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Chemical compound
Psoralen (also called psoralene) is the parent compound in a family of naturally occurring organic compounds known as the linear furanocoumarins. It is
Psoralen
Ultraviolet light therapy treatment
PUVA (psoralen and UVA) is an ultraviolet light therapy treatment for skin diseases: vitiligo, eczema, psoriasis, graft-versus-host disease, mycosis fungoides
PUVA_therapy
Chemical compound
methoxsalen followed by PUVA therapy. Chemically, methoxsalen is a derivative of psoralen and belongs to a class of organic natural molecules known as furanocoumarins
Methoxsalen
Class of phyto-photo toxic compounds
different isomers. The parent compounds of the most common isomers are psoralen and angelicin. Derivatives of these two compounds are referred to respectively
Furanocoumarin
Species of legume
medicine. The seeds of this plant contain a variety of coumarins, including psoralen. Used as a dietary supplement, Cullen corylifolium is of no clinical benefit
Cullen_corylifolium
Class of enzymes
Psoralen synthase (EC 1.14.14.141) is an enzyme that catalyzes the chemical reaction (+)-marmesin O2 2 H2O psoralen + acetone The enzyme is
Psoralen_synthase
Species of flowering plant, or its fruit
quantities of two furanocoumarins, psoralen and bergapten. The essential oil of fig leaves contains more than 10% psoralen, the highest concentration of any
Fig
Chemical compound
Marmesin (nodakenetin) is a chemical compound precursor in psoralen and linear furanocoumarins biosynthesis. Marmesin plays a central role in the biosynthesis
Marmesin
Chemical compound
furanocoumarin and a psoralen derivative. It is obtained from several plants, mainly Psoralea corylifolia. Like other psoralens it causes photosensitization
Trioxsalen
Autoimmune diseases of the skin
administration of psoralen with exposure to ultraviolet A (UVA) light. The mechanism of action of PUVA is unknown, but likely involves activation of psoralen by UVA
Psoriasis
Skin condition where patches lose pigment
needed] UVA treatments are normally carried out in a hospital clinic. Psoralen and ultraviolet A light (PUVA) treatment involves taking a drug that increases
Vitiligo
Darkening of skin in response to ultraviolet light
have used different forms of psoralen, which are known to be photocarcinogenic. Health authorities have banned psoralen since July 1996. In the United
Sun_tanning
Chemical
as well. The best known tanning activator is psoralen which is an ingredient of bergamot oil. Psoralen has been present in sunscreens in order to allow
Tanning_activator
Medical condition
xanthotoxin (also known as methoxsalen), two linear furanocoumarins derived from psoralen, are invariably found in plants associated with phytophotodermatitis. A
Phytophotodermatitis
Heterocyclic compound consisting of fused benzene and furan rings
compound) of many related compounds with more complex structures. For example, psoralen is a benzofuran derivative that occurs in several plants. There are benzofuran
Benzofuran
Citrus fruit
("margarita photodermatitis"). Furanocoumarins, including bergapten, limettin, psoralen, and xanthotoxin, are the primary phototoxic compounds. Lime peel contains
Lime_(fruit)
Chemical compound
In meantime, tribes in India used Psoralea corylifolia which contained psoralen, the isomer of angelicin. Humans also attempted to harvest the plants as
Angelicin
Species of plant
8-[2-(3-methylbutroxy)-3-hydroxy-3-methylbutoxy]psoralen, osthol, ostruthol, oxypeucedanin, phellopterin, psoralen and xanthotoxin, can be isolated from a chloroform
Angelica_archangelica
Genus of flowering plants in the celery family
to sunlight.[citation needed] Of those, at least 25 species contained a psoralen derivative, either bergapten (5-methoxypsoralen) or methoxsalen (8-methoxypsoralen)
Heracleum_(plant)
Citrus fruit
and perfume products, bergamot may cause skin irritation. In the past, psoralen extracted from bergamot oil was used in tanning accelerators and sunscreens
Bergamot_orange
2025 American television series
the siblings. The cause of the family's shared condition is traced to psoralen toxicity from overconsumption of celery. When Shelly is diagnosed with
Watson_(TV_series)
Most common form of cutaneous T-cell lymphoma
most commonly recommended first-line treatment for mycosis fungoides is psoralen plus ultraviolet A (PUVA therapy). PUVA is a photochemotherapy that involves
Mycosis_fungoides
Cold-pressed essential oil
from the bergamot orange. Bergapten, a linear furanocoumarin derived from psoralen, is often found in plants associated with phytophotodermatitis. Note that
Bergamot_essential_oil
Index of chemical compounds with the same molecular formula
g/mol, exact mass: 186.0317 u) may refer to: Angelicin Furanochromone Psoralen, or psoralene This set index page lists chemical structure articles associated
C11H6O3
Type of skin allergy caused by garlic
medication, such as administering acitretin (25 mg/day, orally) or applying psoralen and ultraviolet light to the affected skin area over a period of 12 weeks
Garlic_allergy
Medical condition
with psoriasis who have been treated using UV light and a drug known as psoralen have an increased risk of penile cancer. Penile cancer arises from precursor
Penile_cancer
Inflammatory disease of the skin
individuals with AD. Light therapy using heliotherapy, balneophototherapy, psoralen plus UVA (PUVA therapy), light has tentative support but the quality of
Dermatitis
Class of enzymes
enzymes. The milky sap of the common fig also contains furanocoumarins (psoralen), although oddly enough these are found chiefly in the sap of the leaves
Ficain
Species of virus
1016/0165-7992(82)90201-9. PMID 6289091. Hall JD, Scherer K (December 1981). "Repair of psoralen-treated DNA by genetic recombination in human cells infected with herpes
Herpes_simplex_virus
Species of legume
metal contaminated or degraded soils, (iii) Synthesis of furanocoumarins (psoralen, angelicin, xanthotoxin and bergapten), compounds of broad pharmaceutical
Bituminaria_bituminosa
methacrylate Methyl parathion 1-Methylphenanthrene 7-Methylpyrido[3,4-c]psoralen Methyl red Methyl selenac Microcystis extracts Modacrylic fibres Monuron
IARC_group_3
Genus of flowering plants
photosensitizing agent appears to be bergapten, a linear furanocoumarin derived from psoralen. This claim has been confirmed for lime and bergamot. In particular, bergamot
Citrus
radicals. One medication that has been proven to be photocarcinogenic is psoralen. This drug is used in photodynamic therapy for many inflammatory skin conditions
Photocarcinogen
Species of virus
repaired. In contrast, when multiple viral genomes infected a host cell, psoralen-induced DNA cross-links were repaired; that is, MR occurred. Hall suggested
SV40
Form of electromagnetic radiation
hyper-photosensitive, by taking psoralens is an effective treatment for psoriasis. Due to the potential of psoralens to cause damage to the liver, PUVA
Ultraviolet
Chemically-induced skin irritation following exposure to light
medicines: tetracycline antibiotics, sulfonamides, amiodarone, quinolones, psoralen Many cold pressed citrus essential oils such as bergamot oil Some plant
Phototoxicity
Biopharmaceutical drug
(whole-body) psoriasis treatments, such as ciclosporin, methotrexate or PUVA (psoralen ultraviolet A); active psoriatic arthritis in adults; moderately to severely
Ustekinumab
Family of flowering plants
(September 1962). "The Presently Known Distribution of Furocoumarins (Psoralens) in Plants". Journal of Investigative Dermatology. 39 (3): 225–239. doi:10
Apiaceae
Inflammation of the lips
Busulphan, Clofazimine, Clomipramine, Cyancobalamin, Gold, Methyldopa, Psoralens, Streptomycin, Sulfasalazine and Tetracycline. A condition called "drug-induced
Cheilitis
Form of scleroderma involving isolated patches of hardened skin
prescription vitamin-D with success. Ultraviolet A (UVA) light, with or without psoralens have also been tried. UVA-1, a more specific wavelength of UVA light,
Morphea
Inflammation from allergen or irritant exposure
a photoproduct. Toxins which are associated with PCD include the psoralens. Psoralens are in fact used therapeutically for the treatment of psoriasis,
Contact_dermatitis
Species of plant
mechanism of toxicity isn't known, the furanocoumarins chalepensin and psoralen are likely implicated. Rue can cause photodermatitis of ultraviolet light-exposed
Ruta_graveolens
Correction of DNA replication errors
light, which introduces cyclobutane pyrimidine dimer damages in DNA, or psoralen-plus-light, which introduces pyrimidine adducts, the rate of mutation increases
Proofreading_(biology)
Phenomenon in genetics
linking the 3, 4 (pyrone) or 4', 5’ (furan) edge of psoralen to the 5, 6 double bond of thymine. Psoralens can form two types of monoadducts and one diadduct
Crosslinking_of_DNA
Primary type of cell found in the epidermis
appears after exposure to UVC or UVB radiation or UVA in the presence of psoralens. It shows premature and abnormal keratinization, and has been described
Keratinocyte
Species of plant
furanocoumarins bergapten and xanthotoxin (also known as methoxsalen), two psoralen derivatives well known for their photosensitizing effects. Indeed, A. majus
Ammi_majus
Medical condition
reduce the risk of disease transmission. A technology using the synthetic psoralen (amotosalen HCl) and UVA light (320–400 nm) has been implemented in European
Blood-borne_disease
Bonds linking one polymer chain to another
in DNA. Other crosslinking agents include mustard gas, mitomycin, and psoralen. In proteins, crosslinks are important in generating mechanically stable
Cross-link
Field of medicine dealing with the hair, nails, skin, and its diseases
growths Phototherapy including the use of narrowband UVB, broadband UVB, psoralen, and UVB Tumescent liposuction: Invented by a gynecologist, a dermatologist
Dermatology
Chemical compound
bark of the Bael tree) and furocoumarins such as marmesin, angelicin, and psoralen. Umbelliferone 7-apiosylglucoside can be isolated from the root of Gmelina
Umbelliferone
Species of flowering plant in the celery family
Fitzpatrick, T.B. (1962). "The presently known distribution of furocoumarins (psoralens) in plants". Journal of Investigative Dermatology. 39 (3): 225–239. doi:10
Heracleum_sphondylium
Skin condition
them some antibiotics, diuretics, COX-2 inhibitors, and diabetes drugs. Psoralens, coal tars, photo-active dyes (eosin, acridine orange). Musk ambrette
Photodermatitis
Family of chemical compounds
have the ability to form ICLs are cisplatin, mitomycin C, carmustine, and psoralen. These kinds of lesions are effective at forcing the cell to undergo apoptosis
Nitrogen_mustard
Therapy involving intentional exposure to sunlight
wavelength) or a broader spectrum UVB (280–315 nm wavelength). UVA combined with psoralen, a drug taken orally, is known as PUVA treatment. In UVB phototherapy the
Light_therapy
Jiaxi; Jiang, Miaomiao; Zhou, Kun (2 November 2019). "Long-Term Exposure of Psoralen and Isopsoralen Induced Hepatotoxicity and Serum Metabolites Profiles Changes
List_of_poisonous_plants
blood sample PUD peptic ulcer disease PUO pyrexia of unknown origin PUVA psoralen UV A (photochemical ultraviolet light A waves) p.v. per vagina (as noun:
List of medical abbreviations: P
List_of_medical_abbreviations:_P
Technique for mapping interactions between molecules and their protein targets
mapping genomic binding sites of the DNA intercalating agent psoralen and showed that bio-psoralen preferentially binds to the transcription start site of
Chem-seq
Medical condition
reports of perioral dermatitis have been made by some patients receiving Psoralen and ultraviolet A therapy. An underlying cause can not always be known
Perioral_dermatitis
Medical condition
With good outcomes, different topical photochemotherapy regimens (topical psoralen UVA; PUVA) have been utilized to treat postinflammatory hypopigmentation
Postinflammatory hypopigmentation
Postinflammatory_hypopigmentation
Abnormal hair growth over the body
Minoxidil Antibiotics: Streptomycin Diuretics: Acetazolamide Photosensitizers: Psoralen Acquired hypertrichosis is usually reversible once the causative medications
Hypertrichosis
Medical condition
topical steroids and ultraviolet therapy. The use of narrowband UVB and psoralen have shown to be effective treatments for some patients with pigmented
Majocchi's_disease
Burning of the skin by the sun's radiation
fluoroquinolones, 5-fluorouracil, furosemide, nalidixic acid, phenothiazines, psoralens, retinoids, sulfonamides, sulfonylureas, tetracyclines, thiazides, and
Sunburn
Pharmaceutical drug classification
ATC code D05 Antipsoriatics is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed
ATC_code_D05
Organic compounds derived from coumarin
(7-hydroxycoumarin), aesculetin (6,7-dihydroxycoumarin), herniarin (7-methoxycoumarin), psoralen and imperatorin. 4-Phenylcoumarin is the backbone of the neoflavones, a
Coumarin_derivatives
Physical or chemical agent that increases the rate of genetic mutation
reagent in organic synthesis and a component in many car airbag systems Psoralen combined with ultraviolet radiation causes DNA cross-linking and hence
Mutagen
Medical condition
evidence. For pruritus, phototherapy (broad-band or narrow-band UVB, or psoralen plus UVA) may be beneficial. Other strategies include destructive techniques
Acquired perforating dermatosis
Acquired_perforating_dermatosis
pigmentation, and urticaria, or hives. T-2 toxin Sterigmatocystin Sulfur mustard Psoralen Cantharidin Dermatotoxins have been used for several different substances
Dermatotoxin
Chemical compound
photosensitivity; however, topical application reduces these side effects. Psoralens are commonly used for vitiligo treatment, but have higher phototoxic and
Khellin
Tanning without ultraviolet exposure
retinoids, oestrogens, melanocyte-stimulating hormone, endothelins, psoralens, hydantoin, forskolin, cholera toxin, isobutylmethylxanthine, diacylglycerol
Sunless_tanning
Human disease
and narcotics. H1 antagonists are used to treat urticaria and pruritus. Psoralen combined with UV radiation by preventing mast cells from releasing histamine
Telangiectasia macularis eruptiva perstans
Telangiectasia_macularis_eruptiva_perstans
Rejection of host tissue by a transplanted organ's immune cells
Menillo SA, Goldberg SL, McKiernan P, Pecora AL (October 2001). "Intraoral psoralen ultraviolet A irradiation (PUVA) treatment of refractory oral chronic graft-versus-host
Graft-versus-host_disease
Dubertret with the development of French research on drugs activated by light: psoralen. Dubertret coordinated the research activities of six fundamental research
Louis_Dubertret
Technique to prevent viral contamination
distinct class of chemical agents that require light induction, such as psoralens, 1,5-iodonaphthyl azide, methylene blue, and riboflavin. This process
Virus_inactivation
Chemical compound
iNOS and suppresses the production of NO in osteoarthritic chondrocytes. Psoralen, the parent furocoumarin. Sigurdsson S, Ogmundsdottir HM, Gudbjarnason
Imperatorin
Class of immunosuppressive drug
ustekinumab. In cases where more conventional systemic treatments such as psoralen combined with ultraviolet A treatment (PUVA), methotrexate, and ciclosporin
TNF_inhibitor
Medication for psoriasis and psoriatic arthritis
of other systemic therapies, including cyclosporine, methotrexate, or psoralen and ultraviolet-A light. In the European Union, the drug is contraindicated
Apremilast
Medical condition
Alezzandrini syndrome. The clinical presentation is the basis for the diagnosis. Psoralen plus ultraviolet A (PUVA) treatment is an option for cases with extensive
Alezzandrini_syndrome
Medical condition
been attempted to repigment the lesions of nevus depigmentosus, including psoralen plus ultraviolet A (PUVA) therapy, excimer laser treatment, and different
Nevus_depigmentosus
(Extended-release Bayer 8-Hour), a form of aspirin 8-methoxy-psoralen, also known as methoxsalen (INN) 8-Mop or 8-methoxy-psoralen, also known as methoxsalen (INN)
List_of_drugs:_1–9
Species of plant
following 11 compounds from Dorstenia contrajerva: dorsjervin A, dorsjervin B, psoralen, dorstenin, squalene, γ-sitosterol, cycloartocarpesin,
Dorstenia_contrajerva
Alcoholic beverage originally produced in China using the bones of tigers
effects and reactions in those who use them. Goat blood, python meat, psoralen, cockroaches, bezoars, moss, rhinoceros horns, and Cordyceps sinensis are
Tiger_bone_wine
Species of fern
S (2004). "Orally administered Polypodium leucotomos extract decreases psoralen-UVA-induced phototoxicity, pigmentation, and damage of human skin". J Am
Phlebodium_aureum
Chemical compound
first to remove the hydroxyisopropyl substituent from marmesin (4) to form psoralen (5), and then to add a hydroxyl group to form bergaptol (6). Bergaptol
Bergamottin
Medical condition
granulomas' location in the superficial reticular dermis. Complete excision, psoralen and UVA therapy, intralesional triamcinolone, and high-dose corticosteroids
Perforating granuloma annulare
Perforating_granuloma_annulare
Chemical compound
2-g]chromen-7-one Other names Xyloltenin; 3-(α,α-dimethylallyl)psoralen Identifiers CAS Number 13164-03-9 Y 3D model (JSmol) Interactive image
Chalepensin
Type of skin lesion
keratosis is a precancerous keratotic skin lesion that arises from exposure to psoralen plus ultraviolet A light therapy. PUVA-induced acrobullous dermatosis List
PUVA_keratosis
Form of phototherapy
its expertise in resolving difficult-to-reach tumours. PUVA therapy uses psoralen as photosensitiser and UVA ultraviolet as light source, but this form of
Photodynamic_therapy
Class of pharmaceutical compounds
pigmentation occurs. Psoralen is a natural drug obtained from the fruit of Psoralea corylifolia. Methoxsalen and Trioxsalen are synthetic psoralens. These drugs
Melanizing_agents
Chemical compound
furanocoumarin to be isolated and identified. Bergapten is a derivative of psoralen, the parent compound of a family of naturally occurring organic compounds
Bergapten
Genus of legumes
with itch or with leprosy”. Psoralen occurs naturally in the seeds of Psoralea corylifolia, and is used in PUVA (psoralen + UVA) treatment, for several
Psoralea
To identify peptides binding a target
ISBN 978-0-12-182219-4. PMID 10889994. Kurz M, Gu K, Lohse PA (2000). "Psoralen photo-crosslinked mRNA–puromycin conjugates: a novel template for the rapid
MRNA_display
French chemist (1933–2016)
runs the Eiffel Tower. Sequence specificity in photoreaction of various psoralen derivatives with DNA: Role in biological activity 6,4,4′-Trimethylangelicin
Ethel_Moustacchi
Tanning using an artificial source of ultraviolet light
treat skin conditions. When UV light therapy is used in combination with psoralen, an oral or topical medication, the combined therapy is referred to as
Indoor_tanning
Severe skin reaction to medication
spider bites, iopamidol (used for radiocontrast), lacquers, mercury, psoralen (combined with ultraviolet A to treat psoriasis), and xenobiotics have
Acute generalized exanthematous pustulosis
Acute_generalized_exanthematous_pustulosis
Biological process
naturally occurring chemicals may also promote crosslinking, such as psoralens after activation by UV radiation, and nitrous acid. Interstrand cross-linking
Mutagenesis
imaging – PS-341 – PSA – psammoma body – PSC 833 – pseudomyxoma peritonei – psoralen – PTC – PTCD – PTK787/ZK 222584 – ptosis – pulmonary sulcus tumor – PV701
Index_of_oncology_articles
Species of bacteriophage
(without shoulders) were also obtained for the DNA damaging agents P32 decay, psoralen plus near-UV irradiation (PUVA), N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)
Escherichia_virus_T4
Index of chemical compounds with the same molecular formula
formula C12H8O4 (molar mass : 216.19 g/mol) may refer to: Bergapten, a psoralen found in bergamot essential oil Methoxsalen, a drug used to treat psoriasis
C12H8O4
Form of treatment for skin disorders
any wavelength in the UVB range of 285–320 nanometres. PUVA means UVA + psoralen. It consists of irradiation of the skin with the UVA ultraviolet light
Ultraviolet_light_therapy
14.13.101: senecionine N-oxygenase EC 1.14.13.102: Now EC 1.14.14.141, psoralen synthase EC 1.14.13.103: Now EC 1.14.14.142, 8-dimethylallylnaringenin
List_of_EC_numbers_(EC_1)
PSORALEN
PSORALEN
PSORALEN
PSORALEN
PSORALEN
PSORALEN
PSORALEN
PSORALEN
PSORALEN