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Gene found in fruit flies
The shaker (Sh) gene, when mutated, causes a variety of atypical behaviors in the fruit fly, Drosophila melanogaster. Under ether anesthesia, the fly’s
Shaker_(gene)
Topics referred to by the same term
Look up shaker in Wiktionary, the free dictionary. Shaker or Shakers may refer to: Shakers, a historically significant Christian sect Indian Shakers, a smaller
Shaker
Christian monastic denomination
of Believers in Christ's Second Appearing, more commonly known as the Shakers, are a millenarian restorationist Christian sect founded c. 1747 in England
Shakers
Pore-forming membrane protein
channelopathies. See Category:Channelopathies for a full list.[citation needed] Shaker gene mutations cause a defect in the voltage gated ion channels, slowing down
Ion_channel
Ion channel complex through which calcium ions pass
affecting downstream signaling pathways. The following tables explain gating, gene, location and function of different types of calcium channels, both voltage
Calcium_channel
Water channel protein in cell membranes
and mechanism of potassium channels. Genetic defects involving aquaporin genes have been associated with several human diseases including nephrogenic diabetes
Aquaporin
American neuroscientist (born 1944)
reveal the location of the Shaker gene on the Drosophila polytene chromosome map. These studies validated the Shaker gene as the structural locus of a
Lawrence_B._Salkoff
Family of transport proteins
IUPHAR. The proteins of these channels are named Nav1.1 through Nav1.9. The gene names are referred to as SCN1A through SCN5A, then SCN8A through SCN11A.
Voltage-gated_sodium_channel
Electric current in the heart
12.2 12.3 Kvβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene) Miscellaneous Cl−: Chloride channel Calcium-dependent chloride channels
Pacemaker_current
Type of ion channel transmembrane protein
receptor Metabotropic receptor Ryanodine receptor "Gene Family: Ligand gated ion channels". HUGO Gene Nomenclature Committee. Archived from the original
Ligand-gated_ion_channel
Transmembrane protein allowing sodium ions in and out
IUPHAR. The proteins of these channels are named Nav1.1 through Nav1.9. The gene names are referred to as SCN1A through SCN5A, then SCN8A through SCN11A.
Sodium_channel
Family of transport proteins
12.2 12.3 Kvβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene) Miscellaneous Cl−: Chloride channel Calcium-dependent chloride channels
Light-gated_ion_channel
Class of porin ion channels in the outer mitochondrial membrane
Yeast contains two members of this family (genes POR1 and POR2); vertebrates have at least three members (genes VDAC1, VDAC2 and VDAC3). Humans, like most
Voltage-dependent anion channel
Voltage-dependent_anion_channel
Type of ion channel transmembrane protein
Camino D, Dekker JP, Yellen G (April 2004). "Intracellular gate opening in Shaker K+ channels defined by high-affinity metal bridges". Nature. 428 (6985):
Voltage-gated_ion_channel
12.2 12.3 Kvβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene) Miscellaneous Cl−: Chloride channel Calcium-dependent chloride channels
Membrane_channel
Group of voltage-gated ion channels permeable to Ca2+
channels, muscular contraction, excitation of neurons, up-regulation of gene expression, or release of hormones or neurotransmitters. VGCCs have been
Voltage-gated_calcium_channel
Protein-coding gene in the species Homo sapiens
Shaw-related subfamily, member 4 (KCNC4), also known as Kv3.4, is a human gene. The Shaker gene family of Drosophila encodes components of voltage-gated potassium
KCNC4
Taiwanese-American neuroscientist (born 1947)
were challenged by difficulties cloning the Shaker gene. In 1987, they were successful with cloning Shaker and enabling their team to perform functional
Lily_Jan
Family of transport proteins
secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family". Nat. Genet. 31 (2): 166–170. doi:10.1038/ng889. PMID 12032568. S2CID 40990544
TRPM
Protein family
are categorized as high threshold-activated channels and seen in the Cav2 gene family. The structure of the N-type calcium channel is very similar to other
N-type_calcium_channel
Family of transport proteins
neurohormones and neurotransmitters. They have also been seen to play a role in gene expression, mRNA stability, neuronal survival, ischemic-induced axonal injury
L-type_calcium_channel
Class of transport proteins
TRPC2 is found to be expressed solely in mice and is considered a pseudo-gene in humans; this is partly due to the role of TRPC2 in detecting pheromones
Transient receptor potential channel
Transient_receptor_potential_channel
Class of transport proteins
12.2 12.3 Kvβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene) Miscellaneous Cl−: Chloride channel Calcium-dependent chloride channels
Inositol trisphosphate receptor
Inositol_trisphosphate_receptor
Group of transport proteins
pressure, bacteria can develop resistance through mutations in the porin gene. The mutations may lead to a loss of porins, resulting in the antibiotics
Porin_(protein)
Human protein for regulating body temperature
vanilloid receptor 1, is a protein that, in humans, is encoded by the TRPV1 gene. It was the first isolated member of the transient receptor potential vanilloid
TRPV1
Protein-coding gene in the species Homo sapiens
channel alpha-3 is a protein that in humans is encoded by the CNGA3 gene. This gene encodes a member of the cyclic nucleotide-gated cation channel protein
Cyclic nucleotide-gated channel alpha 3
Cyclic_nucleotide-gated_channel_alpha_3
Mammalian protein found in humans
the CFTR gene. Geneticist Lap-Chee Tsui and his team identified the CFTR gene in 1989 as the gene linked with cystic fibrosis. The CFTR gene codes for
Cystic fibrosis transmembrane conductance regulator
Cystic_fibrosis_transmembrane_conductance_regulator
Protein-coding gene in the species Homo sapiens
human gene that encodes the KCa4.1 protein. KCa4.1 is a member of the calcium-activated potassium channel protein family Mutations in the KCNT1 gene has
KCNT1
Condiment dispensers
Identification & Value Guide, Gene Florence, Collector Books (2002), ISBN 1-57432-257-5, ISBN 978-1-57432-257-6 Collecting Salt & Pepper Shaker Series, Irene Thornburg
Salt_and_pepper_shakers
Protein-coding gene in the species Homo sapiens
alpha (SCN1A), is a protein which in humans is encoded by the SCN1A gene. The SCN1A gene is located on chromosome 2 of humans, and is made up of 26 exons
SCN1A
Intermembrane proteins
voltages near the resting membrane potential. HCN channels are encoded by four genes (HCN1, 2, 3, 4) and are widely expressed throughout the heart and the central
HCN_channel
Ion channel that selectively passes K+
"Electrostatic interaction between charybdotoxin and a tetrameric mutant of Shaker K(+) channels". Biophysical Journal. 78 (5): 2382–2391. Bibcode:2000BpJ
Potassium_channel
Group of proteins which form the intermembrane channels of gap junctions
cytoskeleton and cell migration. For these reasons, mutations in connexin-encoding genes can lead to functional and developmental abnormalities. Connexins are commonly
Connexin
Protein-coding gene in humans
beta-1 is a protein that in humans is encoded by the CACNB1 gene. The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays
CACNB1
Protein-coding gene in the species Homo sapiens
intracellular vesicles located throughout the cell. It is encoded by the AQP2 gene. It is the only aquaporin regulated by vasopressin. The basic job of aquaporin
Aquaporin-2
Protein-coding gene in humans
menthol receptor 1 (CMR1), is a protein that in humans is encoded by the TRPM8 gene. The TRPM8 channel is the primary molecular transducer of cold somatosensation
TRPM8
Family of transport proteins
12.2 12.3 Kvβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene) Miscellaneous Cl−: Chloride channel Calcium-dependent chloride channels
TRPP
Protein-coding gene in the species Homo sapiens
known as TREK-1, is a protein that in humans is encoded by the KCNK2 gene. This gene encodes K2P2.1, a lipid-gated ion channel belonging to the two-pore-domain
KCNK2
Mammalian protein found in humans
KCNH2 also known as hERG (the human Ether-à-go-go-Related Gene) is a protein encoded by the gene KCNH2 Kv11.1, the α subunit of a potassium ion channel.
KCNH2
Class of transport proteins
transport of chloride ions. Mammals have multiple isoforms (at least 6 different gene products plus splice variants) of epithelial chloride channel proteins, catalogued
Chloride_channel
Protein-coding gene in humans
alpha-2/delta-1 is a protein that in humans is encoded by the CACNA2D1 gene. The CACNA2D1 gene is located on chromosome 7q21.11–q22, spanning genomic coordinates
CACNA2D1
Protein and coding gene in humans
that in humans is encoded by the TRPA1 (and in mice and rats by the Trpa1) gene. TRPA1 is an ion channel located on the plasma membrane of many human and
TRPA1
Group of transmembrane proteins that passively transport potassium ions
related to autosomal recessive mutations in Kir6.2. Certain mutations of this gene diminish the channel's ability to regulate insulin secretion, leading to
Inward-rectifier potassium channel
Inward-rectifier_potassium_channel
Membrane protein involved in transportation
12.2 12.3 Kvβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene) Miscellaneous Cl−: Chloride channel Calcium-dependent chloride channels
Membrane_transport_protein
Protein-coding gene in the species Homo sapiens
subfamily K member 5 is a protein that in humans is encoded by the KCNK5 gene. This gene encodes K2P5.1, one of the members of the superfamily of potassium
KCNK5
Group of membrane proteins
homologous subunits α or δ, β, and γ, These subunits are encoded by four genes: SCNN1A, SCNN1B, SCNN1G, and SCNN1D. The ENaC is involved primarily in the
Epithelial_sodium_channel
Protein-coding gene in the species Homo sapiens
member 16A (TMEM16A), is a protein that, in humans, is encoded by the ANO1 gene. Anoctamin-1 is a voltage-gated calcium-activated anion channel, which acts
ANO1
Class of intracellular transport proteins
was traced to homozygous duplication of a mutant RyR2 (Ryanodine Receptor) gene. Normal (wild type) ryanodine receptors are involved in CICR in heart and
Ryanodine_receptor
Protein-coding gene in the species Homo sapiens
is a sodium ion channel subtype that in humans is encoded by the SCN10A gene. Nav1.8-containing channels are tetrodotoxin (TTX)-resistant voltage-gated
Nav1.8
Family of transport proteins
Four genes have been identified as members of the KATP gene family. The sur1 and kir6.2 genes are located in chr11p15.1 while kir6.1 and sur2 genes reside
ATP-sensitive potassium channel
ATP-sensitive_potassium_channel
Cell-cell junction composed of innexins or connexins
the genes coding for the connexin gap junction channels were classified in one of three groups (A, B and C; for example, GJA1, GJC1), based on gene mapping
Gap_junction
Protein-coding gene in the species Homo sapiens
Aquaporin 3 (AQP-3) is the protein product of the human AQP3 gene. It is found in the basolateral cell membrane of principal collecting duct cells and
Aquaporin-3
Protein-coding gene in humans
voltage-gated channel, shaker-related subfamily, member 5, also known as KCNA5 or Kv1.5, is a protein that in humans is encoded by the KCNA5 gene. Potassium channels
KCNA5
Protein-coding gene in the species Homo sapiens
intracellular channel protein 1 is a protein that in humans is encoded by the CLIC1 gene. Chloride channels are a diverse group of proteins that regulate fundamental
CLIC1
Protein subfamily of calcium-activated potassium channels
stress exposure SK potassium channels share the same basic architecture with Shaker-like voltage-gated potassium channels. Four subunits associate to form a
SK_channel
Subgroup of TRP cation channels named after the vanilloid receptor
12.2 12.3 Kvβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene) Miscellaneous Cl−: Chloride channel Calcium-dependent chloride channels
TRPV
Protein-coding gene in the species Homo sapiens
Aquaporin-8 is a protein that in humans is encoded by the AQP8 gene. Aquaporin-8 (AQP-8) is a water channel protein. Aquaporins are a family of small integral
Aquaporin-8
Class of transport proteins
channel genes. Such genetic methods allowed the genetic identification of the "Shaker" K+ channel gene in Drosophila before ion channel gene sequences
Voltage-gated potassium channel
Voltage-gated_potassium_channel
Transmembrane protein in invertebrates
invertebrates. Invertebrate genomes may contain more than a dozen innexin genes. Once the human genome was sequenced, innexin homologues were identified
Innexin
Class of transport proteins
12.2 12.3 Kvβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene) Miscellaneous Cl−: Chloride channel Calcium-dependent chloride channels
Two-pore-domain potassium channel
Two-pore-domain_potassium_channel
Protein-coding gene in the species Homo sapiens
connexin 26 (Cx26) — is a protein that in humans is encoded by the GJB2 gene. Gap junctions were first characterized by electron microscopy as regionally
GJB2
Protein-coding gene in the species Homo sapiens
Aquaporin-4, also known as AQP-4, is a water channel protein encoded by the AQP4 gene in humans. AQP-4 belongs to the aquaporin family of integral membrane proteins
Aquaporin-4
Protein-coding gene in humans
member 2 is a protein that in humans is encoded by the KCNC2 gene. The protein encoded by this gene is a voltage-gated potassium channel subunit (Kv3.2). Kv3
KCNC2
Protein-coding gene in humans
member 3 is a protein that in humans is encoded by the KCNH3 gene. The protein encoded by this gene is a voltage-gated potassium channel subunit. GRCh38: Ensembl
KCNH3
Protein-coding gene in the species Homo sapiens
protein that in humans is encoded by the SCN7A (Sodium channel protein type 7) gene. It is a sodium channel alpha subunit expressed in the heart, the uterus
SCN7A
Protein found in humans
humans is encoded by the SCN4A gene. The Nav1.4 voltage-gated sodium channel is encoded by the SCN4A gene. Mutations in the gene are associated with hypokalemic
Nav1.4
Protein-coding gene in the species Homo sapiens
channel 1 (TPC1) is a human protein encoded by the TPCN1 gene. The protein encoded by this gene is an ion channel. In contrast to other calcium and sodium
TPCN1
Protein-coding gene in the species Homo sapiens
paragraph genetics). SCN5A is the gene that encodes the cardiac sodium channel NaV1.5. SCN5A is a highly conserved gene located on human chromosome 3, where
SCN5A
Protein-coding gene in the species Homo sapiens
4 is a protein, that in humans, is encoded by the KCNH4 gene. The protein encoded by this gene is a voltage-gated potassium channel subunit. GRCh38: Ensembl
KCNH4
Protein family
the mucolipin-1 (MCOLN1), mucolipin-2 (MCOLN2) and mucolipin-3 (MCOLN3) genes, respectively. The three members of the TRPML ("ML" for mucolipin) sub-family
TRPML
Protein family
by CorA. The gene was originally named after the cobalt-resistant phenotype in E. coli that was caused by the gene's inactivation. The gene was genetically
Magnesium_transporter
Protein-coding gene in the species Homo sapiens
voltage-gated channel, shaker-related subfamily, member 3, also known as KCNA3 or Kv1.3, is a protein that in humans is encoded by the KCNA3 gene. Potassium channels
KCNA3
Type of membrane proteins
was found after studies in E. coli spheroplasts. The identification of the gene family necessitated for MS of small conductance was as two different channels
Mechanosensitive_channels
Family of transient receptor potential cation channels in animals
nucleus and induce gene transcription of more TRPC genes. This creates a positive feedback loop, leading to a state of hypertrophic gene expression and thus
TRPC
Protein-coding gene in the species Homo sapiens
inwardly-rectifying channel, subfamily J, member 15, also known as KCNJ15 is a human gene, which encodes the Kir4.2 protein. Potassium channels are present in most
KCNJ15
Potassium channel
channel, subfamily J, member 1) gene. Multiple transcript variants encoding different isoforms have been found for this gene. Potassium channels are present
ROMK
Protein-coding gene in the species Homo sapiens
member 2 is a protein that in humans is encoded by the KCNV2 gene. The protein encoded by this gene is a voltage-gated potassium channel subunit. KCNV2 retinopathy
KCNV2
Protein-coding gene in the species Homo sapiens
channel 2 is a protein that in humans is encoded by the KCNJ6 gene. Mutation in KCNJ6 gene has been proposed to be the cause of Keppen-Lubinsky Syndrome
KCNJ6
Protein found in humans
subunit. Cav2.1 has the alpha-1A subunit, which is encoded by the CACNA1A gene. Mutations in CACNA1A have been associated with various neurologic disorders
Cav2.1
Protein-coding gene in the species Homo sapiens
inward-rectifier potassium ion channel. The gene encoding the channel is called KCNJ11 and mutations in this gene are associated with congenital hyperinsulinism
Kir6.2
Protein-coding gene in the species Homo sapiens
nucleotide-gated ion channel 2 is a protein that in humans is encoded by the HCN2 gene. HCN2 has been shown to interact with HCN1 and HCN4. The function of the
HCN2
Protein-coding gene in humans
voltage-dependent, L type, alpha 1F subunit (CACNA1F), is a human gene. This gene encodes a member of the alpha-1 subunit family; a protein in the voltage-dependent
Cav1.4
Protein found in humans
Calsenilin is a protein that in humans is encoded by the KCNIP3 gene. This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting
Calsenilin
Protein-coding gene in humans
(Cx32), is a transmembrane protein that in humans is encoded by the GJB1 gene. Gap junction beta-1 protein is a member of the gap junction connexin family
GJB1
Protein-coding gene in the species Homo sapiens
member 1 is a protein that in humans is encoded by the KCNF1 gene. The protein encoded by this gene is a voltage-gated potassium channel subunit. GRCh38: Ensembl
KCNF1
Protein family
1E subunit (CACNA1E) or Cav2.3 which in humans is encoded by the CACNA1E gene. They are strongly expressed in cortex, hippocampus, striatum, amygdala and
R-type_calcium_channel
Family of transport proteins
threshold of activation and relatively slow kinetics. Mutations in the CACNA1A gene that encodes this protein are responsible for familial hemiplegic migraine
Q-type_calcium_channel
Protein-coding gene in the species Homo sapiens
Potassium channel subfamily T, member 2, also known as KCNT2 is a human gene that encodes the KNa protein. KCNT2, also known as the Slick channel (sequence
KCNT2
Protein-coding gene in the species Homo sapiens
Cyclic nucleotide gated channel beta 1, also known as CNGB1, is a human gene encoding an ion channel protein. Cyclic nucleotide-gated ion channel GRCh38:
CNGB1
Transport protein and coding gene in humans
found primarily in cardiac muscle. In humans, it is encoded by the RYR2 gene. In the process of cardiac calcium-induced calcium release, RYR2 is the major
Ryanodine_receptor_2
Protein-coding gene in the species Homo sapiens
K2P13.1 or THIK-1, is a protein that in humans is encoded by the KCNK13 gene. It is a potassium channel containing two pore-forming P domains. K2P13.1
KCNK13
Protein-coding gene in the species Homo sapiens
channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes
KCNA4
Family of transport proteins
skeletal muscles. The α1 subunit is encoded specifically by the CACNA1A gene and is composed of four domains, each containing six transmembrane (S1-S6)
P-type_calcium_channel
Classification of membrane proteins including ion channels
family 1.A.13 Epithelial chloride channel family 1.A.14 Testis-enhanced gene transfer family 1.A.15 Nonselective cation channel-2 family 1.A.16 Formate-nitrite
Transporter Classification Database
Transporter_Classification_Database
Protein-coding gene in humans
Kv1.6 is a protein that in humans is encoded by the KCNA6 gene. The protein encoded by this gene is a voltage-gated potassium channel subunit. GRCh38: Ensembl
KCNA6
Protein-coding gene in humans
channel subfamily K member 6 is a protein encoded by the KCNK6 gene in humans. This gene encodes K2P6.1, a member of the superfamily of potassium channel
KCNK6
Protein-coding gene in humans
muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is found in a cluster of five alpha subunit genes on chromosome
SCN3A
Protein-coding gene in the species Homo sapiens
also known as KCNN2, is a protein which in humans is encoded by the KCNN2 gene. KCNN2 is an ion channel protein also known as KCa2.2. Action potentials
KCNN2
Class of transport proteins
proteins are a subfamily of the ENaC/Deg superfamily of ion channels. These genes have splice variants that encode for several isoforms that are marked by
Acid-sensing_ion_channel
Protein-coding gene in the species Homo sapiens
potassium channel 10 is a protein that in humans is encoded by the KCNJ10 gene. This gene encodes a member of the inward rectifier-type potassium channel family
KCNJ10
SHAKER GENE
SHAKER GENE
Surname or Lastname
Muslim
Muslim : variant of Shakir.English : unexplained.
Boy/Male
Arabic, Australian, Egyptian
Thankful Person
Surname or Lastname
English
English : occupational name for someone who made and drove in stakes, or a topographic name for someone who lived near a boundary post for example, from a derivative of Middle English stake ‘post’, ‘stake’.
Boy/Male
Egyptian Muslim
Grateful.
Boy/Male
Indian
Boy/Male
Arabic, Muslim
Patience
Boy/Male
Indian, Sanskrit
Shaker; Agitator
Boy/Male
Muslim
Thankful
Biblical
(or Aijeleth Shahar) the land of the morning
Boy/Male
Arabic, Muslim
Thankful; Grateful
Surname or Lastname
English (Shropshire)
English (Shropshire) : unexplained. Origin unidentified.
Girl/Female
Biblical
Prison, bush, lees, thorn.
Boy/Male
Indian
Thankful
Female
Hebrew
(ש×ַחַר) Variant spelling of Hebrew unisex Shachar, SHAHAR means "dawn" or "morning."
Boy/Male
Arabic, Muslim
Thanking
Male
English
Anglicized form of Hebrew Shamuwr, SHAMER means "a message, tidings" or "that which is heard." In the bible, this is the name of a Levite.
Boy/Male
Arabic, Muslim
Grateful; Very Thankful
Surname or Lastname
English and Scottish
English and Scottish : unexplained; possibly a variant spelling of Hawker.
Boy/Male
Arabic
Sugar
Boy/Male
Arabic, Muslim
Poet
SHAKER GENE
SHAKER GENE
SHAKER GENE
SHAKER GENE
SHAKER GENE
SHAKER GENE
SHAKER GENE