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Biosynthetic pathway
The shikimate pathway (shikimic acid pathway) is a seven-step metabolic pathway used by bacteria, archaea, fungi, algae, some protozoans, and plants for
Shikimate_pathway
Chemical compound
by the enzyme shikimate dehydrogenase, which uses nicotinamide adenine dinucleotide phosphate (NADPH) as a cofactor. The shikimate pathway, named after
Shikimic_acid
Enzyme produced by plants and microorganisms
PMID 22554242. The AAA pathways consist of the shikimate pathway (the prechorismate pathway) and individual postchorismate pathways leading to Trp, Phe,
EPSP_synthase
Amino acid having an aromatic ring
organisms. Phenylalanine is the precursor to tyrosine. In plants, the shikimate pathway first leads to the formation of chorismate, which is the precursor
Aromatic_amino_acid
Class of enzymes
participates in phenylalanine, tyrosine and tryptophan biosynthesis. The shikimate pathway was determined to be a major biosynthetic route for the production
3-dehydroquinate_dehydratase
Enzyme involved in amino acid biosynthesis
tryptophan biosynthesis. Shikimate dehydrogenase is an enzyme that catalyzes one step of the shikimate pathway. This pathway is found in bacteria, plants
Shikimate_dehydrogenase
Systemic herbicide and crop desiccant
PMID 22554242. The AAA pathways consist of the shikimate pathway (the prechorismate pathway) and individual postchorismate pathways leading to Trp, Phe,
Glyphosate
protein. Some plants may have obtained the shikimate pathway from symbiotic fungi. Plant shikimate pathway enzymes share similarities to prokaryote homologs
Plant–fungus horizontal gene transfer
Plant–fungus_horizontal_gene_transfer
Class of enzymes
ATP:shikimate 3-phosphotransferase. Other names in common use include shikimate kinase (phosphorylating), and shikimate kinase II. The shikimate pathway consists
Shikimate_kinase
Series of interconnected biochemical reactions
The mevalonate pathway, also known as the isoprenoid pathway or HMG-CoA reductase pathway is an essential metabolic pathway present in eukaryotes, archaea
Mevalonate_pathway
Set of chemical reactions in organisms
energy. The chemical reactions of metabolism are organized into metabolic pathways, in which one chemical is transformed through a series of steps into another
Metabolism
Class of enzymes
the first enzyme in a series of metabolic reactions known as the shikimate pathway, which is responsible for the biosynthesis of the amino acids phenylalanine
DAHP_synthase
Linked series of chemical reactions occurring within a cell
In biochemistry, a metabolic pathway is a linked series of chemical reactions occurring within a cell. The reactants, products, and intermediates of an
Metabolic_pathway
Chemical compound
3-Dehydroquinic acid (DHQ) is the first carbocyclic intermediate of the shikimate pathway. It is created from 3-deoxyarabinoheptulosonate 7-phosphate, a 7-carbon
3-Dehydroquinic_acid
Anthocyanidin pigment in flowering plant petals and fruits
berry plants through the shikimate pathway and polyketide synthase (PKS) III. The shikimate pathway is a biosynthetic pathways that uses the starting materials
Cyanidin
Series of interconnected biochemical reactions
pentose phosphate pathway (also called the phosphogluconate pathway and the hexose monophosphate shunt or HMP shunt) is a metabolic pathway parallel to glycolysis
Pentose_phosphate_pathway
Polycyclic organic compound having sterane as a core structure
non-mevalonate pathway (MEP pathway) uses pyruvate and glyceraldehyde 3-phosphate as substrates to produce IPP and DMAPP. During diseases pathways otherwise
Steroid
Process of releasing energy from nutrients using inorganic electron acceptors
(2012-11-14). "Pathway: TCA cycle III (animals)". MetaCyc Metabolic Pathway Database. Retrieved 2022-06-20. R. Caspi (2011-12-19). "Pathway: TCA cycle I
Cellular_respiration
Class of enzymes
in the shikimate pathway, and helps catalyze the reaction from prephenate to tyrosine. Gene: (Saccharomyces Cerevisiae) TYR1 Shikimate pathway: Arogenate/Prephenate
Prephenate_dehydrogenase
Metabolic pathway
The non-mevalonate pathway—also appearing as the mevalonate-independent pathway and the 2-C-methyl-D-erythritol 4-phosphate/1-deoxy-D-xylulose 5-phosphate
Non-mevalonate_pathway
Biosynthesis of glucose molecules
Gluconeogenesis (GNG) is a metabolic pathway that results in the biosynthesis of glucose from certain non-carbohydrate carbon substrates. It is a ubiquitous
Gluconeogenesis
Series of interconnected biochemical reactions
Glycolysis is the metabolic pathway that converts glucose (C6H12O6) into pyruvate and, in most organisms, occurs in the liquid part of cells (the cytosol)
Glycolysis
Series of interconnected biochemical reactions
concentrations of H2S. The reductive acetyl CoA pathway (CoA) pathway, also known as the Wood-Ljungdahl pathway uses CO2 as electron acceptor and carbon source
Biological_carbon_fixation
Chemical compound or substance produced by a living organism, found in nature
such as macrolide antibiotics. Shikimate pathway produces aromatic amino acids (AAAs) and phenylpropanoids: Shikimate pathway → aromatic amino acids and phenylpropanoids
Natural_product
Chemical compound
odor. It is a phenylpropanoid that is naturally synthesized by the shikimate pathway. This pale yellow, viscous liquid occurs in the bark of cinnamon trees
Cinnamaldehyde
Energy-carrying molecule in living cells
be produced by a number of distinct cellular processes; the three main pathways in eukaryotes are (1) glycolysis, (2) the citric acid cycle/oxidative phosphorylation
Adenosine_triphosphate
Vitamin B9; nutrient essential for DNA synthesis
from guanosine triphosphate (GTP), while PABA is a product of the shikimate pathway. All of the biological functions of folic acid are performed by THF
Folate
Interconnected biochemical reactions releasing energy
either anaerobically or aerobically (organisms that ferment use different pathways). In addition, the cycle provides precursors of certain amino acids, as
Citric_acid_cycle
manufacture of novel antibiotic drugs. The pathway is a novel variation of the shikimate pathway. The aminoshikimate pathway was first discovered and studied in
Aminoshikimate_pathway
Metabolism involving breakdown of lipids
Lipolysis /lɪˈpɒlɪsɪs/ is the metabolic pathway through which lipid triglycerides are hydrolyzed into a glycerol and free fatty acids. It is used to mobilize
Lipolysis
Biological process to convert light into chemical energy
to be added to the well-known C4 and CAM pathways. However, alarm photosynthesis, in contrast to these pathways, operates as a biochemical pump that collects
Photosynthesis
Chemical compound
is formed via the methylerythritol phosphate pathway and the coumarin is derived from the shikimate pathway. Furanocoumarin Khandy, Maria T.; Sofronova
Pyranocoumarin
Respiration using electron acceptors other than oxygen
fermentation pathway by the reduction of oxidized compounds. These oxidized compounds are often formed during the fermentation pathway itself, but may
Anaerobic_respiration
Breakdown of glycogen
Citrate shuttle Lipogenesis Lipolysis Steroidogenesis MVA pathway MEP pathway Shikimate pathway Transcription & replication Translation Proteolysis Glycosyl-
Glycogenolysis
Chemical compound
furanocoumarins. The biosynthetic pathway is a combination of the shikimate pathway, which produces umbelliferone, and the mevalonate pathway. Umbelliferone is a phenylpropanoid
Methoxsalen
Chemical compound
pathway. It may be used against Plasmodium falciparum, the causative agent of malaria. The molecule is targeting the enzymes of the shikimate pathway
(6S)-6-Fluoroshikimic_acid
Chemical compound
pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534". PEP may be used for the synthesis of chorismate through the shikimate pathway
Phosphoenolpyruvic_acid
Hormone released by the pineal gland
the shikimate pathway from chorismate, found in plants, or obtained from protein catabolism. The initial step in the melatonin biosynthesis pathway is
Melatonin
Biochemical process in living organisms
living organisms. Carbohydrates are central to many essential metabolic pathways. Plants synthesize carbohydrates from carbon dioxide and water through
Carbohydrate_metabolism
Chemical in plants
aromatic amino acids L-phenylalanine or L-tyrosine, both products of the Shikimate pathway. When starting from L-phenylalanine, first the amino acid is non-oxidatively
Apigenin
Series of interconnected biochemical reactions
glyoxylate cycle, a variation of the tricarboxylic acid cycle, is an anabolic pathway occurring in plants, bacteria, protists, and fungi. The glyoxylate cycle
Glyoxylate_cycle
Class of enzyme
chorismate to prephenate in the pathway to the production of phenylalanine and tyrosine, also known as the shikimate pathway. chorismic acid prephenic
Chorismate_mutase
Chemical compound
reaction between tryptamine from shikimate pathway and secologanin from either mevalonate (MVA) pathway or non-mevalonate pathway (MEP). Strictosidine then undergoes
Camptothecin
Amino acid with a branched carbon chain
determined by presence of mRNAs which encode for enzymes in the metabolic pathway. Oxidation of BCAAs may increase fatty acid oxidation and play a role in
Branched-chain_amino_acid
Energy expenditure for processing food
Citrate shuttle Lipogenesis Lipolysis Steroidogenesis MVA pathway MEP pathway Shikimate pathway Transcription & replication Translation Proteolysis Glycosyl-
Specific_dynamic_action
System of communication
called a signal transduction mechanism or pathway. A more complex signal transduction pathway is the MAPK/ERK pathway, which involves changes of protein–protein
Cell_signaling
Class of 8 chemically related vitamins
through two different pathways: the Shikimate pathway and the Methylerythritol Phosphate pathway (MEP pathway). The Shikimate pathway generates the chromanol
Vitamin_E
Chemical compound
polyketide-type pathway, with three units of acetyl-CoA and one unit of 3-hydroxybenzoyl-CoA, this being formed from an early shikimate pathway intermediate
Amarogentin
Chemical compound
anthranilate is derived from the central shikimate pathway metabolite chorismate. Chorismate is made from shikimate and is then attacked by nascent ammonia
Farinamycin
Enzyme
uses NAD+ to catalyze the reaction. This reaction is part of the shikimate pathway which is involved in the biosynthesis of aromatic amino acids. 3-Dehydroquinate
3-dehydroquinate_synthase
Chemical compound
rubicordifolin. Naphthoquinones can be traced back to the shikimate pathway in plants. Shikimate is converted into chorismic acid, which is further converted
Rubicordifolin
Chemical energy animals derive from food
Citrate shuttle Lipogenesis Lipolysis Steroidogenesis MVA pathway MEP pathway Shikimate pathway Transcription & replication Translation Proteolysis Glycosyl-
Food_energy
Poisonous mushroom (death cap)
expresses a phylogenetically conserved pigment palette (derived from the shikimate pathway) under the particular microclimatic conditions of coastal California
Amanita_phalloides
Process
primarily synthesized in the liver, but they follow distinct biosynthetic pathways. However, all nucleotide synthesis requires phosphoribosyl pyrophosphate
Nucleic_acid_metabolism
Metabolic pathway
transport-linked phosphorylation or terminal oxidation, is the metabolic pathway in which cells use enzymes to oxidize nutrients, thereby releasing chemical
Oxidative_phosphorylation
Chemical synthesis of ketone bodies
intermediates (mainly oxaloacetate) have been depleted to feed the gluconeogenesis pathway. The resulting accumulation of acetyl-CoA activates ketogenesis. Insulin
Ketogenesis
Chemical compound
shikimate pathway. Prephenic acid occurs naturally as an intermediate in the biosynthesis of phenylalanine and tyrosine via the shikimic acid pathway
Prephenic_acid
Biochemical process involving the production of fats
lipids to peripheral tissues. Enzymatically, the glycerol-3-phosphate pathway occurs in the endoplasmic reticulum where it is acylated by glycerol-3-phosphate
Lipogenesis
Antibiotic
partially elucidated. A portion of the structure originates from the shikimate pathway, in which aromatic amino acids are formed. The non-proteinogenic amino
Chloramphenicol
Set of biological processes
PMID 24125941. "MetaCyc pathway: stearate biosynthesis I (animals)". MetaCyc Metabolic Pathway Database. BioCyc. "MetaCyc pathway: very long chain fatty
Fatty_acid_metabolism
Protein family
Chorismate synthase catalyzes the last of the seven steps in the shikimate pathway which is used in prokaryotes, fungi and plants for the biosynthesis
Chorismate_synthase
Chemical compound
biosynthetic pathway that generates morphine. As an isoquinoline alkaloid, it is fundamentally derived from tyrosine as part of the shikimate pathway of secondary
Salutaridinol
Process in plant metabolism
have three possible pathways through which they can metabolise 2-phosphoglycolate. They are unable to grow if all three pathways are knocked out, despite
Photorespiration
Chemical compound
phenylalanine, and tryptophan. It is used in the first step of the shikimate pathway. At this stage, phosphoenolpyruvate and erythrose-4-phosphate react
Erythrose_4-phosphate
Metabolic redox process producing energy in the absence of oxygen
enters glycolysis or the pentose phosphate pathway and is converted to pyruvate. From pyruvate, pathways branch out to form a number of end products
Fermentation
Series of interconnected biochemical reactions
ethanol in addition to lactic acid, in a process called the phosphoketolase pathway. Chemical analysis of archaeological finds shows that milk fermentation
Lactic_acid_fermentation
Chemical compound
metabolize them. Bergamottin is derived from components originating in the shikimate pathway. The biosynthesis of this compound starts with the formation of the
Bergamottin
Set of biological pathways
order to understand how life arose, knowledge is required of the chemical pathways that permit formation of the key building blocks of life under plausible
Pyrimidine_metabolism
Shikimate O-hydroxycinnamoyltransferase (EC 2.3.1.133) is an enzyme that catalyzes the chemical reaction shikimic acid + coumaroyl-CoA 4-coumaroylshikimic
Shikimate O-hydroxycinnamoyltransferase
Shikimate_O-hydroxycinnamoyltransferase
Biological synthesis and degradation of lipids
the process of beta oxidation. The main products of the beta oxidation pathway are acetyl-CoA (which is used in the citric acid cycle to produce energy)
Lipid_metabolism
Chemical compound
produce the furan ring. Psoralen originates from coumarins in the shikimate pathway; its biosynthesis is shown in the figure below. The aromatic ring
Psoralen
Drying crops before harvest
and dry out after application. Glyphosate works by poisoning the shikimate pathway which is found in plants and microorganisms but not in animals. Specifically
Crop_desiccation
Quinate/shikimate dehydrogenase (EC 1.1.1.282, YdiB) is an enzyme with systematic name L-quinate:NAD(P)+ 3-oxidoreductase. This enzyme catalyses the following
Quinate/shikimate dehydrogenase
Quinate/shikimate_dehydrogenase
Chemical compound
somniferum begins with chorismic acid, which is synthesized via the shikimate pathway from erythrose 4-phosphate and phosphoenolpyruvate. Chorismic acid
Noscapine
Chemical compound found in a variety of plants
general phenylpropanoid pathway as a hydroxycinnamoyl donor. The hydroxycinnamoyl acceptor substrate comes from the shikimate pathway: shikimic acid, quinic
Rosmarinic_acid
Polymerisation of glucose molecules into glycogen
Citrate shuttle Lipogenesis Lipolysis Steroidogenesis MVA pathway MEP pathway Shikimate pathway Transcription & replication Translation Proteolysis Glycosyl-
Glycogenesis
Psychedelic drug
study. Dimethyltryptamine is an indole alkaloid derived from the shikimate pathway. Its biosynthesis is relatively simple and summarized in the adjacent
Dimethyltryptamine
Chemical compound
is synthesized from chorismate, a compound produced from shikimate via the shikimate pathway. The conversion of chorismate to vitamin K1 comprises a series
Phytomenadione
Set of biochemical reactions
Citrate shuttle Lipogenesis Lipolysis Steroidogenesis MVA pathway MEP pathway Shikimate pathway Transcription & replication Translation Proteolysis Glycosyl-
Urea_cycle
Pharmaceutical drug
5-dihydroxocyclohex-1-ene-carboxylic acid, which is derived from the shikimate pathway. Note that the cyclohexane ring of the starting unit is reduced during
Sirolimus
Topics referred to by the same term
to: 3-Dehydroquinic acid, the first carbocyclic intermediate of the shikimate pathway Digital Humanities Quarterly, a peer-reviewed open-access academic
DHQ
Species of fungus
Gyrocyanin is biosynthesized from intermediates supplied by the shikimate pathway, a metabolic route used by fungi for the synthesis of aromatic amino
Gyroporus_cyanescens
Chemical compound
phenylalanine is formed from the Shikimate pathway, which is the pathway that plants use in order to make aromatic amino acids. This pathway is located in the plant
Kaempferol
Metabolism of fructose
either in the gluconeogenic pathway for glycogen replenishment and/or the complete metabolism in the fructolytic pathway to pyruvate, which enters the
Fructolysis
Type of α-amino acid
algae, some protozoans and plants biosynthesize phenylalanine via the shikimate pathway. While animals cannot synthesize phenylalanine, they can break it
Phenylalanine
Chemical compound
phenylalanine, which in plants is produced via the Shikimate pathway in primary metabolism. The pathway is catalyzed mainly by two cytochrome P450 (CYP)
Prunasin
Process of fatty acid breakdown
glutamate synthesis), some of them can be extracted to the gluconeogenesis pathway, in the liver and kidneys, through phosphoenolpyruvate carboxykinase, and
Beta_oxidation
Plants used in agriculture
shikimate pathway in plants, which is essential for the synthesis of the aromatic amino acids phenylalanine, tyrosine, and tryptophan. The shikimate pathway
Genetically_modified_crops
Type of compounds
luminescens. Chorismate, formed by isochorismate synthase in the shikimate pathway, is a precursor of anthraquinones in Morinda citrifolia. Tests for
Anthraquinones
Chemical compound
genistein respectively. Daidzein is an isoflavonoid derived from the shikimate pathway that forms an oxygen containing heterocycle through a cytochrome P-450-dependent
Daidzein
Group of antibiotics
pathway (PKS I) in which chain extension is performed using 2 acetate and 8 propionate units. AHBA is believed to have originated from the Shikimate pathway
Rifamycin
Amino acid
microorganisms, tyrosine is produced via prephenate, an intermediate on the shikimate pathway. Prephenate is oxidatively decarboxylated with retention of the hydroxyl
Tyrosine
Biochemical shuttle reaction
Citrate shuttle Lipogenesis Lipolysis Steroidogenesis MVA pathway MEP pathway Shikimate pathway Transcription & replication Translation Proteolysis Glycosyl-
Carnitine_shuttle
Class of plant-based pigments
streams of chemical raw materials in the cell: One stream involves the shikimate pathway to produce the amino acid phenylalanine, (see phenylpropanoids) The
Anthocyanin
Chemical compound
chorismate into isochorismate, giving rise to one of the branches of the shikimate pathway. Isochorismate is a precursor in the biosynthesis of many natural
Isochorismic_acid
Soybean that has had DNA introduced into it using genetic engineering techniques
2005.07.013. PMID 16298508. "Aromatic amino acid biosynthesis, The shikimate pathway – synthesis of chorismate". Metabolic Plant Physiology Lecture notes
Genetically_modified_soybean
Chemical compound
type ll polyketide or shikimate pathways. This claim was not disputed until a key intermediate exclusive to the polyketide pathway was isolated. Until then
Carminic_acid
Biochemical process in which fatty acids are derived from acetyl-CoA and NADPH
to reach similarities about the general pathway. In both animals and fungi, all fatty acid synthetic pathways utilize one multifunctional protein complex
Fatty_acid_synthesis
Plant secondary metabolite
malonyl-CoAs through a PKSIII pathway. 4-Hydroxycinnamoyl CoA is biosynthesized from L-phenylalanine through the Shikimate pathway. L-Phenylalanine is first
Catechin
Genetically modified tree
PMC 11591478. PMID 39582156. "Aromatic amino acid biosynthesis, The shikimate pathway – synthesis of chorismate". Metabolic Plant Physiology Lecture notes
Genetically modified eucalyptus
Genetically_modified_eucalyptus
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