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Type of protein or peptide
A mitogen is a small bioactive protein or peptide that induces a cell to begin cell division, or enhances the rate of division (mitosis). Mitogenesis
Mitogen
Type of protein
Pokeweed mitogen is a mitogen derived from the roots of Phytolacca americana. It functions as a lectin and a mitotic stimulus for the division of lymphocytes
Pokeweed_mitogen
Cell signaling pathway
cell, such as cell division. The pathway includes many proteins, such as mitogen-activated protein kinases (MAPKs), originally called extracellular signal-regulated
MAPK/ERK_pathway
P38 mitogen-activated protein kinases
A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of serine/threonine-specific protein kinases involved in directing cellular responses
Mitogen-activated protein kinase
Mitogen-activated_protein_kinase
Class of enzymes
"extracellular signal-regulated kinases", is sometimes used as a synonym for mitogen-activated protein kinase (MAPK), but has more recently been adopted for
Extracellular signal-regulated kinases
Extracellular_signal-regulated_kinases
Chemical compounds
Ser-73 within its transcriptional activation domain. They belong to the mitogen-activated protein kinase family, and are responsive to stress stimuli,
C-Jun_N-terminal_kinases
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase 14, also called p38-α, is an enzyme that in humans is encoded by the MAPK14 gene. MAPK14 encodes p38α mitogen-activated
MAPK14
Protein family
p38 mitogen-activated protein kinases are a class of mitogen-activated protein kinases (MAPKs) that are responsive to stress stimuli, such as cytokines
P38 mitogen-activated protein kinases
P38_mitogen-activated_protein_kinases
Animal cell cycle checkpoint
cycle completion is no longer dependent on the presence of mitogens. Sustained mitogen signaling promotes cell cycle entry largely through regulation
Restriction_point
Enzyme catalyzing transfer of phosphate groups onto specific substrates
Mohamed S.H.; Sebaiy, Mahmoud M.; Elgawish, Mohamed Saleh (2024), "p38 mitogen-activated protein kinase inhibitors", Current Molecular Targets of Heterocyclic
Kinase
Species of bacterium
effects. YopJ, which shares an operon with YpkA, "...interferes with the mitogen-activated protein (MAP) kinase activities of c-Jun N-terminal kinase (JNK)
Yersinia_pseudotuberculosis
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase kinase kinase 15 is a protein that in humans is encoded by the MAP3K15 gene. The protein encoded by this gene is a member
MAP3K15
Class of enzymes
Mitogen Activated Protein (MAP) kinase kinase kinase (MAPKKK, MKKK, M3K, or, MAP3K) is a serine/threonine-specific protein kinase which acts upon MAP
MAP_kinase_kinase_kinase
Kinase enzyme
Mitogen-activated protein kinase kinase (also known as MAP2K, MEK, MAPKK) is a dual-specificity kinase enzyme which phosphorylates mitogen-activated protein
Mitogen-activated protein kinase kinase
Mitogen-activated_protein_kinase_kinase
Pharmaceutical compound
various types of cancer. It is a selective, orally administered inhibitor of mitogen-activated protein kinase kinases 1 and 2 (MEK1/MEK2), developed by Fosun
Luvometinib
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase 4 is an enzyme that in humans is encoded by the MAPK4 gene. Mitogen-activated protein kinase 4 is a member of the mitogen-activated
MAPK4
Protein-coding gene in the species Homo sapiens
Dual specificity mitogen-activated protein kinase kinase 1 is an enzyme that in humans is encoded by the MAP2K1 gene. The protein encoded by this gene
MAP2K1
Species of flowering plant in the family Phytolaccaceae
for some utility in biomedical research (e.g., in studies of pokeweed mitogen). In the wild, it is easily found growing in pastures, recently cleared
Phytolacca_americana
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase 8 (also known as JNK1) is a ubiquitous enzyme that in humans is encoded by the MAPK8 gene. The protein encoded by this
MAPK8
(MKPs) are the largest class of phosphatases involved in down-regulating Mitogen-activated protein kinases (MAPK) signaling. MAPK signalling pathways regulate
MAPK_phosphatase
Protein-coding gene in the species Homo sapiens
Epigen also known as epithelial mitogen is a protein that in humans is encoded by the EPGN gene. The protein encoded by this gene is a member of the epidermal
Epigen
Protein found in humans
also known as mitogen-activated protein kinase kinase kinase 5 (MAP3K5) is a member of MAP kinase family and as such a part of mitogen-activated protein
ASK1
Enzyme found in humans
Mitogen-activated protein kinase 9 is an enzyme that in humans is encoded by the MAPK9 gene. The protein encoded by this gene is a member of the MAP kinase
Mitogen-activated protein kinase 9
Mitogen-activated_protein_kinase_9
Protein-coding gene in the species Homo sapiens
Dual specificity mitogen-activated protein kinase kinase 2 is an enzyme that in humans is encoded by the MAP2K2 gene. It is more commonly known as MEK2
MAP2K2
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 is an enzyme that in humans is encoded by the TAB1 gene. The protein encoded by
TAB1
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase 6 is an enzyme that in humans is encoded by the MAPK6 gene. The protein encoded by this gene is a member of the Ser/Thr
MAPK6
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase kinase kinase 7 (MAP3K7), also known as TAK1, is an enzyme that in humans is encoded by the MAP3K7 gene. TAK1 is an evolutionarily
MAP3K7
Enzyme
Mitogen-activated protein kinase 12 is an enzyme that in humans is encoded by the MAP3K12 gene. The protein encoded by this gene is a member of serine/threonine
MAP3K12
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase 3, also known as p44MAPK and ERK1, is an enzyme that in humans is encoded by the MAPK3 gene. The protein encoded by this
MAPK3
Protein-coding gene in humans
Mitogen-activated protein kinase kinase kinase kinase 2 is an enzyme that in humans is encoded by the MAP4K2 gene. The protein encoded by this gene is
MAP4K2
Protein-produced toxins that create pores in cell membrane
zinc-metalloprotease, which shows specificity for a conserved family of mitogen-activated protein kinases. The loss of these proteins results in a breakdown
Pore-forming_toxin
Chemical compound
muscular dystrophy (FSHD). Losmapimod selectively inhibits enzymes p38α/β mitogen-activated protein kinases (MAPKs), which are modulators of DUX4 expression
Losmapimod
American actress
pharmacology from Yale University, where she studied regulation of oncogenic mitogen-activated protein kinase signaling. Her Erdős-Bacon number is 5. Little
Eunice_Cho
Protein-coding gene in the species Homo sapiens
Dual specificity mitogen-activated protein kinase kinase 3 is an enzyme that in humans is encoded by the MAP2K3 gene. The protein encoded by this gene
MAP2K3
Protein-coding gene in humans
Mitogen-activated protein kinase kinase kinase 11 is an enzyme that in humans is encoded by the MAP3K11 gene. The protein encoded by this gene is called
MAP3K11
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase 1 (MAPK 1), also known as ERK2, is an enzyme that in humans is encoded by the MAPK1 gene. The protein encoded by this
MAPK1
post-phagocytosis. Epithelial immunity is achieved predominantly through mitogen-activated protein kinase (MAPK) signaling, more specifically the p38 pathway
Candidalysin
Mammalian protein found in Homo sapiens
Drosophila ortholog of the mammalian NLK gene. This enzyme is a member of the Mitogen-activated protein kinase (MAPK) family, although not explicitly designated
NLK
Protein found in humans
Mitogen-activated protein kinase kinase kinase 6 is a protein that in humans is encoded by the MAP3K6 gene. This gene encodes a serine/threonine protein
Mitogen-activated protein kinase kinase kinase 6
Mitogen-activated_protein_kinase_kinase_kinase_6
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase 7 also known as MAP kinase 7 is an enzyme that in humans is encoded by the MAPK7 gene. MAPK7 is a member of the MAP kinase
MAPK7
Protein-coding gene in the species Homo sapiens
in humans is encoded by the SIPA1 gene. The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity
SIPA1
Investigational drug
being evaluated for the treatment of autoimmune diseases. It is a p38 mitogen-activated protein kinase inhibitor. It has been evaluated in a phase 2
Pamapimod
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase kinase kinase kinase 1 is a protein kinase that in humans is encoded by the MAP4K1 gene. It is also known as HPK1 (Hematopoietic
MAP4K1
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase 11 is an enzyme that in humans is encoded by the MAPK11 gene. The protein encoded by this gene is a member of the MAP
MAPK11
Investigational drug
the treatment of pancreatic cancer. It is a dual MEK1/MEK2 inhibitor of mitogen-activated protein kinase kinase. Clinical trial number NCT05585320 for
Atebimetinib
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase kinase kinase 14 (MAP3K14), also known as NF-kappa-B-inducing kinase (NIK), is a MAP kinase kinase kinase enzyme that
MAP3K14
the RAS-RAF-MEK-ERK signal transduction cascade, also referred to as the mitogen-activated protein kinase (MAPK) cascade. Activation of RAF kinases requires
RAF_kinase
Protein-coding gene in humans
PT, et al. (December 1993). "The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2". The Biochemical
MAPKAPK2
Family of proteins
Mitogen-activated protein kinase kinase kinase kinase (MAP4K) is a family of proteins involved in cellular signal transduction. MAP4Ks are involved in
MAP kinase kinase kinase kinase
MAP_kinase_kinase_kinase_kinase
Protein-coding gene in the species Homo sapiens
Mitogen-Activated Protein Kinase Kinase Kinase 2 also known as MEKK2 (MEK/ERK Kinase 2) is an enzyme that in humans is encoded by the MAP3K2 gene. The
MAP3K2
Pharmaceutical drug classification
ATC code L01 Antineoplastic agents is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes
ATC_code_L01
Chemical compound
NJK14047 is a drug which acts as a selective inhibitor of the enzyme p38 mitogen-activated protein kinase (p38 MAPK). It has antiviral and antiinflammatory
NJK14047
Protein-coding gene in the species Homo sapiens
Dual specificity mitogen-activated protein kinase kinase 5 is an enzyme that in humans is encoded by the MAP2K5 gene. The protein encoded by this gene
MAP2K5
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase scaffold protein 1 is a scaffold protein that in humans is encoded by the MAPKSP1 gene. The protein encoded by this gene
MAP2K1IP1
Protein-coding gene in the species Homo sapiens
Aliases MAPK1IP1L, C14orf32, MISS, c14_5346, mitogen-activated protein kinase 1 interacting protein 1-like, mitogen-activated protein kinase 1 interacting protein
MAPK1IP1L
Drug class
A MEK inhibitor is a chemical or drug that inhibits the mitogen-activated protein kinase enzymes MEK1 and/or MEK2. They can be used to affect the MAPK/ERK
MEK_inhibitor
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase kinase kinase 19 is a protein that in humans is encoded by the MAP3K19 gene. GRCh38: Ensembl release 89: ENSG00000176601
MAP3K19
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase kinase kinase 8 is an enzyme that in humans is encoded by the MAP3K8 gene. The gene was identified by its oncogenic transforming
MAP3K8
Molecule
Feeser WS, et al. (July 1998). "Identification of a novel inhibitor of mitogen-activated protein kinase kinase". The Journal of Biological Chemistry.
U0126
Class of opioid peptides
not bind to opioid receptors, causes an increase in phosphorylated p38 mitogen-activated protein kinases (MAPK) in microglia in the dorsal horn of the
Dynorphin
Topics referred to by the same term
MKK is mitogen-activated protein kinase kinase, an enzyme. MKK may also refer to: Malmö KK, Swedish swim team from Malmö Main-Kinzig-Kreis, a kreis (district)
MKK_(disambiguation)
Synthetic, cannabinoid-like compound
lowers blood pressure, and induces cell migration, cell proliferation and mitogen-activated protein kinase activation in microglia, but without producing
Abnormal_cannabidiol
Chemical compound
drug in development by Eli Lilly. Although originally thought to be a p38 mitogen-activated protein kinase (MAPK) inhibitor, it has since been reported that
Ralimetinib
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase 13 (MAPK 13), also known as stress-activated protein kinase 4 (SAPK4), is an enzyme that in humans is encoded by the
MAPK13
Psychoactive drug, often called ecstasy
the intracellular compartment by a mechanism independent of phospho-p38-mitogen activated protein kinase activation". Neuroscience. 168 (1): 82–95. doi:10
MDMA
Protein-coding gene in the species Homo sapiens
screen for epidermal growth factor (EGF)-induced mRNAs and initially named mitogen-inducible gene 2 (Mig-2) protein. FERMT2 is a component of extracellular
FERMT2
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase kinase kinase 3 is an enzyme that in humans is encoded by the MAP3K3 gene, which is located on the long arm of chromosome
MAP3K3
Protein family
domain) proteins. These have been identified as inhibitors of the Ras/mitogen-activated protein kinase (MAPK) cascade, a pathway crucial for developmental
SPR_domain
Protein-coding gene in the species Homo sapiens
binding mitogen-activated protein kinase kinase binding vascular endothelial growth factor receptor 2 binding protein homodimerization activity mitogen-activated
DAB2IP
Peptide hormone in animals
Regulation of the CGRP gene is in part controlled by the expression of the mitogen-activated protein kinase (MAPK) signaling pathway and cytokines like TNFα
Calcitonin gene-related peptide
Calcitonin_gene-related_peptide
Class of enzymes
RPS6KA5 RPS6KA4 P70-S6 Kinase 1 RPS6KB2 RPS6KA2 RPS6KA3 RPS6KA1 RPS6KC1 Mitogen-activated protein kinase (EC 2.7.11.24) Extracellular signal-regulated
AMP-activated_protein_kinase
Protein-coding gene in humans
Mitogen-activated protein kinase 15, also known as MAPK15, ERK7, or ERK8, is an enzyme that in humans is encoded by the MAPK15 gene. Evolutionarily, MAPK15
MAPK15
Protein-coding gene in the species Homo sapiens
Dual specificity mitogen-activated protein kinase kinase 7, also known as MAP kinase kinase 7 or MKK7, is an enzyme that in humans is encoded by the MAP2K7
MAP2K7
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase kinase kinase 10 is an enzyme that in humans is encoded by the MAP3K10 gene. The protein encoded by this gene is a member
MAP3K10
Protein-coding gene in the species Homo sapiens
encoded by the NMBR gene. Neuromedin B receptor binds neuromedin B, a potent mitogen and growth factor for normal and neoplastic lung and for gastrointestinal
Neuromedin_B_receptor
Protein-coding gene in the species Homo sapiens
RPS6KA5 RPS6KA4 P70-S6 Kinase 1 RPS6KB2 RPS6KA2 RPS6KA3 RPS6KA1 RPS6KC1 Mitogen-activated protein kinase (EC 2.7.11.24) Extracellular signal-regulated
PKMYT1
Protein-coding gene in the species Homo sapiens
RPS6KA5 RPS6KA4 P70-S6 Kinase 1 RPS6KB2 RPS6KA2 RPS6KA3 RPS6KA1 RPS6KC1 Mitogen-activated protein kinase (EC 2.7.11.24) Extracellular signal-regulated
SMG1
Chemical compound
(1996). "The Selective Protein Kinase C Inhibitor, Ro-31-8220, Inhibits Mitogen-activated Protein Kinase Phosphatase-1 (MKP-1) Expression, Induces c-Jun
Ro-318220
Protein-coding gene in humans
Molecular function MDM2/MDM4 family protein binding NF-kappaB binding mitogen-activated protein kinase binding protein binding ubiquitin-like protein
CDK5RAP3
Chemical compound
PH-797804 is a drug which acts as a selective inhibitor of the enzyme p38 mitogen-activated protein kinase (p38 MAPK). It has antiinflammatory effects and
PH-797804
Lectin (carbohydrate-binding protein)
physiological function in plants, however, is still unknown. ConA is a plant mitogen, and is known for its ability to stimulate mouse T-cell subsets giving
Concanavalin_A
Topics referred to by the same term
a closed United States Air Force radar station in Tennessee MAPK1, p42 mitogen-activated protein kinase Papyrus 42, a biblical manuscript Phosphorus-42
P42
Protein-coding gene in humans
Bochner BS (June 2002). "Eotaxin-2 alters eosinophil integrin function via mitogen-activated protein kinases". Am. J. Respir. Cell Mol. Biol. 26 (6): 645–9
C-C_motif_chemokine_ligand_24
Class of enzymes
RPS6KA5 RPS6KA4 P70-S6 Kinase 1 RPS6KB2 RPS6KA2 RPS6KA3 RPS6KA1 RPS6KC1 Mitogen-activated protein kinase (EC 2.7.11.24) Extracellular signal-regulated
Ca2+/calmodulin-dependent protein kinase II
Ca2+/calmodulin-dependent_protein_kinase_II
Protein complex
significance in diabetes mellitus, which is due to insulin resistance. Mitogens, such as insulin like growth factor 1 (IGF1), can activate the MAPK/ERK
MTORC1
Protein-coding gene in the species Homo sapiens
ion binding phosphoprotein phosphatase activity manganese ion binding mitogen-activated protein kinase kinase kinase binding protein serine/threonine
Protein phosphatase with EF-hand domain 2
Protein_phosphatase_with_EF-hand_domain_2
Signaling glycoprotein regulating cell proliferation
two B subunits (PDGF-BB), or one of each (PDGF-AB). PDGF is a potent mitogen for cells of mesenchymal origin, including fibroblasts, smooth muscle cells
Platelet-derived growth factor
Platelet-derived_growth_factor
American information scientist and health services researcher
School of Public Health Thesis Characterization of betacellulin: a novel mitogen from pancreatic beta cell tumors Academic work Institutions Weill Cornell
Rainu_Kaushal
Genus of fungi
suppresses mast cell-mediated allergic inflammation: Role of calcium, mitogen-activated protein kinase and nuclear factor-κB". Int. J. Mol. Med. 30 (2):
Sparassis
Mitogen-activated protein kinase (MAPK) networks are the pathways and signaling of MAPK, which is a type of serine/threonine-specific protein kinase.
MAPK_networks
Medical condition
findings on the disease's genomic structure, especially mutations in the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway
Erdheim–Chester_disease
Protein-coding gene in the species Homo sapiens
and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which
DUSP2
Protein-coding gene in the species Homo sapiens
reference expression data Gene ontology Molecular function protein binding mitogen-activated protein kinase binding identical protein binding polyubiquitin
TNIP1
Class of enzymes
RPS6KA5 RPS6KA4 P70-S6 Kinase 1 RPS6KB2 RPS6KA2 RPS6KA3 RPS6KA1 RPS6KC1 Mitogen-activated protein kinase (EC 2.7.11.24) Extracellular signal-regulated
(Pyruvate, phosphate dikinase) kinase
(Pyruvate,_phosphate_dikinase)_kinase
Protein-coding gene in the species Homo sapiens
a potential zinc finger transcription factor, by mitogen stimulation in intact cells and by mitogen-activated protein kinase in vitro". J. Biol. Chem
ZFP36
Blood in circulatory system with round nucleus
lipopolysaccharides, phytohaemagglutinin, concanavalin A, and pokeweed mitogen. The effects of these experiments are determined by a change in gene expression
Peripheral blood mononuclear cell
Peripheral_blood_mononuclear_cell
Protein-coding gene in the species Homo sapiens
RPS6KA5 RPS6KA4 P70-S6 Kinase 1 RPS6KB2 RPS6KA2 RPS6KA3 RPS6KA1 RPS6KC1 Mitogen-activated protein kinase (EC 2.7.11.24) Extracellular signal-regulated
PFTK1
compared to sigmoidal curves for cooperative (ultrasensitive) enzymes. In mitogen-activated protein kinase (MAPK) signaling (see example below), the ultrasensitivity
Ultrasensitivity
Protein-coding gene in the species Homo sapiens
Mitogen-activated protein kinase kinase kinase 4 is an enzyme that in humans is encoded by the MAP3K4 gene. The central core of each mitogen-activated
MAP3K4
Type of blood collection equipment for medical testing
Green, Yellow, Purple QuantiFERON 1. Grey (nil) tube 2. Green (TB1 antigen) tube 3. Yellow (TB2 antigen) tube 4. Purple (mitogen) tube Tuberculosis
Vacutainer
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