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Substance related to histamine functions
Histaminergic means "working on the histamine system", and histaminic means "related to histamine". A histaminergic agent (or drug) is a chemical which
Histaminergic
Organic compound involved in immune responses
Arendt-Nielsen L (September 2015). "Human surrogate models of histaminergic and non-histaminergic itch" (PDF). Acta Dermato-Venereologica. 95 (7): 771–7. doi:10
Histamine
Medical condition
itch-scratch cycle. Chronic pruritus in PN is mainly mediated by non-histaminergic pathways, primarily IL-31 directly activating sensory neurons. This
Prurigo_nodularis
Seed of several plants in the legume family
Arendt-Nielsen L (September 2015). "Human surrogate models of histaminergic and non-histaminergic itch" (PDF). Acta Dermato-Venereologica. 95 (7): 771–77.
Bean
Antihistaminic drug
primarily found in the brain and are inhibitory autoreceptors located on histaminergic nerve terminals, which modulate the release of histamine. Histamine
H3_receptor_antagonist
Uncomfortable skin sensation
system has been found to be important for mediating both histaminergic and non-histaminergic itch, where the GRP neurons activate GRPR neurons to promote
Itch
Spinal trigeminal nucleus
thalamus/hypothalamus and a number of dopaminergic, noradrenergic, serotonergic, histaminergic, cholinergic, and glutamatergic brain nuclei. The ARAS is composed of
Reticular_formation
Primary cell of the nervous system
A neuron (American English), neurone (British English), or nerve cell, is a cell that is excitable, firing electric signals called action potentials. Neurons
Neuron
Symptom of narcolepsy
for it even less data is available. Immunoadsorption Alemtuzumab The histaminergic neurons have a very important role in preserving consciousness and in
Cataplexy
Science of drugs and medications and their effects
agonist Dopamine receptor antagonist Dopamine reuptake inhibitor (DRI) Histaminergic Histamine receptor agonist Histamine receptor antagonist (H1 H2 H3)
Pharmacology
Species of flowering plant
Arendt-Nielsen L (September 2015). "Human surrogate models of histaminergic and non-histaminergic itch" (PDF). Acta Dermato-Venereologica. 95 (7): 771–77.
Mucuna_pruriens
Medication to treat narcolepsy
it a first-in-class medication. Pitolisant enhances the activity of histaminergic neurons in the brain that function to improve a person's wakefulness
Pitolisant
Nucleus in the mammalian hypothalamus
histaminergic nucleus located within the posterior third of the hypothalamus. It is part of the tuber cinereum. It largely consists of histaminergic neurons
Tuberomammillary_nucleus
Affecting GABA systems in the brain
Cannabinoidergic Cholinergic Dopaminergic Glutamatergic Glycinergic Histaminergic Melatonergic Monoaminergic Neurotransmission Opioidergic Serotonergic
GABAergic
Plant protein
Arendt-Nielsen, Lars (2015). "Human Surrogate Models of Histaminergic and Non-histaminergic Itch" (PDF). Acta Dermato-Venereologica. 95 (7): 771–7. doi:10
Mucunain
Histamine receptor
cell bodies in the tuberomammillary nucleus of the hypothalamus. The histaminergic neurons of the tuberomammillary nucleus become active during the 'wake'
Histamine_H1_receptor
Drug that blocks histamine or histamine agonists
primarily found in the brain and are inhibitory autoreceptors located on histaminergic nerve terminals, which modulate the release of histamine. Histamine
Antihistamine
Chemical compound
Arendt-Nielsen, Lars (2015-09-01). "Human surrogate models of histaminergic and non-histaminergic itch" (PDF). Acta Dermato-Venereologica. 95 (7): 771–777
Histidine
Mammalian protein found in Homo sapiens
peripheral nervous system, where they act as autoreceptors in presynaptic histaminergic neurons and control histamine turnover by feedback inhibition of histamine
Histamine_H3_receptor
Central nervous system stimulant
activating system (ARAS), which includes noradrenergic, dopaminergic, histaminergic, and serotonergic nuclei that promote wakefulness. Amphetamine's therapeutic
Amphetamine
Anticonvulsant medication
anticonvulsants affect (adrenergic, dopamine D1 and D2, muscarinic, GABA, histaminergic H1, serotonin 5-HT2, and N-methyl-D-aspartate). Inhibitory effects on
Lamotrigine
State of being awoken
cortical arousal and impacts locomotion and mood. The neurons of the histaminergic system are in the tuberomammillary nucleus of the hypothalamus. These
Arousal
Substance having effect(s) on the body of an individual
agonist Dopamine receptor antagonist Dopamine reuptake inhibitor (DRI) Histaminergic Histamine receptor agonist Histamine receptor antagonist (H1 H2 H3)
Drug
Development of hives after contact with water
Greaves MW (1981). "Aquagenic urticaria: Evidence of cholinergic and histaminergic basis". The British Journal of Dermatology. 105 (3): 297–302. doi:10
Aquagenic_urticaria
Chemical substance that enables neurotransmission
which pass through the lateral hypothalamus and reach axons of the histaminergic tubero-mamillary nucleus (TMN), together forming a pathway extending
Neurotransmitter
Atypical antipsychotic medication
alone are not associated with weight gain, olanzapine antagonism at histaminergic H1, muscarinic M3 and dopamine D2 receptors have been associated with
Olanzapine
Parasympathetic nervous system inhibitors
agonist Dopamine receptor antagonist Dopamine reuptake inhibitor (DRI) Histaminergic Histamine receptor agonist Histamine receptor antagonist (H1 H2 H3)
Anticholinergic
Drug that increases alertness
autoreceptors, pitolisant decreases negative feedback to histaminergic neurons, enhancing histaminergic transmission. The precise mechanism of action of some
Stimulant
Type of receptor ligand or drug that blocks a biological response
agonist Dopamine receptor antagonist Dopamine reuptake inhibitor (DRI) Histaminergic Histamine receptor agonist Histamine receptor antagonist (H1 H2 H3)
Receptor_antagonist
Central nervous system stimulant
inhibitory GABA neurotransmission to the tuberomammillary nucleus, a histaminergic projection nucleus that activation-dependently promotes arousal. This
Caffeine
Central nervous system stimulant prodrug
activating system (ARAS), which includes noradrenergic, dopaminergic, histaminergic, and serotonergic nuclei that promote wakefulness. Amphetamine's therapeutic
Lisdexamfetamine
CNS stimulant and isomer of amphetamine
activating system (ARAS), which includes noradrenergic, dopaminergic, histaminergic, and serotonergic nuclei that promote wakefulness. Amphetamine's therapeutic
Dextroamphetamine
Drug mixture used mainly to treat ADHD and narcolepsy
activating system (ARAS), which includes noradrenergic, dopaminergic, histaminergic, and serotonergic nuclei that promote wakefulness. Amphetamine's therapeutic
Adderall
Class of enzymes
is present within the central nervous system (CNS), where it governs histaminergic neurotransmission, that is a process where histamine acts as a messenger
Histamine_N-methyltransferase
Substance that binds to a receptor to change its response to stimuli
agonist Dopamine receptor antagonist Dopamine reuptake inhibitor (DRI) Histaminergic Histamine receptor agonist Histamine receptor antagonist (H1 H2 H3)
Allosteric_modulator
SNRI medication
Duloxetine has no significant affinity for dopaminergic, cholinergic, histaminergic, opioid, glutamate, and GABA transporters, however, and can therefore
Duloxetine
Chemical compound
levels in tissue mast cells, it has many applications in the study of histaminergic systems. It has potent sleep-inducing effects in mice. In the central
Α-Fluoromethylhistidine
Brain state and state of consciousness
PMID 26457552. Takahashi, K; Lin, JS; Sakai, K (2006). "Neuronal activity of histaminergic tuberomammillary neurons during wake-sleep states in the mouse". Journal
Wakefulness
Drug which blocks dopamine receptors
dopamine receptors. They can also block noradrenergic, cholinergic, and histaminergic activity. Benperidol binds D2 and some serotonin receptors. It is absorbed
Dopamine_antagonist
Agents that modulate or mimic monoaminergic neurotransmitters
further divided into adrenergics and dopaminergics), serotonergics, and histaminergics. Examples of monoaminergic drugs include monoamine precursors, monoamine
Monoaminergic
example is opioidergics. Adenosinergic Cannabinoidergic Cholinergic GABAergic Glutamatergic Glycinergic Histaminergic Monoaminergic Opioidergic v t e
Neuropeptidergic
Area of the brain below the thalamus
lies within the posterior hypothalamus. There are approximately 64000 histaminergic neurons per side in humans. These cells project throughout the brain
Hypothalamus
Class of anesthetics
agonist Dopamine receptor antagonist Dopamine reuptake inhibitor (DRI) Histaminergic Histamine receptor agonist Histamine receptor antagonist (H1 H2 H3)
NMDA_receptor_antagonist
Chronic neurological sleep disorder
cerebellum) with dense projections to the noradrenergic locus ceruleus (LC), histaminergic tuberomamillary nucleus (TMN), serotonergic raphe nuclei, cholinergic
Narcolepsy
Chemical compound
regulate the release of histamine. The drug enhances the activity of histaminergic neurons by blocking autoreceptors, leading to greater release of histamine
Thioperamide
Type of drug
agonist Dopamine receptor antagonist Dopamine reuptake inhibitor (DRI) Histaminergic Histamine receptor agonist Histamine receptor antagonist (H1 H2 H3)
Reuptake_inhibitor
Drug that makes neurotransmitter transporters more active
agonist Dopamine receptor antagonist Dopamine reuptake inhibitor (DRI) Histaminergic Histamine receptor agonist Histamine receptor antagonist (H1 H2 H3)
Reuptake_enhancer
Antidepressant
"Interactions with Psychotropic Drugs". In Watanabe T, Wada H (eds.). Histaminergic Neurons: Morphology and Function. CRC Press. p. 272. ISBN 978-0-8493-6425-9
Imipramine
Related to catecholamines (dopamine, adrenaline and noradrenaline)
Adenosinergic Cannabinoidergic Cholinergic GABAergic Glutamatergic Glycinergic Histaminergic Monoaminergic Opioidergic "Definition of CATECHOLAMINERGIC". www.merriam-webster
Catecholaminergic
Affecting glutamate systems in the brain
Cannabinoidergic Cholinergic Dopaminergic GABAergic GHBergic Glycinergic Histaminergic Melatonergic Monoaminergic Opioidergic Serotonergic Sigmaergic "glutamatergic"
Glutamatergic
Subtype of serotonin receptor
affinity for alpha1 adrenergic receptors. It also has high affinity for H1 histaminergic receptors equal to that at 5-HT2A receptors. Compounds chemically related
5-HT2A_receptor
Regulation of neurons by neurotransmitters
agonist Dopamine receptor antagonist Dopamine reuptake inhibitor (DRI) Histaminergic Histamine receptor agonist Histamine receptor antagonist (H1 H2 H3)
Neuromodulation
Inhibits actions of parasympathetic nervous system
agonist Dopamine receptor antagonist Dopamine reuptake inhibitor (DRI) Histaminergic Histamine receptor agonist Histamine receptor antagonist (H1 H2 H3)
Parasympatholytic
Typical antipsychotic medication
It also blocks α1 adrenergic receptors, muscarinic M1 receptors, and histaminergic H1 receptors, and like other phenothiazines, it competitively inhibits
Fluphenazine
Degree of activation of airway muscle
increase in airway tone caused by cholinergic signalling, but exacerbated histaminergic bronchoconstriction, while both signals were attenuated in the present
Airway_tone
Drug to increase activity at histamine receptors
antagonist of the Histamine3 autoreceptor. Antagonizing H3 increases histaminergic tone. Histamine antagonist Sakai, N.; Nishino, S. (2013). "Wake-Promoting
Histamine_agonist
Chemical compound
The histamine H3 receptor is an inhibitory autoreceptor located on histaminergic nerve terminals, and is believed to be involved in modulating the release
Ciproxifan
Class of medications
agonist Dopamine receptor antagonist Dopamine reuptake inhibitor (DRI) Histaminergic Histamine receptor agonist Histamine receptor antagonist (H1 H2 H3)
H2_receptor_antagonist
Adrenergic Cannabinoidergic Cholinergic Dopaminergic GABAergic Glycinergic Histaminergic Melatonergic Monoaminergic Opioidergic Serotonergic Ren, Xiangpeng;
Adenosinergic
Class of compounds
agonist Dopamine receptor antagonist Dopamine reuptake inhibitor (DRI) Histaminergic Histamine receptor agonist Histamine receptor antagonist (H1 H2 H3)
Alpha-1_blocker
Drugs that block the action of histamine
agonist Dopamine receptor antagonist Dopamine reuptake inhibitor (DRI) Histaminergic Histamine receptor agonist Histamine receptor antagonist (H1 H2 H3)
H1_antagonist
Medication used to treat insomnia
sleep–wake regulation, including the noradrenergic locus coeruleus, histaminergic tuberomammillary nucleus, serotonergic raphe nucleus, and dopaminergic
Suvorexant
Type of pharmaceutical drug
agonist Dopamine receptor antagonist Dopamine reuptake inhibitor (DRI) Histaminergic Histamine receptor agonist Histamine receptor antagonist (H1 H2 H3)
Reuptake_modulator
Compounds found in cannabis
agonist Dopamine receptor antagonist Dopamine reuptake inhibitor (DRI) Histaminergic Histamine receptor agonist Histamine receptor antagonist (H1 H2 H3)
Cannabinoid
Working on the endocannabinoid neurotransmitters
Adenosinergic Adrenergic Cholinergic Dopaminergic GABAergic Glycinergic Histaminergic Melatonergic Monoaminergic Opioidergic Serotonergic Palmer, SL; Thakur
Cannabinoidergic
Post-translational modification involving the monoamine histamine
been reported in a number of cells and tissues, including mast cells, histaminergic neurons of the posterior hypothalamic tuberomammillary nucleus (TMN)
Histaminylation
Neurotransmission-modulating substance
agonist Dopamine receptor antagonist Dopamine reuptake inhibitor (DRI) Histaminergic Histamine receptor agonist Histamine receptor antagonist (H1 H2 H3)
Serotonin_receptor_agonist
Region of the basal forebrain
accumbens is one of the few regions that receives a high density of histaminergic projections from the tuberomammillary nucleus (the sole source of histamine
Nucleus_accumbens
Brain region
nucleus, and the paraventricular hypothalamic nucleus. In addition to the histaminergic nucleus, the orexin system also projects onto the ventral tegmental
Lateral_hypothalamus
Chemical agents that inhibit Cholinesterase
agonist Dopamine receptor antagonist Dopamine reuptake inhibitor (DRI) Histaminergic Histamine receptor agonist Histamine receptor antagonist (H1 H2 H3)
Cholinesterase_inhibitor
Class of antidepressant medication
receptors such as muscarinic cholinergic, α1- and α2-adrenergic, H1-histaminergic, and sodium channels in the cardiac muscle, leading to decreased cardiac
Serotonin–norepinephrine reuptake inhibitor
Serotonin–norepinephrine_reuptake_inhibitor
Chemical compound class
agonist Dopamine receptor antagonist Dopamine reuptake inhibitor (DRI) Histaminergic Histamine receptor agonist Histamine receptor antagonist (H1 H2 H3)
NK1_receptor_antagonist
Group of pharmaceuticals that modulate the renin–angiotensin system
agonist Dopamine receptor antagonist Dopamine reuptake inhibitor (DRI) Histaminergic Histamine receptor agonist Histamine receptor antagonist (H1 H2 H3)
Angiotensin II receptor blocker
Angiotensin_II_receptor_blocker
Chemical compound
Newman AH, Katz JL (November 2005). "Assessment of the influence of histaminergic actions on cocaine-like effects of 3alpha-diphenylmethoxytropane analogs"
Difluoropine
Physiological nature of sleep
thalamic nuclei and a number of dopaminergic, noradrenergic, serotonergic, histaminergic, cholinergic, and glutamatergic brain nuclei. When awake, it receives
Neuroscience_of_sleep
Initial drug used as a reference
October 2018. Retrieved 16 October 2018. Watanabe, T.; Wada, H. (1991). Histaminergic Neurons (in Estonian). Taylor & Francis. p. 272. ISBN 978-0-8493-6425-9
Prototype_drug
Organic compound (C11H10Cl2N4)
leading to increased histamine levels in the brain. This enhances histaminergic neurotransmission, which has been implicated in cognitive function,
Metoprine
Typical antipsychotic medication
inhibition of different receptors, including 5-HT (serotonin), dopaminergic, histaminergic, and adrenergic receptors. Blocking these receptors results in a reduction
Tiotixene
Antidepressant
"Interactions with Psychotropic Drugs". In Watanabe T, Wada H (eds.). Histaminergic Neurons. CRC Press. pp. 272–. ISBN 978-0-8493-6425-9. Extein I, Pottash
Trimipramine
Protein and coding gene in humans
Arendt-Nielsen L (September 2015). "Human surrogate models of histaminergic and non-histaminergic itch". Acta Dermato-Venereologica. 95 (7): 771–777. doi:10
TRPA1
Medications that relax muscles of the airways
agonist Dopamine receptor antagonist Dopamine reuptake inhibitor (DRI) Histaminergic Histamine receptor agonist Histamine receptor antagonist (H1 H2 H3)
Beta-adrenergic_agonist
Neuropeptide that regulates arousal, wakefulness, and appetite
JE, Elmquist JK, Torrealba F, Saper CB (June 1998). "Innervation of histaminergic tuberomammillary neurons by GABAergic and galaninergic neurons in the
Orexin
Class of drugs
agonist Dopamine receptor antagonist Dopamine reuptake inhibitor (DRI) Histaminergic Histamine receptor agonist Histamine receptor antagonist (H1 H2 H3)
Adenosine_receptor_antagonist
Type of ion channel transmembrane protein
agonist Dopamine receptor antagonist Dopamine reuptake inhibitor (DRI) Histaminergic Histamine receptor agonist Histamine receptor antagonist (H1 H2 H3)
Ligand-gated_ion_channel
Compound that activates dopamine receptors
agonist Dopamine receptor antagonist Dopamine reuptake inhibitor (DRI) Histaminergic Histamine receptor agonist Histamine receptor antagonist (H1 H2 H3)
Dopamine_agonist
Post-translational modifications involving monoamines
University discovered the H3Q5-histaminylation (H3Q5his) modification in histaminergic neurons. Monoaminylation is catalyzed by transglutaminase 2 (TGM2) in
Monoaminylation
Type of protein
mGluR2, mGluR3, mGluR4, mGluR5, mGluR6, mGluR7 Glycinergic: Glycine Histaminergic: H1, H2, H3. H4 Opioidergic: μ, δ1, δ2, κ Serotonergic: 5-HT1A, 5-HT1B
Neurotransmitter_receptor
agonist Dopamine receptor antagonist Dopamine reuptake inhibitor (DRI) Histaminergic Histamine receptor agonist Histamine receptor antagonist (H1 H2 H3)
Reverse_transport
Class of membrane transport proteins
agonist Dopamine receptor antagonist Dopamine reuptake inhibitor (DRI) Histaminergic Histamine receptor agonist Histamine receptor antagonist (H1 H2 H3)
Neurotransmitter_transporter
Category of drug
agonist Dopamine receptor antagonist Dopamine reuptake inhibitor (DRI) Histaminergic Histamine receptor agonist Histamine receptor antagonist (H1 H2 H3)
GABA_receptor_agonist
Substance related to dopamine functions
and S-adenosyl-L-methionine (SAMe). Adrenergic Cholinergic GABAergic Histaminergic Serotonergic Melinosky C (27 November 2022). "Parkinson's Disease: Glossary
Dopaminergic
Class of pharmaceutical compounds
agonist Dopamine receptor antagonist Dopamine reuptake inhibitor (DRI) Histaminergic Histamine receptor agonist Histamine receptor antagonist (H1 H2 H3)
Glycine_receptor_antagonist
Substance that binds to and regulates the activity of chemical receptors
agonist Dopamine receptor antagonist Dopamine reuptake inhibitor (DRI) Histaminergic Histamine receptor agonist Histamine receptor antagonist (H1 H2 H3)
Receptor_modulator
Measure of relative response to a drug
agonist Dopamine receptor antagonist Dopamine reuptake inhibitor (DRI) Histaminergic Histamine receptor agonist Histamine receptor antagonist (H1 H2 H3)
Intrinsic_activity
French neurobiologist, pharmacist and researcher
in brain: he described its metabolic pathways, identified the main histaminergic neuronal pathways, identified and located the receptors (H1, H2 and
Jean-Charles_Schwartz
Compounds that bind to and activate adrenergic beta-2 receptors
agonist Dopamine receptor antagonist Dopamine reuptake inhibitor (DRI) Histaminergic Histamine receptor agonist Histamine receptor antagonist (H1 H2 H3)
Beta2-adrenergic_agonist
Classification of chemicals that directly modulate opioid neuropeptide systems
Adrenergic Cannabinoidergic Cholinergic Dopaminergic GABAergic Glycinergic Histaminergic Melatonergic Monoaminergic Serotonergic Burford NT, Clark MJ, Wehrman
Opioidergic
Type of medication
agonist Dopamine receptor antagonist Dopamine reuptake inhibitor (DRI) Histaminergic Histamine receptor agonist Histamine receptor antagonist (H1 H2 H3)
Sympatholytic
Drug that binds to but does not activate muscarinic cholinergic receptors
agonist Dopamine receptor antagonist Dopamine reuptake inhibitor (DRI) Histaminergic Histamine receptor agonist Histamine receptor antagonist (H1 H2 H3)
Muscarinic_antagonist
Chemical compound
(2008-11-25) Hellstrand K, Asea A, Dahlgren C, Hermodsson S (December 1994). "Histaminergic regulation of NK cells. Role of monocyte-derived reactive oxygen metabolites"
Histamine_dihydrochloride
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