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SB 408124

  • SB-408124

    • Chemical compound

    SB-408124 is a drug which is a non-peptide antagonist selective for the orexin receptor subtype OX1, with around 70x selectivity for OX1 over OX2 receptors

    SB-408124

    SB-408124

    SB-408124

  • Oveporexton

    • Medication

    Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102

    Oveporexton

    Oveporexton

    Oveporexton

  • Orexin antagonist

    • Class of drugs

    antagonist SB-334867 – first non-peptide selective OX1 antagonist – has been shown to produce sedative and anorectic effects in animals SB-408124 – selective

    Orexin antagonist

    Orexin_antagonist

  • SB-334867

    • Chemical compound

    SB-334867 is an orexin antagonist. It was the first non-peptide antagonist developed that is selective for the orexin receptor subtype OX1, with around

    SB-334867

    SB-334867

    SB-334867

  • Seltorexant

    • Experimental anti-insomnia drug

    Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102

    Seltorexant

    Seltorexant

    Seltorexant

  • Lemborexant

    • Chemical compound

    Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102

    Lemborexant

    Lemborexant

    Lemborexant

  • SB-649868

    • Chemical compound

    SB-649868 is a dual orexin receptor antagonist that was being developed by GlaxoSmithKline as a treatment for insomnia. A phase I clinical trial evaluated

    SB-649868

    SB-649868

    SB-649868

  • Almorexant

    • Orexin antagonist compound

    Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102

    Almorexant

    Almorexant

    Almorexant

  • Balumorexton

    • Pharmaceutical compound

    Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102

    Balumorexton

    Balumorexton

    Balumorexton

  • Orexin receptor

    • G-protein-coupled receptor

    RTIOX-276 – selective OX1 receptor antagonist SB-334867 – selective OX1 receptor antagonist SB-408124 – selective OX1 receptor antagonist Seltorexant

    Orexin receptor

    Orexin_receptor

  • Vornorexant

    • Chemical compound

    Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102

    Vornorexant

    Vornorexant

    Vornorexant

  • Danavorexton

    • Chemical compound

    Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102

    Danavorexton

    Danavorexton

    Danavorexton

  • Fazamorexant

    • Orexin receptor antagonist

    Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102

    Fazamorexant

    Fazamorexant

    Fazamorexant

  • Cleminorexton

    • Pharmaceutical compound

    Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102

    Cleminorexton

    Cleminorexton

    Cleminorexton

  • Daridorexant

    • Medication used to treat insomnia

    Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102

    Daridorexant

    Daridorexant

    Daridorexant

  • Rocavorexant

    • Pharmaceutical compound

    Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102

    Rocavorexant

    Rocavorexant

    Rocavorexant

  • Alixorexton

    • Novel chemistry compound

    Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102

    Alixorexton

    Alixorexton

    Alixorexton

  • Orexin

    • Neuropeptide that regulates arousal, wakefulness, and appetite

    example, blocking the orexin-1 receptor with the selective orexin antagonist SB-334,867 reduced nicotine self-administration in rats; this may explain why

    Orexin

    Orexin

    Orexin

  • Orexin-A

    • Stimulating neuropeptide

    Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102

    Orexin-A

    Orexin-A

  • Ledasorexton

    • Pharmaceutical compound

    Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102

    Ledasorexton

    Ledasorexton

    Ledasorexton

  • Tebideutorexant

    • Chemical compound

    Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102

    Tebideutorexant

    Tebideutorexant

    Tebideutorexant

  • ACT-335827

    • Chemical compound

    Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102

    ACT-335827

    ACT-335827

    ACT-335827

  • Orexin receptor type 2

    • Protein-coding gene in the species Homo sapiens

    approximately 5- to 10-fold selectivity for the OX2 receptor over the OX1 receptor SB-668875 – selective OX2 receptor agonist Suntinorexton – selective OX2 receptor

    Orexin receptor type 2

    Orexin receptor type 2

    Orexin_receptor_type_2

  • EMPA (drug)

    • Chemical compound

    Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102

    EMPA (drug)

    EMPA (drug)

    EMPA_(drug)

  • Suvorexant

    • Medication used to treat insomnia

    doi:10.1002/ana.26641. PMC 10330114. PMID 36897120. S2CID 257444346. Schipper SB, Van Veen MM, Elders PJ, van Straten A, Van Der Werf YD, Knutson KL, et al

    Suvorexant

    Suvorexant

    Suvorexant

  • Firazorexton

    • Chemical compound

    Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102

    Firazorexton

    Firazorexton

    Firazorexton

  • Suntinorexton

    • Chemical compound

    Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102

    Suntinorexton

    Suntinorexton

    Suntinorexton

  • JNJ-10397049

    • Chemical compound

    Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102

    JNJ-10397049

    JNJ-10397049

    JNJ-10397049

  • List of signaling peptide/protein receptor modulators

    • Filorexant Lemborexant Nemorexant RTIOX-276 SB-334867 SB-408124 SB-649868 Suvorexant TCS-1102 Agonists: Orexin (A, B) SB-668875 Antagonists: ACT-335827 ACT-462206

    List of signaling peptide/protein receptor modulators

    List_of_signaling_peptide/protein_receptor_modulators

  • ACT-462206

    • Chemical compound

    Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102

    ACT-462206

    ACT-462206

    ACT-462206

  • Hypocretin (orexin) receptor 1

    • Protein-coding gene in the species Homo sapiens

    RTIOX-276 - selective OX1 antagonist SB-334,867 - selective OX1 antagonist SB-408,124 - selective OX1 antagonist SB-649,868 - dual OX1 and OX2 antagonist

    Hypocretin (orexin) receptor 1

    Hypocretin (orexin) receptor 1

    Hypocretin_(orexin)_receptor_1

  • Nivasorexant

    • Chemical compound

    Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102

    Nivasorexant

    Nivasorexant

    Nivasorexant

  • Filorexant

    • Chemical compound

    Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102

    Filorexant

    Filorexant

    Filorexant

  • RTIOX-276

    • Orexin antagonist

    Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102

    RTIOX-276

    RTIOX-276

    RTIOX-276

  • TCS-OX2-29

    • Orexin antagonist

    Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant (C4X-3256; INDV-2000 RTIOX-276 SB-334867 SB-408124 Suvorexant TCS-1102

    TCS-OX2-29

    TCS-OX2-29

    TCS-OX2-29

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