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Culture of stem cells that can be propagated indefinitely
A stem cell line is a group of stem cells that is cultured in vitro and can be propagated indefinitely. Stem cell lines are derived from either animal
Stem-cell_line
Unspecialized biological cell that can become specialized
multicellular organisms, stem cells are undifferentiated or partially differentiated cells that can change into various types of cells and proliferate indefinitely
Stem_cell
Type of pluripotent blastocystic stem cell
Embryonic stem cells (ESCs) are pluripotent stem cells derived from the inner cell mass of a blastocyst, an early-stage pre-implantation embryo. Human
Embryonic_stem_cell
Ethical concerns about embryonic stem cell research and medical use
stem cells. Not all stem cell research involves human embryos. For example, adult stem cells, amniotic stem cells, and induced pluripotent stem cells
Stem_cell_controversy
Use of stem cells to treat or prevent a disease or condition
Stem-cell therapy uses stem cells to treat or prevent a disease or condition. As of 2024[update], the only FDA-approved therapy using stem cells is hematopoietic
Stem-cell_therapy
Pluripotent stem cell generated directly from a somatic cell
pluripotent stem cells (also known as iPS cells or iPSCs) are a type of pluripotent stem cell that can be generated directly from a somatic cell. The iPSC
Induced_pluripotent_stem_cell
Lineage of cells that evades senescence and continues dividing
also found uses in biotechnology. An immortalised cell line should not be confused with stem cells, which can also divide indefinitely, but form a normal
Immortalised_cell_line
Ability of a cell to differentiate into other cell types
pluripotent stem cells, commonly abbreviated as iPS cells or iPSCs, are a type of pluripotent stem cell artificially derived from a non-pluripotent cell, typically
Cell_potency
Multipotent stem cell in the adult body
Adult stem cells are undifferentiated cells, found throughout the body after development, that multiply by cell division to replenish dying cells and regenerate
Adult_stem_cell
American developmental biologist
embryonic stem cell line in 1998 and for deriving human induced pluripotent stem cells (iPS) in 2007. Human embryonic stem cells [which are cells that reproduce
James Thomson (cell biologist)
James_Thomson_(cell_biologist)
Method of creating a cloned embryo by replacing the egg nucleus with a body cell nucleus
successful stem cell therapies is to create custom stem cell lines for patients. Each custom stem cell line would consist of a collection of identical stem cells
Somatic_cell_nuclear_transfer
Medical procedure to replace blood or immune stem cells
Hematopoietic stem-cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral
Hematopoietic stem cell transplantation
Hematopoietic_stem_cell_transplantation
Stem cell markers are genes and their protein products used by scientists to isolate and identify stem cells. Stem cells can also be identified by functional
Stem_cell_marker
Spermatogonium that does not differentiate into a spermatocyte
A spermatogonial stem cell (SSC), also known as a type A spermatogonium, is a spermatogonium that does not differentiate into a spermatocyte, a precursor
Spermatogonial_stem_cell
Specific location in the body containing stem cells
Stem-cell niche refers to a microenvironment, within the specific anatomic location where stem cells are found, which interacts with stem cells to regulate
Stem-cell_niche
Transformation of a stem cell to a more specialized cell
specification, is the process in which a stem cell changes from one type to a differentiated one. Usually, the cell changes to a more specialized type. Differentiation
Cellular_differentiation
Nonprofit scientific research institute
The New York Stem Cell Foundation, or NYSCF, is an American non-profit research institute focused on stem cell research, technology development, and funding
New_York_Stem_Cell_Foundation
South Korean scientific misconduct scandal
Hwang Woo-suk, who claimed to have created the first human embryonic stem cells by cloning in 2004. Hwang and his research team at the Seoul National
Hwang_affair
Crossing of a hybrid with one of its parents or a genetically similar individual
but also the minimum percentage of genetic material from the original stem cell line. A consomic strain is an inbred strain with one of its chromosomes replaced
Backcrossing
Process by which cells are grown under controlled conditions
in vitro. The major application of human cell culture is in stem cell industry, where mesenchymal stem cells are isolated, cultured, and subjected to
Cell_culture
Oogonial stem cells (OSCs), also known as egg precursor cells or female germline cells, are diploid germline cells with stem cell characteristics: the
Oogonial_stem_cells
Overview article
Embryonic stem cells are capable of self-renewing and differentiating to the desired fate depending on their position in the body. Stem cell homeostasis
Epigenetics in stem-cell differentiation
Epigenetics_in_stem-cell_differentiation
OP9 cells are a cell line derived from mouse bone marrow stromal cells (mesenchyme). These cells are now characterized as stem cells. When co-cultured
OP9_cell
Subsidiary of Thermo Fisher Scientific
polymerase chain reaction, reverse transcription, cloning, culturing, stem cell production, cell therapy, regenerative medicine, immunotherapy, transfection, DNA/RNA
Invitrogen
The International Society for Stem Cell Research (ISSCR) is an independent 501(c)(3) nonprofit organization based in Evanston, Illinois, United States
International Society for Stem Cell Research
International_Society_for_Stem_Cell_Research
Three-dimensional aggregate of pluripotent stem cells
stem cells. These include embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC). EBs are differentiation of human embryonic stem cells
Embryoid_body
Mammalian protein found in Homo sapiens
Stem cell factor (also known as SCF, KIT-ligand, KL, or steel factor) is a cytokine that binds to the c-KIT receptor (CD117). SCF can exist both as a
Stem_cell_factor
Clinical-stage biotechnology company developing novel cell therapies
2020-12-22. "AgeX Therapeutics Sublicenses Stem Cell Line ESI-053 to ImStem Biotechnology for Development of Cell Therapy Candidate IMS001 for COVID-19 and Acute
Lineage_Cell_Therapeutics
Any biological cell forming the body of an organism
multicellular organism other than a gamete, germ cell, gametocyte or undifferentiated stem cell. Somatic cells compose the body of an organism and divide through
Somatic_cell
Academic area of substances harmful to living organisms
2020). "Profiling the ToxCast Library With a Pluripotent Human (H9) Stem Cell Line-Based Biomarker Assay for Developmental Toxicity". Toxicological Sciences
Toxicology
Medical school in Madison, Wisconsin, US
Thomson, cell biologist who derived the first human embryonic stem cell line in 1998 and derived a human induced pluripotent stem cell line in 2007 Terri
School of Medicine and Public Health (University of Wisconsin–Madison)
School_of_Medicine_and_Public_Health_(University_of_Wisconsin–Madison)
Scientific research institute
WiCell Research Institute is a scientific research institute in Madison, Wisconsin that focuses on stem cell research. Independently governed and supported
WiCell
Stem cell laws and policy in the United States have had a complicated legal and political history. Stem cells are cells found in all multi-cellular organisms
Stem cell laws and policy in the United States
Stem_cell_laws_and_policy_in_the_United_States
cost-efficient alternative to keeping cells in culture constantly. Cell banks are commonly used within fields including stem cell research and pharmaceuticals
Cell_bank
Discredited South Korean scientist (born 1953)
in stem cell research and even called the "Pride of Korea". However, he became infamous around November 2005 for fabricating a series of stem cell experiments
Hwang_Woo-suk
Epigenetic phenomenon
stem cells from mature cells such as adult fibroblasts. This allows the production of stem cells for biomedical research, such as research into stem cell
Reprogramming
search for a cure for Juvenile Diabetes, Jill confirms that the Korean stem cell line is contaminated with a virus. Before her ground-breaking results can
List_of_ReGenesis_episodes
Disease causing insufficient blood cells of all types
marrow has 30–70% blood stem cells, but in aplastic anemia, these cells are mostly gone and are replaced by fat. First-line treatment for aplastic anemia
Aplastic_anemia
Israeli Arab researcher in molecular biochemistry
Israel. An expert in embryonic stem cell research, he is most recognized for developing the first bona fide Structured Stem cell-derived Synthetic Embryo Models
Jacob_Hanna
Condition present at birth regardless of cause
(2020). "Profiling the ToxCast Library With a Pluripotent Human (H9) Stem Cell Line-Based Biomarker Assay for Developmental Toxicity". Toxicological Sciences
Birth_defect
Cell type
prevent infection. These monocytes arise from the myeloid stem cell line. Touton giant cells aim to remove harmful substances in the tissue in which they
Touton_giant_cell
neural cell line generates neurons on growth under neural stem cell conditions and exhibits characteristics of radial glial cells". Mol Cell Neurosci
NTERA-2
Founder Cells
asymmetric division of stem cells, resulting in the formation of a daughter stem cell and a specialized cell type. There is one founder cell for each tissue and
Founder_cell
KBM-7 cells are a chronic myelogenous leukemia (CML) cell line used for biomedical research. Like all cancer cell lines, it is immortal and can divide
KBM-7_cells
Cancer of plasma cells
stem cell transplant. Bisphosphonates and radiation therapy are sometimes used to reduce pain from bone lesions. New approaches utilizing CAR-T cell therapy
Multiple_myeloma
Taiwanese-born American philosopher
extraction method, which removes enough pluripotent stem cells from the inner cell mass to form a stem cell line without harming the embryo. Liao has also argued
S._Matthew_Liao
Neuroscientist and biologist
Allele Biotechnology. The institution focuses on antibody development, stem cell line services among other biotechnology-related ventures. Since 2019, Shaner's
Nathan_Shaner
American executive and lawyer (1951–2022)
lawyer. She was the chief executive officer and co-founder of the New York Stem Cell Foundation (NYSCF). Solomon was born in Brooklyn on August 23, 1951. Her
Susan_L._Solomon
Anti-microbial epithelial cell of the small intestine
found in the cecum and appendix. They lie interspersed between intestinal stem cells in the intestinal glands (also called crypts of Lieberkühn) and under
Paneth_cell
Iranian higher education institution
embryonic Stem Cell line establishment in Iran and the region, Royan Institute 2005: Establishment of the first Private Cord Blood Bank in Iran (Royan Stem Cell
Academic Center for Education, Culture and Research
Academic_Center_for_Education,_Culture_and_Research
Introduction of foreign genetic material into a host
effective pluripotent stem cell (PSC) transgenesis. The manipulated gene construct is inserted into totipotent stem cells, cells which can develop into
Transgenesis
Scientific analysis
(2020). "Profiling the ToxCast Library With a Pluripotent Human (H9) Stem Cell Line-Based Biomarker Assay for Developmental Toxicity". Toxicological Sciences
In_vitro_toxicology
Embryonic carcinoma cell line
P19 cells are an embryonic carcinoma cell line derived from an embryo-derived teratocarcinoma in mice. The cell line is pluripotent and can differentiate
P19_cell
Haploid sex cell
derived gametes (IVD), stem cell-derived gametes (SCDGs), and in vitro generated gametes (IVG), are gametes derived from stem cells. The use of such artificial
Gamete
Alumni Research Foundation (WARF) regarding the in vitro cell culture of human embryonic stem cells (hESCs). This case is still currently ongoing in the U
Consumer Watchdog v. Wisconsin Alumni Research Foundation
Consumer_Watchdog_v._Wisconsin_Alumni_Research_Foundation
Mesenchymal bone development that forms the non-long bones
stem cells within mesenchyme or the medullary cavity of a bone fracture initiate the process of intramembranous ossification. A mesenchymal stem cell
Intramembranous_ossification
Characterization of a Highly Tumourigenic and Cancer Stem Cell Enriched Pancreatic Cancer Cell Line as a Well Defined Model System". PLOS ONE. 7 (11) e48503
BxPC-3
widely used in life science research, especially in stem cell biology. The MEF is a limited cell line. After several transmissions, MEFs will senesce and
Mouse_embryonic_fibroblast
Indian biotechnology company
LifeCell International is an Indian biotechnology company established in 2004. It runs India's largest stem cell bank and has also diversified into diagnostics
LifeCell_International
Type of stem cell
Pancreatic progenitor cells are multipotent stem cells originating from the developing fore-gut endoderm which have the ability to differentiate into the
Pancreatic_progenitor_cell
American doctor and academic (born 1950)
Vacanti (born 1950) is an American researcher in tissue engineering and stem cells and the Vandam/Covino Professor of Anesthesiology, Emeritus, at Harvard
Charles_Vacanti
Protein found in humans
identifies cell surface antigens. CD34 was first described as a cell surface glycoprotein on hematopoietic stem cells and functions as a cell-cell adhesion
CD34
Process which produces red blood cells
which produces red blood cells (erythrocytes), which is the development from erythropoietic stem cell to mature red blood cell. It is stimulated by decreased
Erythropoiesis
Mexican biologist
biologist who is the Director of the Stem Cell Center, the Director of the Institute for Epigenetics and Stem Cells (IES), and a Group Leader at the Helmholtz
Maria-Elena_Torres-Padilla
Control of growth and differentiation by deeply conserved genetic mechanisms
reproductive asexual germ-line capable of forming germ-line stem cells (GSCs, referred to as CSCs in cancer) and a somatic cell line without reproductive GSC
Deep_homology
Support-cells in the nervous system
crest. The exception is microglia, which are derived from hematopoietic stem cells. In the adult, microglia are largely a self-renewing population and are
Glia
Ghanaian-British stem cell Scientist
James Affram Adjaye is a Ghanaian British stem cell researcher. He is the Director of the Institute for Stem Cell Research and Regenerative Medicine at the
James_Adjaye
distinct section of cell engineering involves the alteration and tuning of stem cells. Much of the recent research on stem cell therapies and treatments
Cell_engineering
Miniaturized and simplified version of an organ
organ. It is derived from one or a few cells from a tissue, embryonic stem cells, or induced pluripotent stem cells, which can self-organize in three-dimensional
Organoid
Terminally differentiated cell incapable of regeneration
(help) Seiler, AE; Spielmann, H (16 June 2011). "The validated embryonic stem cell test to predict embryotoxicity in vitro". Nature Protocols. 6 (7): 961–978
Permanent_cell
Process of stem cells differentiating into fat cells
adipocytes (fat cells) from stem cells. It involves 2 phases, determination, and terminal differentiation. Determination is mesenchymal stem cells committing
Adipogenesis
Chemical compound
tested the effect of citrinin on cell viability, but in an embryonic stem cell line (ESC-B5) in vitro. The ESC-B5 cells were treated with 10–30 μM CTN for
Citrinin
Research institute in California, United States
a state agency that supports research and education in the fields of stem cell and gene therapies. It was created in 2004 after 59% of California voters
California Institute for Regenerative Medicine
California_Institute_for_Regenerative_Medicine
Early embryonic mass that gives rise to the fetus
subsequently raised in these TE cells, indicating Cdx2 plays a role in suppressing Oct4 in this cell lineage. Moreover, embryonic stem cells can be generated from
Inner_cell_mass
American developmental biologist who derived the first human embryonic stem cell line in 1998 Simon Fraser Tolmie (1867–1937) – Canadian politician Debbye
List_of_veterinarians
Process which produces lymphocytes
progenitor (CLP) cells, which are in turn derived from hematopoietic stem cells. Given that lymphocytes arise from specific types of limited stem cells – which
Lymphopoiesis
Nigerian Neuroscientist
Mahmoud B. Maina (July 21, 2023). "Generation of an induced pluripotent stem cell line from a healthy adult indigenous Nigerian participant". bioRxiv 10.1101/2023
Mahmoud_Maina
Electronics company
96 StemCell cores) ZMS-20 (dual Cortex A9 with 48 StemCell cores) ZMS-08 (single Cortex-A8 with 64 StemCell cores) ZMS-05 (dual ARM9 with 24 StemCell cores)
ZiiLABS
Kenyan medical scientist and researcher
Her area of research interest is stem cell research. It is her goal to generate a uniquely "Kenyan" stem cell line. In 2018, Business Daily Africa, a
Juliet_Obanda_Makanga
Mammalian protein found in Homo sapiens
the inner cell mass. As embryonic stem cells are derived from the inner cell mass at the blastocyst stage, removing them from the inner cell mass also
Leukemia_inhibitory_factor
British-American physiologist
public opinion and criticism due to its creation in 2001 of an embryonic stem cell line, as was noted in a report in the journal, Science. He retired from research
Roger_Gosden
British biologist
biologist who, with Matthew Kaufman, was the first to culture mice embryonic stem cells and cultivate them in a laboratory in 1981. He is also known, along with
Martin_Evans
cells (MIN6 cell line) and mouse pancreatic islet cells. Mouse embryonic fibroblasts (MEF) during reprogramming to the induced pluripotent stem cell state
Hes3_signaling_axis
Organism composed of cells of different genotypes
PMID 6058691. Robertson, EJ (1986). "Pluripotential stem cell lines as a route into the mouse germ line". Trends Genet. 2: 9–13. doi:10.1016/0168-9525(86)90161-7
Chimera_(genetics)
Bone marrow cancer in which lymphocytes are overproduced
growth and expansion of white blood cells. This manifestation typically begins with a single hematopoietic stem cell that acquires certain mutations over
Chronic_lymphocytic_leukemia
American geneticist
research in early embryo development, embryonic-cell differentiation, mechanisms of gene control, and stem cell biology. . In 2006, Brinster received a Canada
Ralph_L._Brinster
Medical condition
modification and replacement of blood forming stem cells in the bone marrow. As of 2021[update], sickle cell disease is estimated to affect about 7.7 million
Sickle_cell_disease
Type of white blood cell
extremely specific, with all BCRs on a B cell recognizing the same epitope. B cells develop from hematopoietic stem cells (HSCs) that originate from bone marrow
B_cell
First cloned mammal (1996–2003)
cloning of Dolly led to advancements in stem cell research, including the discovery of induced pluripotent stem cells. Dolly lived at the Roslin Institute
Dolly_(sheep)
Canadian medical scientist (born 1967)
Hans Keirstead is a medical scientist and entrepreneur specializing in stem cell research. Keirstead received his Ph.D. from the University of British
Hans_Keirstead
Basic unit of life forms
"Asymmetric Behavior in Stem Cells". In Rajasekhar, V. K.; Vemuri, M. C. (eds.). Regulatory Networks in Stem Cells. Stem Cell Biology and Regenerative
Cell_(biology)
Biotechnology company
Inc. (FCDI) is a large scale manufacturer of human cells, created from induced pluripotent stem cells, for use in basic research, drug discovery and regenerative
Cellular Dynamics International
Cellular_Dynamics_International
German-American Immunologist and Hematologist
heterogeneity of hematopoietic stem cells (HSCs). Muller-Sieburg is known for her contributions to the purification of hematopoietic stem cells, the characterization
Christa_Muller-Sieburg
Single-celled hybrid of human and hamster
humster is a hybrid cell line made from a zona-free hamster oocyte fertilized with human sperm. It always consists of single cells and cannot form a multi-cellular
Humster
Main growth tissue in the stems, roots of plants
forming an interrupted ring inside the stem. In woody plants, it forms a cylinder of unspecialized meristem cells, as a continuous ring from which the new
Vascular_cambium
Type of intestinal cell
Enterocytes, or intestinal absorptive cells, are simple columnar epithelial cells which line the inner surface of the small and large intestines. A glycocalyx
Enterocyte
Gamete-producing cell
germ cell cycle are the egg or sperm. Under special conditions in vitro germ cells can acquire properties similar to those of embryonic stem cells (ESCs)
Germ_cell
TF-1 cells are an immortal cell line derived from the human Erythroleukemia used in biomedical research. This cells are proliferatively responsive to interleukin-3
TF-1_cell
Mammalian protein and protein-coding gene
tyrosine-protein kinase KIT, CD117 (cluster of differentiation 117) or mast/stem cell growth factor receptor (SCFR). Multiple transcript variants encoding different
KIT_gene
Rituximab and ICE as second-line therapy before autologous stem cell transplantation for relapsed or primary refractory diffuse large B-cell lymphoma
ICE_(chemotherapy)
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