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Medication used to treat anxiety disorders
Buspirone, sold under the name Buspar among others, is an anxiolytic medication primarily used for the treatment of generalized anxiety disorder. Unlike
Buspirone
Class of medications used to alleviate anxiety
anxiety disorders due to their fast onset but carry the risk of dependence. Buspirone is indicated for GAD, which has much slower onset but with the advantage
Anxiolytic
Pharmaceutical compound
Buspirone/zolmitriptan, also known by its developmental code names AV-2860 and JM-010, is a combination of buspirone, a serotonin 5-HT1A receptor partial
Buspirone/zolmitriptan
Combination drug
Buspirone/testosterone (tentative brand name Lybridos) is a combination of buspirone, a 5-HT1A receptor partial agonist, α2-adrenergic receptor antagonist
Buspirone/testosterone
Antidepressant and anxiolytic drug
active metabolite. However, whereas 1-PP levels with buspirone are 8-fold higher than levels of buspirone itself, 1-PP is only a minor metabolite of ipsapirone
Ipsapirone
Class of psychotropic drugs
(S-20,499) Binospirone (MDL-73,005) BMY-7,378 (CAS number: 21102-95-4 ) Buspirone (Buspar) Enilospirone (CERM-3,726) Eptapirone (F-11,440) Gepirone (Exxua)
Azapirone
Chemical which binds to and activates a biochemical receptor
specific type of receptor. E.g. buspirone is a selective agonist for serotonin 5-HT1A. Partial agonists (such as buspirone, aripiprazole, buprenorphine,
Agonist
Chemical compound
A number of pyrimidinylpiperazine derivatives are drugs, including: Buspirone – anxiolytic Dasatinib – anticancer agent Eptapirone – anxiolytic Gepirone –
Pyrimidinylpiperazine
Pharmaceutical compound
models of anxiety, whereas buspirone was ineffective in the same models. In contrast to diazepam but similarly to buspirone, FR260010 has modest adverse
FR260010
Chemical compound
effectiveness seen with already available 5-HT1A receptor agonists like buspirone and tandospirone, which act merely as weak-to-moderate partial agonists
Eptapirone
Motor symptoms caused by dysfunction of the cerebellum
to moderate cerebellar ataxia may be treatable with buspirone. It is thought that the buspirone increases the serotonin levels in the cerebellum and
Cerebellar_ataxia
Peptide hormone and neuropeptide
receptor agonists like 8-OH-DPAT, buspirone, and ipsapirone increase oxytocin levels in rodents. Both 8-OH-DPAT and buspirone maximally increased oxytocin
Oxytocin
Medication used for major depressive disorder
the D2 receptor (30- to 50-fold lower in comparison to buspirone). However, similarly to buspirone, gepirone metabolizes into 1-(2-pyrimidinyl)piperazine
Gepirone
Drug that blocks hallucinogen effects
psychedelics. Examples include serotonin 5-HT1A receptor agonists like buspirone, serotonin reuptake inhibitors such as selective serotonin reuptake inhibitors
Trip_killer
Pharmaceutical compound
activity than other serotonin 5-HT1A receptor agonists, such as 8-OH-DPAT, buspirone, gepirone, F-15599 (NLX-101), and vilazodone, among others. On the other
TMU4142
Agonist drug having partial efficacy at a receptor
have been classed as partial agonists at particular receptors include buspirone, aripiprazole, buprenorphine, clobazam, nordazepam, nalmefene and norclozapine
Partial_agonist
Drug interactions with grapefruit juice
norbuprenorphine by CYP3A4 Buspirone (Buspar): Grapefruit juice increased peak and AUC plasma concentrations of buspirone 4.3- and 9.2-fold, respectively
Grapefruit–drug_interactions
Moderate-size cluster of nuclei found in brain stem
the brain and decrease the release of serotonin. The anxiolytic drug Buspirone acts as partial agonist against these receptors. Selective serotonin reuptake
Raphe_nuclei
Serotonin receptor protein distributed in the cerebrum and raphe nucleus
5-HT1A receptor agonists like buspirone and flesinoxan show efficacy in relieving anxiety and depression. Buspirone, tandospirone, and gepirone are
5-HT1A_receptor
Anxiolytic and antidepressant medication
azapirone class of drugs and is closely related to other azapirones like buspirone and gepirone. Tandospirone was introduced for medical use in Japan in
Tandospirone
Protein family
weak antagonist at the α2A and α2B subtypes. 1-PP (active metabolite of buspirone and gepirone) Aripiprazole Asenapine Atipamezole Cirazoline Clozapine
Alpha-2_adrenergic_receptor
Symptoms caused by an excess of serotonin in the central nervous system
(TCAs), amphetamines, pethidine (meperidine), tramadol, dextromethorphan, buspirone, L-tryptophan, 5-hydroxytryptophan, St. John's wort, triptans, MDMA, metoclopramide
Serotonin_syndrome
/ dopamine receptor partial agonist and serotonin receptor modulator Buspirone [transdermal] (BuSpar Patch) – serotonin 5-HT1A receptor partial agonist
List of investigational attention deficit hyperactivity disorder drugs
List_of_investigational_attention_deficit_hyperactivity_disorder_drugs
Medication
Mayer N, et al. (June 2002). "Region-dependent effects of flibanserin and buspirone on adenylyl cyclase activity in the human brain". The International Journal
Flibanserin
Antihistamine drug
Insufficient data were available to compare the drug with benzodiazepines and buspirone. Hydroxyzine can also be used for the treatment of allergic conditions
Hydroxyzine
Class of antidepressant medication
(aripiprazole, brexpiprazole, lurasidone, olanzapine, quetiapine, risperidone) Buspirone Lithium (lithium carbonate, lithium citrate) Thyroid hormones (triiodothyronine
Atypical_antidepressant
(Risperdal) Typical antipsychotics include: Trifluoperazine (Stelazine) Buspirone (Buspar) – 5-HT1A receptor partial agonist Lithium (Eskalith, Lithobid)
List_of_antidepressants
Psychoactive drug, often called ecstasy
umespirone, ziprasidone) Azapirones (e.g., alnespirone, binospirone, BMY-7378, buspirone, enilospirone, eptapirone (F-11440), gepirone, ipsapirone, perospirone
MDMA
Investigational anxiety disorder drugs
– corticotropin-releasing hormone (CRH) inhibitor [24] Buspirone controlled release (Buspirone ER) – serotonin 5-HT1A receptor partial agonist and other
List of investigational anxiety disorder drugs
List_of_investigational_anxiety_disorder_drugs
Benzodiazepine sedative
withdrawal symptoms after 6 and 12 weeks' treatment with diazepam or buspirone". The British Journal of Psychiatry. 154 (4): 529–34. doi:10.1192/bjp
Diazepam
Gamma-aminobutyric acid analog
uses v t e Anxiolytics (N05B) 5-HT1ARTooltip 5-HT1A receptor agonists Buspirone Gepirone Tandospirone GABAARTooltip GABAA receptor PAMsTooltip positive
Gabapentin
Pharmaceutical drug classification
Mebutamate N05BC51 Meprobamate, combinations N05BD01 Benzoctamine N05BE01 Buspirone N05BX01 Mephenoxalone N05BX02 Gedocarnil N05BX03 Etifoxine N05BX04 Fabomotizole
ATC_code_N05
Antidepressant medication
receptor. Trazodone is a 5-HT1A receptor partial agonist similarly to buspirone and tandospirone but with comparatively greater intrinsic activity. A
Trazodone
- a long-acting CNS stimulant used to treat ADHD Buspar (buspirone) – an anxiolytic used to treat generalized anxiety disorder Belbuca, Buprenex
List of psychotropic medications
List_of_psychotropic_medications
Class of antidepressant medication
bupropion; and for overall sexual dysfunction, switching to nefazodone. Buspirone is sometimes used off-label to reduce sexual dysfunction associated with
Selective serotonin reuptake inhibitor
Selective_serotonin_reuptake_inhibitor
Chemical compound
5-HT2A receptors. In addition, the serotonin 5-HT1A receptor agonist buspirone markedly suppresses the hallucinogenic effects of psilocybin in humans
Robalzotan
List of pharmaceutical drugs under clinical development for treatment of depression
serotonin reuptake inhibitor and serotonin 5-HT1A and 5-HT1D receptor agonist Buspirone (transdermal; BuSpar Patch) – serotonin 5-HT1A receptor partial agonist
List of investigational antidepressants
List_of_investigational_antidepressants
Main receptor for most antipsychotic drugs
positron emission tomography studies Typical antipsychotics SV 293 Yohimbine Buspirone – D2 presynaptic autoreceptors (low dose) and postsynaptic D2 receptors
Dopamine_receptor_D2
SSRI antidepressant
tricyclic antidepressants, methamphetamine, amphetamine, MDMA, triptans, buspirone, ginseng, dextromethorphan (DXM), linezolid, tramadol, serotonin–norepinephrine
Fluoxetine
Pharmaceutical compound
hyperlocomotion induced by the serotonin 5-HT1A receptor agonists 8-OH-DPAT and buspirone. The chemical synthesis of GR-46611 has been described. GR-46611 was first
GR-46611
Antidepressant medication
(aripiprazole, brexpiprazole, lurasidone, olanzapine, quetiapine, risperidone) Buspirone Lithium (lithium carbonate, lithium citrate) Thyroid hormones (triiodothyronine
Mirtazapine
Head movement in rodents upon 5-HT2A receptor activation
5‐HT1A agonist buspirone (20 mg p.o.) markedly attenuates the visual effects of psilocybin in human volunteers.59 Although buspirone failed to completely
Head-twitch_response
Antidepressant and anxiolytic drug
comparison of two 5-HT1A receptors agonists alnespirone (S-20499) and buspirone on locus coeruleus neuronal activity". Eur J Pharmacol. 459 (1): 17–26
Alnespirone
Prodrug
agonists Clonidine Guanfacine Antidepressants Amitriptyline Bupropion Buspirone Desipramine Duloxetine Imipramine Milnacipran Moclobemide Nortriptyline
Omberacetam
Cast of American crime drama TV series
stopped drinking and that the school doctor gave her a prescription for Buspirone, which Hunter comments is given to treat generalized anxiety disorder
List of The Sopranos characters
List_of_The_Sopranos_characters
Pharmaceutical compound
greater efficacy than certain other serotonin 5-HT1A receptor agonists like buspirone and gepirone. It shows favorable pharmacokinetics in rodents. The chemical
NLX-266
Neurodevelopmental disorder
agonists Clonidine Guanfacine Antidepressants Amitriptyline Bupropion Buspirone Desipramine Duloxetine Imipramine Milnacipran Moclobemide Nortriptyline
Attention deficit hyperactivity disorder
Attention_deficit_hyperactivity_disorder
Pharmaceutical compound
v t e Anxiolytics (N05B) 5-HT1ARTooltip 5-HT1A receptor agonists Buspirone Gepirone Tandospirone GABAARTooltip GABAA receptor PAMsTooltip positive allosteric
Tasipimidine
Brazil's federal drug control statute
Benzoctamine Benzquinamide Biperiden Brexpiprazole Brivaracetam Bupropion Buspirone Butaperazine Butriptyline Cannabidiol - Synthetic form with no other cannabinoid
Brazilian Controlled Drugs and Substances Act
Brazilian_Controlled_Drugs_and_Substances_Act
Anxiety disorder associated with social situations
effects of buspirone in social phobia: a double-blind placebo-controlled study National Library of Medicine. 1993. Retrieved 14 August 2025. Buspirone in social
Social_anxiety_disorder
Medication to prevent nausea and vomiting
umespirone, ziprasidone) Azapirones (e.g., alnespirone, binospirone, BMY-7378, buspirone, enilospirone, eptapirone (F-11440), gepirone, ipsapirone, perospirone
Ondansetron
Pharmaceutical compound
(A-437203; LU-201640) Alpiropride Azapride Bromerguride Bromocriptine Buspirone Carmoxirole Desmethoxyfallypride EEDQ F-15063 F-17464 Fallypride Fananserin
ST-148_(D2L_antagonist)
Central nervous system stimulant
agonists Clonidine Guanfacine Antidepressants Amitriptyline Bupropion Buspirone Desipramine Duloxetine Imipramine Milnacipran Moclobemide Nortriptyline
Methamphetamine
Chemical compound found in some species of mushrooms
5‐HT1A agonist buspirone (20 mg p.o.) markedly attenuates the visual effects of psilocybin in human volunteers.59 Although buspirone failed to completely
Psilocybin
Atypical antipsychotic medication
Kowalki P, Jaskowska J (2012). "An Efficient Synthesis of Aripiprazole, Buspirone and NAN-190 by the Reductive Alkylation of Amines Procedure". Archiv der
Aripiprazole
SNRI medication
(aripiprazole, brexpiprazole, lurasidone, olanzapine, quetiapine, risperidone) Buspirone Lithium (lithium carbonate, lithium citrate) Thyroid hormones (triiodothyronine
Duloxetine
Benzodiazepine medication
v t e Anxiolytics (N05B) 5-HT1ARTooltip 5-HT1A receptor agonists Buspirone Gepirone Tandospirone GABAARTooltip GABAA receptor PAMsTooltip positive allosteric
Alprazolam
Experimental antipsychotic
(A-437203; LU-201640) Alpiropride Azapride Bromerguride Bromocriptine Buspirone Carmoxirole Desmethoxyfallypride EEDQ F-15063 F-17464 Fallypride Fananserin
N-Methylamisulpride
Psychedelic drug
Pharmacodynamics v t e Adrenergic receptor modulators α1 Agonists 6-FNE Amidephrine Buspirone Cirazoline Corbadrine CST-2140 CST-3056 (CuraAX) Deoxyepinephrine (epinine
LSD
Chemical compound
5-HT1A receptor partial agonist. Similarly to other azapirones such as buspirone, revospirone produces 1-(2-pyrimidinyl)piperazine (1-PP) as an active
Revospirone
Form of psychoactive drugs
umespirone, ziprasidone) Azapirones (e.g., alnespirone, binospirone, BMY-7378, buspirone, enilospirone, eptapirone (F-11440), gepirone, ipsapirone, perospirone
Hallucinogenic_snuff
Medication mainly used for depression and smoking cessation
(aripiprazole, brexpiprazole, lurasidone, olanzapine, quetiapine, risperidone) Buspirone Lithium (lithium carbonate, lithium citrate) Thyroid hormones (triiodothyronine
Bupropion
Class of medication used to treat depression and other conditions
(azapirones) Serotonin 5-HT1A receptor partial agonism • Other actions Buspirone (off-label) • Gepirone • Tandospirone 1980s Serotonin–norepinephrine reuptake
Antidepressant
Inability to achieve orgasm despite adequate stimulation
may help to relieve SSRI-induced sexual dysfunction. Cyproheptadine, buspirone, stimulants such as amphetamines (including the antidepressant bupropion)
Anorgasmia
Chemical compound
more potent than 8-OH-DPAT and 100-fold more potent than flesinoxan and buspirone. Other 5-HT1A-mediated effects of S-14671 include induction of flat-body
S-14671
Pharmaceutical compound
(A-437203; LU-201640) Alpiropride Azapride Bromerguride Bromocriptine Buspirone Carmoxirole Desmethoxyfallypride EEDQ F-15063 F-17464 Fallypride Fananserin
Matsupexole
Medical condition
them and are used as treatment by many health professionals. Isoniazid, buspirone hydrochloride, glutethimide, carbamazepine, clonazepam, topiramate, zofran
Intention_tremor
Pharmaceutical compound
v t e Adrenergic receptor modulators α1 Agonists 6-FNE Amidephrine Buspirone Cirazoline Corbadrine CST-2140 CST-3056 (CuraAX) Deoxyepinephrine (epinine
Levisoprenaline
Investigational antipsychotics
receptor antagonist, and other actions – schizophrenia [78] Buspirone controlled release (buspirone ER) – serotonin 5-HT1A receptor agonist – schizophrenia
List of investigational antipsychotics
List_of_investigational_antipsychotics
Mood-stabilizing psychiatric medication
people concurrently on serotonergic medications such as antidepressants, buspirone and certain opioids such as pethidine (meperidine), tramadol, oxycodone
Lithium_(medication)
Dissociative anesthetic and anti-depressant
(A-437203; LU-201640) Alpiropride Azapride Bromerguride Bromocriptine Buspirone Carmoxirole Desmethoxyfallypride EEDQ F-15063 F-17464 Fallypride Fananserin
Ketamine
Central nervous system stimulant
agonists Clonidine Guanfacine Antidepressants Amitriptyline Bupropion Buspirone Desipramine Duloxetine Imipramine Milnacipran Moclobemide Nortriptyline
Methylphenidate
Medication used to treat ADHD and depression
(aripiprazole, brexpiprazole, lurasidone, olanzapine, quetiapine, risperidone) Buspirone Lithium (lithium carbonate, lithium citrate) Thyroid hormones (triiodothyronine
Viloxazine
Antidepressant medication
(aripiprazole, brexpiprazole, lurasidone, olanzapine, quetiapine, risperidone) Buspirone Lithium (lithium carbonate, lithium citrate) Thyroid hormones (triiodothyronine
Vilazodone
Chemical compound
batoprazine, and TFMPP, as well as more distantly to the azapirones such as buspirone. The pharmacology of fluprazine is unknown, but it is likely to act as
Fluprazine
antidepressants, antipsychotics, ergolines, and some piperazines like buspirone, trazodone, nefazodone, etoperidone, and mepiprazole antagonize α1-adrenergic
List_of_adrenergic_drugs
Neurological impairment of voluntary muscle movement
vigabatrin, phosphatidylcholine, acetazolamide, 4-aminopyridine, buspirone, and a combination of coenzyme Q10 and vitamin E. Physical therapy requires
Ataxia
Pharmaceutical compound
v t e Adrenergic receptor modulators α1 Agonists 6-FNE Amidephrine Buspirone Cirazoline Corbadrine CST-2140 CST-3056 (CuraAX) Deoxyepinephrine (epinine
Cianergoline
Investigational Parkinson's disease drugs
ionotropic glutamate NMDA receptor agonist [24] Buspirone/zolmitriptan (AV-2860; JM-010) – combination of buspirone (serotonin 5-HT1A receptor agonist and other
List of investigational Parkinson's disease drugs
List_of_investigational_Parkinson's_disease_drugs
Antipsychotic compound
(A-437203; LU-201640) Alpiropride Azapride Bromerguride Bromocriptine Buspirone Carmoxirole Desmethoxyfallypride EEDQ F-15063 F-17464 Fallypride Fananserin
Dexclamol
Alpha-adrenergic agonist
uses v t e Anxiolytics (N05B) 5-HT1ARTooltip 5-HT1A receptor agonists Buspirone Gepirone Tandospirone GABAARTooltip GABAA receptor PAMsTooltip positive
Clonidine
Biperiden, Brintellix, Bromazepam, Bupropion, Buprenorphine/naloxone, Buspirone Calcium carbimide, Carbamazepine, Chloralhydrate, Chlordiazepoxide, Clomethiazole
List of psychiatric medications
List_of_psychiatric_medications
SNRI antidepressant
might interact with tramadol or other opioids, as well as trazodone and buspirone, so caution is needed while mixing multiple serotonergic agents together
Venlafaxine
Chemical compound, Novel psychoactive substance analog, LSD prodrug
umespirone, ziprasidone) Azapirones (e.g., alnespirone, binospirone, BMY-7378, buspirone, enilospirone, eptapirone (F-11440), gepirone, ipsapirone, perospirone
1S-LSD
Pharmaceutical compound
v t e Adrenergic receptor modulators α1 Agonists 6-FNE Amidephrine Buspirone Cirazoline Corbadrine CST-2140 CST-3056 (CuraAX) Deoxyepinephrine (epinine
CST-3056
dronabinol (a trade name for THC) has proven the most effective. The drugs buspirone and rimonabant have shown some success in helping maintain cannabis abstinence
Effects_of_cannabis
Psychological effect of drug intake
quebracho, vitamin E) Alkyl nitrites Alprostadil Amantadine Bupropion Buspirone Cyproheptadine Dapoxetine Flibanserin Mirtazapine Moxisylyte Oxytocin
Drugs_and_sexual_desire
Medication
Pharmacodynamics v t e Adrenergic receptor modulators α1 Agonists 6-FNE Amidephrine Buspirone Cirazoline Corbadrine CST-2140 CST-3056 (CuraAX) Deoxyepinephrine (epinine
Milsaperidone
SSRI antidepressant
(aripiprazole, brexpiprazole, lurasidone, olanzapine, quetiapine, risperidone) Buspirone Lithium (lithium carbonate, lithium citrate) Thyroid hormones (triiodothyronine
Citalopram
Iranian pharmaceutical company
Stock Exchange since 1997. Acetaminophen+Codeine Amoxicillin Azithromycin Buspirone Carbamazepine Cefalexin Cefazolin Cefepime Cefixime Ceftazidime Ceftriaxone
Loghman_Pharmaceuticals
Anti Parkinson medicine
(A-437203; LU-201640) Alpiropride Azapride Bromerguride Bromocriptine Buspirone Carmoxirole Desmethoxyfallypride EEDQ F-15063 F-17464 Fallypride Fananserin
Carbidopa/levodopa/entacapone
Pharmaceutical compound
umespirone, ziprasidone) Azapirones (e.g., alnespirone, binospirone, BMY-7378, buspirone, enilospirone, eptapirone (F-11440), gepirone, ipsapirone, perospirone
3,4-Dimethoxyamphetamine
Chemical compound
v t e Anxiolytics (N05B) 5-HT1ARTooltip 5-HT1A receptor agonists Buspirone Gepirone Tandospirone GABAARTooltip GABAA receptor PAMsTooltip positive allosteric
Enilospirone
Compounds that bind to and activate adrenergic beta-2 receptors
v t e Adrenergic receptor modulators α1 Agonists 6-FNE Amidephrine Buspirone Cirazoline Corbadrine CST-2140 CST-3056 (CuraAX) Deoxyepinephrine (epinine
Beta2-adrenergic_agonist
Muscle relaxant medication
Pharmacodynamics v t e Adrenergic receptor modulators α1 Agonists 6-FNE Amidephrine Buspirone Cirazoline Corbadrine CST-2140 CST-3056 (CuraAX) Deoxyepinephrine (epinine
Cyclobenzaprine
Psychiatric disorder defined by chronic depression
include lithium (medication), thyroid hormone augmentation, amisulpride, buspirone, bupropion, guanfacine, stimulants, and mirtazapine. Additionally, if
Dysthymia
Robust antidepressant
umespirone, ziprasidone) Azapirones (e.g., alnespirone, binospirone, BMY-7378, buspirone, enilospirone, eptapirone (F-11440), gepirone, ipsapirone, perospirone
NLX-204
Nasal decongestant
v t e Adrenergic receptor modulators α1 Agonists 6-FNE Amidephrine Buspirone Cirazoline Corbadrine CST-2140 CST-3056 (CuraAX) Deoxyepinephrine (epinine
Xylometazoline
Class of medications
(aripiprazole, brexpiprazole, lurasidone, olanzapine, quetiapine, risperidone) Buspirone Lithium (lithium carbonate, lithium citrate) Thyroid hormones (triiodothyronine
Tricyclic_antidepressant
Species of flowering plant
v t e Anxiolytics (N05B) 5-HT1ARTooltip 5-HT1A receptor agonists Buspirone Gepirone Tandospirone GABAARTooltip GABAA receptor PAMsTooltip positive allosteric
Scutellaria_baicalensis
BUSPIRONE
BUSPIRONE
BUSPIRONE
BUSPIRONE
BUSPIRONE
BUSPIRONE
BUSPIRONE
BUSPIRONE
BUSPIRONE