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not want to return. Ultrasensitivity is a cellular system which triggers entry into a different cellular state. Ultrasensitivity gives a small response
Ultrasensitivity
Enzyme kinetics and chemical bonding
that the overall cascade global ultrasensitivity had to be less than or equal to the product of the global ultrasensitivity estimations of each cascade's
Cooperativity
Molecular mechanism
activation. The supra-linearity of the response is sometimes called ultrasensitivity. If an allosteric protein binds to a target that also has a higher
Cooperative_binding
Diagram showing the proportion of a receptor bound to a ligand
; Chernomoretz, A. (2017). "Ultrasensitivity in signaling cascades revisited: Linking local and global ultrasensitivity estimations". PLOS ONE. 12 (6)
Hill_equation_(biochemistry)
Steady-state solution for a 2-state biological system
; Chernomoretz, A. (2017). "Ultrasensitivity in signaling cascades revisited: Linking local and global ultrasensitivity estimations". PLOS ONE. 12 (6)
Goldbeter–Koshland_kinetics
Test based on scientific data to determine if a person is pregnant
test: 1500-2000 mIU/mL, depending on test Qualitative test: 5 to 10 mIU/mL, depending on test Quantitative test: 1 to 2 mIU/mL for an ultrasensitive test
Pregnancy_test
right combination of positive and negative feedback loops can generate ultrasensitivity and bistability, which in turn can generate decisive transitions and
Biochemical switches in the cell cycle
Biochemical_switches_in_the_cell_cycle
Degenerative disease that affects sheep and goats
Sharon Sorensen-Melson, Michael W. Miller. "SOFIA: An Assay Platform for Ultrasensitive Detection of PrPSc in Brain and Blood" (PDF). SUNY Downstate Medical
Scrapie
Ultrasound technique
Tanter [fr]'s team following work on ultrafast imaging and ultrafast Doppler. Ultrasensitive Doppler relies on ultrafast imaging scanners able to acquire images
Functional_ultrasound_imaging
2022 studio album by Mylène Farmer
("l'emprise") of such a person? Feminine or masculine, it doesn't matter. Ultrasensitive beings inhabited by doubts that gnaw at them are ideal prey. The important
L'Emprise
Chemical compound
Seidel CA (January 2007). "Strategies to improve photostabilities in ultrasensitive fluorescence spectroscopy". The Journal of Physical Chemistry A. 111
Chemistry_of_ascorbic_acid
2022 Japanese anime film
exceptional parkour talent, but he avoids others due to a hearing ultrasensitivity. Tokyo Tower continues to be an impossible location to get to because
Bubble_(2022_film)
Method to detect an antigen using an antibody and enzyme
they are often grouped in the same category as ELISAs. In 2012, an ultrasensitive, enzyme-based ELISA test using nanoparticles as a chromogenic reporter
ELISA
American immunologist
in the extracellular environment is also required and essential for ultrasensitivity. Furthermore, all stimulators of integrin inside-out signaling stimulate
Timothy_A._Springer
frequency estimated for somatic mutations. Newman, Aaron M (2014). "An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage"
Recurrence_Index
Species of mole
Condylura. This large amount of specialized receptors makes the star ultrasensitive – about 6 times more sensitive than the human hand, which contains about
Star-nosed_mole
Highly sensitive assay for prion detection
Kitamoto T, Klug G, McGlade A, Collins SJ, Nishida N (February 2011). "Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced
Real-time quaking-induced conversion
Real-time_quaking-induced_conversion
Developer and manufacturer of high performance light measuring solutions
the company introduced ultrasensitive Sona back-illuminated camera platform for fluorescence microscopy, as well as ultrasensitive Marana 4.2B-11 back-illuminated
Andor_Technology
Fatal neurodegenerative disease of cattle
March 2012. Retrieved 21 August 2011. "SOFIA: An Assay Platform for Ultrasensitive Detection of PrPSc in Brain and Blood" (PDF). SUNY Downstate Medical
Bovine spongiform encephalopathy
Bovine_spongiform_encephalopathy
Study of biochemical reaction rates catalysed by an enzyme
tb13510.x. PMID 3301336. Ha SH, Ferrell JE (May 2016). "Thresholds and ultrasensitivity from negative cooperativity". Science. 352 (6288): 990–993. Bibcode:2016Sci
Enzyme_kinetics
Chemical element with atomic number 34 (Se)
early xeroradiography to high resolution X-ray image detectors and ultrasensitive imaging tubes". Physica Status Solidi B. 246 (8): 1794–1805. Bibcode:2009PSSBR
Selenium
the ultrasensitivity in the Sic1-Cdc4 system may be driven at least in part by cumulative electrostatic interactions". In general, an ultrasensitive enzyme
Cell division control protein 4
Cell_division_control_protein_4
attacks for several years. She told Bowling Digest in 2002, "I was so ultrasensitive to everything around me that I could feel the hair on my arms standing
Patty_Costello
Species of fluke
González-Warleta, Marta; Carro, Carmen; Ubeira, Florencio M. (2004). "An Ultrasensitive Capture Elisa for Detection of Fasciola Hepatica Coproantigens in Sheep
Fasciola_hepatica
South Korean-born American biophysicist (born 1968)
optical tweezers. Combining biophysical manipulation techniques and ultrasensitive fluorescence imaging to manipulate protein, RNA, and DNA molecules and
Taekjip_Ha
Hexagonal lattice made of carbon atoms
Z. (1 September 2014). "Generic epitaxial graphene biosensors for ultrasensitive detection of cancer risk biomarker" (PDF). 2D Materials. 1 (2) 025004
Graphene
Analytical technique based on determining mass to charge ratio of ions
ISBN 978-0-470-51634-8. Tuniz C (1998). Accelerator mass spectrometry: ultrasensitive analysis for global science. Boca Raton: CRC Press. ISBN 978-0-8493-4538-8
Mass_spectrometry
Interdisciplinary branch of biology and engineering
Colman-Lerner A, Chernomoretz A (2017). "Ultrasensitivity in signaling cascades revisited: Linking local and global ultrasensitivity estimations". PLOS ONE. 12 (6)
Synthetic_biology
Chaoyin; Chen, DeJie; Xu, Ying (2021-02-11). "A novel biosensor for the ultrasensitive detection of the lncRNA biomarker MALAT1 in non-small cell lung cancer"
Gold_nanocage
molecules in microfluidic device[10]. These bio-marker sensors can have ultrasensitivity in body fluids, blood, saliva, and urine[11]. Almost all diseases are
Chih-Ming_Ho
Wirthensohn DC, Lee SF, Vincke C, Muyldermans S, et al. (June 2017). "Ultrasensitive Measurement of Ca2+ Influx into Lipid Vesicles Induced by Protein Aggregates"
Biochemistry of Alzheimer's disease
Biochemistry_of_Alzheimer's_disease
Gene editing method
PMC 6956564. PMID 31548639. Ding X, Yin K, Li Z, Liu C (March 2020). "Ultrasensitive and visual detection of SARS-CoV-2 using all-in-one dual CRISPR-Cas12a
CRISPR_gene_editing
American physician (born 1951)
Limor; Jiang, Hua; Molloy, Kelly R.; Chait, Brian T. (2023-09-12). "Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker"
David_C._Christiani
Electrical conductivity with exactly zero resistance
cryogenic micro-calorimeter photon detectors. The same effect is used in ultrasensitive bolometers made from superconducting materials. Superconducting nanowire
Superconductivity
French multinational biotechnology company
Partnership with Quanterix in 2012 for the development of a new generation of ultrasensitive, multiplex immunoassays. BioFire Diagnostics Inc., a privately held
BioMérieux
Study of DNA modifications that do not change its sequence
PMID 19335899. Sneppen K, Micheelsen MA, Dodd IB (15 April 2008). "Ultrasensitive gene regulation by positive feedback loops in nucleosome modification"
Epigenetics
Relationship between biological organs
course of the reproductive cycle. For instance, the FSHβ gene exhibits ultrasensitive behavior in response to GnRH pulse frequency, with its expression sharply
Hypothalamic–pituitary–gonadal axis
Hypothalamic–pituitary–gonadal_axis
Meteorites with high levels of primordial gases
Gilmour, J.; Lyon, I.; Johnston, W.; Turner, G. (Mar 1994). "RELAX: An ultrasensitive; resonance ionization mass spectrometer for xenon". Review of Scientific
Gas-rich_meteorites
Genetically encoded calcium indicator
TJ, Sun Y, Pulver SR, Renninger SL, Baohan A, et al. (July 2013). "Ultrasensitive fluorescent proteins for imaging neuronal activity". Nature. 499 (7458):
GCaMP
Mammalian protein found in humans
S2CID 205121835. Zhang Q, Bhattacharya S, Andersen ME (April 2013). "Ultrasensitive response motifs: basic amplifiers in molecular signalling networks"
Factor_VII
Set of waveguides including a closed loop
study cavity quantum electrodynamics with laser-cooled atoms or as ultrasensitive detectors for the detection of single trapped atoms.” Ring resonators
Optical_ring_resonators
Failure of cells to respond appropriately to insulin
PMC 2874695. PMID 20299466. Wang G, Zhang M (February 2016). "Tunable ultrasensitivity: functional decoupling and biological insights". Scientific Reports
Insulin_resistance
British physicist (born 1942)
of superconducting quantum interference devices (SQUIDs), which are ultrasensitive detectors of magnetic flux. In 1985, Clarke, John M. Martinis (his Ph
John_Clarke_(physicist)
New technologies actively in development
Z. (1 September 2014). "Generic epitaxial graphene biosensors for ultrasensitive detection of cancer risk biomarker" (PDF). 2D Materials. 1 (2) 025004
List_of_emerging_technologies
Metamaterial that uses surface plasmons to achieve optical properties not seen in nature
Zeng, S.; et al. (2015). "Graphene-gold metasurface architectures for ultrasensitive plasmonic biosensing". Advanced Materials. 27 (40): 1–7. Bibcode:2015AdM
Plasmonic_metamaterial
Award
commercial potential." 2024 Molly Stevens "for pioneering nanomaterials for ultrasensitive disease diagnostics and advanced therapeutic delivery, for the benefit
Armourers and Brasiers' Company Prize
Armourers_and_Brasiers'_Company_Prize
Type of statistical analysis
resonance energy transfer (FRET) Rigler R. and Widengren J. (1990). Ultrasensitive detection of single molecules by fluorescence correlation spectroscopy
Fluorescence correlation spectroscopy
Fluorescence_correlation_spectroscopy
American physicist
S2CID 4415638. Roukes, M.L. & Ekinci, K.L, Apparatus and method for ultrasensitive nanoelectromechanical mass detection, U.S. Provisional Patent Application
Michael_Roukes
Clear, colorless bodily fluid found in the brain and spinal cord
S2CID 19776406. Merril CR, Goldman D, Sedman SA, Ebert MH (March 1981). "Ultrasensitive stain for proteins in polyacrylamide gels shows regional variation in
Cerebrospinal_fluid
Iron ore mineral
7683K. doi:10.1073/pnas.89.16.7683. PMC 49775. PMID 1502184. Using an ultrasensitive superconducting magnetometer in a clean-lab environment, we have detected
Magnetite
Arrangement of chemical sensors
"Welding Metallophthalocyanines into Bimetallic Molecular Meshes for Ultrasensitive, Low-Power Chemiresistive Detection of Gases". Journal of the American
Chemical_sensor_array
Public research institution and postgraduate university
control light, heat, radio waves, and sound for future optical computers, ultrasensitive cameras, and cell phone technology Structural biology: Combining physics
CUNY_Graduate_Center
Chest pain due to heart muscles that is easily provoked
setting of transient stress test-induced myocardial ischaemia using an ultrasensitive assay: results from TIMI 35". European Heart Journal. 30 (2): 162–169
Unstable_angina
Suspension of gold nanoparticles in a liquid
Salinas FG (2000). "Colloidal Au-Enhanced Surface Plasmon Resonance for Ultrasensitive Detection of DNA Hybridization". Journal of the American Chemical Society
Colloidal_gold
Style of musical composition and poetry developed in 18th-century Germany
the adjective empfindsam is sometimes rendered as "sentimental" or "ultrasensitive". "Empfindsamkeit" is also sometimes translated, and may even be derived
Empfindsamkeit_(music)
German scientist (born 1953)
Schwager, Christian; Zenke, Martin (1987). "Automated DNA sequencing: ultrasensitive detection of fluorescent bands during electrophoresis". Nucleic Acids
Martin_Zenke
Chemical compound
Lopez-Sanchez, O.; Lembke, D.; Kayci, M.; Radenovic, A.; Kis, A. (2013). "Ultrasensitive photodetectors based on monolayer MoS2". Nature Nanotechnology. 8 (7):
Molybdenum_disulfide
Process of removing land mines
Retrieved 23 July 2007. Fisher, Mark (2006). "7. Explosives detection using ultrasensitive electronic vapor sensors: Field experience". In Woodfin, Ronald L. (ed
Demining
Branch of biology
for enzyme substrate reactions and Goldbeter–Koshland kinetics for ultrasensitive transcription factors, afterwards the parameters of the equations (rate
Mathematical and theoretical biology
Mathematical_and_theoretical_biology
American biologist (born 1955)
kinase activity, and cell fate. These studies helped demonstrate how ultrasensitivity, positive feedback, and bistability can allow cells to switch between
James_Ferrell_(biologist)
nanotechnology to make smart, portable and inexpensive sensing systems for ultrasensitive and rapid detection of biological and chemical species. Sioux Electronics
DevLab_(research_alliance)
Accelerator that accelerates ions to high speeds before analysis
1002/mas.20172. ISSN 0277-7037. PMID 18470926. Litherland, A. E. (1980). "Ultrasensitive mass spectrometry with accelerators". Annual Review of Nuclear and Particle
Accelerator_mass_spectrometry
Chemical compound
Claus A. M. Seidel (2007). "Strategies to Improve Photostabilities in Ultrasensitive Fluorescence Spectroscopy". The Journal of Physical Chemistry A. 111
Propyl_gallate
Canadian scientist
Clifford, Jason; Klem, Ethan; Levina, Larissa; Sargent, Edward H. (2006). "Ultrasensitive solution-cast quantum dot photodetectors". Nature. 442 (7099): 180–183
Ted_Sargent
P38 mitogen-activated protein kinases
Library of Medicine Medical Subject Headings (MeSH) Model of MAPK ultrasensitivity in BioModels Database Drosophila rolled – The Interactive Fly Portal:
Mitogen-activated protein kinase
Mitogen-activated_protein_kinase
Degraded DNA fragments circulating in bodily fluids
Merritt RE, Shrager JB, Loo BW, Alizadeh AA, Diehn M (May 2014). "An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage"
Circulating_free_DNA
American chemist and spectroscopist
University of Virginia, where he has continued his work in development of ultrasensitive spectroscopic methods with applications in trace gas detection, as well
Kevin_K._Lehmann
Marcus; Synal, Hans-Arno; Xing, Shan; Hou, Shaochun (17 June 2021). "Ultrasensitive Analytical Method for Direct Search of Primordial 244 Pu in Bastnaesite"
Isotopes_of_plutonium
American physicist
Magnetization Studies of Semiconductor Heterostructures, in which he developed ultrasensitive micromechanical sensors and used them to study quantum Hall systems
Jack_Harris_(physicist)
Drug experimentation technique
PMID 15993808. Lappin G, Wagner CC, Langer O, van de Merbel N (May 2009). "New ultrasensitive detection technologies and techniques for use in microdosing studies"
Microdosing
device arrays and the cost-effective device fabrication, the surface ultrasensitivity of FET-based biosensors makes it an attractive alternative to existing
Biotransducer
Extremely small diamonds used for their thermal, mechanical and optoelectronic properties
Nanodiamonds containing nitrogen-vacancy defects have been used as an ultrasensitive label for in vitro diagnostics, using a microwave field to modulate
Nanodiamond
Model plant species in the family Brassicaceae
thaliana to glow in the dark when touched. The effect was visible to ultrasensitive cameras.[better source needed] Multiple efforts, including the Glowing
Arabidopsis_thaliana
Surround optical-fiber immunoassay (SOFIA) is an ultrasensitive, in vitro diagnostic platform incorporating a surround optical-fiber assembly that captures
Surround optical-fiber immunoassay
Surround_optical-fiber_immunoassay
Protein found in humans
Wirthensohn DC, Lee SF, Vincke C, Muyldermans S, et al. (June 2017). "Ultrasensitive Measurement of Ca2+ Influx into Lipid Vesicles Induced by Protein Aggregates"
Alpha-synuclein
American scientist and academic
University Gazette. The laboratory has also been active in developing ultrasensitive assays for SARS-CoV-2 antigens, vaccines, host antibodies, neutralization
David_R._Walt
Hormone
etiology. However, this diagnostic approach has been superseded by ultrasensitive TSH assays and is nowadays only seldom employed. TRH promotes release
Thyrotropin-releasing_hormone
Set of techniques to measure and visualize aspects of the nervous system
blood flow or hemodynamic changes. Functional ultrasound relies on Ultrasensitive Doppler and ultrafast ultrasound imaging which allows high sensitivity
Neuroimaging
Chemical compound responsible for rotten fish odor
Zhang J, Pacifico R, Cawley D, Feinstein P, Bozza T (February 2013). "Ultrasensitive detection of amines by a trace amine-associated receptor". J. Neurosci
Trimethylamine
Source of the first botulinum antitoxin
of Minnesota. DTIC ADB141387. Doellgast, George (1 February 1992). Ultrasensitive Detection of Toxins Using Immunoassay Amplification. Phase 1. Defense
First Flight (medical research horse)
First_Flight_(medical_research_horse)
Fluid containing nanometer-sized particles, called nanoparticles
magnetic field on pressure was not as significant. A nanofluid-based ultrasensitive optical sensor changes its colour on exposure to low concentrations
Nanofluid
Electric current produced in living cells
163. PMID 20342775. Jaffe, Lionel F.; Nuccitelli, Richard (1974). "An Ultrasensitive Vibrating Probe for Measuring Steady Extracellular Currents". The Journal
Developmental_bioelectricity
South Korean medical professor
Technology (KAST) 2011. Artificially engineered magnetic nanoparticles for ultrasensitive molecular imaging. Nature Medicine 13,95-99(2007) In vivo magnetic resonance
Suh_Jin-suck
Australian physicist
George A.; Rubinsztein‐Dunlop, Halina; Bowen, Warwick P. (2014). "Ultrasensitive Optomechanical Magnetometry". Advanced Materials. 26 (36): 6348–6353
Warwick_Bowen
, and reveals that she has been compared to Hattie Jacques. She is ultrasensitive about her weight; Mrs. Golightly says that it is her glands, but her
List of Adrian Mole characters
List_of_Adrian_Mole_characters
J (September 19, 2014). "Generic epitaxial graphene biosensors for ultrasensitive detection of cancer risk biomarker" (PDF). 2D Materials. 1 (2) 025004
Potential applications of graphene
Potential_applications_of_graphene
Belgian theoretical biologist and academic (born 1947)
collaboration with Daniel Koshland he analyzed the phenomenon of zero-order ultrasensitivity in biochemical systems regulated through phosphorylation-dephosphorylation
Albert_Goldbeter
Class of materials
Yu; Kahn, Olivier (1992). "Molecular-based magnets studied with an ultrasensitive SQUID magnetometer". Journal of Magnetism and Magnetic Materials. 104–107:
Molecule-based_magnets
"Fluctuations and quality of control in biological cells – Zero order ultrasensitivity reinvestigated". Biophys. J. 79 (3): 1228–36. Bibcode:2000BpJ....79
Johan_Paulsson
Indian physicist (born 1951)
condensed matter like micelle composed viscoelastic gels. He developed an ultrasensitive immunoassay by subjecting colloids to an electrical field, thus generating
Ajay_K._Sood
Endocrinological condition
psychiatric patients: evidence for hyperthyrotropinemia as measured by an ultrasensitive thyrotropin assay". Metabolism: Clinical and Experimental. 39 (5): 538–43
Euthyroid_sick_syndrome
Dutch chemist and physicist specialized in photochemistry
C.; Dal Peraro, M.; Maček, P.; Zuber, B.; Roke, S. (2022-04-14). "Ultrasensitive Label-Free Detection of Protein–Membrane Interaction Exemplified by
Sylvie_Roke
British biophysicist (1926–2016)
creation by Daya Kishore Hazra working in Ekins laboratory in 1975 of the ultrasensitive TSH assay which revolutionized the management of thyroid diseases by
Roger_Ekins
being activated by the mating pheromone. Kss1 does not exhibit the ultrasensitivity that Fus3 does, but instead is activated rapidly and has a graded dose-response
Fus3
Process to excite an atom beyond its ionization potential to form an ion
the high selectivity that is desired in spectroscopy methods with ultrasensitivity, thus making resonance ionization useful when analyzing complex samples
Resonance_ionization
Immunochromatographic testing devices
Qin, Zhenpeng; Sackrison, James; Bischof, John C. (23 March 2021). "Ultrasensitive and Highly Specific Lateral Flow Assays for Point-of-Care Diagnosis"
Lateral_flow_test
Thin semiconductors
applications. Atomic layers of MoS2 have been used as a phototransistor and ultrasensitive detectors. Phototransistors are important devices: the first with a
Transition metal dichalcogenide monolayers
Transition_metal_dichalcogenide_monolayers
Quality of a system having two stable equilibrium states
(speciation). Bistability can be generated by a positive feedback loop with an ultrasensitive regulatory step. Positive feedback loops, such as the simple X activates
Bistability
Autocorrelation functions realized in optics
direct electric-field reconstruction Roth, J. M., Murphy, T. E. & Xu, C. Ultrasensitive and high-dynamic-range two-photon absorption in a GaAs photomultiplier
Optical_autocorrelation
for enzyme substrate reactions and Goldbeter–Koshland kinetics for ultrasensitive transcription factors, afterwards the parameters of the equations (rate
Cellular_model
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