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Medical condition
Sickle cell disease (SCD), also simply called sickle cell, is a group of inherited hemoglobin-related blood disorders. Sickle cell disease is caused by
Sickle_cell_disease
Medical condition
symptoms of sickle cell disease that occur in a person who has two copies of that allele (is homozygous). Those who are heterozygous for the sickle cell allele
Sickle_cell_trait
Medical condition where an erection lasts excessively long
only somewhat hard. Very rarely, clitoral priapism occurs in women. Sickle cell disease is the most common cause of ischemic priapism. Other causes include
Priapism
Gene therapy
brand name Casgevy, is a gene therapy used for the treatment of sickle cell disease and transfusion-dependent beta thalassemia. It was developed by Vertex
Exagamglogene_autotemcel
Amino acid
oral powder, marketed as Endari, to reduce severe complications of sickle cell disease in people aged five years and older with the disorder. The safety
Glutamine
Infection of the bones
the best antibiotic treatment is for osteomyelitis in people with sickle cell disease as of 2019. Hemicorporectomy is performed in severe cases of Terminal
Osteomyelitis
Disorders of the blood and related organs
Hematologic diseases include rare genetic disorders, anemia, HIV, sickle cell disease and complications from chemotherapy or transfusions. Hemoglobinopathies
Hematologic_disease
2024 British television series
British people, unified by family history of sickle cell disease. The sickle cell issues manifest as a super cell ("supacell") in their bodies when they unexpectedly
Supacell
Medical condition
state is called hemoglobin SC disease, and is generally more severe than hemoglobin C disease, but milder than sickle cell anemia. HbC was discovered by
Hemoglobin_C
Medical condition
trait, HbD-thalassemia, HbS-D (sickle cell) disease, and, very rarely, homozygous (inherited in both chromosome 11) HbD disease. It is the fourth hemoglobin
Hemoglobin_D
Assembly of proteins inside biological cells
red blood cells responsible for transporting oxygen. The most dangerous of the sickle cell diseases is known as sickle cell anemia. Sickle cell anemia is
Protein_biosynthesis
Oxygen carrier protein in the human fetus
Hydroxyurea in sickle-cell disease (archived December 28, 2014 at [2]) Chapter 26 Fetal Hemoglobin Induction; Management of Sickle-Cell Disease 4th Edition
Fetal_hemoglobin
British medical researcher (1938–2025)
1938 – 25 March 2025) was a British medical researcher who studied sickle-cell disease in Jamaica, setting up screening programmes and a cohort study from
Graham_Roger_Serjeant
Normal human hemoglobin in adults
symptoms of sickle cell disease. However, HbAS does not cause vaso-occlusive crisis, which is known to be associated with sickle cell disease. Patients
Hemoglobin_A
Human genetic adaptation
inherited disease. Therefore, they are commonly referred to by the names of the blood disorders associated with them, including sickle-cell disease, thalassemia
Human genetic resistance to malaria
Human_genetic_resistance_to_malaria
Medical condition
Sickle cell nephropathy is a type of kidney disease associated with sickle cell disease which causes kidney complications as a result of sickling of red
Sickle_cell_nephropathy
American lawyer
Environmental Contributions to Sickle Cell Disease and Leg Ulcers Study), a longitudinal interdisciplinary study exploring sickle cell disease in adults that covers
Vence_L._Bonham_Jr.
Medical technology
focused on diseases caused by single-gene defects, such as cystic fibrosis, haemophilia, muscular dystrophy, thalassemia, and sickle cell anemia. alipogene
Gene_therapy
Malaysian haematologist
works on the pathophysiology of haemoglobin disorders including sickle cell disease and thalassemia. Thein was born in 1952 in Kuala Lumpur, Malaysia
Swee_Lay_Thein
Medication
treatment of sickle cell disease. Voxelotor is the first hemoglobin oxygen-affinity modulator. Voxelotor has been shown to have disease-modifying potential
Voxelotor
Hereditary blood disorder causing anemia
with sickle cell disease (a fault in the beta globin gene), and followed by clinical trials in which a number of patients with either sickle cell or beta
Beta_thalassemia
1949 scientific paper by Linus Pauling et al.
"Sickle Cell Anemia, a Molecular Disease" is a 1949 scientific paper by Linus Pauling, Harvey A. Itano, Seymour J. Singer and Ibert C. Wells that established
Sickle Cell Anemia, a Molecular Disease
Sickle_Cell_Anemia,_a_Molecular_Disease
Exchange and transfusion blood
transfusion is used in the treatment of a number of diseases, including sickle-cell disease and hemolytic disease of the newborn. Partial exchange might be required
Exchange_transfusion
Medical condition
the sickle cell disease to be less severe. In essence, the HbF inhibits polymerization of HbS. A similar mechanism occurs with persons who have sickle cell
Hereditary persistence of fetal hemoglobin
Hereditary_persistence_of_fetal_hemoglobin
Loss of function of the spleen
to infection. Autosplenectomy can occur in cases of sickle-cell disease where the misshapen cells block blood flow to the spleen, causing scarring and
Autosplenectomy
blood cells (erythrocytes) from donors contain normal hemoglobin (HbA), and transfusion of normal red blood cells into people with sickle cell disease reduces
Transfusion therapy (Sickle-cell disease)
Transfusion_therapy_(Sickle-cell_disease)
Member of Provincial Parliament for Barrie-Innisfil
March 1, 2020, Khanjin and Cuzzetto introduced an Act to proclaim Sickle Cell Disease Awareness Day and Thalassemia Awareness Day, and; she co-sponsored
Andrea_Khanjin
Medical condition
PMC 299598. PMID 2825199. "Sickle Cell Disease". medlineplus.gov. Retrieved 2025-09-19. "Sickle cell anemia-Sickle cell anemia". Mayo Clinic. March 9
Congenital_hemolytic_anemia
Gene editing method
was officially approved for use in the United Kingdom, to cure sickle-cell disease and beta thalassemia. On 2 December 2023, the Kingdom of Bahrain
CRISPR_gene_editing
Any of various genetic disorders of blood
one gene for hemoglobin S (sickle cell) and one gene for hemoglobin C, The symptoms are very similar to sickle cell disease. Hemoglobin variants are not
Hemoglobinopathy
Cancer affecting the kidneys
individuals with this type of cancer have sickle cell trait or rarely sickle cell disease, suggesting that the sickle cell trait may be a risk factor for this
Renal_medullary_carcinoma
PMID 35274702. "Sickle cell disease: MedlinePlus Genetics". medlineplus.gov. Retrieved 2025-04-05. Tebbi, Cameron K. (2022-05-30). "Sickle Cell Disease, a Review"
Human_β-globin_locus
Red rash due to infection with parvovirus B19
cause prolonged anemia in the affected individuals. In people with sickle-cell disease or other forms of chronic hemolytic anemia, a blood disorder, the
Fifth_disease
Gene therapy
Lyfgenia, is a lentiviral gene therapy used for the treatment of sickle cell disease. The most common side effects include stomatitis (mouth sores of
Lovotibeglogene_autotemcel
American hematologist and professor (1930–2019)
research team that discovered the first effective treatment for sickle cell disease, a painful and sometimes fatal blood disorder that mainly affects
Samuel_Charache
Medication
in sickle-cell disease, essential thrombocythemia, chronic myelogenous leukemia, polycythemia vera, and cervical cancer. In sickle-cells disease it increases
Hydroxycarbamide
American football former player (born 1979)
Steelers in Super Bowl XLIII, and made a Pro Bowl in 2011. Clark has a sickle cell trait condition which made it dangerous for him to play at high altitudes
Ryan Clark (American football)
Ryan_Clark_(American_football)
Mammalian protein found in Homo sapiens
disorders such as sickle-cell disease and beta thalassemia, as well as beneficial traits such as genetic resistance to malaria. At least 50 disease-causing mutations
Hemoglobin_subunit_beta
Medical condition
Sickle cell retinopathy can be defined as retinal changes due to blood vessel damage in the eye of a person with a background of sickle cell disease. It
Sickle_cell_retinopathy
Influence of a single gene on multiple phenotypic traits
Sickle Cell Disease?". NHLBI. Retrieved 2024-08-05. "Mutations and Disease". The Tech Interactive. Archived from the original on 2012-05-11. "Sickle cell
Pleiotropy
Biological entity that causes disease in its host
dust, genetic disorders like sickle cell disease, and autoimmune diseases like lupus. Pathogenicity is the potential disease-causing capacity of pathogens
Pathogen
Metalloprotein that binds with oxygen
cause no disease, but some cause a group of hereditary diseases called hemoglobinopathies. The best known hemoglobinopathy is sickle-cell disease, which
Hemoglobin
Procedure widely used in eye surgery
Moe, Soe; Ni, Han (2022-12-12). "Laser therapy for retinopathy in sickle cell disease". The Cochrane Database of Systematic Reviews. 2022 (12) CD010790
Laser_coagulation
Swiss-American biotechnology company
various diseases including sickle cell disease, beta thalassemia, various cancers, type 1 diabetes, and cardiovascular diseases. The CEO is Samarth Kulkarni
CRISPR_Therapeutics
Marfan syndrome Niemann–Pick disease[citation needed] Phenylketonuria Porphyria Retinoblastoma[citation needed] Sickle-cell disease Sanfilippo syndrome[citation
Mendelian_traits_in_humans
Currently disadvantageous part of the genome
As a recessive gene, Sickle-cell disease is only present if homozygous, with no dominant gene to beat them out. Sickle-cell disease, originating in people
Evolutionary_baggage
Stroke with no outward symptoms associated with stroke
cells in sickle cell disease are abnormally shaped (sickle-shaped) and may form clots or block blood vessels. Estimates of children with sickle cell anemia
Silent_stroke
Rupturing of red blood cells and release of their contents
genetic disorders (e.g., Sickle-cell disease or G6PD deficiency), or blood with too low a solute concentration (hypotonic to cells). Hemolysis can lead to
Hemolysis
Genetic point mutation that results in an amino acid change in a protein
notable examples of human diseases caused by missense mutations are Rett syndrome, cystic fibrosis, and sickle-cell disease. Missense mutation refers
Missense_mutation
British geneticist (1925–2014)
groups and genetic markers such as for sickle-cell disease. At the time it was a scientific puzzle that the disease was prevalent even though it killed people
Anthony_Clifford_Allison
Family of inherited blood disorders
with sickle cell disease (a fault in the beta globin gene), and followed by clinical trials in which a number of patients with either sickle cell or beta
Thalassemia
Disease characterized by constriction of brain arteries
hemoglobinopathies, such as sickle cell disease, are known to cause a syndrome which is clinically similar to moyamoya disease, but which is due to occlusion
Moyamoya_disease
Medical condition
similar to sickle cell disease. Patients with sickle cell-beta thalassemia may present with painful crises similar to patients with sickle cell disease[citation
Sickle_cell-beta_thalassemia
Exagamglogene autotemcel (Casgevy): treatment for sickle cell disease. Gendicine: treatment for head and neck squamous cell carcinoma Idecabtagene vicleucel (Abecma):
List_of_gene_therapies
American anthropologist
Press, 2004) Uncertain Suffering: Racial Healthcare Disparities and Sickle Cell Disease (University of California Press, 2009) Televised Redemption: Black
Carolyn_Rouse
Potentially lethal blockage of lung vasculature in sickle cell anaemia
vaso-occlusive crisis of the pulmonary vasculature commonly seen in people with sickle cell anemia. This condition commonly manifests with a new opacification of
Acute_chest_syndrome
Pharmaceutical compound
that is being evaluated by FORMA Therapeutics for the treatment of sickle cell disease and thalassemia. It is an allosteric activator of the erythrocyte
Etavopivat
focuses on benign hemoglobinopathies, particularly thalassemia and sickle cell disease. His work has helped advance both clinical care and research in the
Ali_T._Taher
Ghanaian physician-scientist (1930–2025)
Haemoglobinopathy/Sickle Cell States, in Harley Street, London. He was one of the world's foremost experts on sickle-cell disease. Felix Israel Domeno
Felix_Konotey-Ahulu
Artist and sickle cell advocate
the lived experience of sickle cell disease, Black identity, and social justice. As a person living with sickle cell disease, Nazaire became a prominent
Hertz_Nazaire
2019 documentary film
sickle cell disease at its genetic source. Porteus is set to start a clinical trial at Stanford University using CRISPR to treat sickle cell disease.
Human_Nature_(2019_film)
Form of sickle cell crisis in sickle cell anaemia
common painful complication of sickle cell anemia in adolescents and adults. It is a form of sickle cell crisis. Sickle cell anemia – most common in those
Vaso-occlusive_crisis
The Sickle Cell Disease Association of America, Inc. (SCDAA) is a nonprofit organization with the sole purpose of supporting research, education and funding
Sickle Cell Disease Association of America
Sickle_Cell_Disease_Association_of_America
Spirit in Igbo mythology
once unknown diseases that often claimed the lives of children (such as SIDS and sickle cell disease), as the inheritance of these diseases within families
Ogbanje
Absence of pain management therapy
pain were prescribed them. Around 100,000 Americans are affected by sickle cell disease (SCD), the majority of whom are of African or Hispanic descent, and
Undertreatment_of_pain
American physician
practiced and taught in Chicago. He is credited with the description of sickle-cell disease and was one of the first physicians to describe the symptoms of myocardial
James_B._Herrick
Organizations advocating for people affected by sickle cell disease in Africa
development related to sickle cell disease (SCD) across the African continent. Africa bears the largest global burden of sickle cell disease, accounting for
Sickle cell advocacy organizations in Africa
Sickle_cell_advocacy_organizations_in_Africa
Class of pharmaceutical drugs
hypertension, systemic sclerosis, and sickle cell disease. In 1998, the role of nitric oxide (NO) in cardiovascular disease received the Nobel Prize in Physiology
Soluble guanylate cyclase stimulator
Soluble_guanylate_cyclase_stimulator
First patient to be treated by gene-editing
CRISPR for sickle-cell disease. This marked the initial indication that a cure is attainable for individuals born with sickle-cell disease and another
Victoria_Gray
Routine laboratory test of blood cells
example, the presence of sickle cells is indicative of sickle cell disease, and a high number of fragmented red blood cells (schistocytes) requires urgent
Complete_blood_count
Oxygen-delivering blood cell and the most common type of blood cell
B12 is needed for the production of red blood cells and hemoglobin. Sickle-cell disease is a genetic disease that results in abnormal hemoglobin molecules
Red_blood_cell
American pharmaceutical company
sickle cell disease and cerebral adrenoleukodystrophy. It is also developing T cell product candidates to treat acute myeloid leukemia, Merkel-cell carcinoma
Bluebird_bio
American biotechnology company
ristoglogene autogetemcel, a CRISPR-based gene therapy for treatment of sickle cell disease. CRISPR Therapeutics Editas Medicine Intellia Therapeutics Prime
Beam_Therapeutics
American pathologist (1900–1995)
for sickle cell disease at the University, which later endowed a Professor of Medicine position named after him. His Morphology of Human Blood Cells, which
Lemuel_Diggs
Inflammation of the alveoli of the lungs
pneumonia include cystic fibrosis, chronic obstructive pulmonary disease (COPD), sickle cell disease, asthma, diabetes, heart failure, a history of smoking, a
Pneumonia
Monoclonal antibody
painful complication of sickle cell disease that occurs when blood circulation is obstructed by sickled red blood cells (red cells are usually round and
Crizanlizumab
Blood test
hemoglobin. The test can detect hemoglobin S, the form associated with sickle cell disease, as well as other abnormal types of hemoglobin, such as hemoglobin
Hemoglobin_electrophoresis
Ghanaian physician
Isaac Odame is a Ghanaian academic and physician who specialises in sickle cell disease. He is a professor of Hematology and Oncology at the Paediatrics
Isaac_Odame
Gene therapy
improved lentiviral vector for the treatment of β-thalassemia and sickle cell disease" (PDF). Current Gene Therapy. 15 (1): 64–81. doi:10.2174/1566523214666141127095336
Betibeglogene_autotemcel
Health problem from genome abnormalities
acyl-CoA dehydrogenase deficiency, cystic fibrosis, sickle cell disease, Tay–Sachs disease, Niemann–Pick disease, spinal muscular atrophy, and Roberts syndrome
Genetic_disorder
American hematologist
factors, and pioneering gene therapy and gene editing approaches for sickle cell disease and thalassemia. He is a member of the National Academy of Sciences
Stuart_Orkin
2007 nonfiction book by Harriet A. Washington
Academy barring cadets. Sickle cell disease is recessive, meaning individuals must inherit two genes to develop the disease. The genetic screenings were
Medical_Apartheid
the case of sickle cell disease. Each person has two sets of genes, one set inherited from the father, one from the mother. Sickle cell anemia is a blood
Price_equation_examples
Type of jaundice
causes include: Sickle cell disease, in which a mutation in the globin gene causes the formation of sickle hemoglobin. This disease is marked by the
Hemolytic_jaundice
ischemic stroke, acute kidney injury, trauma, circulatory arrest, sickle cell disease and sleep apnea. Whether resulting from traumatic vessel disruption
Ischemia-reperfusion injury of the appendicular musculoskeletal system
Ischemia-reperfusion_injury_of_the_appendicular_musculoskeletal_system
American singer (1944–1980)
lupus, and still suffering from sickle cell disease. Her doctor advised her to leave show business for good, as the disease worsened. She continued to work
Georgeanna_Tillman
Monoclonal antibody
against P-selectin being developed primarily for the treatment of sickle cell disease with vaso-occlusive crises. Inclacumab is a recombinant monoclonal
Inclacumab
American singer (born 1970)
opened up to the public about the disease in 1996; she later became one of the spokespersons for Sickle Cell Disease Association of America. In 2002, she
Tionne_Watkins
Medical condition
postinfection, iatrogenic, or secondary to a systemic disease such as cancer, sickle cell disease, pseudohyperparathyroidism, Turner's syndrome, Down syndrome
Brachymetatarsia
Part of the eye; protective outer layer covering the sclera
Pinguecula Pterygium Rougine Subconjunctival hemorrhage Diabetes Sickle-cell disease Slit lamp Sagittal section through the upper eyelid Extrinsic eye
Conjunctiva
British charity group
The Sickle Cell Society, established as a registered charity in 1979, was founded by a group of people with sickle cell disease, their parents and their
The_Sickle_Cell_Society
Blood that has been modified for therapeutic or other purposes
cells are then able to produce red blood cells with the factors which promote proper red blood cell shape reducing the effects of sickle cell disease
Gene therapy for blood diseases
Gene_therapy_for_blood_diseases
American pediatrician (1925–2026)
an American pediatrician known for her groundbreaking research on sickle cell disease. While studying the normal developement of African American children
Angella_D._Ferguson
American actor (born 1975)
Michael Jackson biopic Michael. Tate is a national spokesman for sickle cell disease. Willis, John; Monush, Barry (April 1, 2006). Screen World: 2005
Larenz_Tate
American nonprofit scientific research institute
use of CRISPR to address severe combined immunodeficiency disease and sickle cell disease. The IGI partnered with AstraZeneca and Agilent Technologies
Innovative_Genomics_Institute
Efforts to decrease the girth or length of the human penis
macrophallic penile dimensions. The causes of macrophallism can range from sickle cell disease to priapism. The age range of individuals who have undergone treatment
Penis_reduction
1182/blood.V82.2.656.656. PMID 8329719. Retrieved 7 April 2011. "What Is Sickle Cell Disease?". National Heart, Lung, and Blood Institute. 30 September 2024.
List of hematologic conditions
List_of_hematologic_conditions
Nigerian pharmacist and academic
clinical trials, drug interaction PK/PD, and non-communicable diseases (Sickle cell disease and cancer). She developed a High-performance liquid chromatography
Chinedum_Babalola
American physician
Services Administration. She is most famous for her work studying sickle cell disease (SCD). Marilyn Hughes Gaston was born in 1939 in Cincinnati, Ohio
Marilyn_Gaston
Variant of hemoglobin A
hemoglobin molecules) and is approximately normal in people with sickle-cell disease. Its biological importance is not yet known. HbA2 may seem physiologically
Hemoglobin_A2
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