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Search references for BCL11A. Phrases containing BCL11A
See searches and references containing BCL11A!BCL11A
Protein-coding gene in the species Homo sapiens
lymphoma/leukemia 11A is a protein that in humans is encoded by the BCL11A gene. The BCL11A gene encodes for a regulatory C2H2 type zinc-finger protein, that
BCL11A
American hematologist
and colleagues identified BCL11A as a key repressor of fetal hemoglobin (HbF). His group later showed that silencing BCL11A could reverse sickle cell
Stuart_Orkin
Malaysian haematologist
located within the BCL11A gene. Whilst it was known that BCL11A was involved with cancer, Thein was the first to show that BCL11A was associated with
Swee_Lay_Thein
Family of genes
as "BCL1") BCL2 BCL3 BCL5 BCL6 BCL6B BCL7A BCL7B BCL7C BCL8 BCL9 BCL10 BCL11A BCL11B Bcl-2 family "Chronic lymphocytic leukaemia (CLL) and small lymphocytic
B-cell_CLL/lymphoma
Medical condition
eventually resume production of blood cells. Casgevy works by editing the BCL11A gene, which normally inhibits haemoglobin F (foetal haemoglobin) production
Sickle_cell_disease
Medical condition
promoter region. In addition HbF levels are influenced by polymorphisms in the BCL11A gene and in the MYB gene enhancer. In HPFH the percentage of HbF varies
Hereditary persistence of fetal hemoglobin
Hereditary_persistence_of_fetal_hemoglobin
Oxygen carrier protein in the human fetus
form with an alanine at position 136, whereas HBG2 codes for a glycine BCL11A and ZBTB7A are major repressor proteins of hemoglobin F production, by binding
Fetal_hemoglobin
Family of inherited blood disorders
and in the United States in January 2024. Casgevy works by editing the BCL11A gene, which normally inhibits the production of HbF in adults. The edit
Thalassemia
2018 scientific and bioethical controversy
School, Boston. In both studies, the gene involved in blood cell formation BCL11A was modified in the bone marrow extracted from the individuals. Both the
He_Jiankui_affair
Australian molecular biologist
for repressors, BCL11A or ZBTB7A. This is how he discovered ZBTB7A was one of the two major fetal globin repressors, and is how BCL11A was found to directly
Merlin_Crossley
ENSG00000114439 HMG/Sox Known motif – High-throughput in vitro [65] TGAWCDNYGWTCA BCL11A ENSG00000119866 C2H2 ZF Known motif – In vivo/Misc source [66] DDRRGGAASTGARAV
List of human transcription factors
List_of_human_transcription_factors
Swiss pediatric hematologist-oncologist
its molecular cause. He has contributed to research on lineage-specific BCL11A knockdown strategies to reverse the sickle cell phenotype and has studied
Raffaele_Renella
Method used to analyze protein interactions with DNA
promoters have used CUT&RUN to investigate the involvement of the protein BCL11A in mediating the function of the HBBP1 gene region, highlighting a potential
CUT&RUN_sequencing
Chemical compound
pathway influences BCL11A translation in humans, and additional regulators such as ATF4 and MYB have been reported to enhance BCL11A expression. Modulating
Embryonic_hemoglobin
Medical condition
including: AHSA2, activator of heat shock 90kDa protein ATPase homolog BCL11A, B-cell lymphoma/leukemia 11A C2orf74, Uncharacterized protein C2orf74 FANCL
2p15-16.1 microdeletion syndrome
2p15-16.1_microdeletion_syndrome
Hereditary blood disorder causing anemia
and in the United States in January 2024. Casgevy works by editing the BCL11A gene, which normally inhibits the production of HbF in adults. The edit
Beta_thalassemia
Protein found in humans
conserved among other ZF transcriptional repressors, including FOG-1, FOG-2, BCL11A, and SALL1. ZNF521 mRNA has been detected in most cases of acute myelogenous
Zinc_finger_protein_521
American neuroscientist
investigated Ctip2/Bcl11b, Fezl/Fezf2, Sox5, Bhlhb5, Lmo4, RORb, Sox6, Ctip1/Bcl11a, Fog2, and a number of other widely known controls over neuron subtype and
Jeffrey_Macklis
Protein-coding gene in the species Homo sapiens
gene encodes a Cys2His2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies.
BCL11B
HGNC:1008; O00512 1489 BCL9L HGNC:23688; Q86UU0 1490 BCL10 HGNC:989; O95999 1491 BCL11A HGNC:13221; Q9H165 1492 BCL11B HGNC:13222; Q9C0K0 1493 BCLAF1 HGNC:16863;
List of human protein-coding genes 1
List_of_human_protein-coding_genes_1
Protein-coding gene in the species Homo sapiens
D, Costa FF, Hirschhorn JN, Orkin SH (2008). "DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels
HBS1-like_protein
Protein found in humans
palindromes of the 5'-AGGTCA-3' motif. COUP-TFI has been shown to interact with: BCL11A, BCL11B, COPS2, and ESR1. Mutations in this gene have been associated with
COUP-TFI
Angeles Times) (Cancer Prev. Res.) 13 October – Silencing a protein known as BCL11A can reactivate fetal hemoglobin production in adult mice and effectively
2011_in_science
Finnish-American physician
hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A". Science. 322 (5909): 1839–1842. doi:10.1126/SCIENCE.1165409. ISSN 0036-8075
Hanna_Mikkola
Blood that has been modified for therapeutic or other purposes
interferes with creation of adult hemoglobin. This gene is known as the BCL11A, and when people have Beta thalassemia, their bodies do not make enough
Gene therapy for blood diseases
Gene_therapy_for_blood_diseases
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