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Agents that modulate or mimic monoaminergic neurotransmitters
serotonin, dopamine, norepinephrine, epinephrine, and histamine. A monoaminergic, or monoaminergic drug, is a chemical, which functions to directly modulate the
Monoaminergic
Class of compounds in the nervous system
Monoaminergic activity enhancers (MAE), also known as catecholaminergic/serotonergic activity enhancers (CAE/SAE), are a class of drugs that enhance the
Monoaminergic activity enhancer
Monoaminergic_activity_enhancer
Compounds that damage or destroy monoaminergic neurons
monoamine neurotoxin, or monoaminergic neurotoxin, is a drug that selectively damages or destroys monoaminergic neurons. Monoaminergic neurons are neurons
Monoamine_neurotoxin
Class of compounds
(MRIs) and monoaminergic activity enhancers (MAEs), which similarly increase synaptic monoamine neurotransmitter levels and enhance monoaminergic signaling
Monoamine_releasing_agent
Neuron cell collection
Monoaminergic cell groups refers to collections of neurons in the central nervous system that have been demonstrated by histochemical fluorescence to
Monoaminergic_cell_groups
Pleasurable phenomenon elicited via direct stimulation of specific brain regions
addiction liability for drugs of many classes, including those that act on monoaminergic, opioid, and cholinergic neurotransmission. These data correlate well
Brain_stimulation_reward
Pharmaceutical compound
code name V-111), also known as 4-bromomethamphetamine (4-BMA), is a monoaminergic drug of the amphetamine family related to para-chloroamphetamine (PCA;
Para-Bromomethamphetamine
Tetrahydropyridine, a chemical causing Parkinson's disease symptoms
classified as a tetrahydropyridine. It is of interest as a precursor to the monoaminergic neurotoxin MPP+, which causes permanent symptoms of Parkinson's disease
MPTP
Typical antipsychotic medication
Besides the preceding mechanisms, haloperidol metabolizes into HPP+, a monoaminergic neurotoxin related to MPTP. This might be involved in the extrapyramidal
Haloperidol
Type of receptor located in the membranes of nerve cells
receptor 1 (TAAR1), a G-Coupled Protein Receptor GPCR, to regulate monoaminergic systems in the brain. Active TAAR1 opposes the autoreceptor's activity
Autoreceptor
Monoaminergic neurotoxin
HPTP is a monoaminergic neurotoxin related to MPTP. It is the dehydration product of haloperidol. The agent is specifically a dopaminergic and serotonergic
HPTP
Chemical compound
6-hydroxydopamine (6-OHDA) or 2,4,5-trihydroxyphenethylamine, is a synthetic monoaminergic neurotoxin used by researchers to selectively destroy dopaminergic and
Oxidopamine
Syrian-American neuroscientist (born 1945)
1016/S0022-3565(25)03823-6. ISSN 1521-0103. Akil, Huda; Liebeskind, John C. (1975). "Monoaminergic mechanisms of stimulation-produced analgesia". Brain Research. 94 (2):
Huda_Akil
Chemical compound
the brand names Contralac (veterinary) and Liserdol (clinical), is a monoaminergic medication of the ergoline group which is used as a prolactin inhibitor
Metergoline
Dopamine agonist medication
"Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs
Bromocriptine
Affecting GABA systems in the brain
Cholinergic Dopaminergic Glutamatergic Glycinergic Histaminergic Melatonergic Monoaminergic Neurotransmission Opioidergic Serotonergic Froestl, Wolfgang (2011)
GABAergic
Chemical compound
"Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs
Apomorphine
Organic compound, a stimulant in humans
psychostimulant-like effect, in TAAR1 knockout mice. Phenethylamine is a monoaminergic activity enhancer (MAE) of serotonin, norepinephrine, and dopamine in
Phenethylamine
Protein found in humans
similarity, and TAAR1 mRNA is highly expressed in the same important monoaminergic regions of both species. These regions include the dorsal and ventral
TAAR1
biological targets of many drugs; such drugs may be referred to as "monoaminergic". Monoamine receptors include the following classes: Adrenergic receptors
Monoamine_receptor
Chemical compound
FPFS-1169) is an experimental drug related to selegiline which acts as a monoaminergic activity enhancer (MAE). It is orally active in animals. BPAP is a highly
Benzofuranylpropylaminopentane
Benzofuranylpropylaminopentane
Mood disorder
depression is not completely understood, but current theories center around monoaminergic systems, the circadian rhythm, immunological dysfunction, HPA-axis dysfunction
Major_depressive_disorder
Chronic multi-symptomatic pain disorder
fibromyalgia. Supporting the monoamine related theories is the efficacy of monoaminergic antidepressants in fibromyalgia. Glutamate/creatine ratios within the
Fibromyalgia
Drug used to treat high blood pressure
Eiden LE, Weihe E (January 2011). "VMAT2: a dynamic regulator of brain monoaminergic neuronal function interacting with drugs of abuse". Annals of the New
Reserpine
Dopamine agonist medication
"Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. II. Agonist and antagonist properties at subtypes of dopamine
Pramipexole
Tricyclic antidepressant
phase III v t e Neuropathic pain and fibromyalgia pharmacotherapies Monoaminergics SNRIsTooltip Serotonin–norepinephrine reuptake inhibitor (e.g., duloxetine
Amitriptyline
Synthetic monoaminergic activity enhancer drug
Indolylpropylaminopentane (IPAP), also known as α,N-dipropyltryptamine (α,N-DPT), is a monoaminergic activity enhancer (MAE) that is closely related to benzofuranylpropylaminopentane
Indolylpropylaminopentane
Medication used to treat anxiety disorders
an aryl-piperazine anxiolytic drug, on aggressive behavior and brain monoaminergic neurotransmission". Naunyn-Schmiedeberg's Archives of Pharmacology.
Buspirone
Pharmaceutical compound
N-propyl-1,3-benzodioxolylpentanamine (PDBP), or propyl-K, is a monoaminergic activity enhancer (MAE) of the phenethylamine, amphetamine, and α-propylphenethylamine
Methylenedioxyphenylpropylaminopentane
Methylenedioxyphenylpropylaminopentane
Branch of biology concerning depressive disorders in humans
regions are innervated by a monoaminergic nucleus, and tentative evidence suggests a potential role for abnormal monoaminergic activity. Historically, candidate
Biology_of_depression
Central nervous system stimulant
Eiden LE, Weihe E (January 2011). "VMAT2: a dynamic regulator of brain monoaminergic neuronal function interacting with drugs of abuse". Annals of the New
Methylphenidate
Chemical compound
Lisuride, sold under the brand name Dopergin among others, is a monoaminergic medication of the ergoline family which is used in the treatment of Parkinson's
Lisuride
Monoamine that acts as a neurotransmitter or neuromodulator
enzymes known as monoamine oxidases which clip off the amine group. Monoaminergic systems, i.e., the networks of neurons that use monoamine neurotransmitters
Monoamine_neurotransmitter
Nervous system disease affecting nerves beyond the brain and spinal cord
v t e Neuropathic pain and fibromyalgia pharmacotherapies Monoaminergics SNRIsTooltip Serotonin–norepinephrine reuptake inhibitor (e.g., duloxetine, milnacipran)
Peripheral_neuropathy
Central nervous system stimulant
amine-associated receptor 1 (TAAR1), a G-protein coupled receptor that regulates monoaminergic systems in the brain; activation of TAAR1 may restore impaired dopaminergic
Amphetamine
v t e Neuropathic pain and fibromyalgia pharmacotherapies Monoaminergics SNRIsTooltip Serotonin–norepinephrine reuptake inhibitor (e.g., duloxetine, milnacipran)
List of investigational analgesics
List_of_investigational_analgesics
Monoaminergic activity enhancer antagonist
of benzofuranylpropylaminopentane (BPAP) and is an antagonist of the monoaminergic activity enhancer (MAE) effects of the tryptamine-related BPAP. Conversely
3-F-BPAP
Monoaminergic neurotoxin related to MPTP and metabolites of haloperidol
HPP+, also known as haloperidol pyridinium, is a monoaminergic neurotoxin and a metabolite of haloperidol. HPP+ is formed from haloperidol, and its dehydration
HPP+
Group of stereoisomers
Activation of the TAAR1 may auto-inhibit and thereby constrain the monoaminergic effects of these agents. Lack of TAAR1 agonism in the case of aminorex
4-Methylaminorex
Metabolite of the amino acid tryptophan
serotonin–norepinephrine–dopamine releasing agent (SNDRA). Tryptamine is a monoaminergic activity enhancer (MAE) of serotonin, norepinephrine, and dopamine in
Tryptamine
Dopamine agonist medication
"Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs
Pergolide
example is opioidergics. Adenosinergic Cannabinoidergic Cholinergic GABAergic Glutamatergic Glycinergic Histaminergic Monoaminergic Opioidergic v t e
Neuropeptidergic
Drug class
monoamine-depleting agents, as do various other agents, for instance monoaminergic neurotoxins. Monoamine reuptake inhibitor Monoamine releasing agent
Monoamine-depleting_agent
Antidepressant
v t e Neuropathic pain and fibromyalgia pharmacotherapies Monoaminergics SNRIsTooltip Serotonin–norepinephrine reuptake inhibitor (e.g., duloxetine, milnacipran)
Dosulepin
Drug that increases alertness
Eiden LE, Weihe E (January 2011). "VMAT2: a dynamic regulator of brain monoaminergic neuronal function interacting with drugs of abuse". Ann. N. Y. Acad
Stimulant
Synthetic opioid pain medication
v t e Neuropathic pain and fibromyalgia pharmacotherapies Monoaminergics SNRIsTooltip Serotonin–norepinephrine reuptake inhibitor (e.g., duloxetine, milnacipran)
Tramadol
Class of drug
Psilocybin therapy v t e Neuropathic pain and fibromyalgia pharmacotherapies Monoaminergics SNRIsTooltip Serotonin–norepinephrine reuptake inhibitor (e.g., duloxetine
Opioid
Antidepressant medication
v t e Neuropathic pain and fibromyalgia pharmacotherapies Monoaminergics SNRIsTooltip Serotonin–norepinephrine reuptake inhibitor (e.g., duloxetine, milnacipran)
Nortriptyline
Hungarian psychopharmacologist who developed selegiline
related agents for many decades. Knoll also developed the concepts of monoaminergic activity enhancers (MAEs) and the mesencephalic enhancer regulation
József_Knoll
SNRI medication
v t e Neuropathic pain and fibromyalgia pharmacotherapies Monoaminergics SNRIsTooltip Serotonin–norepinephrine reuptake inhibitor (e.g., duloxetine, milnacipran)
Duloxetine
Medication used to treat dyskinesia
found to increase dopamine levels in the striatum. It does not act as a monoaminergic activity enhancer. Amantadine is a phosphodiesterase inhibitor, for
Amantadine
Drug class
one or more of these neurotransmitters and therefore an increase in monoaminergic neurotransmission. The majority of currently approved antidepressants
Monoamine_reuptake_inhibitor
Symptom of narcolepsy
drugs is to suppress the REM component and to increase the brainstem monoaminergic levels. Improvement can be seen within 48 hours after the drug is administered
Cataplexy
Antihistamine used to treat allergies
S2CID 21236268. Carlsson A, Lindqvist M (July 1969). "Central and peripheral monoaminergic membrane-pump blockade by some addictive analgesics and antihistamines"
Chlorphenamine
Catecholaminergic neurotoxin
scientific literature by 1969. Kostrzewa RM (2022). "Survey of Selective Monoaminergic Neurotoxins Targeting Dopaminergic, Noradrenergic, and Serotoninergic
6-Hydroxydopa
Chemical substance that enables neurotransmission
Eiden LE, Weihe E (January 2011). "VMAT2: a dynamic regulator of brain monoaminergic neuronal function interacting with drugs of abuse". Annals of the New
Neurotransmitter
Medication used to treat premature ejaculation
McKenna KE, Chester A, Lovenberg T, Bonaventure P, Gupta SK (2005). "Monoaminergic transporter binding and inhibition profile of dapoxetine, a medication
Dapoxetine
Related to catecholamines (dopamine, adrenaline and noradrenaline)
Cannabinoidergic Cholinergic GABAergic Glutamatergic Glycinergic Histaminergic Monoaminergic Opioidergic "Definition of CATECHOLAMINERGIC". www.merriam-webster.com
Catecholaminergic
Chemical compound
Monoaminergics v t e Adrenergic receptor modulators α1 Agonists 6-FNE Amidephrine Buspirone Cirazoline Corbadrine CST-2140 CST-3056 (CuraAX) Deoxyepinephrine
Carbenzide
Drugs that lower neurotransmission levels, reducing brain activity
which include facilitation of GABA and inhibition of glutamatergic or monoaminergic activity. Other examples are chemicals that modify the electrical signaling
Depressant
Chemical compound
where TAAR1 has relatively low expression. The effects of RO5166017 on monoaminergic neuron firing frequencies were absent in TAAR1 knockout mice and could
RO5166017
Brain region
ventral tegmental area (VTA). ... Orexin neurons project to and activate monoaminergic and cholinergic neurons involved in the maintenance of a long "awake"
Lateral_hypothalamus
Chemical compound
(Ki = 40 pM). Unlike selegiline, clorgiline does not appear to be a monoaminergic activity enhancer (MAE). Clorgiline is also a multidrug efflux pump
Clorgiline
Substance related to histamine functions
Cannabinoidergic Cholinergic Dopaminergic GABAergic Glycinergic Melatonergic Monoaminergic Opioidergic Serotonergic "Histamine Agents | DrugBank Online". go.drugbank
Histaminergic
Thiamine analogue
v t e Neuropathic pain and fibromyalgia pharmacotherapies Monoaminergics SNRIsTooltip Serotonin–norepinephrine reuptake inhibitor (e.g., duloxetine, milnacipran)
Benfotiamine
Pharmaceutical compound
(NPAP), also known as 2-naphthyl-α,N-dipropylphenethylamine, is a monoaminergic activity enhancer (MAE) of the α-propylphenethylamine and naphthylaminopropane
Naphthylpropylaminopentane
Monoaminergic drug
Monoaminergic drug
Α-Methylisotryptamine
Species of mantis shrimp
fight. These aggressive behaviors are in large part facilitated through monoaminergic signaling, with neurotransmitters inducing changes in brain activity
Haptosquilla_trispinosa
Monoaminergic neurotoxin
2′-amino-MPTP, is a monoaminergic neurotoxin that was derived from MPTP and is used in scientific research to lesion brain monoaminergic systems in animals
2′-NH2-MPTP
Antidepressant
antidepressant around the same time, imipramine resulted in the establishment of monoaminergic drugs as antidepressants. In the late 1950s, imipramine was the first
Imipramine
Chemical compound
"Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs
Terguride
Entactogen drug
discrimination tests. Further, also in common with MDMA, methylone acts on monoaminergic systems. In vitro, methylone has one third the potency of MDMA at inhibiting
Methylone
Neurodegenerative disorder
et al. (July 2003). "REM sleep behavior disorder is related to striatal monoaminergic deficit in MSA". Neurology. 61 (1): 29–34. doi:10.1212/01.wnl.0000073745
Multiple_system_atrophy
ropren from coniferous plants on the key enzymes of the cholinergic and monoaminergic types of nervous transmission". Doklady. Biochemistry and Biophysics
Biochemistry of Alzheimer's disease
Biochemistry_of_Alzheimer's_disease
Spinal trigeminal nucleus
neurons in the ARAS were identified much more recently relative to the monoaminergic and cholinergic nuclei; the glutamatergic component of the ARAS includes
Reticular_formation
Cognitive system for temporarily holding information
(2009). "The neuropsychopharmacology of fronto-executive function: monoaminergic modulation". Annual Review of Neuroscience. 32: 267–287. doi:10.1146/annurev
Working_memory
Pharmaceutical compound
ring-substituted stimulants MDMA, methylone and MDPV differentially affect human monoaminergic systems". Journal of Psychopharmacology. 33 (7): 831–841. doi:10.1177/0269881119844185
4-Hydroxy-3-methoxymethcathinone
4-Hydroxy-3-methoxymethcathinone
Chemical substance that alters brain function
PMID 16139309. Dhingra D, Kumar V (2008). "Evidences for the involvement of monoaminergic and GABAergic systems in antidepressant-like activity of garlic extract
Psychoactive_drug
Stimulant drug of the substituted phenethylamine class
first major paper in 1992. It led to the development of the improved monoaminergic activity enhancer (MAE) benzofuranylpropylaminopentane (BPAP) in 1999
Phenylpropylaminopentane
Chemical compound
"Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs
Cabergoline
Medical condition
Palmieri A, Tavolato B, Vincent A. Immunotherapy-reversed compulsive, monoaminergic, circadian rhythm disorder in Morvan syndrome. Neurology. 2008 9;71:2008-10
Morvan's_syndrome
Psychoactive drug, often called ecstasy
serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI). MDMA enters monoaminergic neurons via the MATs and then, via poorly understood mechanisms, reverses
MDMA
Class of medication used to treat depression and other conditions
antidepressant effects. Most currently marketed antidepressants, which are monoaminergic in their actions, are theoretically consistent with the monoamine hypothesis
Antidepressant
Subtype of delusion
caused by substances such as L-DOPA and isoniazid which modify the monoaminergic neurotransmitter function. Vitamin B12 deficiency, uremia, hyperthyroidism
Delusions_of_grandeur
Chemical compound used as an herbicide
v t e Monoaminergic neurotoxins Dopaminergic 2′-CH3-MPTP (2′-methyl-MPTP) 2,4,5-THA 2,4,5-THMA 4-MMA 5-S-Cysteinyldopamine 5,6-DHT 6-Hydroxydopa 6-OHDA
Paraquat
Chemical compound
inhibitors • Monoamine releasing agents • Monoamine neurotoxins v t e Monoaminergic activity enhancers Endogenous Phenylethylamine (PEA) Tryptamine Tyramine
Desmethylselegiline
Investigational fibromyalgia drugs
v t e Neuropathic pain and fibromyalgia pharmacotherapies Monoaminergics SNRIsTooltip Serotonin–norepinephrine reuptake inhibitor (e.g., duloxetine, milnacipran)
List of investigational fibromyalgia drugs
List_of_investigational_fibromyalgia_drugs
MDMA analogue
hdl:11584/325355. PMID 34655576. Kostrzewa RM (2022). "Survey of Selective Monoaminergic Neurotoxins Targeting Dopaminergic, Noradrenergic, and Serotoninergic
ODMA_(drug)
Serotonergic neurotoxin
5,6-Dihydroxytryptamine (5,6-DHT) is a monoaminergic neurotoxin and tryptamine derivative related to serotonin (5-hydroxytryptamine) and 5,7-dihydroxytryptamine
5,6-Dihydroxytryptamine
Pharmaceutical compound
(PIMA), also known as 4-iodo-N-methylamphetamine (4-IMA) or as D-9, is a monoaminergic drug of the amphetamine family related to para-chloroamphetamine (PCA)
Para-Iodomethamphetamine
Danish-Canadian Neuroscientist
neurotransmission Research Brain energy metabolism, cerebral blood flow, monoaminergic neurotransmission Awards Fellow, Royal Society of Canada (FRSC) Fellow
Albert_Gjedde
Species of tree
leaves of Schinus molle L. in mice: Evidence for the involvement of the monoaminergic system", Progress in Neuro-Psychopharmacology and Biological Psychiatry
Schinus_molle
Affecting glutamate systems in the brain
Dopaminergic GABAergic GHBergic Glycinergic Histaminergic Melatonergic Monoaminergic Opioidergic Serotonergic Sigmaergic "glutamatergic". Merriam-Webster
Glutamatergic
Chemical element with atomic number 19 (K)
concentrating ability fluid and electrolyte balance local cortical monoaminergic norepinephrine, serotonin, and dopamine levels, and through them, sleep/wake
Potassium
Central nervous system stimulant prodrug
amine-associated receptor 1 (TAAR1), a G-protein coupled receptor that regulates monoaminergic systems in the brain; activation of TAAR1 may restore impaired dopaminergic
Lisdexamfetamine
Chemical compound
and analgesic of the pyrazolone group related to metamizole. It has monoaminergic properties, including inhibition of monoamine oxidase, augmentation
Difenamizole
French pharmacist and professor (1936–2020)
neuropeptides (including tachykinins), metabolic and functional properties of monoaminergic and cholinergic regulatory systems, neural circuits of the basal ganglia
Jacques_Glowinski
Chemical compound
Borght, TM; Albin, RL; Gilman, S; Kuhl, DE (December 1996). "Presynaptic monoaminergic vesicles in Parkinson's disease and normal aging" (PDF). Annals of Neurology
Dihydrotetrabenazine
Chemical compound
(9 September 2011). "Contribution of Pharmacology to Development of Monoaminergic Hypotheses of Depression". In López-Muñoz F, Álamo C (eds.). Neurobiology
PPPA_(drug)
Toxic mercury cation
v t e Monoaminergic neurotoxins Dopaminergic 2′-CH3-MPTP (2′-methyl-MPTP) 2,4,5-THA 2,4,5-THMA 4-MMA 5-S-Cysteinyldopamine 5,6-DHT 6-Hydroxydopa 6-OHDA
Methylmercury
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