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Pharmaceutical compound
4-PIOL, also known as 5-(4-piperidyl)isoxazol-3-ol, is a GABAA receptor agonist that was derived from THIP (gaboxadol). It is a non-ring-fused analogue
4-PIOL
Pharmaceutical compound
Thio-4-PIOL, also known as 5-(piperidin-4-yl)isothiazol-3-ol, is a GABAA receptor weak partial agonist or antagonist related to 4-PIOL. The drug acts
Thio-4-PIOL
Main inhibitory neurotransmitter in the mammalian brain
during postnatal development in the rat brain". PLoS ONE. 4 (2) e4371. Bibcode:2009PLoSO...4.4371P. doi:10.1371/journal.pone.0004371. PMC 2629816. PMID 19190758
GABA
Chemical compound
γ-Hydroxybutyric acid (GHB), also known as 4-hydroxybutanoic acid, is a naturally occurring neurotransmitter and a depressant drug. It is a precursor
Γ-Hydroxybutyric_acid
Chemical compound
colorless, water-miscible liquid with a pleasant odor. It is the simplest 4-carbon lactone. It is mainly used as an intermediate in the production of
Γ-Butyrolactone
Explosive chemical compound
plasticizers or phlegmatizers (desensitizers); it is the explosive agent in C-4 plastic explosive and a key ingredient in Semtex. It is stable in storage
RDX
Australian soccer player
Ariath Deng Piol (born 11 October 2004) is an Australian soccer player who plays as a striker for Real Salt Lake in Major League Soccer. Piol was born in
Ariath_Piol
Naturally occurring sedative and hallucinogen
acid, dihydromuscimol, thiomuscimol, piperidine-4-sulphonic acid (P4S), gaboxadol (THIP), 4-AHP, 4-PIOL, isonipecotic acid, guvacine, isoguvacine, THPO
Muscimol
Loop diuretic medication
(hrs) 2 Prolonged in congestive heart failure (mean 3.4 hrs) Prolonged in severe kidney failure (4 – 6 hrs) and anephric patients (1.5 – 9 hrs) Time to
Furosemide
Category of drug
Ibotenic acid Imidazole-4-acetic acid (IAA) Isoguvacine Isonipecotic acid Methylglyoxal Muscimol Nefiracetam Picamilon 4-PIOL Piperidine-4-sulfonic acid (P4S)
GABA_receptor_agonist
Group of antibiotics derived from fungi
174–81. ISBN 978-0-7020-5516-4. Kim KK, Chae DS (2015). "Nicolau syndrome: A literature review". World Journal of Dermatology. 4 (2): 103. doi:10.5314/wjd
Penicillin
Pharmaceutical compound
thiomuscimol (40), substituting the isoxazole ring for an isothiazole ring. 4- PIOL (41), a piperidine substituted isoxazole which led to low efficacy and
4-AHP
GABAB receptor agonist and phenibut analogue
4-Fluorophenibut (developmental code name CGP-11130; also known as β-(4-fluorophenyl)-γ-aminobutyric acid or β-(4-fluorophenyl)-GABA) is a GABAB receptor
4-Fluorophenibut
Ionotropic receptor and ligand-gated ion channel
gaboxadol, isoguvacine, muscimol, progabide, beta-alanine, taurine, piperidine-4-sulfonic acid (partial agonist). Orthosteric antagonists: bicuculline, gabazine
GABAA_receptor
Pharmaceutical compound
agonists to be identified. Isonipecotic acid (P4C) Imidazole-4-acetic acid (IAA) 4-PIOL Thio-4-PIOL Frølund B, Ebert B, Kristiansen U, Liljefors T, Krogsgaard-Larsen
Piperidine-4-sulfonic_acid
Pharmaceutical compound
Isonipecotic acid, also known as piperidine-4-carboxylic acid (P4C), is a conformationally constrained derivative of γ-aminobutyric acid (GABA) and a
Isonipecotic_acid
Medication to treat symptoms of narcolepsy
around 3.2 g/day) is lower than the one for the treatment of narcolepsy (4.5–9 g/night). In 2023, a PhD thesis conducted at the University of Amsterdam
Sodium_oxybate
CNS depressant medication
GABA analogues including baclofen (β-(4-chlorophenyl)-GABA), 4-fluorophenibut (β-(4-fluorophenyl)-GABA), tolibut (β-(4-methylphenyl)-GABA), pregabalin ((S)-β-isobutyl-GABA)
Phenibut
Chemical compound
resistance development. Fipronil (IUPAC name 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-(trifluoromethylsulfinyl)pyrazole-3-carbonitrile) is a white
Fipronil
Endogenous GABA precursor
N-Acetyl-γ-aminobutyric acid (N-acetyl-GABA), also known as N-acetyl-4-aminobutyric acid, is a metabolic intermediate in the biosynthesis of γ-aminobutyric
N-Acetyl-γ-aminobutyric_acid
Pharmaceutical compound
Phenibut Picamilon 4-PIOL P4S Progabide Propofol Quisqualamine SL-75102 Taurine TACA TAMP Terpenoids (e.g., borneol) Thio-4-PIOL Thiomuscimol Tolgabide
Gabamide
Anti-seizure medication
Neurosurgery. 130 (4): 1274–1282. doi:10.3171/2017.10.JNS172236. PMID 29701546. "Phenytoin". Lexi-Comp Online. Archived from the original on 4 March 2016. Retrieved
Phenytoin
Chemical compound
gamma-hydroxyvaleric acid in human urine samples". J Anal Toxicol. 37 (4): 250–4. doi:10.1093/jat/bkt013. PMID 23486087. Fred Smith (31 December 2004)
Γ-Valerolactone
Amino acid
average, compared to subjects who received a placebo (median 3 vs. median 4), fewer hospitalizations for sickle cell pain (median 2 vs. median 3), and
Glutamine
Fluoroquinolone antibiotic
1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-(oxo-alkyl)-1-piperazinyl ... – Google Patents". "Patent US4544658 – 1-Cyclopropyl-6-fluoro-1,4-dihydro-4
Ciprofloxacin
Chemical compound
(Z)-4-Amino-2-butenoic acid (cis-4-aminocrotonic acid) is a GABA receptor partial agonist selective for the GABAA-ρ (previously known as GABAC) subtype
(Z)-4-Amino-2-butenoic_acid
Chemical compound
Phenibut Picamilon 4-PIOL P4S Progabide Propofol Quisqualamine SL-75102 Taurine TACA TAMP Terpenoids (e.g., borneol) Thio-4-PIOL Thiomuscimol Tolgabide
Dihydropicrotoxinin
Chemical compound
Phenibut Picamilon 4-PIOL P4S Progabide Propofol Quisqualamine SL-75102 Taurine TACA TAMP Terpenoids (e.g., borneol) Thio-4-PIOL Thiomuscimol Tolgabide
EBOB
Index of chemical compounds with the same molecular formula
C8H12N2O2 (molar mass: 168.193 g/mol) may refer to: Hexamethylene diisocyanate 4-PIOL Pyridoxamine This set index page lists chemical structure articles associated
C8H12N2O2
Anticonvulsant drug
as of γ-hydroxybutyric acid (GHB), phenibut (β-phenyl-GABA), baclofen (β-(4-chlorophenyl)-GABA), and pregabalin (β-isobutyl-GABA). GABOB has been referred
Γ-Amino-β-hydroxybutyric_acid
Antibiotic medication
amenable to oral administration. Its elimination half-life is about 3 to 4 hours with 250 mg administered every 12 h, but increased to 5 to 7 h with
Clarithromycin
One of four stable isomers of butanediol
that uses a genetically modified organism. The biosynthesis proceeds via 4-hydroxybutyrate. Butane-1,4-diol is used industrially as a solvent[additional
1,4-Butanediol
Chemical compound
(androst-5-ene-3β,17β-diol), androstenedione (androst-4-ene-3,17-dione), and testosterone (androst-4-en-17β-ol-3-one). DHEA is the 5-dehydro analogue of
Dehydroepiandrosterone
Chemical compound
Phenibut Picamilon 4-PIOL P4S Progabide Propofol Quisqualamine SL-75102 Taurine TACA TAMP Terpenoids (e.g., borneol) Thio-4-PIOL Thiomuscimol Tolgabide
Γ-Hydroxybutyraldehyde
Group of four possible stereoisomers found in various plants: a.o., absinthe and mint
averaged 25.4 mg/L A 2005 study recreated three 1899 high-wormwood recipes and tested with GC–MS, and found that the highest contained 4.3 mg/L thujone
Thujone
Antibiotic
proper monitoring of the infant, combined with delaying breastfeeding for 4–6 hours after taking levofloxacin. Levofloxacin is not approved in most countries
Levofloxacin
Protein-coding gene in humans
Phenibut Picamilon 4-PIOL P4S Progabide Propofol Quisqualamine SL-75102 Taurine TACA TAMP Terpenoids (e.g., borneol) Thio-4-PIOL Thiomuscimol Tolgabide
GABRA6
Chemical compound
synthesis of cicutoxin was reported in 1955. Though the overall yield was only 4% and the product was the racemic mixture, the synthesis has been described
Cicutoxin
Chemical compound
Phenibut Picamilon 4-PIOL P4S Progabide Propofol Quisqualamine SL-75102 Taurine TACA TAMP Terpenoids (e.g., borneol) Thio-4-PIOL Thiomuscimol Tolgabide
Ro15-4513
Chemical compound
include γ-aminobutyric acid (GABA), muscimol, 4-AHP, thio-THIP, aza-THIP, iso-THIP, THAZ, THPO, piperidine-4-sulfonic acid (P4S), isonipecotic acid, and
Gaboxadol
Muscle relaxant medication
excreted unchanged by the kidneys. The serum half-life of baclofen is roughly 2–4 hours; however, one source gives a half-life of 6.8 hours, using a more complex
Baclofen
Hallucinogenic drug
include 4-AHP, dihydromuscimol, imidazole-4-acetic acid (IAA, IMA), isoguvacine, isonipecotic acid, methylglyoxal, nefiracetam (DM-9384), 4-PIOL, piperidine-4-sulfonic
GABAA_receptor_agonist
Class of chemical compound
(in the narrow sense) have the 2-phenylchromen-4-one backbone, isoflavonoids have the 3-phenylchromen-4-one backbone with no hydroxyl group substitution
Isoflavonoid
Chemical compound
green and ripened pineapple (Ananas comosus). J Agric Food Chem 1992; 40:599-603. doi:10.1021/jf00016a014 常温下4-乙酰氧基丁酸乙酯的催化合成方法. 1994. CN1047589C v t e
Ethyl_acetoxy_butanoate
Chemical compound
Phenibut Picamilon 4-PIOL P4S Progabide Propofol Quisqualamine SL-75102 Taurine TACA TAMP Terpenoids (e.g., borneol) Thio-4-PIOL Thiomuscimol Tolgabide
L-655,708
Chemical compound
chemical was proved to be toxic to the local rodent population for up to 4 years. Continued experiments conducted by the U.S. Forest Service found no
Tetramethylenedisulfotetramine
Tetramethylenedisulfotetramine
Chemical compound
(1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid (TPMPA) is a GABA antagonist selective for the GABAA-ρ (previously known as GABAC) subtype. Li,
(1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid
(1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic_acid
Class of transport proteins
acid] and blocked by TPMPA [(1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic acid]; not sensitive to the GABAB agonist baclofen nor
GABAA-rho_receptor
GABA receptor antagonist drug and benzodiazepine antidote
hostility and aggression in patients who had been free of benzodiazepines for 4–266 weeks. This may suggest a role for flumazenil in treating protracted benzodiazepine
Flumazenil
Combination drug
8 March 2026. Jazz Pharmaceuticals. Jazz Pharmaceuticals showcases Phase 4 data demonstrating Xywav® treatment effects and real-world evidence. Published
Xywav
Affecting GABA systems in the brain
Phenibut Picamilon 4-PIOL P4S Progabide Propofol Quisqualamine SL-75102 Taurine TACA TAMP Terpenoids (e.g., borneol) Thio-4-PIOL Thiomuscimol Tolgabide
GABAergic
Organic compound and GABA analogue and precursor
4-Amino-1-butanol, or 4-aminobutanol, also known as 4-hydroxybutylamine, is an alkanolamine and an analogue and precursor of the neurotransmitter γ-aminobutyric
4-Amino-1-butanol
Class of chemical compounds
Phenibut Picamilon 4-PIOL P4S Progabide Propofol Quisqualamine SL-75102 Taurine TACA TAMP Terpenoids (e.g., borneol) Thio-4-PIOL Thiomuscimol Tolgabide
Bicyclic_phosphate
Chemical compound
mechanism for aristolochic acid nephropathy". Biochem Biophys Res Commun. 423 (4): 832–7. doi:10.1016/j.bbrc.2012.06.049. PMID 22713464. Sullivan, Carl J.;
Methylglyoxal
Chemical compound
Phenibut Picamilon 4-PIOL P4S Progabide Propofol Quisqualamine SL-75102 Taurine TACA TAMP Terpenoids (e.g., borneol) Thio-4-PIOL Thiomuscimol Tolgabide
Iomazenil
Protein-coding gene in humans
I/M site. The amino acid change occurs in the transmembrane domain 3. The 4 transmembrane domains of each of the 5 subunits that make up the receptor
GABRA3
Antibiotic to treat bacterial infections
excretion, as well. Plasma elimination half-life is around 4 to 5 hours in patients and 6.4 to 7.4 hours in elderly patients. Ofloxacin is a racemic mixture
Ofloxacin
Pharmaceutical compound
been extensively used in animal studies. Thiomuscimol Gaboxadol (THIP) 4-AHP 4-PIOL Krogsgaard-Larsen P, Frølund B, Liljefors T, Ebert B (October 2004).
Dihydromuscimol
Chemical compound
Phenibut Picamilon 4-PIOL P4S Progabide Propofol Quisqualamine SL-75102 Taurine TACA TAMP Terpenoids (e.g., borneol) Thio-4-PIOL Thiomuscimol Tolgabide
Isoguvacine
Chemical compound
Phenibut Picamilon 4-PIOL P4S Progabide Propofol Quisqualamine SL-75102 Taurine TACA TAMP Terpenoids (e.g., borneol) Thio-4-PIOL Thiomuscimol Tolgabide
Loreclezole
Carboxylic acid – CH3(CH2)3COOH
free dictionary. List of saturated fatty acids List of carboxylic acids 4-Hydroxy-4-methylpentanoic acid Pivalic acid (2,2-dimethylpropanoic acid) 3-Methylbutanoic
Valeric_acid
Pharmaceutical compound
as a novel designer drug online in 2024. Dihydromuscimol Thio-THIP Thio-4-PIOL 4-AHP Lykkeberg J, Krogsgaard-Larsen P, Garegg PJ, Norberg T, Pilotti AM
Thiomuscimol
Protein-coding gene in humans
promoter of the human GABAA receptor alpha 1 subunit gene". J. Neurochem. 62 (4): 1643–1646. doi:10.1046/j.1471-4159.1994.62041643.x. PMID 8133292. S2CID 84579971
Gamma-aminobutyric acid receptor subunit alpha-1
Gamma-aminobutyric_acid_receptor_subunit_alpha-1
Chemical compound
Phenibut Picamilon 4-PIOL P4S Progabide Propofol Quisqualamine SL-75102 Taurine TACA TAMP Terpenoids (e.g., borneol) Thio-4-PIOL Thiomuscimol Tolgabide
Isopregnanolone
Inhalational anaesthetic
analgesic effects in mice". Pharmacological Reports. 62 (4): 621–626. doi:10.1016/s1734-1140(10)70319-4. PMID 20885002. Burns WB, Eger EI (August 2011). "Ross
Sevoflurane
Chemical compound
receptor: the action of (+)-ROD188". British Journal of Pharmacology. 131 (4): 843–850. doi:10.1038/sj.bjp.0703558. PMC 1572371. PMID 11030736. Sigel E
ROD-188
Class of drugs
the neurotransmitter gamma-Aminobutyric acid (GABA) (the IUPAC of which is 4-aminobutanoic acid). Many GABA analogues are used as drugs, especially as
GABA_analogue
Chemical compound
Phenibut Picamilon 4-PIOL P4S Progabide Propofol Quisqualamine SL-75102 Taurine TACA TAMP Terpenoids (e.g., borneol) Thio-4-PIOL Thiomuscimol Tolgabide
Nefiracetam
Pharmaceutical compound
obstructive sleep apnea and narcolepsy". Expert Opinion on Emerging Drugs. 20 (4): 571–582. doi:10.1517/14728214.2015.1115480. PMID 26558298. JZP-386 is a
JZP-386
Chemical compound
mechanism of the pentylenetetrazol convulsions". Acta Biologica Hungarica. 38 (3–4): 349–361. PMID 3503442. Morris G, Heiland M, Lamottke K, Guan H, Hill TD
Pentylenetetrazol
Antihypertensive drug of the calcium channel blocker class
Internal Medicine (21st ed.). New York: McGraw Hill. ISBN 978-1-264-26850-4. Huang RI, Patel P, Walinsky P, Fischman DL, Ogilby JD, Awar M, et al. (November
Nicardipine
Chemical compound
Phenibut Picamilon 4-PIOL P4S Progabide Propofol Quisqualamine SL-75102 Taurine TACA TAMP Terpenoids (e.g., borneol) Thio-4-PIOL Thiomuscimol Tolgabide
Bamaluzole
Antiandrogen medication used in treatment of prostate cancer
difference), while another found respective IC50 values of 36 nM and 159 nM (4.4-fold difference). In accordance, clinical findings suggest that enzalutamide
Enzalutamide
Protein found in humans
HB, Cook S, Dawson GR, et al. (March 2002). "6,7-Dihydro-2-benzothiophen-4(5H)-ones: a novel class of GABA-A alpha5 receptor inverse agonists". Journal
GABRA5
Chemical compound
Phenibut Picamilon 4-PIOL P4S Progabide Propofol Quisqualamine SL-75102 Taurine TACA TAMP Terpenoids (e.g., borneol) Thio-4-PIOL Thiomuscimol Tolgabide
PWZ-029
Chemical compound
Phenibut Picamilon 4-PIOL P4S Progabide Propofol Quisqualamine SL-75102 Taurine TACA TAMP Terpenoids (e.g., borneol) Thio-4-PIOL Thiomuscimol Tolgabide
3-APPA
Chemical compound
Phenibut Picamilon 4-PIOL P4S Progabide Propofol Quisqualamine SL-75102 Taurine TACA TAMP Terpenoids (e.g., borneol) Thio-4-PIOL Thiomuscimol Tolgabide
Α5IA
Chemical compound
Azodicarbonamide-Treated Flour: A Model Study". J. Agric. Food Chem. 52 (18): 5730–4. Bibcode:2004JAFC...52.5730B. doi:10.1021/jf0495385. PMID 15373416. Maria
Semicarbazide
Chemical compound
Phenibut Picamilon 4-PIOL P4S Progabide Propofol Quisqualamine SL-75102 Taurine TACA TAMP Terpenoids (e.g., borneol) Thio-4-PIOL Thiomuscimol Tolgabide
Bicuculline
Chemical compound
Phenibut Picamilon 4-PIOL P4S Progabide Propofol Quisqualamine SL-75102 Taurine TACA TAMP Terpenoids (e.g., borneol) Thio-4-PIOL Thiomuscimol Tolgabide
Monastrol
Chemical compound
John E. (February 1979). "Structure-toxicity relationships of 1-substituted-4-alkyl-2,6,7-trioxabicyclo[2.2.2.]octanes". Toxicology and Applied Pharmacology
IPTBO
Organochlorine chemical and an isomer of hexachlorocyclohexane
original (PDF) on 2007-06-07. LINDANE: Risk Profile. UNEP/POPS/POPRC.2/17/Add.4, Stockholm Convention of Persistent Organic Pollutants "Lindane Reregistration
Lindane
Chemical compound
acid): systematic review of the literature". Nutrition Journal. 4: 3. doi:10.1186/1475-2891-4-3. PMC 548511. PMID 15673472. Santillo MF, Sprando RL (April
Picamilon
Chemical compound
Phenibut Picamilon 4-PIOL P4S Progabide Propofol Quisqualamine SL-75102 Taurine TACA TAMP Terpenoids (e.g., borneol) Thio-4-PIOL Thiomuscimol Tolgabide
Lesogaberan
Chemical compound
Baicalein Chaenomeles speciosa Urolithin A 5,7-Dihydroxy-6-methoxy-2-(4-phenoxyphenyl)chromen-4-one Li H, Chen F (2005). "Isolation and purification of baicalein
Oroxylin_A
Chemical compound
developmental code names Bio 66, U-1258), or 11-oxoprogesterone, also known as pregn-4-ene-3,11,20-trione, is a pregnane steroid related to cortisone (11-keto-17α
11-Ketoprogesterone
Carbapenem antibiotic
Resistance" (PDF). Archived from the original (PDF) on 3 March 2016. Retrieved 4 May 2012. "Imipenem-Cilastatin". LiverTox: Clinical and Research Information
Imipenem
Chemical compound
Aceburic acid (INN), also known as 4-acetoxybutanoic acid or 4-hydroxybutyric acid acetate, is a drug described as an analgesic which was never marketed
Aceburic_acid
Chemical compound
Phenibut Picamilon 4-PIOL P4S Progabide Propofol Quisqualamine SL-75102 Taurine TACA TAMP Terpenoids (e.g., borneol) Thio-4-PIOL Thiomuscimol Tolgabide
ORG-20599
Chemical compound
and recombinant gamma-aminobutyric acid(B) receptors by 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its aldehyde analog CGP13501"
CGP-7930
Chemical compound
Phenibut Picamilon 4-PIOL P4S Progabide Propofol Quisqualamine SL-75102 Taurine TACA TAMP Terpenoids (e.g., borneol) Thio-4-PIOL Thiomuscimol Tolgabide
ADX-71441
Chemical compound
Phenibut Picamilon 4-PIOL P4S Progabide Propofol Quisqualamine SL-75102 Taurine TACA TAMP Terpenoids (e.g., borneol) Thio-4-PIOL Thiomuscimol Tolgabide
BHF-177
Naturally occurring glutamate receptor agonist neurotoxin
brains is kept frozen in a phosphate-buffered Saline Solution at a pH of 7.4, and can be kept for up to a year with no loss in toxicity. Injection of
Ibotenic_acid
Pharmaceutical compound
Sexual Interest and Arousal Disorder". Current Sexual Health Reports. 9 (4): 192–199. doi:10.1007/s11930-017-0124-3. PMC 5711968. PMID 29225554. BP101
Orenetide
Inhalational anesthesia medication
atmospheric lifetime of desflurane at 14.1 years is similar to methane at 12.4 years. Some argue that GWP is not a suitable metric for such short lived climate
Desflurane
Chemical compound
in Hemlock Water Dropwort Poisoning". Human Toxicology. 4 (4): 355–364. Bibcode:1985HETox...4..355K. doi:10.1177/096032718500400401. PMID 4018815. S2CID 19201342
Oenanthotoxin
Chemical compound
Aminooxyacetic acid, often abbreviated AOA or AOAA, is a compound that inhibits 4-aminobutyrate aminotransferase (GABA-T) activity in vitro and in vivo, leading
Aminooxyacetic_acid
Chemical compound
Phenibut Picamilon 4-PIOL P4S Progabide Propofol Quisqualamine SL-75102 Taurine TACA TAMP Terpenoids (e.g., borneol) Thio-4-PIOL Thiomuscimol Tolgabide
Hopantenic_acid
Chemical compound
Coque du Levant, Menispermum cocculus". Bulletin de Pharmacie (in French). 4: 5–34. Menispermum cocculus" has been renamed "Anamirta cocculus" (Boullay
Picrotoxin
Chemical compound
chemical and physical properties of Indoklon". Journal of Neuropsychiatry. 4: 153–6. PMID 13989984. Krantz JC, Loecher CK (1967). "ANESTHESIA LXX: effect
Flurothyl
4 PIOL
4 PIOL
4 PIOL
4 PIOL
4 PIOL
4 PIOL
4 PIOL
4 PIOL
4 PIOL