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Search references for RUNX1. Phrases containing RUNX1
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Protein-coding gene in humans
Runt-related transcription factor 1 (RUNX1) also known as acute myeloid leukemia 1 protein (AML1) or core-binding factor subunit alpha-2 (CBFA2) and it
RUNX1
Medical condition
RUNX1 familial platelet disorder (RUNX1-FPD), also known as familial platelet disorder with associated myeloid malignancies (FPDMM), is a rare inherited
RUNX1 familial platelet disorder
RUNX1_familial_platelet_disorder
their expression of Ly6A-GFP (Sca1), CD31, CD34, cKit, CD27, CD41, Gata2, Runx1, Notch1, and BMP amongst others. The aorta-gonad-mesonephros (AGM) region
Aorta-gonad-mesonephros
Blood cancer characterized by overproduction of lymphoblasts
specific abnormality in childhood B-ALL is the t(12;21) ETV6–RUNX1 translocation, in which the RUNX1 gene, encoding a protein involved in transcriptional control
Acute_lymphoblastic_leukemia
Tumors that affect the blood, bone marrow, lymph, and lymphatic system
neoplasms with germline DDX41 mutation Myeloid neoplasms with germline RUNX1 mutation Myeloid neoplasms with germline ANKRD26 mutation Myeloid neoplasms
Tumors of the hematopoietic and lymphoid tissues
Tumors_of_the_hematopoietic_and_lymphoid_tissues
Pharmaceutical compound
selective inhibitor of the protein Runt-related transcription factor 1 (RUNX1). Inhibition of this protein is useful in numerous medical applications
Ro5-3335
Evolutionary conserved protein domain
The Runt domain is an evolutionary conserved protein domain. The AML1/RUNX1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia
Runt_domain
Chemical compound
disrupts protein-protein interaction between CBFβ-SMMHC and tumor suppressor RUNX1. This inhibitor is under development as an anti-leukemic drug. Core-binding
AI-10-49
Type of transcription factor
(InterPro: IPR003417) Human: CBFB a DNA-binding CBFα chain (InterPro: IPR016554) Human: RUNX1, RUNX2, RUNX3 de Bruijn M, Speck N (2004). "Core-binding factors in hematopoiesis
Core_binding_factor
Genetic disorder
ABL; 22 BCR) Acute myeloblastic leukemia with maturation t(8 RUNX1T1;21 RUNX1) Acute promyelocytic leukemia t(15 PML,17 RARA) Acute megakaryoblastic leukemia
Down_syndrome
Cancer of the myeloid line of blood cells
c-KIT pharmacologically. It is expected that additional markers (e.g., RUNX1, ASXL1, and TP53) that have consistently been associated with an inferior
Acute_myeloid_leukemia
Medical condition
acute myeloid leukemia is the formation of a fusion protein, AML1-ETO or RUNX1-RUNX1T1, due to a translocation of chromosome 8 to chromosome 21 or t(8;21)
Acute myeloblastic leukemia with maturation
Acute_myeloblastic_leukemia_with_maturation
Protein-coding gene in the species Homo sapiens
each other in the promoter sequence site. Near the start of transcription, RunX1 and Bcl11B are found opposite in the double strand, indicating competition
C6orf118
X chromosome monosomy
ABL; 22 BCR) Acute myeloblastic leukemia with maturation t(8 RUNX1T1;21 RUNX1) Acute promyelocytic leukemia t(15 PML,17 RARA) Acute megakaryoblastic leukemia
Turner_syndrome
Medical condition
hemophagocytosis. These translocations yield the formation of chimeric proteins (RUNX1-RUNX1T1 and PML-RARA, respectively) which disrupt normal myeloid precursor
Acute_monocytic_leukemia
Natural premature termination of pregnancy
ABL; 22 BCR) Acute myeloblastic leukemia with maturation t(8 RUNX1T1;21 RUNX1) Acute promyelocytic leukemia t(15 PML,17 RARA) Acute megakaryoblastic leukemia
Miscarriage
Medical condition
mutation is found in 10% of cases. Mutations in transcription factors such as RUNX1, CEBPA, NPM1, and WT1 have been found in up to 30% of cases. Mutations of
Chronic myelomonocytic leukemia
Chronic_myelomonocytic_leukemia
Diverse collection of blood-related cancers
with germ line predisposition and organ dysfunction includes CEBPA/DDX41/RUNX1 disorders, GATA2 deficiency and SAMD9/9L syndromes. The goals of therapy
Myelodysplastic_syndrome
Condition present at birth regardless of cause
ABL; 22 BCR) Acute myeloblastic leukemia with maturation t(8 RUNX1T1;21 RUNX1) Acute promyelocytic leukemia t(15 PML,17 RARA) Acute megakaryoblastic leukemia
Birth_defect
Biological term
HSC production, Runx1 overexpression in the zebrafish mutant mindbomb that lacks Notch signaling rescues HSC production, suggesting Runx1 is downstream
Hematopoietic_stem_cell_niche
Protein-coding gene in humans
which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory
CBFB
Persistence of some cancer cells during remission
translocations such as t(9;22) BCR-ABL, t(15;17) PML-RARA and t(12;21) ETV6-RUNX1 (TEL-AML1). Patient-specific MRD detection using immunoglobulin (IG) or
Minimal_residual_disease
Medical condition
ABL; 22 BCR) Acute myeloblastic leukemia with maturation t(8 RUNX1T1;21 RUNX1) Acute promyelocytic leukemia t(15 PML,17 RARA) Acute megakaryoblastic leukemia
Fryns–Aftimos_syndrome
Family of regulator genes
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
Myc
Family of proteins
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
Winged-helix transcription factors
Winged-helix_transcription_factors
Protein-coding gene in the species Homo sapiens
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
PROX1
Medical condition
kinase type of enzyme involved in promoting cellular proliferation; and RUNX1, which codes for a transcription factor that regulates the maturation of
Transient myeloproliferative disease
Transient_myeloproliferative_disease
Protein-coding gene in the species Homo sapiens
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
LHX3
Protein-coding gene in humans
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
DMRT1
Immune response protein
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
FOXP3
Nuclear receptor protein found in humans
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
Peroxisome proliferator-activated receptor gamma
Peroxisome_proliferator-activated_receptor_gamma
Expansion of blood cells
progression, while splicing factor genes, JAK2, TP53, IDH1, IDH2, FLT3, and RUNX1 have the highest risk. The clonal hematopoiesis risk score (CHRS) can be
Clonal_hematopoiesis
Protein-coding gene in the species Homo sapiens
Schoenmakers EF, van Kraaij M, et al. (2006). "Identification of truncated RUNX1 and RUNX1-PRDM16 fusion transcripts in a case of t(1;21)(p36;q22)-positive therapy-related
PRDM16
Protein-coding gene in humans
and STUB1. and SMOC1. miR-133 and CyclinD1/CDK4 directly inhibits Runx2. RUNX1 RUNX3 GRCh38: Ensembl release 89: ENSG00000124813 – Ensembl, May 2017 GRCm38:
RUNX2
Protein molecule receiving signals for a cell
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
Receptor_(biochemistry)
Mammalian protein found in Homo sapiens
interact with: BCL3, COBRA1, CSNK2A1, CSNK2A2, DDIT3, JUN NCOA1, NCOR2, RELA, RUNX1, RUNX2, SMAD3, and TBP. Leptomycin c-Jun Egr-1 Ion channel G proteins
Protein_c-Fos
Protein-coding gene in humans
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
Steroidogenic_factor_1
Research area in which no drugs are currently approved
2013). "A novel disease-modifying osteoarthritis drug candidate targeting Runx1". Annals of the Rheumatic Diseases. 72 (5): 748–753. doi:10.1136/annrheumdis-2012-201745
Disease-modifying osteoarthritis drug
Disease-modifying_osteoarthritis_drug
Sensory neuron that detects pain
(GDNF). This transition is assisted by runt-related transcription factor 1 (RUNX1) which is vital in the development of nonpeptidergic nociceptors. On the
Nociceptor
Protein
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
Nuclear_receptor
Family of transcription factor protein complexes
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
NF-κB
Human chromosome
processing 1 homolog B RSPH1: encoding protein radial spoke head 1 homolog RUNX1: encoding protein Runt-related transcription factor 1 RWDD2B: encoding protein
Chromosome_21
Protein that initiates male sex determination in therian mammals
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
Sex-determining region Y protein
Sex-determining_region_Y_protein
Protein-coding gene in humans
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
SMAD3
Transcription factor activated by vitamin D
transcription activation: BAG1, CAV3, MED12, MED24, NCOR1, NCOR2, NCOA2 RXRA, RUNX1, RUNX1T1, SNW1, STAT1, and ZBTB16. Click on genes, proteins and metabolites
Vitamin_D_receptor
Mammalian protein found in Homo sapiens
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
Nuclear_receptor_4A1
ENSG00000124782 C2H2 ZF Known motif – In vivo/Misc source [786] MCMCMAMMCAMCMMCHMMSV RUNX1 ENSG00000159216 Runt Known motif – In vivo/Misc source [787] VACCACAV RUNX2
List of human transcription factors
List_of_human_transcription_factors
Transcription factor gene of the SOX family
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
SOX2
Protein-coding gene in humans
human longevity. Also, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid
YTHDF2
Protein-coding gene in the species Homo sapiens
is a protein in humans encoded by the RUNX1 gene. It is also known as runt-related transcription factor 1 (RUNX1) and core-binding factor subunit alpha-2
Lymphoid enhancer-binding factor 1
Lymphoid_enhancer-binding_factor_1
Protein-coding gene in the species Homo sapiens
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
MNX1
Class of proteins
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
Small_Maf
Protein-coding gene in humans
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
CBX1
Group of proteins
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
High-mobility_group
Protein-coding gene in the species Homo sapiens
Robarge J, Ott J, Kwok PY, Menter A, Bowcock AM (Dec 2003). "A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is associated with susceptibility
NAT9
Protein-coding gene in humans
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
AEBP2
Protein-coding gene in the species Homo sapiens
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
EBF1
Protein-coding gene in humans
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
ASCL1
Transcriptional repressor protein
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
YY1
Mammalian protein found in Homo sapiens
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
HMGB1
New Zealand haematologist
Kathryn E Crosier (1 April 2002). "Runx1 is required for zebrafish blood and vessel development and expression of a human RUNX1-CBF2T1 transgene advances a model
Kathryn_Crosier
Protein-coding gene in the species Homo sapiens
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
IRF3
Human protein and coding gene
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
NFE2L2
Protein found in humans
translocation produces a chimeric gene made up of the 5′-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric
CBFA2T2
Protein-coding gene in humans
translocation produces a chimeric gene made up of the 5′-region of the RUNX1 gene fused to the 3′-region of this gene. The chimeric protein is thought
RUNX1T1
Cell type
share many of the same markers, including Flk1, Vegf, CD34, Scl, Gata2, Runx1, and Pecam-1. Furthermore, it was shown that depletion of Flk1 in the developing
Hemangioblast
Nuclear receptor that mediates the effects of the mineralocorticoid hormone Aldosterone
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
Mineralocorticoid_receptor
Protein that regulates the rate of DNA transcription
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
Transcription_factor
Mammalian protein found in humans
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
Androgen_receptor
Protein-coding gene in the species Homo sapiens
and matrix metalloproteinase-9 codistribute with transcription factors RUNX1/AML1 and ETV5/ERM at the invasive front of endometrial and ovarian carcinoma"
ETS_variant_5
Nuclear receptor
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
Liver_X_receptor
Mammalian protein found in humans
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
P53
Receptor regulated SMAD proteins
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
R-SMAD
Protein-coding gene in the species Homo sapiens
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
TCF7
14190 RUNDC3A HGNC:16984; Q59EK9 14191 RUNDC3B HGNC:30286; Q96NL0 14192 RUNX1 HGNC:10471; Q01196 14193 RUNX1T1 HGNC:1535; Q06455 14194 RUNX2 HGNC:10472;
List of human protein-coding genes 7
List_of_human_protein-coding_genes_7
Protein-coding gene in the species Homo sapiens
transcription. T-bet also recruits other transcription factors like HLX, RUNX1, RUNX3 which aid it in setting Th1 transcription profile. Apart from promoting
TBX21
1,132-amino acid
AFF1-NUTM1, C17orf78-NUTM1 (C17orf78 is also termed ATAD5), CHD4-NUTM1, RUNX1-NUTM1, IKZF1-NUTM1, and SLC12A6-NUTM1 fusion genes. Individuals with these
Nuclear protein in testis gene
Nuclear_protein_in_testis_gene
Abnormal multiples of one or more chromosomes
ABL; 22 BCR) Acute myeloblastic leukemia with maturation t(8 RUNX1T1;21 RUNX1) Acute promyelocytic leukemia t(15 PML,17 RARA) Acute megakaryoblastic leukemia
Polysomy
Protein-coding gene in the species Homo sapiens
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
RING1
Receptor to which cortisol and other glucocorticoids bind
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
Glucocorticoid_receptor
Small structural protein motif found mostly in transcriptional proteins
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
Zinc_finger
Protein-coding gene in the species Homo sapiens
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
Activating transcription factor 2
Activating_transcription_factor_2
Protein-coding gene in the species Homo sapiens
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
Heat_shock_factor_protein_1
Protein-coding gene in the species Homo sapiens
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
KMT2A
Protein-coding gene in humans
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
BHLHE41
Protein-coding gene in the species Homo sapiens
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
Transcription_factor_Sp3
Protein-coding gene in humans
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
PAX6
Mammalian protein found in humans
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
Retinoblastoma_protein
Medical condition
immunological cells), GATA2 interacts with other transcription factors (viz., RUNX1, SCL/TAL1, GFI1, GFI1b, MYB, IKZF1, Transcription factor PU.1, LYL1) and
GATA2_deficiency
Protein-coding gene in humans
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
ERG_(gene)
Protein-coding gene in the species Homo sapiens
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
ISL1
Protein-coding gene in the species Homo sapiens
susceptible to tyrosine kinase inhibitor therapy. However, children with ETV6-RUNX1-associated acute lymphoblastic leukemia are in an especially good-risk subgroup
ETV6
Type of nuclear receptor
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
Retinoic_acid_receptor
Zinc finger containing transcription factor
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
Ci_protein
Protein
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
FOXO4
Protein-coding gene in the species Homo sapiens
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
DPF2
Protein family
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
ETS transcription factor family
ETS_transcription_factor_family
Vaginal abnormality
(2013). "Diethylstilbestrol induces vaginal adenosis by disrupting SMAD/RUNX1-mediated cell fate decision in the Müllerian duct epithelium". Developmental
Vaginal_adenosis
Protein-coding gene in the species Homo sapiens
M, et al. (March 2022). "NOXA expression drives synthetic lethality to RUNX1 inhibition in pancreatic cancer". Proceedings of the National Academy of
Phorbol-12-myristate-13-acetate-induced protein 1
Phorbol-12-myristate-13-acetate-induced_protein_1
Protein-coding gene in the species Homo sapiens
(4.10) Cold-shock domain YBX1 YBX2 YBX3 (4.11) Runt CBF CBFA2T2 CBFA2T3 RUNX1 RUNX2 RUNX3 RUNX1T1 (0) Other transcription factors (0.2) HMGI(Y) HMGA 1
HIF3A
RUNX1
RUNX1
RUNX1
RUNX1
RUNX1
RUNX1
RUNX1
RUNX1
RUNX1