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HESX1

  • HESX1

    • Protein-coding gene in the species Homo sapiens

    is a homeobox protein that in humans is encoded by the HESX1 gene. Expression of HEX1 and HESX1 marks the anterior visceral endoderm of the embryo. The

    HESX1

    HESX1

    HESX1

  • Septo-optic dysplasia

    • Medical condition

    reported, suggesting at least one genetic form (HESX1). Five homozygous and eight heterozygous pathogenic HESX1 mutations have been discovered. Patients with

    Septo-optic dysplasia

    Septo-optic dysplasia

    Septo-optic_dysplasia

  • Joshua Brickman

    • American / British biologist

    M, Wales JK, Hindmarsh PC, Krauss S. Mutations in the homeobox gene HESX1/Hesx1 associated with septo-optic dysplasia in human and mouse. Nature Genetics

    Joshua Brickman

    Joshua Brickman

    Joshua_Brickman

  • Hypopituitarism

    • Decreased output of hormones by the pituitary gland

    combined pituitary hormone deficiencies (CPHD) in childhood. These are HESX1, PROP1, POU1F1, LHX3, LHX4, TBX19, SOX2 and SOX3. Each transcription factor

    Hypopituitarism

    Hypopituitarism

    Hypopituitarism

  • Pickardt syndrome

    • Rare form of tertiary hypothyroidism

    variant of Pickardt's syndrome that is associated with certain mutations (HESX1 or LHX4) is referred to as pituitary stalk interruption syndrome (PSIS)

    Pickardt syndrome

    Pickardt syndrome

    Pickardt_syndrome

  • List of human transcription factors

    • ENSG00000179111 bHLH Known motif – High-throughput in vitro [341] YGGCACGTGCCR HESX1 ENSG00000163666 Homeodomain Known motif – High-throughput in vitro [342]

    List of human transcription factors

    List_of_human_transcription_factors

  • Receptor (biochemistry)

    • Protein molecule receiving signals for a cell

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    Receptor (biochemistry)

    Receptor (biochemistry)

    Receptor_(biochemistry)

  • NFE2L2

    • Human protein and coding gene

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    NFE2L2

    NFE2L2

    NFE2L2

  • ASCL1

    • Protein-coding gene in humans

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    ASCL1

    ASCL1

    ASCL1

  • Peroxisome proliferator-activated receptor

    • Group of nuclear receptor proteins

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    Peroxisome proliferator-activated receptor

    Peroxisome proliferator-activated receptor

    Peroxisome_proliferator-activated_receptor

  • CLOCK

    • Human protein and coding gene

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    CLOCK

    CLOCK

    CLOCK

  • NF-κB

    • Family of transcription factor protein complexes

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    NF-κB

    NF-κB

    NF-κB

  • FOXP3

    • Immune response protein

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    FOXP3

    FOXP3

    FOXP3

  • KMT2A

    • Protein-coding gene in the species Homo sapiens

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    KMT2A

    KMT2A

    KMT2A

  • Homeobox

    • DNA pattern affecting anatomy development

    DMBX1; DPRX; DRGX; DUXA, DUXB, DUX (1, 2, 3, 4, 4c, 5); ESX1; GSC, GSC2; HESX1; HOPX; ISX; LEUTX; MIXL1; NOBOX; OTP; OTX1, OTX2, CRX; PAX2, PAX3, PAX4

    Homeobox

    Homeobox

    Homeobox

  • RING1

    • Protein-coding gene in the species Homo sapiens

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    RING1

    RING1

    RING1

  • AEBP2

    • Protein-coding gene in humans

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    AEBP2

    AEBP2

    AEBP2

  • Genetics of GnRH deficiency conditions

    • Autosomal dominant 1 report 617264 SRA1 SRA1 19q13.33 Unknown Rare 601802 HESX1 HESX1 3p14.3 Septo-optic dysplasia. Combined pituitary hormone deficiency.

    Genetics of GnRH deficiency conditions

    Genetics of GnRH deficiency conditions

    Genetics_of_GnRH_deficiency_conditions

  • Nuclear receptor 4A2

    • Protein-coding gene in the species Homo sapiens

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    Nuclear receptor 4A2

    Nuclear receptor 4A2

    Nuclear_receptor_4A2

  • PAX6

    • Protein-coding gene in humans

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    PAX6

    PAX6

    PAX6

  • SOX2

    • Transcription factor gene of the SOX family

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    SOX2

    SOX2

    SOX2

  • Progesterone receptor B

    • Isoform of the progesterone receptor

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    Progesterone receptor B

    Progesterone_receptor_B

  • Retinoid X receptor

    • Genes on human chromosome 9

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    Retinoid X receptor

    Retinoid_X_receptor

  • Ci protein

    • Zinc finger containing transcription factor

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    Ci protein

    Ci_protein

  • SPI1

    • Protein-coding gene in the species Homo sapiens

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    SPI1

    SPI1

    SPI1

  • HMGB1

    • Mammalian protein found in Homo sapiens

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    HMGB1

    HMGB1

    HMGB1

  • Anti-sigma factors

    • Antagonists of a youth's slang

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    Anti-sigma factors

    Anti-sigma_factors

  • KAT6B

    • Protein-coding gene in the species Homo sapiens

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    KAT6B

    KAT6B

    KAT6B

  • LBX2

    • Protein-coding gene in the species Homo sapiens

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    LBX2

    LBX2

    LBX2

  • List of human protein-coding genes 4

    • HGNC:19764; Q5TA89 7030 HES6 HGNC:18254; Q96HZ4 7031 HES7 HGNC:15977; Q9BYE0 7032 HESX1 HGNC:4877; Q9UBX0 7033 HEXA HGNC:4878; P06865 7034 HEXB HGNC:4879; P07686

    List of human protein-coding genes 4

    List_of_human_protein-coding_genes_4

  • Nuclear receptor

    • Protein

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    Nuclear receptor

    Nuclear receptor

    Nuclear_receptor

  • Transcription factor Sp3

    • Protein-coding gene in the species Homo sapiens

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    Transcription factor Sp3

    Transcription factor Sp3

    Transcription_factor_Sp3

  • Retinoic acid receptor

    • Type of nuclear receptor

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    Retinoic acid receptor

    Retinoic acid receptor

    Retinoic_acid_receptor

  • STAT5

    • Protein family

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    STAT5

    STAT5

    STAT5

  • ATF3

    • Protein-coding gene in humans

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    ATF3

    ATF3

    ATF3

  • ARID1B

    • Protein-coding gene in humans

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    ARID1B

    ARID1B

    ARID1B

  • HOXD13

    • Protein

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    HOXD13

    HOXD13

    HOXD13

  • Retinoid X receptor gamma

    • Protein-coding gene in the species Homo sapiens

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    Retinoid X receptor gamma

    Retinoid X receptor gamma

    Retinoid_X_receptor_gamma

  • FOXP1

    • Protein-coding gene in the species Homo sapiens

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    FOXP1

    FOXP1

    FOXP1

  • PHOX2B

    • Protein-coding gene in the species Homo sapiens

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    PHOX2B

    PHOX2B

    PHOX2B

  • CEBPA

    • Protein-coding gene in humans

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    CEBPA

    CEBPA

    CEBPA

  • SOX10

    • Transcription factor gene of the SOX family

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    SOX10

    SOX10

    SOX10

  • PRDM1

    • Protein-coding gene in the species Homo sapiens

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    PRDM1

    PRDM1

    PRDM1

  • FOSB

    • Protein

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    FOSB

    FOSB

    FOSB

  • STAT protein

    • Family of intracellular transcription factors

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    STAT protein

    STAT protein

    STAT_protein

  • Mineralocorticoid receptor

    • Nuclear receptor that mediates the effects of the mineralocorticoid hormone Aldosterone

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    Mineralocorticoid receptor

    Mineralocorticoid receptor

    Mineralocorticoid_receptor

  • Aryl hydrocarbon receptor

    • Vertebrate receptor protein and transcription factor

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    Aryl hydrocarbon receptor

    Aryl hydrocarbon receptor

    Aryl_hydrocarbon_receptor

  • Myc

    • Family of regulator genes

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    Myc

    Myc

  • Transcription factor II D

    • General transcription factors

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    Transcription factor II D

    Transcription_factor_II_D

  • PRDM2

    • Protein-coding gene in the species Homo sapiens

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    PRDM2

    PRDM2

    PRDM2

  • Transcription factor II A

    • Nuclear protein

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    Transcription factor II A

    Transcription_factor_II_A

  • FOXM1

    • Protein-coding gene in humans

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    FOXM1

    FOXM1

    FOXM1

  • BCL11A

    • Protein-coding gene in the species Homo sapiens

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    BCL11A

    BCL11A

    BCL11A

  • DAX1

    • Protein-coding gene in humans

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    DAX1

    DAX1

    DAX1

  • IRF5

    • Protein-coding gene in the species Homo sapiens

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    IRF5

    IRF5

    IRF5

  • Pregnane X receptor

    • Mammalian protein found in Homo sapiens

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    Pregnane X receptor

    Pregnane X receptor

    Pregnane_X_receptor

  • Hepatocyte nuclear factors

    • Transcription factors

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    Hepatocyte nuclear factors

    Hepatocyte_nuclear_factors

  • Leucine zipper

    • DNA-binding structural motif

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    Leucine zipper

    Leucine zipper

    Leucine_zipper

  • Thyroid hormone receptor

    • Nuclear protein

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    Thyroid hormone receptor

    Thyroid_hormone_receptor

  • Sterol regulatory element-binding protein 1

    • Protein-coding gene in the species Homo sapiens

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    Sterol regulatory element-binding protein 1

    Sterol regulatory element-binding protein 1

    Sterol_regulatory_element-binding_protein_1

  • Wilms tumor protein

    • Transcription factor gene involved in the urogenital system

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    Wilms tumor protein

    Wilms tumor protein

    Wilms_tumor_protein

  • Hepatocyte nuclear factor 4 alpha

    • Protein-coding gene in the species Homo sapiens

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    Hepatocyte nuclear factor 4 alpha

    Hepatocyte nuclear factor 4 alpha

    Hepatocyte_nuclear_factor_4_alpha

  • GTF2A1

    • Protein-coding gene in the species Homo sapiens

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    GTF2A1

    GTF2A1

    GTF2A1

  • CooA

    • Heme-containing transcription factor

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    CooA

    CooA

    CooA

  • Sterol regulatory element-binding protein

    • Protein family

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    Sterol regulatory element-binding protein

    Sterol regulatory element-binding protein

    Sterol_regulatory_element-binding_protein

  • PDX1

    • Protein involved in the pancreas and duodenum differentiation

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    PDX1

    PDX1

    PDX1

  • TCF/LEF family

    • Group of genes

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    TCF/LEF family

    TCF/LEF family

    TCF/LEF_family

  • DPF2

    • Protein-coding gene in the species Homo sapiens

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    DPF2

    DPF2

    DPF2

  • Steroid hormone receptor

    • Group of protein families

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    Steroid hormone receptor

    Steroid_hormone_receptor

  • TCF7

    • Protein-coding gene in the species Homo sapiens

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    TCF7

    TCF7

    TCF7

  • GATA transcription factor

    • Transcription factor

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    GATA transcription factor

    GATA transcription factor

    GATA_transcription_factor

  • ATF1

    • Protein-coding gene in humans

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    ATF1

    ATF1

    ATF1

  • ELF5

    • Protein-coding gene

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    ELF5

    ELF5

    ELF5

  • NKX3-2

    • Protein-coding gene in the species Homo sapiens

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    NKX3-2

    NKX3-2

    NKX3-2

  • EHF (gene)

    • Protein-coding gene in the species Homo sapiens

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    EHF (gene)

    EHF (gene)

    EHF_(gene)

  • EMX2

    • Protein-coding gene in the species Homo sapiens

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    EMX2

    EMX2

    EMX2

  • PHOX2A

    • Protein-coding gene in humans

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    PHOX2A

    PHOX2A

    PHOX2A

  • HOXB1

    • Protein-coding gene in the species Homo sapiens

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    HOXB1

    HOXB1

    HOXB1

  • ID3 (gene)

    • Protein-coding gene in the species Homo sapiens

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    ID3 (gene)

    ID3 (gene)

    ID3_(gene)

  • POU2F1

    • Protein-coding gene in the species Homo sapiens

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    POU2F1

    POU2F1

    POU2F1

  • NFATC1

    • Protein-coding gene in the species Homo sapiens

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    NFATC1

    NFATC1

    NFATC1

  • Forkhead box protein O1

    • Protein

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    Forkhead box protein O1

    Forkhead box protein O1

    Forkhead_box_protein_O1

  • BCL6

    • Transcription factor for converting Naive T cells to TFH

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    BCL6

    BCL6

    BCL6

  • FOXH1

    • Protein-coding gene in the species Homo sapiens

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    FOXH1

    FOXH1

    FOXH1

  • MAFB (gene)

    • Protein-coding gene in the species Homo sapiens

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    MAFB (gene)

    MAFB (gene)

    MAFB_(gene)

  • RUNX1T1

    • Protein-coding gene in humans

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    RUNX1T1

    RUNX1T1

    RUNX1T1

  • HSF2

    • Protein-coding gene in the species Homo sapiens

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    HSF2

    HSF2

    HSF2

  • GTF3A

    • Protein-coding gene in the species Homo sapiens

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    GTF3A

    GTF3A

    GTF3A

  • NKX2-2

    • Protein-coding gene in the species Homo sapiens

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    NKX2-2

    NKX2-2

    NKX2-2

  • HIVEP3

    • Protein-coding gene in the species Homo sapiens

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    HIVEP3

    HIVEP3

    HIVEP3

  • FOXA3

    • Protein-coding gene in the species Homo sapiens

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    FOXA3

    FOXA3

    FOXA3

  • KMT2D

    • Protein-coding gene in humans

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    KMT2D

    KMT2D

    KMT2D

  • TBX1

    • Protein-coding gene in the species Homo sapiens

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    TBX1

    TBX1

    TBX1

  • HOXC11

    • Protein-coding gene in the species Homo sapiens

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    HOXC11

    HOXC11

    HOXC11

  • Myelin regulatory factor

    • Mammalian protein found in Homo sapiens

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    Myelin regulatory factor

    Myelin regulatory factor

    Myelin_regulatory_factor

  • POU domain

    • Protein family

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    POU domain

    POU_domain

  • PROP1

    • Human gene

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    PROP1

    PROP1

    PROP1

  • Heat shock factor

    • Transcription factor

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    Heat shock factor

    Heat shock factor

    Heat_shock_factor

  • Testicular receptor 2

    • Human protein-coding gene

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    Testicular receptor 2

    Testicular receptor 2

    Testicular_receptor_2

  • Aristaless related homeobox

    • Protein-coding gene in humans

    HMX3 6-1 6-2 NOTO TLX1 TLX2 TLX3 VAX1 VAX2 other ARX CRX CUTL1 FHL 1 2 3 HESX1 HOPX LMX 1A 1B NOBOX TALE IRX 1 2 3 4 5 6 MKX MEIS 1 2 PBX 1 2 3 PKNOX 1

    Aristaless related homeobox

    Aristaless related homeobox

    Aristaless_related_homeobox

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