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ROMIDEPSIN

  • Romidepsin

    • Chemical compound

    Romidepsin, sold under the brand name Istodax, is an anticancer agent used in cutaneous T-cell lymphoma (CTCL) and other peripheral T-cell lymphomas (PTCLs)

    Romidepsin

    Romidepsin

    Romidepsin

  • Gregory L. Verdine

    • American chemical biologist

    NASDAQ. His companies have succeeded in developing two FDA-approved drugs, romidepsin and paritaprevir, which are, respectively, an anticancer agent used in

    Gregory L. Verdine

    Gregory L. Verdine

    Gregory_L._Verdine

  • List of chemotherapeutic agents

    • Drugs that are useful against cancer

    Docetaxel Larotaxel Paclitaxel Taxotere Tesetaxel Ixabepilone Entinostat Romidepsin Vorinostat Zabadinostat Belotecan Camptothecin Exatecan Gimatecan Irinotecan

    List of chemotherapeutic agents

    List_of_chemotherapeutic_agents

  • Histone deacetylase inhibitor

    • Compounds that inhibit histone deacetylases

    cyclic tetrapeptides (such as trapoxin B), and the depsipeptides such as: romidepsin, bocodepsin hydrochloride. 3. benzamides : entinostat (MS-275), tacedinaline

    Histone deacetylase inhibitor

    Histone_deacetylase_inhibitor

  • Epigenetic priming

    • Type of modification to a cell's epigenome

    5-azacytidine, romidepsin and other DMNT inhibitors (i.e. 5-azacytidine, hydralazine, 5-Aza-2'-deoxycytidine) and HDAC inhibitors (i.e. romidepsin, belinostat

    Epigenetic priming

    Epigenetic priming

    Epigenetic_priming

  • Cutaneous T-cell lymphoma

    • Type of immune system cancer

    Vorinostat (Zolinza) a hydroxymate histone deacetylase (HDAC) inhibitor (2009) Romidepsin (Istodax) a cyclic peptide histone deacetylase (HDAC) inhibitor (2018)

    Cutaneous T-cell lymphoma

    Cutaneous T-cell lymphoma

    Cutaneous_T-cell_lymphoma

  • Depsipeptide

    • Type of peptide

    inhabiting bacteria. An example of a depsipeptide drug is the anticancer agent romidepsin, a known histone deacetylase inhibitor (HDACi). It was first isolated

    Depsipeptide

    Depsipeptide

    Depsipeptide

  • Chromatin remodeling

    • Form of dynamic modification

    in October 2006 for the treatment of cutaneous T cell lymphoma (CTCL). Romidepsin (trade name Istodax) was licensed by the US FDA in Nov 2009 for cutaneous

    Chromatin remodeling

    Chromatin_remodeling

  • Ketone bodies

    • Chemicals produced during fat metabolism

    Remetinostat Resminostat RGFP109 RGFP136 RGFP963 RGFP966 Ricolinostat (ACY-1215) Romidepsin Scriptaid Sulforaphane Synapsinostat (CN13) Tacedinaline (CI-994; N-acetyldinaline)

    Ketone bodies

    Ketone bodies

    Ketone_bodies

  • Givinostat

    • Chemical compound

    Remetinostat Resminostat RGFP109 RGFP136 RGFP963 RGFP966 Ricolinostat (ACY-1215) Romidepsin Scriptaid Sulforaphane Synapsinostat (CN13) Tacedinaline (CI-994; N-acetyldinaline)

    Givinostat

    Givinostat

  • Nitrogen mustard

    • Family of chemical compounds

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Nitrogen mustard

    Nitrogen mustard

    Nitrogen_mustard

  • Sézary disease

    • Rare type of lymphoma

    effects involving the skin. It is only available at a few institutions. Romidepsin, vorinostat and a few others are second-line drugs for cutaneous T-cell

    Sézary disease

    Sézary disease

    Sézary_disease

  • Sulforaphane

    • Chemical compound

    Remetinostat Resminostat RGFP109 RGFP136 RGFP963 RGFP966 Ricolinostat (ACY-1215) Romidepsin Scriptaid Sulforaphane Synapsinostat (CN13) Tacedinaline (CI-994; N-acetyldinaline)

    Sulforaphane

    Sulforaphane

    Sulforaphane

  • Nicotinamide

    • Dietary supplement and medication

    Remetinostat Resminostat RGFP109 RGFP136 RGFP963 RGFP966 Ricolinostat (ACY-1215) Romidepsin Scriptaid Sulforaphane Synapsinostat (CN13) Tacedinaline (CI-994; N-acetyldinaline)

    Nicotinamide

    Nicotinamide

    Nicotinamide

  • Cisplatin

    • Chemical compound and pharmaceutical drug

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Cisplatin

    Cisplatin

    Cisplatin

  • Crebinostat

    • Pharmaceutical compound

    Remetinostat Resminostat RGFP109 RGFP136 RGFP963 RGFP966 Ricolinostat (ACY-1215) Romidepsin Scriptaid Sulforaphane Synapsinostat (CN13) Tacedinaline (CI-994; N-acetyldinaline)

    Crebinostat

    Crebinostat

  • Neurinostat

    • Pharmaceutical compound

    Remetinostat Resminostat RGFP109 RGFP136 RGFP963 RGFP966 Ricolinostat (ACY-1215) Romidepsin Scriptaid Sulforaphane Synapsinostat (CN13) Tacedinaline (CI-994; N-acetyldinaline)

    Neurinostat

    Neurinostat

  • Acute myeloblastic leukemia with maturation

    • Medical condition

    correlated with the reduction of DNA repair enzymes (Garcia et al., 2008). Romidepsin, a drug in phase two clinical trials, has demonstrated higher efficacy

    Acute myeloblastic leukemia with maturation

    Acute myeloblastic leukemia with maturation

    Acute_myeloblastic_leukemia_with_maturation

  • Cyclophosphamide

    • Medication used as chemotherapy and to suppress the immune system

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Cyclophosphamide

    Cyclophosphamide

    Cyclophosphamide

  • Fluorouracil

    • Chemotherapy medication

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Fluorouracil

    Fluorouracil

  • Curcumin

    • Principal curcuminoid of turmeric

    Remetinostat Resminostat RGFP109 RGFP136 RGFP963 RGFP966 Ricolinostat (ACY-1215) Romidepsin Scriptaid Sulforaphane Synapsinostat (CN13) Tacedinaline (CI-994; N-acetyldinaline)

    Curcumin

    Curcumin

    Curcumin

  • Tributyrin

    • Triglyceride found in butter

    Remetinostat Resminostat RGFP109 RGFP136 RGFP963 RGFP966 Ricolinostat (ACY-1215) Romidepsin Scriptaid Sulforaphane Synapsinostat (CN13) Tacedinaline (CI-994; N-acetyldinaline)

    Tributyrin

    Tributyrin

    Tributyrin

  • Mitomycin C

    • Chemical compound

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Mitomycin C

    Mitomycin C

    Mitomycin_C

  • Vorinostat

    • Pharmaceutical drug

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Vorinostat

    Vorinostat

  • Valproate

    • Medication used for epilepsy, bipolar disorder and migraine

    Remetinostat Resminostat RGFP109 RGFP136 RGFP963 RGFP966 Ricolinostat (ACY-1215) Romidepsin Scriptaid Sulforaphane Synapsinostat (CN13) Tacedinaline (CI-994; N-acetyldinaline)

    Valproate

    Valproate

    Valproate

  • Butyric acid

    • Chemical compound (CH3CH2CH2COOH)

    Remetinostat Resminostat RGFP109 RGFP136 RGFP963 RGFP966 Ricolinostat (ACY-1215) Romidepsin Scriptaid Sulforaphane Synapsinostat (CN13) Tacedinaline (CI-994; N-acetyldinaline)

    Butyric acid

    Butyric acid

    Butyric_acid

  • Celecoxib

    • Nonsteroidal anti-inflammatory medication

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Celecoxib

    Celecoxib

    Celecoxib

  • Busulfan

    • Chemical compound

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Busulfan

    Busulfan

    Busulfan

  • Β-Hydroxybutyric acid

    • Chemical compound

    Remetinostat Resminostat RGFP109 RGFP136 RGFP963 RGFP966 Ricolinostat (ACY-1215) Romidepsin Scriptaid Sulforaphane Synapsinostat (CN13) Tacedinaline (CI-994; N-acetyldinaline)

    Β-Hydroxybutyric acid

    Β-Hydroxybutyric acid

    Β-Hydroxybutyric_acid

  • Capsaicin

    • Pungent chemical compound in chili peppers

    Remetinostat Resminostat RGFP109 RGFP136 RGFP963 RGFP966 Ricolinostat (ACY-1215) Romidepsin Scriptaid Sulforaphane Synapsinostat (CN13) Tacedinaline (CI-994; N-acetyldinaline)

    Capsaicin

    Capsaicin

    Capsaicin

  • High-dose chemotherapy

    • acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    High-dose chemotherapy

    High-dose chemotherapy

    High-dose_chemotherapy

  • Vincristine

    • Chemical compound; chemotherapy medication

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Vincristine

    Vincristine

    Vincristine

  • Mitoxantrone

    • Chemical compound

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Mitoxantrone

    Mitoxantrone

    Mitoxantrone

  • Temozolomide

    • Cancer medication

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Temozolomide

    Temozolomide

    Temozolomide

  • FRM-0334

    • Pharmaceutical compound

    Remetinostat Resminostat RGFP109 RGFP136 RGFP963 RGFP966 Ricolinostat (ACY-1215) Romidepsin Scriptaid Sulforaphane Synapsinostat (CN13) Tacedinaline (CI-994; N-acetyldinaline)

    FRM-0334

    FRM-0334

  • Pelabresib

    • Investigational oral small-molecule drug

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Pelabresib

    Pelabresib

    Pelabresib

  • Martinostat

    • Chemical compound

    Remetinostat Resminostat RGFP109 RGFP136 RGFP963 RGFP966 Ricolinostat (ACY-1215) Romidepsin Scriptaid Sulforaphane Synapsinostat (CN13) Tacedinaline (CI-994; N-acetyldinaline)

    Martinostat

    Martinostat

    Martinostat

  • Sapacitabine

    • Chemical compound

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Sapacitabine

    Sapacitabine

    Sapacitabine

  • Methotrexate

    • Chemotherapy and immunosuppressant medication

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Methotrexate

    Methotrexate

    Methotrexate

  • Arsenic trioxide

    • Industrial chemical and medication

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Arsenic trioxide

    Arsenic trioxide

    Arsenic_trioxide

  • Tioguanine

    • Chemical compound

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Tioguanine

    Tioguanine

    Tioguanine

  • Azacitidine

    • Chemical compound

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Azacitidine

    Azacitidine

    Azacitidine

  • Utidelone

    • Drug for treatment of breast cancer

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Utidelone

    Utidelone

    Utidelone

  • Crosslinking of DNA

    • Phenomenon in genetics

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Crosslinking of DNA

    Crosslinking of DNA

    Crosslinking_of_DNA

  • Bortezomib

    • Chemical compound

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Bortezomib

    Bortezomib

    Bortezomib

  • Doxorubicin

    • Chemotherapy medication

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Doxorubicin

    Doxorubicin

    Doxorubicin

  • Fludarabine

    • Chemical compound

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Fludarabine

    Fludarabine

    Fludarabine

  • Vorasidenib

    • Anti-cancer medication

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Vorasidenib

    Vorasidenib

    Vorasidenib

  • Gemcitabine

    • Chemical compound

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Gemcitabine

    Gemcitabine

    Gemcitabine

  • CKD-506

    • Pharmaceutical compound

    Remetinostat Resminostat RGFP109 RGFP136 RGFP963 RGFP966 Ricolinostat (ACY-1215) Romidepsin Scriptaid Sulforaphane Synapsinostat (CN13) Tacedinaline (CI-994; N-acetyldinaline)

    CKD-506

    CKD-506

  • Asparaginase

    • Enzyme used as medication and in food manufacturing

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Asparaginase

    Asparaginase

    Asparaginase

  • ATC code L01

    • Pharmaceutical drug classification

    Bortezomib L01XG02 Carfilzomib L01XG03 Ixazomib L01XH01 Vorinostat L01XH02 Romidepsin L01XH03 Panobinostat L01XH04 Belinostat L01XH05 Entinostat L01XH06 Tucidinostat

    ATC code L01

    ATC_code_L01

  • Peptidomimetic

    • Class of compounds designed to mimic features of peptides

    properties. Many peptidomimetics are utilized as FDA-approved drugs, such as Romidepsin (Istodax), Atazanavir (Reyataz), Saquinavir (Invirase), Octreotide (Sandostatin)

    Peptidomimetic

    Peptidomimetic

    Peptidomimetic

  • Panobinostat

    • Chemical compound

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Panobinostat

    Panobinostat

    Panobinostat

  • Proteasome inhibitor

    • Drug

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Proteasome inhibitor

    Proteasome inhibitor

    Proteasome_inhibitor

  • Venetoclax

    • Medication

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Venetoclax

    Venetoclax

    Venetoclax

  • Chemotherapy-induced nausea and vomiting

    • Common side effects in chemotherapy treatment

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Chemotherapy-induced nausea and vomiting

    Chemotherapy-induced_nausea_and_vomiting

  • Vepdegestrant

    • Chemical compound

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Vepdegestrant

    Vepdegestrant

    Vepdegestrant

  • Acetoacetic acid

    • Organic compound

    Remetinostat Resminostat RGFP109 RGFP136 RGFP963 RGFP966 Ricolinostat (ACY-1215) Romidepsin Scriptaid Sulforaphane Synapsinostat (CN13) Tacedinaline (CI-994; N-acetyldinaline)

    Acetoacetic acid

    Acetoacetic acid

    Acetoacetic_acid

  • Tretinoin

    • Medication

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Tretinoin

    Tretinoin

    Tretinoin

  • Camptothecin

    • Chemical compound

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Camptothecin

    Camptothecin

    Camptothecin

  • Vusolimogene oderparepvec

    • Medication

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Vusolimogene oderparepvec

    Vusolimogene_oderparepvec

  • GABA

    • Main inhibitory neurotransmitter in the mammalian brain

    Remetinostat Resminostat RGFP109 RGFP136 RGFP963 RGFP966 Ricolinostat (ACY-1215) Romidepsin Scriptaid Sulforaphane Synapsinostat (CN13) Tacedinaline (CI-994; N-acetyldinaline)

    GABA

    GABA

    GABA

  • Capecitabine

    • Chemical compound

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Capecitabine

    Capecitabine

    Capecitabine

  • Oxaliplatin

    • Pharmaceutical drug

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Oxaliplatin

    Oxaliplatin

    Oxaliplatin

  • Sodium butyrate

    • Chemical compound

    Remetinostat Resminostat RGFP109 RGFP136 RGFP963 RGFP966 Ricolinostat (ACY-1215) Romidepsin Scriptaid Sulforaphane Synapsinostat (CN13) Tacedinaline (CI-994; N-acetyldinaline)

    Sodium butyrate

    Sodium butyrate

    Sodium_butyrate

  • Indole-3-carbinol

    • Chemical compound

    Remetinostat Resminostat RGFP109 RGFP136 RGFP963 RGFP966 Ricolinostat (ACY-1215) Romidepsin Scriptaid Sulforaphane Synapsinostat (CN13) Tacedinaline (CI-994; N-acetyldinaline)

    Indole-3-carbinol

    Indole-3-carbinol

    Indole-3-carbinol

  • Carboplatin

    • Medication used to treat cancer

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Carboplatin

    Carboplatin

    Carboplatin

  • Melphalan

    • Chemical compound

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Melphalan

    Melphalan

    Melphalan

  • Protein-bound paclitaxel

    • Cancer drug

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Protein-bound paclitaxel

    Protein-bound_paclitaxel

  • Epstein–Barr virus–associated lymphoproliferative diseases

    • Group of disorders

    bone marrow transplantation. Newer drug approaches using Pralatrexate, Romidepsin, Brentuximab vedotin, Belinostat, Bendamustine, lenalidomide, and alisertib

    Epstein–Barr virus–associated lymphoproliferative diseases

    Epstein–Barr virus–associated lymphoproliferative diseases

    Epstein–Barr_virus–associated_lymphoproliferative_diseases

  • Etoposide

    • Chemotherapy medication

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Etoposide

    Etoposide

    Etoposide

  • Lisocabtagene maraleucel

    • Gene therapy medication

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Lisocabtagene maraleucel

    Lisocabtagene_maraleucel

  • Ricolinostat

    • Pharmaceutical compound

    Remetinostat Resminostat RGFP109 RGFP136 RGFP963 RGFP966 Ricolinostat (ACY-1215) Romidepsin Scriptaid Sulforaphane Synapsinostat (CN13) Tacedinaline (CI-994; N-acetyldinaline)

    Ricolinostat

    Ricolinostat

    Ricolinostat

  • Alkylating antineoplastic agent

    • Pharmaceutical drugs

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Alkylating antineoplastic agent

    Alkylating antineoplastic agent

    Alkylating_antineoplastic_agent

  • Tazemetostat

    • Chemical compound

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Tazemetostat

    Tazemetostat

    Tazemetostat

  • Protein kinase inhibitor

    • Enzymes that block actions of protein kinases

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Protein kinase inhibitor

    Protein_kinase_inhibitor

  • Sodium phenylbutyrate

    • Chemical compound

    Remetinostat Resminostat RGFP109 RGFP136 RGFP963 RGFP966 Ricolinostat (ACY-1215) Romidepsin Scriptaid Sulforaphane Synapsinostat (CN13) Tacedinaline (CI-994; N-acetyldinaline)

    Sodium phenylbutyrate

    Sodium phenylbutyrate

    Sodium_phenylbutyrate

  • Imetelstat

    • Medication

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Imetelstat

    Imetelstat

    Imetelstat

  • Decitabine/cedazuridine

    • Medication

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Decitabine/cedazuridine

    Decitabine/cedazuridine

    Decitabine/cedazuridine

  • Dactinomycin

    • Chemical compound

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Dactinomycin

    Dactinomycin

    Dactinomycin

  • Histone deacetylase

    • Class of enzymes important in regulating DNA transcription

    lymphoma (CTCL) that have failed previous treatments. A second HDI, Istodax (romidepsin), was approved in 2009 for patients with CTCL. The exact mechanisms by

    Histone deacetylase

    Histone deacetylase

    Histone_deacetylase

  • Tegafur/gimeracil/oteracil

    • Combination drug

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Tegafur/gimeracil/oteracil

    Tegafur/gimeracil/oteracil

  • Docetaxel

    • Chemotherapy medication

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Docetaxel

    Docetaxel

    Docetaxel

  • Glyceryl-tris-3-hydroxybutyrate

    • Chemical compound

    Remetinostat Resminostat RGFP109 RGFP136 RGFP963 RGFP966 Ricolinostat (ACY-1215) Romidepsin Scriptaid Sulforaphane Synapsinostat (CN13) Tacedinaline (CI-994; N-acetyldinaline)

    Glyceryl-tris-3-hydroxybutyrate

    Glyceryl-tris-3-hydroxybutyrate

    Glyceryl-tris-3-hydroxybutyrate

  • Talazoparib

    • Chemical compound

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Talazoparib

    Talazoparib

    Talazoparib

  • Idecabtagene vicleucel

    • Gene therapy medication

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Idecabtagene vicleucel

    Idecabtagene_vicleucel

  • Vinblastine

    • Chemotherapy medication

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Vinblastine

    Vinblastine

    Vinblastine

  • Antimetabolite

    • Chemical that inhibits the use of a metabolite

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Antimetabolite

    Antimetabolite

    Antimetabolite

  • Paclitaxel

    • Medication used for cancer

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Paclitaxel

    Paclitaxel

    Paclitaxel

  • Dordaviprone

    • Chemical compound

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Dordaviprone

    Dordaviprone

    Dordaviprone

  • Hydroxycarbamide

    • Medication

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Hydroxycarbamide

    Hydroxycarbamide

    Hydroxycarbamide

  • Tacedinaline

    • Pharmaceutical compound

    Remetinostat Resminostat RGFP109 RGFP136 RGFP963 RGFP966 Ricolinostat (ACY-1215) Romidepsin Scriptaid Sulforaphane Synapsinostat (CN13) Tacedinaline (CI-994; N-acetyldinaline)

    Tacedinaline

    Tacedinaline

    Tacedinaline

  • Belinostat

    • Pharmaceutical drug

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Belinostat

    Belinostat

    Belinostat

  • Divarasib

    • Experimental cancer drug

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Divarasib

    Divarasib

    Divarasib

  • Stanford V

    • acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Stanford V

    Stanford_V

  • Eganelisib

    • Chemical compound

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Eganelisib

    Eganelisib

    Eganelisib

  • Veliparib

    • Chemical compound

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Veliparib

    Veliparib

    Veliparib

  • Daunorubicin/cytarabine

    • Pharmaceutical drug

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Daunorubicin/cytarabine

    Daunorubicin/cytarabine

    Daunorubicin/cytarabine

  • Mafosfamide

    • Chemical compound

    acetate Olaparib Rucaparib) HDAC (Belinostat Entinostat Panobinostat Romidepsin Vorinostat) PIKI (Pi3K) (Alpelisib Copanlisib‡ Duvelisib Idelalisib Inavolisib

    Mafosfamide

    Mafosfamide

    Mafosfamide

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