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Chemical compound
SB-216641 is a drug which is a selective antagonist for the serotonin receptor 5-HT1B, with around 25x selectivity over the closely related 5-HT1D receptor
SB-216641
Pharmaceutical compound
SB-272183 is a selective serotonin 5-HT1A, 5-HT1B, and 5-HT1D receptor antagonist. It shows high affinity for these receptors, with Ki values of 10 nM
SB-272183
Pharmaceutical compound
SB-247853 is a highly selective serotonin 5-HT2C receptor inverse agonist which was under development for the treatment of major depressive disorder but
SB-247853
Medication to prevent nausea and vomiting
May 2016. Retrieved 11 February 2017. Schnadower D, Finkelstein Y, Freedman SB (January 2015). "Ondansetron and probiotics in the management of pediatric
Ondansetron
Pharmaceutical compound
SB-616234 is a selective serotonin 5-HT1B receptor antagonist. In terms of affinity, it shows 50-fold selectivity for the serotonin 5-HT1B receptor over
SB-616234
Chemical compound
SB-200646 is a 5-HT2 receptor antagonist with anxiolytic properties in rats. It was the first 5-HT2 antagonist discovered to exhibit selectivity for the
SB-200646
Pharmaceutical compound
SB-221284 is a selective serotonin 5-HT2C and 5-HT2B receptor antagonist which is used in scientific research. Its affinities (Ki) are 2.2 to 2.5 nM for
SB-221284
Antidepressant medication
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Trazodone
Pharmaceutical compound
SB-245570 is a serotonin 5-HT1B receptor antagonist which was under development for the treatment of major depressive disorder but was never marketed.
SB-245570
Chemical compound
SB-204070 is a drug which acts as a potent and selective 5-HT4 serotonin receptor antagonist (or weak partial agonist), and is used for research into the
SB-204070
Psychoactive drug, often called ecstasy
Sciences. 49 (1): 57–64. doi:10.1016/j.ejps.2013.01.014. PMID 23395913. Hamida SB, Tracqui A, de Vasconcelos AP, Szwarc E, Lazarus C, Kelche C, et al. (July
MDMA
Chemical compound
SB-243213 is a drug which acts as a selective inverse agonist for the 5-HT2C receptor and has anxiolytic effects. It has better than 100x selectivity for
SB-243213
Chemical compound
SB-699551 is a drug which was the first compound developed to act as a selective antagonist for the serotonin receptor 5-HT5A, with selectivity of around
SB-699551
Chemical compound
List of investigational antidepressants AR-A000002 GR-55562 GR-127935 SB-216641 "SB 236057". AdisInsight. 16 February 2006. Retrieved 24 January 2026. Middlemiss
SB-236057
SSRI antidepressant
(10): 2134–2147. doi:10.1111/bcp.13321. PMC 5595931. PMID 28513059. Soumerai SB, Koppel R, Naci H, Madden JM, Fry A, Halbisen A, et al. (October 2024). "Intended
Fluoxetine
South American psychoactive decoction
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Ayahuasca
Beta blocker drug
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Propranolol
Atypical antipsychotic medication
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Aripiprazole
Muscle relaxant medication
RISKS" (PDF). Archived from the original (PDF) on 27 November 2014. Chabria SB (July 2006). "Rhabdomyolysis: a manifestation of cyclobenzaprine toxicity"
Cyclobenzaprine
Mushrooms containing psychoactive indole alkaloids
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Psilocybin_mushroom
Chemical compound
SB-649915 is a serotonin reuptake inhibitor and serotonin 5-HT1A and 5-HT1B receptor antagonist which is being investigated for its antidepressant effects
SB-649915
Colourless non-flammable greenhouse gas
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Nitrous_oxide
Chemical compound
SB-269970 is a drug and research chemical developed by GlaxoSmithKline used in scientific studies. It is believed to act as a selective 5-HT7 receptor
SB-269970
Psychedelic drug
277–289. doi:10.1007/978-3-030-55920-5_16. ISBN 978-3-030-55919-9. Vogt SB, Liechti ME (2025). "Clinical Pharmacology". In Nutt DJ, Thurgur H (eds.)
LSD
Medication used to treat anxiety disorders
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Buspirone
Chemical compound
Collin LJ, Duckworth M, Gaster L, Göthert M, et al. (September 1997). "SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and
BRL-15572
Pharmacodynamics and pharmacokinetics of ethanol
doi:10.15288/jsa.1981.42.547. PMID 7289599. Maskell PD, Jones AW, Heymsfield SB, Shapses S, Johnston A (November 2020). "Total body water is the preferred
Pharmacology_of_ethanol
Chemical element with atomic number 54 (Xe)
AuXe2+ 4, which contains Xe–Au bonds. This ion occurs in the compound AuXe 4(Sb 2F 11) 2, and is remarkable in having direct chemical bonds between two notoriously
Xenon
Pharmaceutical compound
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Nuciferine
Naturally occurring psychedelic compound
PMC 6165951. PMID 29850881. Uthaug MV, Davis AK, Haas TF, Davis D, Dolan SB, Lancelotta R, et al. (March 2022). "The epidemiology of mescaline use: Pattern
Mescaline
Psychedelic drug
Law. 2 2050324515578080. doi:10.1177/2050324515578080. ISSN 2050-3245. Vogt SB, Liechti ME (2025). "Clinical Pharmacology". In Nutt DJ, Thurgur H (eds.)
2C-B
Group of chemical compounds
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Β-Carboline
Chemical compound
SB-228357 is a drug which acts as a selective antagonist of the serotonin 5-HT2B and 5-HT2C receptors. It has antidepressant and anxiolytic effects in
SB-228357
Chemical compound
SB-204741 is a drug which acts as a potent and selective antagonist at the serotonin 5-HT2B receptor, with around 135x selectivity over the closely related
SB-204741
Common name for more than 1,000 species of flowering plants in the family Convolvulaceae
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Morning_glory
Synthetic opioid pain medication
receptor antagonist ondansetron, and the 5-HT7 receptor antagonists SB-269970 and SB-258719. Pharmacologically, tramadol is similar to tapentadol and methadone
Tramadol
Chemical compound
SB-258585 is a drug which is used in scientific research. It acts as a potent, selective and orally active 5-HT6 receptor antagonist, with a Ki of 8.9nM
SB-258585
Drug
SB-258719 is a drug developed by GlaxoSmithKline which acts as a selective 5-HT7 receptor partial inverse agonist, and was the first such ligand identified
SB-258719
Antihistamine drug
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Hydroxyzine
Designer drug combination mimicking MDMA
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Borax_combo
Species of flowering plant
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Valerian_(herb)
Species of psychoactive cactus
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Peyote
Pharmaceutical compound
SB-224289 is a selective serotonin 5-HT1B receptor antagonist or inverse agonist which is used in scientific research. It is more than 75-fold selective
SB-224289
Chemical compound
SB-206553 is a drug which acts as a mixed antagonist for the 5-HT2B and 5-HT2C serotonin receptors. It has anxiolytic properties in animal studies and
SB-206553
Psychoactive substance found in plants in the family Apocynaceae
Tribune. Retrieved 12 June 2025. "Texas Legislature Online - 89(R) History for SB 2308". capitol.texas.gov. Retrieved 12 June 2025. Trump DJ (18 April 2026)
Ibogaine
Chemical compound
SB-271046 is a drug which is used in scientific research. It was one of the first selective 5-HT6 receptor antagonists to be discovered, and was found
SB-271046
Chemical compound
brain, and has anxiolytic effects in animal studies. GR-55562 GR-127935 SB-216641 SB-236057 Hudzik TJ, Yanek M, Porrey T, Evenden J, Paronis C, Mastrangelo
AR-A000002
Atypical antipsychotic
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Lumateperone
Chemical compound
SB-399885 is a drug which is used in scientific research. It acts as a potent, selective and orally active 5-HT6 receptor antagonist, with a Ki of 9.0nM
SB-399885
Medication mainly used for depression and smoking cessation
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Bupropion
Chemical compound
SB-215505 is a drug which acts as a potent and selective antagonist at the serotonin 5-HT2B receptor, with good selectivity over the related 5-HT2A and
SB-215505
Tricyclic antidepressant
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Amitriptyline
Sedating antidepressant
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Doxepin
Atypical antidepressant classified primarily as a melatonin receptor agonist
properties of SB 206553 and SB 242084. Indeed, as revealed by in vitro experiments in CHO cells expressing the 5-HT2C receptor (see Figs. 5 and 6), SB 206553
Agomelatine
Antihistamine medication
original on 28 July 2017. Retrieved 27 August 2019. Salahudeen MS, Duffull SB, Nishtala PS (March 2015). "Anticholinergic burden quantified by anticholinergic
Diphenhydramine
Antidepressant medication
00982.x. PMID 10762339. S2CID 23098292. Graves SM, Napier TC (June 2012). "SB 206553, a putative 5-HT2C inverse agonist, attenuates methamphetamine-seeking
Mirtazapine
DMT-infused smoking blend
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Changa_(drug)
Chemical compound
SB-242084 is a selective serotonin 5-HT2C receptor antagonist which is used in scientific research. It has anxiolytic effects-like effects in rodents,
SB-242084
Monoamine neurotransmitter
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Serotonin
Chemical compound
SB-357134 is a drug which is used in scientific research. It acts as a potent, selective and orally active 5-HT6 receptor antagonist. SB-357134 and other
SB-357134
Sedating antihistamine
Elsevier Health Sciences. p. 113. ISBN 978-0-323-07596-1. Page CB, Duffull SB, Whyte IM, Isbister GK (February 2009). "Promethazine overdose: clinical effects
Promethazine
Species of amphibian
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Colorado_River_toad
Protein-coding gene in the species Homo sapiens
RA-7 (1-(2-diphenyl)piperazine) Ritanserin SB-258,719 SB-258741 SB-269970 (highly 5-HT7 selective) SB-656104-A SB-691673 Sertindole Spiperone Tenilapine TFMPP
5-HT7_receptor
Blood pressure medication
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Carvedilol
Serotonin receptor protein distributed mainly in the choroid plexus
Metergoline Methiothepin Pizotifen Ritanserin S-32212 SB-206,553 SB-228,357 SB-242,084 SB-243,213 SB-247853 Tenilapine Exogenous PAMs of the serotonin 5-HT2C
5-HT2C_receptor
Pharmaceutical compound
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
IHCH-8110
Class of psychoactive drugs that produce empathic experiences
serotonin 5-HT1B, 5-HT2A, 5-HT2C, and 5-HT4 receptors (SB-216641), volinanserin (MDL-100907), SB-242084, and SB-204070, respectively) were all ineffective in suppressing
Entactogen
Medication
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Tegaserod
Species of plant
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Ipomoea_tricolor
Atypical antipsychotic medicine
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Cariprazine
Pharmaceutical compound
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Remlifanserin
Medication for nausea, psychosis, and anxiety
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Prochlorperazine
Pharmaceutical compound
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Setoperone
Medication
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Milsaperidone
Species of cactus
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Echinopsis_lageniformis
Pharmaceutical compound
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
UCSF648
Experimental drug
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Bexicaserin
Chemical compound in the ergot family of alkaloids
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Ergotamine
Active ingredient in fermented drinks
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Alcohol_(drug)
Antidepressant medication
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Vilazodone
Medication
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Metoclopramide
Psychedelic drug
"TIHKAL" - #13 HARMALINE". www.erowid.org. Retrieved 11 April 2025. Vogt SB, Liechti ME (2025). "Clinical Pharmacology". In Nutt DJ, Thurgur H (eds.)
5-MeO-DMT
CHCl3, historical anaesthetic and common solvent
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Chloroform
Dopamine antagonist medication
1016/s1590-8658(03)00061-6. PMID 12801035. Arshad A, Irfan M, Inam M, Hussain NH, Ismail SB (2022). "Levosulpiride for Premature Ejaculation: A Systematic Review and
Levosulpiride
Atypical antipsychotic medication
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Quetiapine
Serotonin modulator antidepressant
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Vortioxetine
Form of psychoactive drugs
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Hallucinogenic_snuff
Pharmaceutical compound
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
NBoc-DMT
Chemical compound
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
1V-LSD
Medication used for the treatment of migraine headaches
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Rizatriptan
Chemical compound
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
LY-310762
Species of plant
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Silene_undulata
Atypical antipsychotic medication
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Pimavanserin
Phytocannabinoid discovered in 1940
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Cannabidiol
Psychedelic drug
2023-07-25). Archived from the original on 2023-08-27. Retrieved 2023-08-27. Vogt SB, Liechti ME (2025). "Clinical Pharmacology". In Nutt DJ, Thurgur H (eds.)
Dimethyltryptamine
Opioid analgesic
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Desmetramadol
Typical antipsychotic medication
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Levomepromazine
Pharmaceutical compound
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
VA012
Mammalian protein found in Homo sapiens
Penbutolol Propranolol Risperidone SB-216641 SB-224289 (inverse agonist) SB-236057 (inverse agonist) SB-245570 SB-272183 SB-616234 SB-649915 Tertatolol Yohimbine
5-HT1B_receptor
Weight loss medication
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Phentermine
SB 216641
SB 216641
SB 216641
SB 216641
SB 216641
SB 216641
SB 216641
SB 216641
SB 216641
n.
An abbreviation standing for the name of an element and consisting of the initial letter of the Latin or New Latin name, or sometimes of the initial letter with a following one; as, C for carbon, Na for sodium (Natrium), Fe for iron (Ferrum), Sn for tin (Stannum), Sb for antimony (Stibium), etc. See the list of names and symbols under Element.
n.
An elementary substance, resembling a metal in its appearance and physical properties, but in its chemical relations belonging to the class of nonmetallic substances. Atomic weight, 120. Symbol, Sb.