small cell lung cancer
Auranofin
Chemical compound
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Fenbendazole
Dormant volcano in Easter Island
coming out of the crater wall. Geography portal List of volcanoes in Chile Sirolimus "Rano Kau". Rapa Nui Travel Guide. Retrieved 17 February 2026. "Volcanoes
Rano_Kau
Medical condition
immunosuppressive drugs such as infliximab, tacrolimus, 6-mercaptopurine, sirolimus, azathioprine, mycophenolate mofetil, rituximab, and cyclosporine have
Autoimmune_enteropathy
Thyroid hormone medication
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Levothyroxine
Antihistamine medication
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Loratadine
Medical condition
Akbal, Erdem; Can, Murat; Duranay, Murat (April 15, 2012). "Effect of sirolimus on the regression of peritoneal sclerosis in an experimental rat model"
Encapsulating peritoneal sclerosis
Encapsulating_peritoneal_sclerosis
Reduction of average diameter of a solid's particles
several U.S. Food and Drug Administration–approved products, including sirolimus (Rapamune oral tablet, approved 2000), aprepitant (Emend, 2003), fenofibrate
Micronization
Tumor originating in adipose (fat) tissue
trial is nearing completion to evaluate the efficacy of sirolimus (an inhibitor of MTOR; sirolimus is also known as rapamycin) plus cyclophosphamide (a chemotherapy
Liposarcoma
Blood pressure medication
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Telmisartan
Medical condition
immunosuppression.Drugs used include:[citation needed] Cyclosporin A Tacrolimus Sirolimus Rituximab Currently, the standard treatment for IPEX is a bone marrow
IPEX_syndrome
Flowering plant in the St John's wort family
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Hypericum_perforatum
Family of multi-domain enzymes that produce polyketides
by polyketide synthases. Other industrially important polyketides are sirolimus (immunosuppressant), erythromycin (antibiotic), lovastatin (anticholesterol
Polyketide_synthase
Laxatives/stool softeners
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Docusate
Medication and insecticide
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Permethrin
Branch of pharmacology
Ethosuximide Phenobarbital Primidone Digoxin Lidocaine Ciclosporin Tacrolimus Sirolimus Everolimus Mycophenolate Gentamicin Tobramycin Amikacin Vancomycin Bronchodilator
Pharmacokinetics
Corticosteroid medication
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Dexamethasone
Genetic disorder that causes early aging
rim, and it now has a more normal state.[citation needed] Studies of sirolimus, an mTOR Inhibitor, demonstrate that it can minimize the phenotypic effects
Progeria
Mammalian protein found in humans
respectively, leading to full activation of IGF-IR and InsR. Rapamycin (Sirolimus) inhibits mTORC1, resulting in the suppression of cellular senescence
MTOR
oligomycins MeSH D02.540.505.620.750 – rutamycin MeSH D02.540.505.760 – sirolimus MeSH D02.540.505.810 – tacrolimus MeSH D02.540.505.905 – tylosin MeSH D02
List_of_MeSH_codes_(D02)
Anticonvulsant medication
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Carbamazepine
Corticosteroid medication
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Prednisolone
Chemotherapy medication
instead of conventional advertising. Combination therapy experiments with sirolimus (rapamycin) and doxorubicin have shown promise in treating Akt-positive
Doxorubicin
Lipid-lowering medication
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Simvastatin
Medical condition
Medication is also used to treat this disease, including Octreotide, Sirolimus, Anti-plasmin and, at least in one case, Trametinib. Dog breeds commonly
Lymphangiectasia
Species of bacterium
from soil from the Easter Island. Streptomyces rapamycinicus produces sirolimus. List of Streptomyces species LPSN bacterio.net UniProt Deutsche Sammlung
Streptomyces_rapamycinicus
Medical condition
Medication is also used to treat this disease, including octreotide, sirolimus, anti-plasmin and, at least in one case, trametinib. The disease was first
Waldmann_disease
Sensory neuropathy caused by damage of nerve cells in the dorsal root ganglion
immunoglobulin therapy, plasma exchange, cyclophosphamide, rituximab and sirolimus. Immunomodulatory treatments are more efficacious if started early in
Sensory_neuronopathy
Sex hormone
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Progesterone
Antifungal chemical compound
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Ketoconazole
Medication used for cancer
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Paclitaxel
Pharmaceutical drug classification
L01EG01 Temsirolimus L01EG02 Everolimus L01EG03 Ridaforolimus L01EG04 Sirolimus L01EH01 Lapatinib L01EH02 Neratinib L01EH03 Tucatinib L01EH04 Zongertinib
ATC_code_L01
Psychoactive component of cannabis
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Tetrahydrocannabinol
Medical condition
tumor); and in individuals with tuberous sclerosis, topical application of sirolimus, i.e. rapamycin, (1% solution). Some of the latter methods have been used
Koenen's_tumor
Efficacy of Sirolimus Trial (The MILES Trial)". ClinicalTrials.gov (NIH). 6 January 2007. Retrieved 10 January 2007. "Sirolimus in Treating Patients
Timeline of tuberous sclerosis
Timeline_of_tuberous_sclerosis
Group of drugs used against malaria
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Artemisinin
Medical device company based in Singapore
lactic acid. The Biolimus A9 drug, a highly lipophilic derivative of sirolimus. The S-Stent stent platform. An automated stent coating technology that
Biosensors_International
Chemical compound
triiodothyronine Rifampicin Rifaximin Rimexolone Riodipine Ritonavir Simvastatin Sirolimus Spironolactone Spiroxatrine SR-12813 Suberoylanilide Sulfisoxazole Suramin
Meclizine
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