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Polyamine involved in cellular metabolism
Spermine is a polyamine involved in cellular metabolism that is found in all eukaryotic cells. The precursor for synthesis of spermine is the amino acid
Spermine
Medical condition
instructions for producing the enzyme spermine synthase. Spermine synthase in turn helps the body produce spermine, a polyamine critical to cell processes
Snyder–Robinson_syndrome
Spermine synthase (EC 2.5.1.22, spermidine aminopropyltransferase, spermine synthetase) is an enzyme that converts spermidine into spermine. This enzyme
Spermine_synthase
Protein-coding gene in the species Homo sapiens
Diamine acetyltransferase 1 (also termed spermidine/spermine N(1)-acetyltransferase 1, SSAT, and SAT1) is an enzyme that in humans is encoded by the SAT1
SAT1_(gene)
Type of organic compound
The principal examples are the triamine spermidine and the tetraamine spermine. They are structurally and biosynthetically related to the diamines putrescine
Polyamine
Spermine oxidase (EC 1.5.3.16, PAOh1/SMO, AtPAO1, AtPAO4, SMO) is an enzyme with systematic name spermidine:oxygen oxidoreductase (spermidine-forming)
Spermine_oxidase
Foul-smelling organic chemical compound
is combined with another S-adenosylmethioninamine and gets converted to spermine. Putrescine is synthesized in small quantities by healthy living cells
Putrescine
Chemical compound
inhibition of NOS. Also, spermidine is a precursor to other polyamines, such as spermine and thermospermine, some of which contribute to tolerance against drought
Spermidine
Class of naturally occurring chemical compounds
ephedrine. Polyamine alkaloids – derivatives of putrescine, spermidine, and spermine. Peptide and cyclopeptide alkaloids. Pseudoalkaloids – alkaloid-like compounds
Alkaloid
Chemical compound
is a spermine metabolite of cholesterol. The steroid ring consists of a cholestane with a hydroxyl group at C-7 and sulfate group at C-24; spermine is conjugated
Trodusquemine
Chemical compound
that is required for the biosynthesis of polyamines including spermidine, spermine, and thermospermine. It is produced by decarboxylation of S-adenosyl methionine
S-Adenosylmethioninamine
Chemical compound
castor sacs of the mature beaver. A mixture of 5-methoxysalicylic acid and spermine can be used as a matrix for oligonucleotides analysis in MALDI mass spectrometry
5-Methoxysalicylic_acid
Foul-smelling diamine compound
Willems, M.I. (1997). "Acute and subacute toxicity of tyramine, spermidine, spermine, putrescine and cadaverine in rats". Food and Chemical Toxicology. 35 (3–4):
Cadaverine
grams (0.95 oz) of pure putrescine. For comparison the similar substance spermine, found in semen, is over 3 times as toxic. Neurine "Mass burials do more
Health_risks_from_dead_bodies
Protein-coding gene in the species Homo sapiens
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase is an enzyme that in humans is encoded by the PAOX gene. GRCh38: Ensembl release 89: ENSG00000148832
PAOX
putrescine (diamine)-acetylating enzyme, diamine acetyltransferase, spermidine/spermine N1-acetyltransferase, spermidine N1-acetyltransferase, acetyl-coenzyme
Diamine_N-acetyltransferase
Reproductive biofluid of male or hermaphroditic animals
compensate for this hostile environment. Basic amines such as putrescine, spermine, spermidine and cadaverine are responsible for the smell and flavor of
Semen
process of creating branched-chain polyamines, and producing spermidine and spermine. It has a singular ligand in its structure involved with Fe3+ and PLIP
BpsA
Species of spider
Histamine and adenosine were detected at 0.14% and 0.10% with the polyamine spermine noted in trace amounts at 0.002%. A female (left) and male (right) in courtship
Cobalt_blue_tarantula
Enzyme
Spermine oxidase is an enzyme that in humans is encoded by the SMOX gene. The product of this gene is the polyamine oxidase. This enzyme potentially represents
SMOX
Species of spider
Analysis of these neurotoxins within the venom revealed the presence of spermine, a polyamine involved in cellular metabolism, and 1,3-diaminopropane. These
Aphonopelma_chalcodes
Class of short biopolymers
oligonucleotides after automated synthesis. A mixture of 5-methoxysalicylic acid and spermine can be used as a matrix for oligonucleotides analysis in MALDI mass spectrometry
Oligonucleotide
Class of depressant drugs derived from barbituric acid
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
Barbiturate
Dissociative anesthetic and anti-depressant
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
Ketamine
Spice made from crocus flowers
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
Saffron
Glutamate receptor and ion channel protein found in nerve cells
receptor binding sites for zinc, proteins and the polyamines spermidine and spermine are also modulators for the NMDA receptor channels. The GluN2B subunit
NMDA_receptor
Dissociative hallucinogenic drug, mostly used recreationally
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
Phencyclidine
Chemical element with atomic number 12 (Mg)
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
Magnesium
Measure of an acid's strength in solution
}{\ce {(-SH)}}+K_{\mathrm {a} }{\ce {(-NH3+)}}.} Similarly, a base such as spermine has more than one site where protonation can occur. For example, mono-protonation
Acid_dissociation_constant
Explosive chemical compound
GLO/NO JS-K Methylamine hexamethylene methylamine/NO (MAHMA/NO) PROLI/NO Spermine/NO (SPER/NO) V-PYRRO/NO Heterocyclic compounds: Furoxans: Furoxan REC15/2739;
Pentaerythritol_tetranitrate
Active ingredient in fermented drinks
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
Alcohol_(drug)
Diuretic medication
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
Hydrochlorothiazide
Chemical element with atomic number 30 (Zn)
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
Zinc
Synthetic opioid pain medication
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
Tramadol
(1972). "Biosynthesis and metabolism of 1,4-diaminobutane, spermidine, spermine, and related amines. IIE2a Speridine dehydrogenase". Adv. Enzymol. Relat
Spermidine_dehydrogenase
Bacteria known or suspected to cause cancer
Lastly, CagA also induces the expression of the enzyme spermine oxidase (SMOX) that converts spermine to spermidine. As a by-product H2O2 is produced which
Carcinogenic_bacteria
Class of enzymes
2007). "Putative spermine synthases from Thalassiosira pseudonana and Arabidopsis thaliana synthesize thermospermine rather than spermine". FEBS Letters
Thermospermine_synthase
Hao, Quan (2005-05-13). "Crystal structures of Fms1 and its complex with spermine reveal substrate specificity". Journal of Molecular Biology. 348 (4): 951–959
Polyamine_oxidase
Amino acid
Putrescine can then be converted into spermidine and subsequently into spermine, the other polyamines. The relative contributions of agmatine and ornithine
Arginine
Chemical compound
GLO/NO JS-K Methylamine hexamethylene methylamine/NO (MAHMA/NO) PROLI/NO Spermine/NO (SPER/NO) V-PYRRO/NO Heterocyclic compounds: Furoxans: Furoxan REC15/2739;
Amyl_nitrite
Class of enzymes
methionine to S-adenosylmethioninamine. Polyamines such as spermidine and spermine are essential for cellular growth under most conditions, being implicated
Adenosylmethionine decarboxylase
Adenosylmethionine_decarboxylase
Ubiquitous antioxidant compound in living organisms
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
Glutathione
Protein-coding gene in the species Homo sapiens
gene that encodes the enzyme spermine synthase in humans. The protein encoded by this gene belongs to the spermidine/spermine synthases family. This gene
SMS_(gene)
Chemical compound
tylamino]propyl]propanamide Other names N(1),N(12)-bis(dihydrocaffeoyl)spermine AC1NSXD9 BDBM50240622 DNC013917 C17615 Identifiers CAS Number 75288-96-9 Y
Kukoamines
Medication used to treat epilepsy and migraine
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
Topiramate
Medication used to treat Alzheimer's disease
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
Memantine
Chemical compound
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
Dehydroepiandrosterone
Polyatomic ion (NO3, charge –1) found in explosives and fertilisers
GLO/NO JS-K Methylamine hexamethylene methylamine/NO (MAHMA/NO) PROLI/NO Spermine/NO (SPER/NO) V-PYRRO/NO Heterocyclic compounds: Furoxans: Furoxan REC15/2739;
Nitrate
Topics referred to by the same term
may refer to: Smoothened, a gene that encodes a protein of the same name Spermine oxidase, an enzyme Styrene monooxygenase, an enzyme Sequential minimal
SMO
Pharmacodynamics and pharmacokinetics of ethanol
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
Pharmacology_of_ethanol
Chemical compound found in all domains of life with largely unexplored effects
n-propylamine group in the biosynthesis of polyamines such as spermidine and spermine from putrescine. SAM is required for cellular growth and repair. It is
S-Adenosyl_methionine
Aromatic hydrocarbon
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
Toluene
Vasodilating drug
GLO/NO JS-K Methylamine hexamethylene methylamine/NO (MAHMA/NO) PROLI/NO Spermine/NO (SPER/NO) V-PYRRO/NO Heterocyclic compounds: Furoxans: Furoxan REC15/2739;
PDE5_inhibitor
Protein family
ammonium. PAOs in plants, bacteria and protozoa oxidise spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved
Flavin-containing amine oxidoreductase
Flavin-containing_amine_oxidoreductase
Group of transmembrane proteins that passively transport potassium ions
is the result of high-affinity block by endogenous polyamines, namely spermine, as well as magnesium ions, that plug the channel pore at positive potentials
Inward-rectifier potassium channel
Inward-rectifier_potassium_channel
Psychoactive substance found in plants in the family Apocynaceae
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
Ibogaine
Topics referred to by the same term
software), surface-water modeling software SMS (gene), which encodes the spermine synthase enzyme Stiff-man syndrome (primarily known as stiff-person syndrome)
SMS_(disambiguation)
Chemical compound
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
Deoxymethoxetamine
Muscle relaxant medication
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
Carisoprodol
Short-acting barbiturate
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
Pentobarbital
Division of plant life
half of the nucleus merges with the carpogonium's nucleus. The polyamine spermine is produced, which triggers carpospore production. Spermatangia may have
Red_algae
Drug for erectile dysfunction and hypertension
GLO/NO JS-K Methylamine hexamethylene methylamine/NO (MAHMA/NO) PROLI/NO Spermine/NO (SPER/NO) V-PYRRO/NO Heterocyclic compounds: Furoxans: Furoxan REC15/2739;
Sildenafil
Amino acid and neurotransmitter
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
Glutamic_acid
Class of enzymes
aminopropyl moiety. Spermidine is a precursor to other polyamines, such as spermine and its structural isomer thermospermine. The active form of ornithine
Ornithine_decarboxylase
Protein-coding gene in the species Homo sapiens
Medicine. Coleman CS, Stanley BA, Jones AD, Pegg AE (Nov 2004). "Spermidine/spermine-N1-acetyltransferase-2 (SSAT2) acetylates thialysine and is not involved
SAT2
Medication
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
Esketamine
Barbiturate general anesthetic
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
Sodium_thiopental
Medication used to treat dyskinesia
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
Amantadine
Colourless non-flammable greenhouse gas
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
Nitrous_oxide
Dissociative anesthetic designer drug
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
Diphenidine
Medication for swelling and high blood pressure
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
Bumetanide
Chemical compound
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
Piracetam
Typical antipsychotic medication
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
Haloperidol
Medication used to treat ADHD
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
Atomoxetine
English physiologist (1868 – 1953)
Hampstead along with Rosenheim. They studied spermine, having established the conditions for the reproduction of spermine phosphate crystals while at King's College
Mary_Tebb
Chemical compound
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
2F-NENDCK
Chemical compound
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
3-Fluorodeschloroketamine
Sex chromosome present in both sexes in the XY and X0 sex-determination systems
protein Probable global transcription activator SNF2L1 SMS: encoding enzyme Spermine synthase SPANXN1: encoding protein SPANX family member N1 SPANXN5: encoding
X_chromosome
Chemical element with atomic number 54 (Xe)
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
Xenon
Carbamate derivative used as an anti-anxiety medication
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
Meprobamate
Class of anesthetics
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
NMDA_receptor_antagonist
Colorless gas with the formula NO
GLO/NO JS-K Methylamine hexamethylene methylamine/NO (MAHMA/NO) PROLI/NO Spermine/NO (SPER/NO) V-PYRRO/NO Heterocyclic compounds: Furoxans: Furoxan REC15/2739;
Nitric_oxide
Organic chemical compound
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
Diethyl_ether
New Psychoactive Substance Dissociative Eticyclidine Derivative
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
3-Me-PCE
Skeletal muscle relaxant
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
Orphenadrine
Loop diuretic medication
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
Furosemide
Volatile anaesthesia medication
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
Methoxyflurane
Chemical compound
GLO/NO JS-K Methylamine hexamethylene methylamine/NO (MAHMA/NO) PROLI/NO Spermine/NO (SPER/NO) V-PYRRO/NO Heterocyclic compounds: Furoxans: Furoxan REC15/2739;
Nitroglycerin
Medication of the barbiturate type
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
Phenobarbital
Amino acid
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
Glycine
Withdrawn opioid medication
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
Dextropropoxyphene
Topics referred to by the same term
transporter 2 (SAT2), a protein encoded by the gene 'SLC38A2' spermidine/spermine N1-acetyltransferase family member 2 (SAT2), a protein enzyme; see sex
SAT_2
Chemical compound
Pharmacology Routes of administration Oral Related compounds Related compounds Spermine Arginylglycylaspartic acid Dibutylhexamethylenediamine Except where otherwise
Synthalin
Chemical compound
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
Dimethylglycine
Pharmaceutical compound
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
Ketamine/temsirolimus
Spermine
List of chemical compounds with unusual names
List_of_chemical_compounds_with_unusual_names
Antagonist of the NMDA receptor at the glycine site
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
ZD-9379
Cough suppressant and dissociative drug
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
Dextromethorphan
C2HCl3, widely used industrial solvent
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
Trichloroethylene
Experimental antidepressant
Rapastinel (GLYX-13) Sarcosine; Polyamine site agonists: Neomycin Spermidine Spermine; Other positive allosteric modulators: 24S-Hydroxycholesterol DHEATooltip
Osavampator
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