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ASCL1

  • ASCL1
  • Protein-coding gene in humans

    Achaete-scute homolog 1 is a protein that in humans is encoded by the ASCL1 gene. Because it was discovered subsequent to studies on its homolog in Drosophila

    ASCL1

    ASCL1

    ASCL1

  • Thalamus
  • Structure within the brain

    proneural gene Neurogenin1 in the major (caudal) part of the thalamus, and Ascl1 (formerly Mash1) in the remaining narrow stripe of rostral thalamic cells

    Thalamus

    Thalamus

    Thalamus

  • Retinal regeneration
  • but neuron generation only occurred with concurrent overexpression of Ascl1. More recently, robust Muller glia proliferation and subsequent neuronal

    Retinal regeneration

    Retinal regeneration

    Retinal_regeneration

  • SOX18
  • Protein-coding gene in the species Homo sapiens

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    SOX18

    SOX18

    SOX18

  • NF-κB
  • Family of transcription factor protein complexes

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    NF-κB

    NF-κB

    NF-κB

  • SOX17
  • Protein-coding gene in the species Homo sapiens

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    SOX17

    SOX17

    SOX17

  • Thomas Reh
  • American scientist and author

    Claire K.; Hooper, Marcus J.; Reh, Thomas A. (2020). "Microglia Suppress Ascl1-Induced Retinal Regeneration in Mice". Cell Reports. 33 (11) 108507. Elsevier

    Thomas Reh

    Thomas_Reh

  • Neurogenins
  • Protein family

    differentiation also expressed during early neural development include NeuroD and ASCL1. Neurogenins primarily govern the transition of neural progenitor cells

    Neurogenins

    Neurogenins

  • Anna Philpott
  • British biologist and Professor

    Barker, Roger A.; Philpott, Anna (June 2014). "The phosphorylation status of Ascl1 is a key determinant of neuronal differentiation and maturation in vivo

    Anna Philpott

    Anna_Philpott

  • DBX1
  • Protein-coding gene in the species Homo sapiens

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    DBX1

    DBX1

    DBX1

  • GTF2H1
  • Protein-coding gene in the species Homo sapiens

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    GTF2H1

    GTF2H1

    GTF2H1

  • ISL1
  • Protein-coding gene in the species Homo sapiens

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    ISL1

    ISL1

    ISL1

  • DPF2
  • Protein-coding gene in the species Homo sapiens

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    DPF2

    DPF2

    DPF2

  • Receptor (biochemistry)
  • Protein molecule receiving signals for a cell

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    Receptor (biochemistry)

    Receptor (biochemistry)

    Receptor_(biochemistry)

  • Retinoic acid receptor
  • Type of nuclear receptor

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    Retinoic acid receptor

    Retinoic acid receptor

    Retinoic_acid_receptor

  • ZNF300
  • Human protein-coding gene

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    ZNF300

    ZNF300

    ZNF300

  • Activating transcription factor
  • Class of DNA-binding proteins that regulate gene transcription

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    Activating transcription factor

    Activating_transcription_factor

  • Hypoxia-inducible factor
  • Protein that responds to low oxygen

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    Hypoxia-inducible factor

    Hypoxia-inducible_factor

  • Retinoblastoma protein
  • Mammalian protein found in humans

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    Retinoblastoma protein

    Retinoblastoma protein

    Retinoblastoma_protein

  • DNAAF8
  • Protein-coding gene in the species Homo sapiens

    Transcription factor Associated functions Ascl1 (Mammaliam achaete scute homolog 1) B-cell differentiation, maturation, and development Negative regulation

    DNAAF8

    DNAAF8

    DNAAF8

  • Sex-determining region Y protein
  • Protein that initiates male sex determination in therian mammals

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    Sex-determining region Y protein

    Sex-determining region Y protein

    Sex-determining_region_Y_protein

  • Steroid hormone receptor
  • Group of protein families

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    Steroid hormone receptor

    Steroid_hormone_receptor

  • Pregnane X receptor
  • Mammalian protein found in Homo sapiens

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    Pregnane X receptor

    Pregnane X receptor

    Pregnane_X_receptor

  • SPT20
  • Transcription factor

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    SPT20

    SPT20

    SPT20

  • CREB
  • Class of proteins

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    CREB

    CREB

    CREB

  • List of human protein-coding genes 1
  • Q8N9N2 1129 ASCC2 HGNC:24103; Q9H1I8 1130 ASCC3 HGNC:18697; Q8N3C0 1131 ASCL1 HGNC:738; P50553 1132 ASCL2 HGNC:739; Q99929 1133 ASCL3 HGNC:740; Q9NQ33

    List of human protein-coding genes 1

    List_of_human_protein-coding_genes_1

  • Basic helix–loop–helix
  • Protein structural motif

    G, M is A or C and K is G or T. AHR; AHRR; ARNT; ARNT2; ARNTL; ARNTL2; ASCL1; ASCL2; ASCL3; ASCL4; ATOH1; ATOH7; ATOH8; BHLHB2; BHLHB3; BHLHB4; BHLHB5;

    Basic helix–loop–helix

    Basic helix–loop–helix

    Basic_helix–loop–helix

  • Estrogen receptor
  • Proteins activated by the hormone estrogen

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    Estrogen receptor

    Estrogen receptor

    Estrogen_receptor

  • NeuroD
  • Basic helix-loop-helix transcription factor

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    NeuroD

    NeuroD

  • EPAS1
  • Protein found in humans

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    EPAS1

    EPAS1

    EPAS1

  • NKX 2-9
  • Transcription factor

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    NKX 2-9

    NKX_2-9

  • Basic helix-loop-helix ARNT-like protein 1
  • Human protein and coding gene

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    Basic helix-loop-helix ARNT-like protein 1

    Basic helix-loop-helix ARNT-like protein 1

    Basic_helix-loop-helix_ARNT-like_protein_1

  • PAX6
  • Protein-coding gene in humans

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    PAX6

    PAX6

    PAX6

  • Sulk
  • 1982 studio album by the Associates

    Format Catalog United Kingdom 14 May 1982 Associates/ Beggars Banquet LP ASCL1 Cassette ASCC1 Europe WEA LP 240 005-1 United States 4 October 1982 Sire

    Sulk

    Sulk

  • Estrogen-related receptor beta
  • Protein-coding gene in the species Homo sapiens

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    Estrogen-related receptor beta

    Estrogen-related receptor beta

    Estrogen-related_receptor_beta

  • GATA transcription factor
  • Transcription factor

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    GATA transcription factor

    GATA transcription factor

    GATA_transcription_factor

  • Retinoic acid receptor alpha
  • Protein found in humans

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    Retinoic acid receptor alpha

    Retinoic acid receptor alpha

    Retinoic_acid_receptor_alpha

  • Peroxisome proliferator-activated receptor alpha
  • Nuclear receptor protein found in humans

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    Peroxisome proliferator-activated receptor alpha

    Peroxisome proliferator-activated receptor alpha

    Peroxisome_proliferator-activated_receptor_alpha

  • TCF3
  • Protein-coding gene in the species Homo sapiens

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    TCF3

    TCF3

    TCF3

  • FOXF1
  • Protein-coding gene in the species Homo sapiens

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    FOXF1

    FOXF1

    FOXF1

  • NFIC (gene)
  • Protein-coding gene in the species Homo sapiens

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    NFIC (gene)

    NFIC (gene)

    NFIC_(gene)

  • Zinc finger
  • Small structural protein motif found mostly in transcriptional proteins

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    Zinc finger

    Zinc finger

    Zinc_finger

  • PROX1
  • Protein-coding gene in the species Homo sapiens

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    PROX1

    PROX1

    PROX1

  • Pocket protein family
  • Protein family

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    Pocket protein family

    Pocket_protein_family

  • MYF5
  • Protein-coding gene in the species Homo sapiens

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    MYF5

    MYF5

    MYF5

  • Homeobox protein Nkx-2.5
  • Protein-coding gene in humans

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    Homeobox protein Nkx-2.5

    Homeobox protein Nkx-2.5

    Homeobox_protein_Nkx-2.5

  • SALL4
  • Protein-coding gene in the species Homo sapiens

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    SALL4

    SALL4

    SALL4

  • MTA3
  • Protein-coding gene in the species Homo sapiens

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    MTA3

    MTA3

    MTA3

  • RUNX1T1
  • Protein-coding gene in humans

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    RUNX1T1

    RUNX1T1

    RUNX1T1

  • CEBPB
  • Protein-coding gene in humans

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    CEBPB

    CEBPB

    CEBPB

  • STAT6
  • Protein and coding gene in humans

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    STAT6

    STAT6

    STAT6

  • HOXB3
  • Protein-coding gene in the species Homo sapiens

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    HOXB3

    HOXB3

    HOXB3

  • N-Myc
  • Protein-coding gene in the species Homo sapiens

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    N-Myc

    N-Myc

    N-Myc

  • LHX3
  • Protein-coding gene in the species Homo sapiens

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    LHX3

    LHX3

    LHX3

  • ARID3A
  • Protein-coding gene in humans

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    ARID3A

    ARID3A

    ARID3A

  • ParaHox
  • Gene cluster

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    ParaHox

    ParaHox

  • FOXE3
  • Protein-coding gene in the species Homo sapiens

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    FOXE3

    FOXE3

    FOXE3

  • BHLHB2
  • Protein-coding gene in humans

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    BHLHB2

    BHLHB2

    BHLHB2

  • DMRT1
  • Protein-coding gene in humans

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    DMRT1

    DMRT1

    DMRT1

  • Liver X receptor alpha
  • Nuclear receptor protein found in humans

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    Liver X receptor alpha

    Liver X receptor alpha

    Liver_X_receptor_alpha

  • MAFB (gene)
  • Protein-coding gene in the species Homo sapiens

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    MAFB (gene)

    MAFB (gene)

    MAFB_(gene)

  • Protein AATF
  • Protein-coding gene in the species Homo sapiens

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    Protein AATF

    Protein AATF

    Protein_AATF

  • MXD1
  • Protein-coding gene in the species Homo sapiens

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    MXD1

    MXD1

    MXD1

  • Heterochromatin protein 1
  • Protein family

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    Heterochromatin protein 1

    Heterochromatin_protein_1

  • TEAD3
  • Protein-coding gene in the species Homo sapiens

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    TEAD3

    TEAD3

    TEAD3

  • HIC2
  • Protein-coding gene in the species Homo sapiens

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    HIC2

    HIC2

    HIC2

  • ATF6
  • Protein-coding gene in the species Homo sapiens

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    ATF6

    ATF6

    ATF6

  • ATF3
  • Protein-coding gene in humans

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    ATF3

    ATF3

    ATF3

  • PHOX2A
  • Protein-coding gene in humans

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    PHOX2A

    PHOX2A

    PHOX2A

  • BZIP domain
  • Protein domain

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    BZIP domain

    BZIP domain

    BZIP_domain

  • SOX gene family
  • Family of transcription factors

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    SOX gene family

    SOX_gene_family

  • Catabolite activator protein
  • Trans-acting transcriptional activator

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    Catabolite activator protein

    Catabolite activator protein

    Catabolite_activator_protein

  • List of human transcription factors
  • ENSG00000004848 Homeodomain Known motif – High-throughput in vitro [35] TAATYNRATTA ASCL1 ENSG00000139352 bHLH Known motif – High-throughput in vitro [36] RCASSTGY

    List of human transcription factors

    List_of_human_transcription_factors

  • MNX1
  • Protein-coding gene in the species Homo sapiens

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    MNX1

    MNX1

    MNX1

  • SALL3
  • Protein-coding gene in the species Homo sapiens

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    SALL3

    SALL3

    SALL3

  • POU3F2
  • Protein-coding gene in the species Homo sapiens

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    POU3F2

    POU3F2

    POU3F2

  • FOXH1
  • Protein-coding gene in the species Homo sapiens

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    FOXH1

    FOXH1

    FOXH1

  • TOX
  • Protein-coding gene in the species Homo sapiens

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    TOX

    TOX

    TOX

  • BCL11A
  • Protein-coding gene in the species Homo sapiens

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    BCL11A

    BCL11A

    BCL11A

  • P53
  • Mammalian protein found in humans

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    P53

    P53

    P53

  • IRF3
  • Protein-coding gene in the species Homo sapiens

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    IRF3

    IRF3

    IRF3

  • Zbtb7
  • Mammalian protein found in Homo sapiens

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    Zbtb7

    Zbtb7

  • T-box
  • Genes that affect limb and heart development

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    T-box

    T-box

    T-box

  • Winged-helix transcription factors
  • Family of proteins

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    Winged-helix transcription factors

    Winged-helix transcription factors

    Winged-helix_transcription_factors

  • Retinoblastoma-like protein 1
  • Mammalian protein found in Homo sapiens

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    Retinoblastoma-like protein 1

    Retinoblastoma-like protein 1

    Retinoblastoma-like_protein_1

  • ZNF318
  • Protein-coding gene in humans

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    ZNF318

    ZNF318

    ZNF318

  • HAND1
  • Protein-coding gene in the species Homo sapiens

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    HAND1

    HAND1

    HAND1

  • TRPS1
  • Protein-coding gene in the species Homo sapiens

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    TRPS1

    TRPS1

    TRPS1

  • SOX10
  • Transcription factor gene of the SOX family

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    SOX10

    SOX10

    SOX10

  • ETV6
  • Protein-coding gene in the species Homo sapiens

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    ETV6

    ETV6

    ETV6

  • IRX6
  • Protein-coding gene in the species Homo sapiens

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    IRX6

    IRX6

    IRX6

  • Twist-related protein 2
  • Protein-coding gene in the species Homo sapiens

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    Twist-related protein 2

    Twist-related protein 2

    Twist-related_protein_2

  • ZNF471
  • Protein-coding gene in the species Homo sapiens

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    ZNF471

    ZNF471

    ZNF471

  • ZNF219
  • Protein-coding gene in humans

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    ZNF219

    ZNF219

    ZNF219

  • Transcription factor II D
  • General transcription factors

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    Transcription factor II D

    Transcription_factor_II_D

  • EGR3
  • Protein-coding gene in humans

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    EGR3

    EGR3

    EGR3

  • MEIS2
  • Protein-coding gene in the species Homo sapiens

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    MEIS2

    MEIS2

    MEIS2

  • ETS variant 5
  • Protein-coding gene in the species Homo sapiens

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    ETS variant 5

    ETS variant 5

    ETS_variant_5

  • MYC
  • Protein-coding gene in the species Homo sapiens

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    MYC

    MYC

    MYC

  • FOXM1
  • Protein-coding gene in humans

    NFIL3 NRL NRF 1 2 3 XBP1 (1.2) Basic helix–loop–helix (bHLH) Group A AS-C ASCL1 ASCL2 ATOH1 HAND 1 2 MESP2 Myogenic regulatory factors MyoD Myogenin MYF5

    FOXM1

    FOXM1

    FOXM1

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