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FILOREXANT

  • Filorexant

    • Chemical compound

    Filorexant (INNTooltip International Nonproprietary Name, USANTooltip United States Approved Name; developmental code name MK-6096) is an orexin antagonist

    Filorexant

    Filorexant

    Filorexant

  • Orexin antagonist

    • Class of drugs

    the drug was abandoned in January 2011 EMPA – selective OX2 antagonist Filorexant (MK-6096) – dual OX1 and OX2 antagonist – half-life 3–6 hours – development

    Orexin antagonist

    Orexin_antagonist

  • Ledasorexton

    • Pharmaceutical compound

    Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant

    Ledasorexton

    Ledasorexton

    Ledasorexton

  • Orexin receptor

    • G-protein-coupled receptor

    Daridorexant (Quviviq; ACT-541468) – dual OX1 and OX2 receptor antagonist Filorexant (MK-6096) – dual OX1 and OX2 receptor antagonist GSK-649868 (SB-649868)

    Orexin receptor

    Orexin_receptor

  • Orexin-A

    • Stimulating neuropeptide

    Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant

    Orexin-A

    Orexin-A

  • Lemborexant

    • Chemical compound

    Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant

    Lemborexant

    Lemborexant

    Lemborexant

  • Oveporexton

    • Medication

    Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant

    Oveporexton

    Oveporexton

    Oveporexton

  • ACT-335827

    • Chemical compound

    Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant

    ACT-335827

    ACT-335827

    ACT-335827

  • Suvorexant

    • Medication used to treat insomnia

    and daridorexant in 2022. Development of almorexant (ACT-078573) and filorexant (MK-6096) was discontinued, while seltorexant (MIN-202, JNJ-42847922)

    Suvorexant

    Suvorexant

    Suvorexant

  • Suntinorexton

    • Chemical compound

    Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant

    Suntinorexton

    Suntinorexton

    Suntinorexton

  • Nivasorexant

    • Chemical compound

    Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant

    Nivasorexant

    Nivasorexant

    Nivasorexant

  • C24H25FN4O2

    • Index of chemical compounds with the same molecular formula

    molecular formula C24H25FN4O2 (molar mass: 420.479 g/mol) may refer to: Filorexant (MK-6096) Ocaperidone This set index page lists chemical structure articles

    C24H25FN4O2

    C24H25FN4O2

  • List of investigational insomnia drugs

    • Investigational insomnia drugs

    Osemozotan (MKC-242; MN-305) – serotonin 5-HT1A receptor agonist Filorexant (MK-6096) – orexin OX1 and OX2 receptor antagonist HEC-83518 – orexin

    List of investigational insomnia drugs

    List_of_investigational_insomnia_drugs

  • List of investigational headache and migraine drugs

    • Investigational antimigraine drugs

    (E4; Donesta) – estrogen (estrogen receptor agonist) – migraine [48] Filorexant (MK-6096) – orexin OX1 and OX2 receptor antagonist – migraine [49] Flunarizine

    List of investigational headache and migraine drugs

    List_of_investigational_headache_and_migraine_drugs

  • Seltorexant

    • Experimental anti-insomnia drug

    Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant

    Seltorexant

    Seltorexant

    Seltorexant

  • Orexin receptor type 2

    • Protein-coding gene in the species Homo sapiens

    (nemorexant) - Dual OX1 and OX2 antagonist EMPA - Selective OX2 antagonist Filorexant - Dual OX1 and OX2 antagonist JNJ-10397049 (600x selective for OX2 over

    Orexin receptor type 2

    Orexin receptor type 2

    Orexin_receptor_type_2

  • Firazorexton

    • Chemical compound

    Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant

    Firazorexton

    Firazorexton

    Firazorexton

  • Danavorexton

    • Chemical compound

    Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant

    Danavorexton

    Danavorexton

    Danavorexton

  • Rocavorexant

    • Pharmaceutical compound

    Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant

    Rocavorexant

    Rocavorexant

    Rocavorexant

  • Balumorexton

    • Pharmaceutical compound

    Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant

    Balumorexton

    Balumorexton

    Balumorexton

  • Orexin

    • Neuropeptide that regulates arousal, wakefulness, and appetite

    Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant

    Orexin

    Orexin

    Orexin

  • Daridorexant

    • Medication used to treat insomnia

    Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant

    Daridorexant

    Daridorexant

    Daridorexant

  • Almorexant

    • Orexin antagonist compound

    Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant

    Almorexant

    Almorexant

    Almorexant

  • Cleminorexton

    • Pharmaceutical compound

    Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant

    Cleminorexton

    Cleminorexton

    Cleminorexton

  • Alixorexton

    • Novel chemistry compound

    Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant

    Alixorexton

    Alixorexton

    Alixorexton

  • EMPA (drug)

    • Chemical compound

    Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant

    EMPA (drug)

    EMPA (drug)

    EMPA_(drug)

  • Tebideutorexant

    • Chemical compound

    Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant

    Tebideutorexant

    Tebideutorexant

    Tebideutorexant

  • RTIOX-276

    • Orexin antagonist

    Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant

    RTIOX-276

    RTIOX-276

    RTIOX-276

  • Fazamorexant

    • Orexin receptor antagonist

    Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant

    Fazamorexant

    Fazamorexant

    Fazamorexant

  • Vornorexant

    • Chemical compound

    Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant

    Vornorexant

    Vornorexant

    Vornorexant

  • SB-649868

    • Chemical compound

    last study posted to ClinicalTrials.gov completed in 2010. Almorexant Filorexant Lemborexant Suvorexant Renzulli C, Nash M, Wright M, Thomas S, Zamuner

    SB-649868

    SB-649868

    SB-649868

  • List of signaling peptide/protein receptor modulators

    • Agonists: Orexin (A, B) Antagonists: ACT-335827 ACT-462206 Almorexant Filorexant Lemborexant Nemorexant RTIOX-276 SB-334867 SB-408124 SB-649868 Suvorexant

    List of signaling peptide/protein receptor modulators

    List_of_signaling_peptide/protein_receptor_modulators

  • List of investigational antidepressants

    • List of pharmaceutical drugs under clinical development for treatment of depression

    growth factor 1 (FGF-1) – fibroblast growth factor receptor (FGFR) agonist Filorexant (MK-6096) – orexin OX1 and OX2 receptor antagonist GEA-857 (alaproclate

    List of investigational antidepressants

    List_of_investigational_antidepressants

  • TCS-OX2-29

    • Orexin antagonist

    Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant

    TCS-OX2-29

    TCS-OX2-29

    TCS-OX2-29

  • SB-334867

    • Chemical compound

    Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant

    SB-334867

    SB-334867

    SB-334867

  • JNJ-10397049

    • Chemical compound

    Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant

    JNJ-10397049

    JNJ-10397049

    JNJ-10397049

  • Hypocretin (orexin) receptor 1

    • Protein-coding gene in the species Homo sapiens

    Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant

    Hypocretin (orexin) receptor 1

    Hypocretin (orexin) receptor 1

    Hypocretin_(orexin)_receptor_1

  • SB-408124

    • Chemical compound

    Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant

    SB-408124

    SB-408124

    SB-408124

  • ACT-462206

    • Chemical compound

    Almorexant AZD-4041 CR-5542 CVN-766 Daridorexant Fazamorexant (YZJ-1139) Filorexant GSK-649868 (SB-649868) Lemborexant Nivasorexant (ACT-539313) Rocavorexant

    ACT-462206

    ACT-462206

    ACT-462206

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