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Class of depressant drugs derived from barbituric acid
Barbiturates are a class of depressant drugs that are chemically derived from barbituric acid. They are effective when used medically as anxiolytics, hypnotics
Barbiturate
Medical condition
Barbiturate overdose is poisoning due to excessive doses of barbiturates. Symptoms of barbiturate overdose typically include difficulty thinking, poor
Barbiturate_overdose
Medical procedure
An induced coma – also known as a medically induced coma (MIC), barbiturate-induced coma, or drug-induced coma – is a temporary coma (a deep state of
Induced_coma
Medical condition
Barbiturate dependence develops with regular use of barbiturates. This in turn may lead to a need for increasing doses of the drug to get the original
Barbiturate_dependence
Combination drug
was the brand name of a discontinued combination drug composed of two barbiturate sodium salts (secobarbital and amobarbital) in equal proportions. Tuinal
Tuinal
Chemical compound
atypical barbiturate. This compound can be either convulsant or anticonvulsant depending on which enantiomer is used. Diberal, unlike most barbiturates, can
Diberal
Dictator of Germany from 1933 to 1945
stomach problems and other ailments. He regularly consumed amphetamine, barbiturates, opiates, and cocaine, as well as potassium bromide and atropa belladonna
Adolf_Hitler
Medication of the barbiturate type
sold under the brand name Luminal among others, is a medication of the barbiturate type. It is recommended by the World Health Organization (WHO) for the
Phenobarbital
Barbiturate general anesthetic
and sold under the brand name Pentothal, is a rapid-onset short-acting barbiturate general anesthetic. It is the thiobarbiturate analog of pentobarbital
Sodium_thiopental
Combination medication
tension headaches and migraine headaches. It contains butalbital, a barbiturate and paracetamol (acetaminophen), an analgesic. Versions also containing
Butalbital/acetaminophen
Chemical compound
odorless powder soluble in water. Barbituric acid is the parent compound of barbiturate drugs, although barbituric acid itself is not pharmacologically active
Barbituric_acid
Short-acting barbiturate
Pentobarbital (US) or pentobarbitone (British and Australian) is a short-acting barbiturate typically used as a sedative, a preanesthetic, and to control convulsions
Pentobarbital
Form of execution involving injection of chemicals into the bloodstream
the practice of injecting one or more drugs into a person (typically a barbiturate, paralytic, and potassium chloride) for the express purpose of causing
Lethal_injection
Class of neurotransmitter modulators
(Valium) and alprazolam (Xanax), Z-drugs such as zolpidem (Ambien) and the barbiturate drugs. The GABAA receptors have historically been a target of drug treatment
GABAA receptor positive allosteric modulator
GABAA_receptor_positive_allosteric_modulator
Obsolete sedative-hypnotic
Secobarbital, sold under the brand name Seconal among others, is a short-acting barbiturate drug originally used for the treatment of insomnia. It was patented by
Secobarbital
Discontinued medication
methamphetamine hydrochloride (HCl) and 30 mg of the CNS depressant ("downer") barbiturate, pentobarbital sodium. Manufactured by Abbott Laboratories as a scored
Desbutal
Combination drug
Secobarbital/brallobarbital/hydroxyzine Combination of Brallobarbital Barbiturate Secobarbital Barbiturate Hydroxyzine Antihistamine Clinical data Trade names Vesparax
Secobarbital/brallobarbital/hydroxyzine
Secobarbital/brallobarbital/hydroxyzine
American singer and actor (1935–1977)
health was in serious decline. Twice during the year he overdosed on barbiturates, spending three days in a coma in his hotel suite after the first incident
Elvis_Presley
Chemical compound
Thialbarbital (Intranarcon) is a barbiturate derivative invented in the 1960s. It has sedative effects, and was used primarily for induction in surgical
Thialbarbital
Medication
depressant drug of the piperidine chemical class, one of many non-barbiturate, "barbiturate-like" GABAergic medications exhibiting general calming, relaxing
Glutethimide
Mexican actress (1908–1944)
Vélez died at age 36 in December 1944 of an intentional overdose of the barbiturate drug Seconal. Her death and the circumstances surrounding it were the
Lupe_Vélez
Death of American musician Jimi Hendrix
aspirated his own vomit and died of asphyxia while intoxicated with barbiturates. At the inquest, the coroner, finding no evidence of suicide, and lacking
Death_of_Jimi_Hendrix
Lebanese-French film producer
age 43, in his suite at the Plaza Athénée, the cause of death being barbiturate overdose, in 1985. With his brother-in-law, Claude Berri, they played
Jean-Pierre_Rassam
Chemical compound
Benzylbutylbarbiturate (5-benzyl-5-n-butylbarbituric acid) is a rare example of a barbiturate designer drug, possibly the only such compound encountered in recent
Benzylbutylbarbiturate
English music entrepreneur (1934–1967)
Black and The Big Three. In 1967, he died of a combined alcohol and barbiturate overdose, ruled as accidental, at the age of 32. Epstein's grandfather
Brian_Epstein
1962 death of Marilyn Monroe by overdose
August 4, 1962, American actress Marilyn Monroe died at age 36 of a barbiturate overdose inside her home at 12305 Fifth Helena Drive in Brentwood, Los
Death_of_Marilyn_Monroe
Discontinued medication
dextroamphetamine, to elevate mood and suppress appetite, whereas the concomitant barbiturate was included to broadly counteract potential adverse effects from dextroamphetamine
Dexamyl
Chemical compound
structurally related to the barbiturates and similar drugs such as primidone. It is metabolized once inside the body to form the barbiturate proxibarbital (proxibarbal)
Valofane
Chemical compound
in acid and sodium salt forms as Citopan, Evipan, and Tobinal, is a barbiturate derivative having hypnotic and sedative effects. It was used in the 1940s
Hexobarbital
Barbiturate
amylobarbitone or sodium amytal as the soluble sodium salt) is a drug that is a barbiturate derivative. It has sedative-hypnotic properties. It is a white crystalline
Amobarbital
Barbiturate drug used for headaches
Butalbital is a barbiturate with an intermediate duration of action. Butalbital is often combined with other medications, such as paracetamol (acetaminophen)
Butalbital
Barbiturate medication used to treat seizures and tremors
Primidone, sold under various brand names (including Mysoline), is a barbiturate medication that is used to treat partial and generalized seizures and
Primidone
Chemical compound
Thialbutal, Transithal, Ulbreval), or buthalitone sodium (BAN), is a barbiturate derivative which was under development as a short-acting anesthetic.
Buthalital
Chemical compound
and Medinal for the sodium salt, was the first commercially available barbiturate. It was used as a sleeping aid (hypnotic) from 1903 until the mid-1950s
Barbital
Obsolete sedative–hypnotic drug
through cardiac or respiratory arrest. Methaqualone overdose resembles barbiturate poisoning, but with increased motor difficulties and a lower incidence
Methaqualone
Chemical compound
aprobarbitone), sold under the brand names Oramon, Somnifaine, and Allonal, is a barbiturate derivative invented in the 1920s by Ernst Preiswerk. It has sedative
Aprobarbital
Carbamate derivative used as an anti-anxiety medication
has most of the pharmacological effects and dangers of barbiturates and acts at the barbiturate binding site (though it is less sedating at effective doses)
Meprobamate
Topics referred to by the same term
"Barbie" a 2023 song by D-Block Europe Barbecue Barbecue grill Barbiturate Barbiturate overdose ZTF20abrbeie (nicknamed "Barbie"), a very energetic transient
Barbie_(disambiguation)
Twin American gynecologists
possible suicide pact. It was first assumed that the brothers had died of barbiturate withdrawal, but the final report excluded this (the original toxicological
Stewart_and_Cyril_Marcus
Convulsant barbiturate
convulsant barbiturate. Its mechanism of action is not fully understood. CHEB has uncommon action compared to other barbiturates. While other barbiturates such
CHEB
Application of a pharmaceutical drug under the tongue
sublingual administration, including cardiovascular drugs, steroids, barbiturates, benzodiazepines, opioid analgesics and tincture of cannabis. Some proteins
Sublingual_administration
Chemical compound
which is a short-acting barbiturate derivative that is used as an anesthetic. It has been used in veterinary medicine. Barbiturate Macdonald F (1997). Dictionary
Thiotetrabarbital
Group of chemical compounds
act as positive allosteric modulators of the GABAA receptor via the barbiturate binding site. They include the following compounds: Cartazolate (SQ-65
Pyrazolopyridines
English osteopath (1912–1963)
August. On 9 August, a coroner's jury ruled Ward's death as suicide by barbiturate poisoning. According to reports, Ward left several notes, one of which
Stephen_Ward
Class of enzymes
(EC 3.5.2.1) is a zinc-containing amidohydrolase. Its systemic name is barbiturate amidohydrolase (3-oxo-3-ureidopropanoate-forming). Barbiturase acts as
Barbiturase
American doorman
in the early 1980s. At the gathering Montaug swallowed five Seconal barbiturate pills, and went into a deep labored sleep, but kept breathing, to the
Haoui_Montaug
1966 single by the Beatles
Some listeners viewed the song as a code for drugs, particularly the barbiturate Nembutal which was sold in yellow capsules, or as a symbol for escapism
Yellow_Submarine_(song)
Sedative/Hypnotic medication for alcohol withdrawal
and anticonvulsant, having the same mechanism of action as traditional barbiturates. It is also used for the management of agitation, restlessness, and Parkinson's
Clomethiazole
German figure skater and painter
cause of death was asphyxiation through aspiration of vomit due to a barbiturate overdose. After Hendrix's death, Dannemann became romantically involved
Monika_Dannemann
German physician
sugar, confirming his suspicion. Josef von Mering helped to discover barbiturates, a class of sedative drugs used for insomnia, epilepsy, anxiety, and
Joseph_von_Mering
Drug that reduces excitement without inducing sleep
care to make people with dementia easier to manage. [citation needed] Barbiturates Amobarbital Benzylbutylbarbiturate Butalbital (Fioricet) Butabarbital
Sedative
French teacher
blood tests revealed a toxic concentration of the drug pentobarbital, a barbiturate that is not available in French pharmacies but is used elsewhere in the
Chantal_Sébire
Drugs that lower neurotransmission levels, reducing brain activity
there). Barbiturates were once common treatments for insomnia, anxiety, and seizures, although their use has waned in recent decades. Barbiturates are sometimes
Depressant
American actor (1900–1967)
insomnia throughout his life. As a result, Tracy became dependent on barbiturates to sleep, followed by dexedrine to function. Hepburn, who adopted a nursing
Spencer_Tracy
Chemical compound
Tetrabarbital (INN; Butysal, Butysedal, Tetramal) is a barbiturate derivative used as a hypnotic. Barbiturate Pentobarbital Ganellin CR, Triggle DJ, Macdonald
Tetrabarbital
2011 American documentary film
with Dignity Act that allows terminally ill patients to self-administer barbiturates prescribed by their physician to end their own life, referred to as assisted
How_to_Die_in_Oregon
Drug class
Analeptics have recently been used to better understand the treatment of a barbiturate overdose. Through the use of agents, researchers were able to treat obtundation
Analeptic
American actress (1903–1955)
frequently using barbiturates. In February 1955, Berman found Munson dead in their Manhattan apartment, having committed suicide via a barbiturate overdose.
Ona_Munson
American screenwriter
death as "accidental", he had been drinking all day; capsules of the barbiturate Seconal were found around his bed, and a plastic bag was draped over
Alan_Campbell_(screenwriter)
Singaporean politician (1928–1986)
overdose of amytal barbiturate. On 20 January 1987, the State Coroner returned a verdict of suicide due to an overdose of amytal barbiturate. Lee Kuan Yew
Teh_Cheang_Wan
Effect of drug opposite to expectation
no phenobarbital administered in previous days.[better source needed] Barbiturates such as pentobarbital have been shown to cause paradoxical hyperactivity
Paradoxical_reaction
Sedative-hypnotic drug
because benzodiazepines (such as Librium and Valium) had replaced non-barbiturate sedatives in clinical practice; by the end of 2001 remaining supplies
Ethchlorvynol
Drug-containing solution for intentionally ending life
the suffering of the objects by preventing the terminal gasp caused by barbiturates. Anaesthetics are drugs that reduce the pain felt by the animals or humans
Euthanasia_solution
Thiobarbituric acid reactive substances
both barbiturate and thiobarbiturate, and the end-product of the TBARS assay is almost identical to the end product of the pyridine-barbiturate cyanide
TBARS
Veterinary medical products classification subgroup
QN51AA01 Pentobarbital QN51AA02 Secobarbital QN51AA30 Combinations of barbiturates QN51AA51 Pentobarbital, combinations QN51AA52 Secobarbital, combinations
ATCvet_code_QN51
Medical condition (poisoning)
Pharmaceutical Drug overdoses Nervous Alcohol Anticholinesterase Aspirin Barbiturates Benzodiazepines Cocaine Lithium Opioids Paracetamol Serotonergic substances
Methanol_toxicity
Medical condition
Because the hydantoins take 15–30 minutes to work, a benzodiazepine or barbiturate is often coadministered. Because of diazepam's short duration of action
Status_epilepticus
Chemical compound
Crotylbarbital (Mepertan, Kalipnon, Barotal), also known as crotarbital, is a barbiturate derivative developed by Eli Lilly in the 1930s. It has sedative and hypnotic
Crotylbarbital
Chemical compound
the barbiturate family. It was used in Europe for the treatment of insomnia from the 1950s onwards, but has since been discontinued. Barbiturate Breimer
Heptabarb
Chemical compound
Talbutal (Lotusate) is a barbiturate with a short to intermediate duration of action. It is a structural isomer of butalbital. Talbutal is a schedule
Talbutal
British-American actress (1934–1972)
Noguchi reported her cause of death was from accidental "acute ethanol and barbiturate intoxication". Scala is interred in the Holy Cross Cemetery in Culver
Gia_Scala
WWII era drug
Blue 88 was a blue-colored pill that was a mix of calming drugs, mainly barbiturates such as sodium amytal, used to treat American soldiers in the Second
Blue_88
Wife of Reggie Kray (1943–1967)
subsequent coroner's inquest at Shoreditch ruled the cause of death as a barbiturate overdose, and recorded a verdict of suicide. Kray was buried in June
Frances_Kray
Veterinary euthanasia drug
Phenytoin/pentobarbital Combination of Phenytoin Sodium channel blocker Pentobarbital Barbiturate Clinical data Trade names Beuthanasia-D Special Routes of administration
Phenytoin/pentobarbital
Abrupt cessation of substance use
Sudden withdrawal from drugs such as alcohol, benzodiazepines, and barbiturates can be extremely dangerous, leading to potentially fatal seizures. For
Cold_turkey
American writer and journalist (1917–1993)
William Clark Brinkley (September 10, 1917 – November 22, 1993) was an American writer and journalist, best known for his novels Don't Go Near the Water
William_Brinkley
American musician (1949–2019)
show. In 1980, after drinking alcohol, Money overdosed on a synthetic barbiturate that he mistook for cocaine. He suffered damage to the sciatic nerve
Eddie_Money
Medication used to treat anxiety disorders
Buspirone is not effective as a treatment for benzodiazepine withdrawal, barbiturate withdrawal, or alcohol withdrawal. SSRI and SNRI antidepressants such
Buspirone
Medical condition
However, combinations of high doses of benzodiazepines with alcohol, barbiturates, opioids or tricyclic antidepressants are particularly dangerous, and
Benzodiazepine_overdose
Continual use of drugs despite negative consequences
nicotine (including tobacco), cocaine and amphetamines; benzodiazepines; barbiturates; and other substances. In the DSM-5 (2013), the DSM-IV diagnoses of substance
Substance_use_disorder
Use of multiple psychoactive substances
death when mixed with other CNS depressants such as opioids, alcohol, or barbiturates. Alcohol and cocaine (for example coca wine) increase cardiovascular
Polysubstance_use
Chemical compound
Thiobarbital is a drug which is a barbiturate derivative. It is the thiobarbiturate analogue of barbital. It is of note that although the drug can be
Thiobarbital
Recreational drug beverage
v t e Recreational drug use Major recreational drugs Depressants Barbiturates Benzodiazepines Carbamates Ethanol (alcohol) Alcoholic beverage Beer Wine
Lean_(drug)
Chemical compound
drug related to nikethamide. It was mainly used in the treatment of barbiturate overdose and chronic obstructive pulmonary disease, but has now largely
Etamivan
Chemical compound
Carbubarb (carbubarbital, trade name Nogexan) is a carbamate-substituted barbiturate derivative, which has sedative effects. US patent 4428887, Tou, J. S
Carbubarb
Psychosis beginning suddenly in the first two weeks after childbirth
confusional states have also been reported during withdrawal from opium and barbiturates. One would expect acquired immunodeficiency syndrome (HIV/AIDS) encephalitis
Postpartum_psychosis
1967 film by Mark Robson
industry. As their careers take different paths, all three descend into barbiturate addiction. Susan Hayward, Paul Burke, and Lee Grant co-star. Valley of
Valley_of_the_Dolls_(film)
Greek socialite
family's private island Spetsopoula, having died from an overdose of barbiturates. An inquiry into the circumstances of her death exonerated her husband
Eugenia_Livanos
Discontinued medication
Tuinal, another withdrawn drug product containing a combination of barbiturate sedatives. Ndubuisi PO (2021). "Evaluating the Ethical Climate of the
Tafrodol
Orexin receptor antagonist
(alcohol) Diethylpropanediol Ethchlorvynol Methylpentynol Trichloroethanol Barbiturates Allobarbital Amobarbital Aprobarbital Barbital Butabarbital Butobarbital
Fazamorexant
Benzodiazepine medication
been observed, similar to those seen on withdrawal from alcohol and barbiturates. Lorazepam, as with other benzodiazepine drugs, can cause physical dependence
Lorazepam
Muscle relaxant medication
as tybamate, have the potential to produce physical dependence of the barbiturate type following periods of prolonged use. Withdrawal of the drug after
Carisoprodol
Barbiturate
Cyclobarbital, cyclobarbitol or cyclobarbitone is a barbiturate derivative developed in the early 1920s in Germany. It was available in Russia until 2019
Cyclobarbital
Italian actress (1932–1971)
tumultuous marriage to singer Vic Damone. She died at the age of 39 of a barbiturate overdose. Her twin sister, Marisa Pavan, was also an actress. Angeli
Pier_Angeli
Tranquilizer based with herbs Valerian, hops, peppermint & phenobarbital, a barbiturate
Corvalol (Корвалол, Corvalolum, Korvalol) is a tranquilizer based on the barbiturate phenobarbital and containing various natural components, such as herb
Corvalol
Painting by Francis Bacon (artist)
"Black Triptychs" completed after Bacon's lover George Dyer died from a barbiturates overdose on 24 October 1971, the eve of the artist's retrospective at
In_Memory_of_George_Dyer
Medical condition
Psychological dependence Withdrawal Disorders Drugs Alcoholism Amphetamine Barbiturate Benzodiazepine Caffeine Cannabis Cocaine Nicotine Opioid Non-drug stimuli
Amphetamine_dependence
American actress (1919–1948)
Carole Landis (born Frances Lillian Mary Ridste; January 1, 1919 – July 5, 1948) was an American actress. She worked as a contract player for Twentieth
Carole_Landis
Tricyclic antidepressant
Lorazepam# Medazepam Nordazepam Oxazepam Pinazepam Prazepam; Others: Alpidem‡ Barbiturates (e.g., phenobarbital) Carbamates (e.g., meprobamate) Carisoprodol Chlormezanone‡
Amitriptyline
Scottish peer (1903–1973)
addicted to alcohol, gambling and prescription drugs amphetamine and barbiturates. The Duke was also accused of physical and emotional abuse by his wives
Ian Campbell, 11th Duke of Argyll
Ian_Campbell,_11th_Duke_of_Argyll
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