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Protein found in humans
Caspase-3 is a caspase protein that interacts with caspase-8 and caspase-9. It is encoded by the CASP3 gene. CASP3 orthologs have been identified in numerous
Caspase_3
Protein domain
Apoptotic caspases are subcategorised as: Initiator Caspases (Caspase 2, Caspase 8, Caspase 9, Caspase 10) Executioner Caspases (Caspase 3, Caspase 6 and
Caspase
Type of programmed cell death
a different set of caspases as compared to apoptosis, for example, caspase-1/4/5 in humans and caspase-11 in mice. These caspases contribute to the maturation
Pyroptosis
Form of programmed cell death
of caspases: initiator caspases (caspases 2, 8, 9, 10, 11, and 12) and effector caspases (caspases 3, 6, and 7). The activation of initiator caspases requires
Apoptosis
Enzyme found in humans
Caspase-9 is an enzyme that in humans is encoded by the CASP9 gene. It is an initiator caspase, critical to the apoptotic pathway found in many tissues
Caspase-9
Protein found in humans
form of a heterotetramer. The precursor of this caspase is cleaved by caspase 3, caspase 10, and caspase 9. It is activated upon cell death stimuli and
Caspase_7
Enzyme found in humans
Caspase 2 (EC 3.4.22.55), also known as ICH-1, NEDD-2, caspase-2L, caspase-2S, neural precursor cell expressed developmentally down-regulated protein 2
Caspase_2
Protein found in humans
Caspase-8 is a caspase protein, encoded by the CASP8 gene. It most likely acts upon caspase-3. CASP8 orthologs have been identified in numerous mammals
Caspase_8
Protein found in humans
the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments
Caspase-activated_DNase
Protein complex involved in the cellular apoptotic process
Apaf-1 and therefore the apoptosome. These routes are also independent of caspase-3 and 9. These hidden pathways for apoptosis are slower, but may prove useful
Apoptosome
Protein-coding gene in the species Homo sapiens
disease type 2. XIAP has been shown to interact with: ALS2CR2, Caspase 3. Caspase 7, Caspase-9, Diablo homolog HtrA serine peptidase 2, MAGED1, MAP3K2, TAB1
XIAP
Irreversible condensation of chromatin in the nucleus of a dying cell
proteins include, for example, caspase 9, caspase 6, caspase 7, and caspase 3. The caspase cascade directly activates caspase-activated DNase (CAD) which
Pyknosis
Kenyan molecular biologist
tissue injury. Among his contributions are the identification of caspase-3 and caspase-8 as central regulators of apoptosis, elucidation of death receptor
Vishva_Dixit
Purported geroprotective agent
introduction of short peptides before carotid artery occlusion on behaviour and caspase-3 activity in the brain of old rats]". Advances in Gerontology = Uspekhi
Pinealon
Enzyme found in humans
acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive
Caspase_10
Enzyme found in humans
Caspase-1/Interleukin-1 converting enzyme (ICE) is an evolutionarily conserved enzyme that proteolytically cleaves other proteins, such as the precursors
Caspase_1
Enzyme found in humans
Caspase-6 is an enzyme that in humans is encoded by the CASP6 gene. CASP6 orthologs have been identified in numerous mammals for which complete genome
Caspase_6
Chinese-American biochemist
cleaves procaspase-9 to the active form caspase-9, which in turn cleaves procaspase-3 to the active caspase 3. Apart from apoptosis, Wang also discovered
Xiaodong_Wang_(biochemist)
Chemical compound
kinases and c-Jun N-terminal kinases. It induces caspase-8 and caspase-9, which results in caspase-3 activation and poly(adp-ribose) polymerases cleavage
Indole-3-acetic_acid
Death of a cell mediated by intracellular program, often as part of development
and releases the caspases which leads to the activation of caspase 3. This initiator caspase may cause the cleaving of inactive caspase 3, causing it to
Programmed_cell_death
Protein-coding gene in the species Homo sapiens
the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments
DFFA
Class of enzymes
Murine caspase-11, and its human homologs caspase-4 and caspase-5, are mammalian intracellular receptor proteases activated by TLR4 and TLR3 signaling
Caspase_11
Lipidation modification
complex composed of numerous proteins including several caspases, including caspase 3. Caspase 3 cleaves a number of proteins that are subsequently myristoylated
Myristoylation
Proteins that control apoptosis
mutated or improperly regulated. Many of these inhibitors act to block caspases, a family of cysteine proteases that play an integral role in apoptosis
Inhibitor_of_apoptosis
Surface glycoprotein
purification of proteins from apoptotic cells since it is cleaved by Caspase-3 and / or Caspase-7 after its sequence DVPD, causing it to lose its immunoreactivity
HA-tag
Mammalian protein found in humans
proteases called caspases. It is an inflammatory caspase, along with caspase 1, caspase 4 and the murine caspase 4 homolog caspase 11, and has a role
Caspase_5
Cleavage of DNA into tiny pieces during apoptosis
characterized by the activation of endogenous endonucleases, particularly the caspase-3 activated DNase (CAD), with subsequent cleavage of nuclear DNA into internucleosomal
Apoptotic_DNA_fragmentation
Class of compounds
Xiao, Y (2003). "Apoptotic Cells Induce Migration of Phagocytes via Caspase-3-Mediated Release of a Lipid Attraction Signal". Cell. 113 (6): 717–730
Lysophosphatidylcholine
protease), similarly to caspases. The phytaspase displays a strict substrate specificity, which resembles that of the animal caspase-3. It recognizes a tetrapetide
Phytaspase
Protein-coding gene in the species Homo sapiens
Fagol Caspase recruitment domain-containing protein 16 is an enzyme that in humans is encoded by the CARD16 gene. It functions as a caspase inhibitor
COP1
Enzyme
interaction, trans-nitrosylates the active site cysteine of caspase-3 thus inactivating caspase-3 and preventing induction of apoptosis. As might be expected
Formaldehyde_dehydrogenase
Human protein and coding gene
circovirus type 2 (PERK-eIF2α-ATF4 -CHOP-BCL2 pathway) HIV (XBP-1-CHOP-Caspase 3/9 pathway) Infectious bronchitis virus (PERK-eIF2α-ATF4/PKR-eIF2α-ATF4
DNA damage-inducible transcript 3
DNA_damage-inducible_transcript_3
Protein-coding gene in the species Homo sapiens
Bcl2L12 directly neutralizes caspase-7 (CASP7) and indirectly neutralizes caspase-3 (CASP3) by an indirect mechanism. Both caspase enzymes are known to play
BCL2L12
Family of proteins
While in vitro cleavage by caspase occurs throughout the caspase family, preliminary data suggest that caspase-3 and caspase-7 are responsible for in vivo
Poly_(ADP-ribose)_polymerase
Class of proteins
activates apoptosis by activating caspases (especially caspase-3), which cleaves many substrates, including caspase-activated DNase to execute cell death
Granzyme
Protein found in humans
Caspase 12 is a protein that in humans is encoded by the CASP12 gene. The protein belongs to a family of enzymes called caspases which cleave their substrates
Caspase_12
Chemical compound
[citation needed] In cells, the executioner protein, caspase-3, is stored in its inactive form, procaspase-3. This way, the cell can quickly undergo apoptosis
PAC-1
Biological process
caspase activation, particularly caspase-3. Oligonuclosomal DNA fragmentation is initiated by caspase-activated deoxyribonuclease following caspase-3
Ischemic_cell_death
Protein-coding gene in the species Homo sapiens
"Caspase-2-induced apoptosis is dependent on caspase-9, but its processing during UV- or tumor necrosis factor-dependent cell death requires caspase-3"
BH3 interacting-domain death agonist
BH3_interacting-domain_death_agonist
in nerve growth factor withdrawal, caspase-3 and -9 are activated, causing cell death, which are the very caspases blocked by NAIP. Hippocalcin is a neuronal
Nerve_tissue_protein
Antibiotic medication
RJ, Fink KB, Zhu S, et al. (July 2000). "Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of
Minocycline
Enzyme found in humans
called caspases. The function of caspase 4 is not fully known, but it is believed to be an inflammatory caspase, along with caspase 1, caspase 5 (and
Caspase_4
Species of flowering plant
proteins involved in apoptosis, such as cleaved caspase-3 and PARP. Further experiments using a caspase inhibitor (Z-VAD-FMK) and small interfering RNA
Taraxacum_mongolicum
Protein found in humans
cytochrome c in turn activates caspase 9, a cysteine protease. Caspase 9 can then go on to activate caspase 3 and caspase 7, which destroy the cell from
Cytochrome_c
Protein-coding gene in the species Homo sapiens
cell death is caused in Huntington's disease (via the caspase-3 route). The role of Hip-1 in caspase mediated cell death remains unclear. Huntingtin interacting
Huntingtin-interacting protein 1
Huntingtin-interacting_protein_1
Condition of not having enough sleep
well since they sleep a third of the duration of REM sleep of humans and caspase-3, the main effector of apoptosis, kills three times the number of cells
Sleep_deprivation
Protein-coding gene in the species Homo sapiens
only WNK3 has been shown to regulate and increase cell survival in a caspase-3-dependent pathway. To be able to understand how these components regulate
LINGO1
Enzyme
Leu-Gln-Thr-Asp!Gly Caspase-10 is an initiator caspase, as are caspase-2 (EC 3.4.22.55), caspase-8 (EC 3.4.22.61) and caspase-9 (EC 3.4.22.62). Chang HY
Caspase-10
Protein-coding gene in the species Homo sapiens
co-factor for axon guidance. Intracellularly, DCC has been shown to have a caspase-3 proteolysis site at Asp 1290. DCC and neogenin, two of the netrin-1 receptors
Netrin_receptor_DCC
Type of cysteine protease
Death regulator Nedd2-like caspase (Nc, Nedd2-like caspase or Dronc) was firstly identified and characterised in Drosophila in 1999 as a cysteine protease
Death regulator Nedd2-like caspase
Death_regulator_Nedd2-like_caspase
Fish sauce originating from east coast of Peninsular Malaysia
induce apoptosis in a human lymphoma cell (U937) through the increase of caspase-3 and −8 activities". Ann N Y Acad Sci. 1010 (1): 399–404. Bibcode:2003NYASA1010
Budu_(sauce)
elegans CED-4, participates in cytochrome c-dependent activation of caspase-3". It identified and reconstituted the mitochondrial pathway to apoptosis
History_of_apoptosis_research
Chemical compound
1-chloro-3-tosylamido-4-phenyl-2-butanone. TPCK is an irreversible inhibitor of chymotrypsin. Also inhibits some cysteine proteases such as caspase, papain
Tosyl phenylalanyl chloromethyl ketone
Tosyl_phenylalanyl_chloromethyl_ketone
Relative preservation of neurons
alpha-synuclein in neuronal cell lines is associated with the inhibition of caspase-3 but not caspase-9 activity". Journal of Neurochemistry. 93 (6): 1542–1550. doi:10
Neuroprotection
Chemical compound
nux-vomica proceeds via apoptosis and is mediated by cyclooxygenase 2 and caspase 3 in SMMC 7221 cells". Food and Chemical Toxicology. 45 (9): 1700–1708.
Isostrychnine
Protein-coding gene in the species Caenorhabditis elegans
prototypical caspase (procaspase) where the active cysteine residue cleaves aspartate residues, thus becoming a functional caspase. Ced-3 is an executioner
Ced-3
Class of chemical compounds
phosphodiesterase inhibitors as related to modulation of cell-cycle elements and caspase-3 activation". Neuroscience Letters. 418 (2): 165–9. doi:10.1016/j.neulet
PDE4_inhibitor
Protein found in humans
82–98), a former nuclear export signal (NES residues 239–250) and 3 putative caspase-3 cleavage sites (residues 13, 89, 219). In December 2021 the structure
TAR_DNA-binding_protein_43
Species of bacterium
human ileal and colonic epithelium in vitro and necrotize it. Through the caspase-3 pathway, this toxin can cause apoptosis of affected cells. This toxin
Clostridium_perfringens
Mammalian protein found in humans
that once CD59 had been targeted, there is an upregulation in fas and caspase-3, creating an increase in apoptosis and tumor growth suppression in MCF-7
CD59
Protein-coding gene in the species Homo sapiens
inside of the cage. GroEL has been shown to interact with GroES, ALDH2, Caspase 3 and Dihydrofolate reductase. The genes of bacteriophage (phage) T4 that
GroEL
Contraceptive pest control product
Richard N.; Yuan, Junying; Flavell, Richard A. (2003-01-01). "Bax, caspase-2, and caspase-3 are required for ovarian follicle loss caused by 4-vinylcyclohexene
ContraPest
Chemical compound
intercalation. In cancer models, ECG induces apoptosis in breast cancer cells via caspase-3 activation and inhibits DNA methyltransferase, reactivating silenced genes
Epicatechin_gallate
Parasitic microorganism that causes giardiasis
factor α (TNF-α) and apoptosis-inducing factor (AIF), independent of caspase-3 activity. These findings suggest that Giardia enolase is a critical virulence
Giardia_duodenalis
Species of fungus
and the three metabolized by C. elatum have also been found to inhibit Caspase 3 which is involved in cell death. Phenolic compounds have shown to possess
Chaetomium_elatum
Destructive fragmentation of the nucleus of a dying cell
also resulting in caspase activation and nuclear envelope degradation. In both pathways, executioner caspases, particularly caspase-3, cleave nuclear lamins
Karyorrhexis
Medication
arrest during cell cycle, upregulates p53, and triggers apoptosis via caspase-3 stimulation and poly (ADP-ribose) polymerase cleavage. In several studies
Tirbanibulin
Human gene
development of zebrafish. Knocking down RPRML in this model, increases caspase-3 activity in the hemogenic endothelium, hindering the formation of hematopoietic
Reprimo-like
Chemical compound
cells to monocrotophos, the levels of protein and mRNA expression of caspase-3, caspase-9, BAX, p53, p21, PUMA, and cytochrome-c were significantly upregulated
Monocrotophos
Chemical compound
increased expression of caspase-3 and caspase-8. Caspase proteins are crucial mediators of apoptosis, with caspase-3 and caspase-8 being death proteases
Rhododendrol
Protein found in humans
result from abnormal expression of Bcl-2 and increased expression of caspase-3. Antibodies to Bcl-2 can be used with immunohistochemistry to identify
Bcl-2
Enzyme found in humans
Caspase 14 is an enzyme that in humans is encoded by the CASP14 gene. Orthologs of this gene also exist in other mammals, such as sirenians and cetaceans
Caspase_14
Protein-coding gene in the species Homo sapiens
humans is encoded by the GAS2 gene. The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape
GAS2
Mammalian protein found in humans
includes release of cytochrome c in cytoplasm and the activation of caspase-9 and caspase-3. The apoptosis is dependent on GAGs binding on cell surface and
CCL5
Mammalian protein found in Homo sapiens
study indicated that ECP caused cytotoxicity in HL-60 and HeLa cells via caspase-3 like activity. Accordingly, cytotoxic RNases play an important role in
Eosinophil_cationic_protein
Type III intermediate filament protein
to be detrimental to cytoskeleton formation as well as an increase in caspase 3 activity, which would lead to increased apoptosis of cells with these
Glial fibrillary acidic protein
Glial_fibrillary_acidic_protein
Protein-coding gene in the species Homo sapiens
are two aspartic acids, D276 and D290, which serve as binding sites for caspase-3. The overall function of MuD remains unclear. It is known, however, that
AP5M1
Protein-coding gene in the species Homo sapiens
apoptosis family that inhibit apoptosis by interfering with the activation of caspases. The encoded protein inhibits apoptosis induced by serum deprivation but
Baculoviral IAP repeat-containing protein 3
Baculoviral_IAP_repeat-containing_protein_3
Reoccurrence of cancer
"Paracrine control of tissue regeneration and cell proliferation by Caspase-3". Cell Death & Disease. 4 (7): e725. doi:10.1038/cddis.2013.250. ISSN 2041-4889
Recurrent_cancer
apoptotic process, a model showed that a positive feedback of inhibition of caspase 3 (Casp3) and Casp9 by inhibitors of apoptosis can bring about ultrasensitivity
Ultrasensitivity
Species of fluke
parasite will inhibit apoptosis which can cause the decrease in caspase-3 and NF-jB. Caspase-3 and NF-jB are proteins that are essential to induce programmed
Heterophyes_heterophyes
Cytosolic multiprotein complex that mediates the activation of Caspase 1
Activation and assembly of the inflammasome promotes the activation of caspase-1, which then proteolytically cleaves pro-inflammatory cytokines, interleukin
Inflammasome
Post-translational carbohydrate modification of proteins
reported to suppress apoptosis. Caspase-3, caspase-8, and caspase-9 have been reported to be modified by O-GlcNAc. Caspase-8 is modified near its cleavage/activation
O-GlcNAc
Protein-coding gene in humans
Li Y, Xu D, Shi Y, Tang H (March 2005). "Specific cleavage of Mcl-1 by caspase-3 in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced
MCL1
Protein-coding gene in the species Homo sapiens
while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein
Interleukin_16
Bovine protein
Caspase 13 or ERICE ("evolutionarily related interleukin-1β converting enzyme") is a protein that was identified in cattle. It belongs to a family of
Caspase_13
Protein-coding gene in the species Homo sapiens
activation of effector caspases, like caspase-3 and caspase-7, which then execute the final stages of programmed cell death. Caspase-2 has similar structure
LRDD
Cellular stress response
by proteins that cause mitochondrial damage, cytochrome c release and caspase 3 activation. Wolfram syndrome represents a prototype human disorder caused
Unfolded_protein_response
Chemical compound
that one way in which staurosporine induces apoptosis is by activating caspase-3. At lower concentration, depending on the cell type, staurosporine induces
Staurosporine
Infection of the brain caused by the Japanese encephalitis virus
"Minocycline neuroprotects, reduces microglial activation, inhibits caspase 3 induction, and viral replication following Japanese encephalitis". J.
Japanese_encephalitis
Protein found in humans
increase in cortical precursors that stained immunopositive for cleaved caspase-3. BDNF can also promote NSC and NPC proliferation through Akt activation
Brain-derived neurotrophic factor
Brain-derived_neurotrophic_factor
InterPro Domain
in inactive procaspases (cysteine proteases) and proteins that regulate caspase activation in the apoptosis cascade such as FAS-associating death domain-containing
Death_effector_domain
Ability of some viruses to lie dormant within a cell
high levels of the herpes simplex virus type 1 LAT are refractory to caspase 3 activation and DNA laddering following cold shock induced apoptosis".
Virus_latency
Class of enzymes
in host cells. Both 2A(pro) and 3C(pro) induce caspase-8-mediated by activation of caspase-3. Caspase stands for cysteine-aspartic acid protease and play
Picornain_3C
American surgeon
low-level exposure to thiomersal caused membrane and DNA damage, as well as caspase-3-dependent apoptosis, to human neurons and fibroblasts. In 2008, controversial
David_Baskin
Indian biomedical researcher
is associated with activation of the key executioner cysteine protease,caspase-3. Most importantly, these compounds are more potent against cancer cells
Ramesh_Chandra_(academic)
Upregulation of Caspase-3, Caspase-9, and Inhibition of NF-κB and COX-2 Expressions". The American Journal of Chinese Medicine. 38 (3): 613–24. doi:10
List_of_vegetable_oils
Effect of alcohol consumption on the brain
inflammatory mediators by ethanol is also associated with an increase in caspase 3 activity and a corresponding increase in cell apoptosis. The exact mechanism
Long-term impact of alcohol on the brain
Long-term_impact_of_alcohol_on_the_brain
Protein-coding gene in humans
early apoptotic signaling in human endothelial cells, FAK is cleaved by caspase 3 at Asp-772, generating two FAK fragments of approximately 90 and 130 kDa
PTK2
Species of amphibian
Xiao; Yan, Fan; Zhu, Guangxiang; Wang, Qin (2022-07-29). "Mechanisms of Caspases 3/7/8/9 in the Degeneration of External Gills of Chinese Giant Salamanders
Chinese_giant_salamander
CASPASE 3
CASPASE 3
Boy/Male
Farsi, French, German, Parsi, Spanish
Wealthy Man; Treasurer; He who Guards the Treasure; Form of Caspar
Girl/Female
Anglo Saxon
A cascade.
Male
Italian
Italian form of Portuguese/Spanish Gaspar, GASPARE means "treasure bearer."Â
Boy/Male
Tamil
Pita Vasase | பிதா வாஸஸே
One wearing yellow robes
Pita Vasase | பிதா வாஸஸே
Boy/Male
American, Australian, British, English, Latin
Wealthy Man; Vain; Diminutive of Caspar
Girl/Female
American, Anglo, Arabic, Australian, British, Christian, English, Spanish
Waterfall; A Cascade; Lake; Pool; Pretty
Girl/Female
Anglo Saxon Arthurian Legend English
A cascade.
Girl/Female
Christian & English(British/American/Australian)
A Cascade
Male
Dutch
, treasure master, or, jasper.
Girl/Female
American, Anglo, Australian, British, Christian, English, German, Spanish
Abbreviation of Lynnette who Accompanied Sir Gareth on a Knightly Quest in Arthurian Legend; Waterfall; A Cascade; Lake; Good Looking; Pretty
Girl/Female
Anglo, Australian, British, Christian, Danish, English, German, Spanish, Swedish
A Cascade; Pretty; Weak; Soft; Tender; Gentle
Boy/Male
English Persian
Wealthy man.
Boy/Male
Polish
Keeper of the treasure. Form of Caspar.
Girl/Female
American, Anglo, Australian, British, Chinese, Christian, Danish, Dutch, English, Greek, Hebrew, Jamaican, Spanish, Swedish
Waterfall; Pretty; A Cascade; Lake; Pool; Pond
Surname or Lastname
English (of Norman origin)
English (of Norman origin) : via Old French from the Germanic personal name Milo, of unknown etymology. The name was introduced to England by the Normans in the form Miles (oblique case Milon). In English documents of the Middle Ages the name sometimes appears in the Latinized form Milo (genitive Milonis), although the normal Middle English form was Mile, so the final -s must usually represent the possessive ending, i.e. ‘son or servant of Mile’.English : patronymic from the medieval personal name Mihel, an Old French contracted form of Michael.English : occupational name for a servant or retainer, from Latin miles ‘soldier’, sometimes used as a technical term in this sense in medieval documents.Irish (County Mayo) : when not the same as 1 or 3, an Anglicized form of Gaelic Ó Maolmhuire, Myles being used as the English equivalent of the Gaelic personal name Maol Muire (see Mullery).Jewish (eastern Ashkenazic) : unexplained.Dutch : variant of Miels, a variant of Miele 3.John Miles or Myles (c.1621–83), born probably in Herefordshire, England, was a pioneer American Baptist minister who emigrated to New England in 1662 and had a pastorate in Swansea, MA. Many of his descendants spell their name Myles.
Boy/Male
Hindu
One wearing yellow robes
Girl/Female
American, Anglo, Australian, British, Danish, English, Netherlands, Spanish
Waterfall; A Cascade; Variant of the Irish Gaelic Word Lann; House; Church; Form of Linda; Pretty; Lake
Surname or Lastname
Irish
Irish : variant of Mullen.English : from Old French Milon, an inflected form of the personal name Miles (see Miles 1).English : from Middle English milne, adjectival form of mille ‘mill’, or perhaps a topographic name for someone living in a lane leading to a mill, from Middle English mille, milne ‘mill’ + lane, lone ‘lane’.Dutch : patronymic from Miele 3.
Surname or Lastname
Americanized form of the Latin personal name Januarius or its Italian derivative Gennaro, which was borne by a number of early Christian saints, most famously a 3rd-century bishop of Benevento who became the patron of Naples.English
Americanized form of the Latin personal name Januarius or its Italian derivative Gennaro, which was borne by a number of early Christian saints, most famously a 3rd-century bishop of Benevento who became the patron of Naples.English : altered form of Janeway.In New England, a translation of French Janvier.
Boy/Male
Anglo, Australian, British, Dutch, English, French, German, Indian, Parsi, Swedish
Who Guards the Treasure; The Treasurer; Name of One of the Three Wise Men in the New Testament
CASPASE 3
CASPASE 3
CASPASE 3
CASPASE 3
CASPASE 3
CASPASE 3
CASPASE 3