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ALMOREXANT

  • Almorexant

    • Orexin antagonist compound

    Almorexant (INN), also known by its development code ACT-078573, is an orexin antagonist, acting as a competitive antagonist of the OX1 and OX2 orexin

    Almorexant

    Almorexant

    Almorexant

  • Orexin receptor

    • G-protein-coupled receptor

    ACT-462206, currently in human clinical trials. Another drug in development, almorexant (ACT-078573) by Actelion, was abandoned due to adverse effects. Lemborexant

    Orexin receptor

    Orexin_receptor

  • Orexin antagonist

    • Class of drugs

    phase 2 – half-life 14–25 hours ACT-335827 – selective OX1 antagonist Almorexant (ACT-078573) – dual OX1 and OX2 antagonist – half-life 13–19 hours – development

    Orexin antagonist

    Orexin_antagonist

  • Eszopiclone

    • Hypnotic medication

    through, and GSK instead launched a $3.3 billion deal to market Actelion's almorexant sleeping tablet, which entered phase 3 medical trials before development

    Eszopiclone

    Eszopiclone

    Eszopiclone

  • Oveporexton

    • Medication

    AEX-5 AEX-19 AEX-24 Orexin (A, B) Antagonists: ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant

    Oveporexton

    Oveporexton

    Oveporexton

  • Orexin-A

    • Stimulating neuropeptide

    AEX-5 AEX-19 AEX-24 Orexin (A, B) Antagonists: ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant

    Orexin-A

    Orexin-A

  • Seltorexant

    • Experimental anti-insomnia drug

    AEX-5 AEX-19 AEX-24 Orexin (A, B) Antagonists: ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant

    Seltorexant

    Seltorexant

    Seltorexant

  • ACT-335827

    • Chemical compound

    AEX-5 AEX-19 AEX-24 Orexin (A, B) Antagonists: ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant

    ACT-335827

    ACT-335827

    ACT-335827

  • Balumorexton

    • Pharmaceutical compound

    AEX-5 AEX-19 AEX-24 Orexin (A, B) Antagonists: ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant

    Balumorexton

    Balumorexton

    Balumorexton

  • Lemborexant

    • Chemical compound

    AEX-5 AEX-19 AEX-24 Orexin (A, B) Antagonists: ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant

    Lemborexant

    Lemborexant

    Lemborexant

  • Nivasorexant

    • Chemical compound

    AEX-5 AEX-19 AEX-24 Orexin (A, B) Antagonists: ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant

    Nivasorexant

    Nivasorexant

    Nivasorexant

  • SB-408124

    • Chemical compound

    AEX-5 AEX-19 AEX-24 Orexin (A, B) Antagonists: ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant

    SB-408124

    SB-408124

    SB-408124

  • EMPA (drug)

    • Chemical compound

    (September 2009). "Biochemical and electrophysiological characterization of almorexant, a dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist: comparison

    EMPA (drug)

    EMPA (drug)

    EMPA_(drug)

  • Suntinorexton

    • Chemical compound

    AEX-5 AEX-19 AEX-24 Orexin (A, B) Antagonists: ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant

    Suntinorexton

    Suntinorexton

    Suntinorexton

  • Suvorexant

    • Medication used to treat insomnia

    followed by lemborexant in 2019 and daridorexant in 2022. Development of almorexant (ACT-078573) and filorexant (MK-6096) was discontinued, while seltorexant

    Suvorexant

    Suvorexant

    Suvorexant

  • Filorexant

    • Chemical compound

    AEX-5 AEX-19 AEX-24 Orexin (A, B) Antagonists: ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant

    Filorexant

    Filorexant

    Filorexant

  • List of investigational insomnia drugs

    • Investigational insomnia drugs

    (NNC 01-0687; CEE-03-310; NNC-687) – dopamine D1 receptor antagonist Almorexant (ACT-078573) – orexin OX1 and OX2 receptor antagonist ANPH-101 – undefined

    List of investigational insomnia drugs

    List_of_investigational_insomnia_drugs

  • Orexin

    • Neuropeptide that regulates arousal, wakefulness, and appetite

    AEX-5 AEX-19 AEX-24 Orexin (A, B) Antagonists: ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant

    Orexin

    Orexin

    Orexin

  • Orexin receptor type 2

    • Protein-coding gene in the species Homo sapiens

    selective OX2 receptor agonist Cleminorexton - selective OX2 receptor agonist Almorexant - Dual OX1 and OX2 antagonist Daridorexant (nemorexant) - Dual OX1 and

    Orexin receptor type 2

    Orexin receptor type 2

    Orexin_receptor_type_2

  • Tebideutorexant

    • Chemical compound

    AEX-5 AEX-19 AEX-24 Orexin (A, B) Antagonists: ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant

    Tebideutorexant

    Tebideutorexant

    Tebideutorexant

  • Firazorexton

    • Chemical compound

    AEX-5 AEX-19 AEX-24 Orexin (A, B) Antagonists: ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant

    Firazorexton

    Firazorexton

    Firazorexton

  • SB-649868

    • Chemical compound

    with the last study posted to ClinicalTrials.gov completed in 2010. Almorexant Filorexant Lemborexant Suvorexant Renzulli C, Nash M, Wright M, Thomas

    SB-649868

    SB-649868

    SB-649868

  • Rocavorexant

    • Pharmaceutical compound

    AEX-5 AEX-19 AEX-24 Orexin (A, B) Antagonists: ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant

    Rocavorexant

    Rocavorexant

    Rocavorexant

  • Danavorexton

    • Chemical compound

    AEX-5 AEX-19 AEX-24 Orexin (A, B) Antagonists: ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant

    Danavorexton

    Danavorexton

    Danavorexton

  • TCS-OX2-29

    • Orexin antagonist

    specificity of action compared to non-selective orexin antagonists like almorexant. Hirose M, Egashira S, Goto Y, Hashihayata T, Ohtake N, Iwaasa H, et al

    TCS-OX2-29

    TCS-OX2-29

    TCS-OX2-29

  • Alixorexton

    • Novel chemistry compound

    AEX-5 AEX-19 AEX-24 Orexin (A, B) Antagonists: ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant

    Alixorexton

    Alixorexton

    Alixorexton

  • Daridorexant

    • Medication used to treat insomnia

    AEX-5 AEX-19 AEX-24 Orexin (A, B) Antagonists: ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant

    Daridorexant

    Daridorexant

    Daridorexant

  • Cleminorexton

    • Pharmaceutical compound

    AEX-5 AEX-19 AEX-24 Orexin (A, B) Antagonists: ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant

    Cleminorexton

    Cleminorexton

    Cleminorexton

  • Ledasorexton

    • Pharmaceutical compound

    AEX-5 AEX-19 AEX-24 Orexin (A, B) Antagonists: ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant

    Ledasorexton

    Ledasorexton

    Ledasorexton

  • Metofoline

    • Chemical compound

    with significantly increased analgesic activity of over x50 codeine. Almorexant Papaverine US patent 3067203, "Tetrahydroisoquinoline Derivatives", issued

    Metofoline

    Metofoline

    Metofoline

  • Fazamorexant

    • Orexin receptor antagonist

    AEX-5 AEX-19 AEX-24 Orexin (A, B) Antagonists: ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant

    Fazamorexant

    Fazamorexant

    Fazamorexant

  • RTIOX-276

    • Orexin antagonist

    AEX-5 AEX-19 AEX-24 Orexin (A, B) Antagonists: ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant

    RTIOX-276

    RTIOX-276

    RTIOX-276

  • Hypocretin (orexin) receptor 1

    • Protein-coding gene in the species Homo sapiens

    64% identity with OX2. Orexin-A ACT-335827 - selective OX1 antagonist Almorexant - dual OX1 and OX2 antagonist Lemborexant - dual OX1 and OX2 antagonist

    Hypocretin (orexin) receptor 1

    Hypocretin (orexin) receptor 1

    Hypocretin_(orexin)_receptor_1

  • Vornorexant

    • Chemical compound

    AEX-5 AEX-19 AEX-24 Orexin (A, B) Antagonists: ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant

    Vornorexant

    Vornorexant

    Vornorexant

  • JNJ-10397049

    • Chemical compound

    AEX-5 AEX-19 AEX-24 Orexin (A, B) Antagonists: ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant

    JNJ-10397049

    JNJ-10397049

    JNJ-10397049

  • SB-334867

    • Chemical compound

    AEX-5 AEX-19 AEX-24 Orexin (A, B) Antagonists: ACT-335827 ACT-462206 Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant

    SB-334867

    SB-334867

    SB-334867

  • List of signaling peptide/protein receptor modulators

    • here instead. Agonists: Orexin (A, B) Antagonists: ACT-335827 ACT-462206 Almorexant Filorexant Lemborexant Nemorexant RTIOX-276 SB-334867 SB-408124 SB-649868

    List of signaling peptide/protein receptor modulators

    List_of_signaling_peptide/protein_receptor_modulators

  • List of drugs: Al

    • almestrone (INN) alminoprofen (INN) almitrine (INN) almokalant (INN) almorexant INN almotriptan (INN) almoxatone (INN) almurtide (INN) alnespirone (INN)

    List of drugs: Al

    List_of_drugs:_Al

  • ACT-462206

    • Chemical compound

    dual orexin receptor antagonist, comparing its pharmacodynamics with almorexant". Journal of Clinical Pharmacology. 54 (9): 979–986. doi:10.1002/jcph

    ACT-462206

    ACT-462206

    ACT-462206

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