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Pharmaceutical compound
SB-616234 is a selective serotonin 5-HT1B receptor antagonist. In terms of affinity, it shows 50-fold selectivity for the serotonin 5-HT1B receptor over
SB-616234
Medication to prevent nausea and vomiting
May 2016. Retrieved 11 February 2017. Schnadower D, Finkelstein Y, Freedman SB (January 2015). "Ondansetron and probiotics in the management of pediatric
Ondansetron
Pharmaceutical compound
SB-247853 is a highly selective serotonin 5-HT2C receptor inverse agonist which was under development for the treatment of major depressive disorder but
SB-247853
Chemical compound
SB-200646 is a 5-HT2 receptor antagonist with anxiolytic properties in rats. It was the first 5-HT2 antagonist discovered to exhibit selectivity for the
SB-200646
Pharmaceutical compound
SB-272183 is a selective serotonin 5-HT1A, 5-HT1B, and 5-HT1D receptor antagonist. It shows high affinity for these receptors, with Ki values of 10 nM
SB-272183
Chemical compound
SB-243213 is a drug which acts as a selective inverse agonist for the 5-HT2C receptor and has anxiolytic effects. It has better than 100x selectivity for
SB-243213
Chemical compound
SB-228357 is a drug which acts as a selective antagonist of the serotonin 5-HT2B and 5-HT2C receptors. It has antidepressant and anxiolytic effects in
SB-228357
Chemical compound
SB-271046 is a drug which is used in scientific research. It was one of the first selective 5-HT6 receptor antagonists to be discovered, and was found
SB-271046
Chemical compound
SB-204070 is a drug which acts as a potent and selective 5-HT4 serotonin receptor antagonist (or weak partial agonist), and is used for research into the
SB-204070
Pharmaceutical compound
SB-245570 is a serotonin 5-HT1B receptor antagonist which was under development for the treatment of major depressive disorder but was never marketed.
SB-245570
Pharmaceutical compound
SB-221284 is a selective serotonin 5-HT2C and 5-HT2B receptor antagonist which is used in scientific research. Its affinities (Ki) are 2.2 to 2.5 nM for
SB-221284
Chemical compound
SB-699551 is a drug which was the first compound developed to act as a selective antagonist for the serotonin receptor 5-HT5A, with selectivity of around
SB-699551
South American psychoactive decoction
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Ayahuasca
Atypical antipsychotic medication
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Olanzapine
Muscle relaxant medication
RISKS" (PDF). Archived from the original (PDF) on 27 November 2014. Chabria SB (July 2006). "Rhabdomyolysis: a manifestation of cyclobenzaprine toxicity"
Cyclobenzaprine
Drug
SB-258719 is a drug developed by GlaxoSmithKline which acts as a selective 5-HT7 receptor partial inverse agonist, and was the first such ligand identified
SB-258719
Pharmaceutical compound
SB-224289 is a selective serotonin 5-HT1B receptor antagonist or inverse agonist which is used in scientific research. It is more than 75-fold selective
SB-224289
Atypical antipsychotic medication
1177/0957154X07070335. PMID 17580753. S2CID 21086497. Li XH, Zhong XM, Lu L, Zheng W, Wang SB, Rao WW, et al. (March 2020). "The prevalence of agranulocytosis and related
Clozapine
Chemical compound
SB-216641 is a drug which is a selective antagonist for the serotonin receptor 5-HT1B, with around 25x selectivity over the closely related 5-HT1D receptor
SB-216641
Medication used to treat anxiety disorders
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Buspirone
Species of psychoactive cactus
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Peyote
Chemical compound
SB-269970 is a drug and research chemical developed by GlaxoSmithKline used in scientific studies. It is believed to act as a selective 5-HT7 receptor
SB-269970
Psychedelic drug found in toads, mushrooms and plants
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Bufotenin
Tricyclic antidepressant
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Amitriptyline
Chemical compound
SB-236057 is a compound which is a potent and selective inverse agonist for the serotonin receptor 5-HT1B, acting especially at 5-HT1B autoreceptors on
SB-236057
Chemical compound
SB-258585 is a drug which is used in scientific research. It acts as a potent, selective and orally active 5-HT6 receptor antagonist, with a Ki of 8.9nM
SB-258585
Weight loss medication
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Phentermine
Antidepressant medication
00982.x. PMID 10762339. S2CID 23098292. Graves SM, Napier TC (June 2012). "SB 206553, a putative 5-HT2C inverse agonist, attenuates methamphetamine-seeking
Mirtazapine
Common name for more than 1,000 species of flowering plants in the family Convolvulaceae
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Morning_glory
Pharmaceutical compound
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Nuciferine
Antihistamine drug
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Hydroxyzine
Species of flowering plant
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Valerian_(herb)
Atypical antipsychotic medication
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Aripiprazole
Antidepressant medication
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Trazodone
Chemical compound
SB-242084 is a selective serotonin 5-HT2C receptor antagonist which is used in scientific research. It has anxiolytic effects-like effects in rodents,
SB-242084
Medication mainly used to treat gout
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Colchicine
Psychoactive substance found in plants in the family Apocynaceae
Tribune. Retrieved 12 June 2025. "Texas Legislature Online - 89(R) History for SB 2308". capitol.texas.gov. Retrieved 12 June 2025. Trump DJ (18 April 2026)
Ibogaine
Antihistamine medication
original on 28 July 2017. Retrieved 27 August 2019. Salahudeen MS, Duffull SB, Nishtala PS (March 2015). "Anticholinergic burden quantified by anticholinergic
Diphenhydramine
Atypical antipsychotic
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Lumateperone
Medication mainly used for depression and smoking cessation
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Bupropion
Beta blocker drug
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Propranolol
Type of medication
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Monoamine_oxidase_inhibitor
Monoamine neurotransmitter
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Serotonin
Dopamine agonist medication
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Ropinirole
Chemical compound
SB-206553 is a drug which acts as a mixed antagonist for the 5-HT2B and 5-HT2C serotonin receptors. It has anxiolytic properties in animal studies and
SB-206553
Chemical element with atomic number 54 (Xe)
AuXe2+ 4, which contains Xe–Au bonds. This ion occurs in the compound AuXe 4(Sb 2F 11) 2, and is remarkable in having direct chemical bonds between two notoriously
Xenon
Serotonin receptor agonist
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
4-Hydroxytryptamine
Typical antipsychotic medication
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Chlorpromazine
Chemical compound
Intepirdine (INN; developmental codes SB-742457, RVT-101) is a selective 5-HT6 receptor antagonist with potential cognition, memory, and learning-enhancing
Intepirdine
Active ingredient in fermented drinks
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Alcohol_(drug)
Medication used for the treatment of migraine headaches
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Rizatriptan
Medication
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Metoclopramide
DMT-infused smoking blend
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Changa_(drug)
Pharmaceutical compound
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
AB0124
Species of amphibian
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Colorado_River_toad
Drug combination prescribed for weight loss; later withdrawn from market
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Fenfluramine/phentermine
Pharmaceutical compound
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Irindalone
Sedating antihistamine
Elsevier Health Sciences. p. 113. ISBN 978-0-323-07596-1. Page CB, Duffull SB, Whyte IM, Isbister GK (February 2009). "Promethazine overdose: clinical effects
Promethazine
Chemical compound
SB-215505 is a drug which acts as a potent and selective antagonist at the serotonin 5-HT2B receptor, with good selectivity over the related 5-HT2A and
SB-215505
Medication for nausea, psychosis, and anxiety
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Prochlorperazine
Robust antidepressant
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
NLX-204
Medication
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Flibanserin
Mushrooms containing psychoactive indole alkaloids
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Psilocybin_mushroom
CHCl3, historical anaesthetic and common solvent
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Chloroform
Chemical compound
SB-649915 is a serotonin reuptake inhibitor and serotonin 5-HT1A and 5-HT1B receptor antagonist which is being investigated for its antidepressant effects
SB-649915
Atypical antidepressant classified primarily as a melatonin receptor agonist
properties of SB 206553 and SB 242084. Indeed, as revealed by in vitro experiments in CHO cells expressing the 5-HT2C receptor (see Figs. 5 and 6), SB 206553
Agomelatine
Colourless non-flammable greenhouse gas
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Nitrous_oxide
Chemical compound in the ergot family of alkaloids
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Ergotamine
Pharmaceutical compound
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
IHCH-8110
Serotonin modulator antidepressant
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Vortioxetine
Dopamine antagonist medication
1016/s1590-8658(03)00061-6. PMID 12801035. Arshad A, Irfan M, Inam M, Hussain NH, Ismail SB (2022). "Levosulpiride for Premature Ejaculation: A Systematic Review and
Levosulpiride
Pharmaceutical compound
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
IPLA
Entactogen, stimulant, and psychedelic drug of the amphetamine family
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
3,4-Methylenedioxyamphetamine
Atypical antipsychotic medication
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Quetiapine
Blood pressure medication
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Carvedilol
Atypical antipsychotic medicine
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Cariprazine
Typical antipsychotic medication
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Trifluoperazine
Synthetic opioid pain medication
receptor antagonist ondansetron, and the 5-HT7 receptor antagonists SB-269970 and SB-258719. Pharmacologically, tramadol is similar to tapentadol and methadone
Tramadol
Pharmaceutical compound
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Remlifanserin
Class of antidepressants
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Noradrenergic and specific serotonergic antidepressant
Noradrenergic_and_specific_serotonergic_antidepressant
Phytocannabinoid discovered in 1940
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Cannabidiol
Medication used for high blood pressure and ADHD
OCLC 1264172789. Kornfield R, Watson S, Higashi AS, Conti RM, Dusetzina SB, Garfield CF, et al. (April 2013). "Effects of FDA advisories on the pharmacologic
Guanfacine
Chemical compound
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
DLX-2270
SSRI antidepressant
(10): 2134–2147. doi:10.1111/bcp.13321. PMC 5595931. PMID 28513059. Soumerai SB, Koppel R, Naci H, Madden JM, Fry A, Halbisen A, et al. (October 2024). "Intended
Fluoxetine
Chemical compound
SB-204741 is a drug which acts as a potent and selective antagonist at the serotonin 5-HT2B receptor, with around 135x selectivity over the closely related
SB-204741
Chemical compound
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Indole
Mammalian protein found in Homo sapiens
Penbutolol Propranolol Risperidone SB-216641 SB-224289 (inverse agonist) SB-236057 (inverse agonist) SB-245570 SB-272183 SB-616234 SB-649915 Tertatolol Yohimbine
5-HT1B_receptor
Chemical compound
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Cisapride
Pharmaceutical compound
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
2C-D
Serotonin dopamine partial agonist atypical antipsychotic
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Brexpiprazole
Group of chemical compounds
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Β-Carboline
Pharmaceutical compound
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
2,5-Dimethoxyamphetamine
Chemical compound
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
5-Hydroxytryptophan
Pharmaceutical compound
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Usmarapride
Pharmaceutical compound
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Buspirone/zolmitriptan
Hallucinogenic class of psychoactive drug
PMID 37874826. Simonsson O, Hendricks PS, Chambers R, Osika W, Goldberg SB (1 April 2023). "Prevalence and associations of challenging, difficult or
Psychedelic_drug
Medication
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Milsaperidone
Pharmaceutical compound
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
JPC0323
Atypical antipsychotic medication
F-14258 GR-127935 LY-393558 Metitepine (methiothepin) SB-216641 SB-224289 SB-236057 SB-272183 SB-616234 Trelanserin Yohimbine Negative allosteric modulators:
Lurasidone
Psychedelic drug
2023-07-25). Archived from the original on 2023-08-27. Retrieved 2023-08-27. Vogt SB, Liechti ME (2025). "Clinical Pharmacology". In Nutt DJ, Thurgur H (eds.)
Dimethyltryptamine
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