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Pungent chemical compound in chili peppers
Capsaicin (8-methyl-N-vanillyl-6-nonenamide) (/kæpˈseɪ.ə.sɪn/, commonly /kæpˈseɪsɪn/) is a toxin that is the main active component of chili peppers and
Capsaicin
Scale for measuring spiciness of peppers
(SHU). It is based on the concentration of capsaicinoids, among which capsaicin is the predominant component. The scale is named after its creator, American
Scoville_scale
Varieties of pepper of the genus ''Capsicum''
(spicy heat). They are used as a spice to add pungency in many cuisines. Capsaicin and the related capsaicinoids give chili peppers their intensity when
Chili_pepper
Inflammatory agent
spray, capsaicin spray, mace, or capsicum spray is a lachrymator (tear gas) product containing as its active ingredient the chemical compound capsaicin, which
Pepper_spray
Genus of flowering plants
produce any capsaicin, although the highest concentration of capsaicin can be found in the white pith around the seeds. Most of the capsaicin in a pungent
Capsicum
Chemical compound
poissonii found in northern Nigeria. It is a potent functional analog of capsaicin, the active ingredient in chili peppers. Resiniferatoxin has a score of
Resiniferatoxin
Hot or spicy flavor
horseradish and mustard. The primary substances responsible for pungency are capsaicin (in chilis), piperine (in peppercorns) and allyl isothiocyanate (in radishes
Pungency
Human protein for regulating body temperature
potential cation channel subfamily V member 1 (TRPV1), also known as the capsaicin receptor and the vanilloid receptor 1, is a protein that, in humans, is
TRPV1
Chemical compound
is a chemical compound that is an intermediate in the biosynthesis of capsaicin. Vanillylamine is produced from vanillin by the enzyme vanillin aminotransferase
Vanillylamine
Ground fruit of the family Piperaceae
compound piperine, which is a different kind of spiciness from that of capsaicin characteristic of chilli peppers. It is ubiquitous in the Western world
Black_pepper
Family of flowering plants
as well as one of the most toxic plants in the world. The presence of capsaicin in Capsicum species gives their fruits their signature pungency, which
Solanaceae
Spicy food additive
but is commonly manufactured synthetically. It is more heat-stable than capsaicin. Nonivamide is used as a food additive to add pungency to seasonings,
Nonivamide
Spicy snack food challenge
cardiopulmonary arrest after eating a substance containing a high amount of capsaicin, and had cardiomegaly, a congenital heart defect. Paqui responded by stating
One_Chip_Challenge
Chemical compound
vanilloid or capsaicin receptor 1 that reduces pain, and improves articular functions.[unreliable medical source?] It is the cis-isomer of capsaicin. Civamide
Zucapsaicin
Chemical compound
Dihydrocapsaicin is a capsaicinoid and analog and congener of capsaicin in chili peppers (Capsicum). Like capsaicin, it is an irritant. It accounts for about 22% of
Dihydrocapsaicin
Type of aerosol spray bear deterrent
capsaicin and related capsaicinoids, that is used to deter aggressive or charging bears. The key active ingredients of bear spray are 1–2% capsaicin,
Bear_spray
Species of flowering plant in the nightshade family
Similar to other variants the Chiltepin pepper produces and contains capsaicin which is responsible for its intense heat ranging from 100,000 to 200
Capsicum_annuum
Cultivar of Capsicum chili pepper
by the Carolina Reaper. While the seeds of the chili pepper produce no capsaicin, the chemical which produces the pepper's heat, the chemical is produced
Pepper_X
Nausea and vomiting resulting from cannabis use
example being hydration). There is tentative evidence for the use of capsaicin cream on the abdomen during an acute episode. Frequent hot showers or
Cannabinoid hyperemesis syndrome
Cannabinoid_hyperemesis_syndrome
Neuropathy causing itching between the shoulder blades
the condition. Available treatments include local anesthetics, topical capsaicin, topical corticosteroids, hydroxyzine, oxcarbazepine, palmitoylethanolamide
Notalgia_paresthetica
Condiment made from chili peppers
2017. Capsaicin extract - The hottest sauces are made from capsaicin extract. These range from extremely hot pepper sauce blends to pure capsaicin extracts
Hot_sauce
Medical condition
England Journal of Medicine in 1981. It occurs when the phytochemical capsaicin, which can be present in very high concentrations in certain varieties
Hunan_hand_syndrome
lack of pain-related behaviours to capsaicin. Birds, for instance, are unaffected by capsaicin because their capsaicin receptor proteins do not respond
Pain_in_invertebrates
Chemical compound
Nordihydrocapsaicin is a capsaicinoid and analog and congener of capsaicin in chili peppers (Capsicum). Like capsaicin, it is an irritant. Nordihydrocapsaicin accounts
Nordihydrocapsaicin
Variety of chilli pepper
identify the amount of colour that can be extracted from the chilli. The capsaicin value is 0.325%. They are mild, reading 1000–2000 SHU on the Scoville
Kashmiri_red_chilli
Chemical compound
similar to uses of capsaicin. Tinyatoxin is about one third as strong as resiniferatoxin but is still an ultrapotent analogue of capsaicin, with a heat intensity
Tinyatoxin
Pain due to peripheral nerve damage following infection by the shingles virus
is the main goal of treatment. Medications applied to the skin such as capsaicin or topical anesthetics (e.g., lidocaine) are used for mild pain and can
Postherpetic_neuralgia
Chemical weapon
have been reports of these antacids being helpful for tear gas, and for capsaicin-induced skin pain. In 2019, Hong Kong protesters invented a way of using
Tear_gas
Hot pepper
Healthwise; Husney, MD, Adam; Romito, MD, Kathleen. "Capsaicin". WebMD.com. Retrieved 4 August 2015. "Capsaicin Material Safety Data Sheet". sciencelab.com. Archived
Jalapeño
Balkan condiment
Southeast Europe. Homemade ajvar is made of roasted peppers. Depending on the capsaicin content in bell peppers and the amount of added chili peppers, it can
Ajvar
Chili pepper cultivated in Northeast India
For comparison, Tabasco red pepper sauce rates at 2,500–5,000, and pure capsaicin (the chemical responsible for the pungency of pepper plants) rates at
Ghost_pepper
Irritation of the skin of the anus, causing itching
double-blind trial with 44 patients found that capsaicin may be an effective treatment. By applying topical capsaicin mixed with paraffin wax (both available
Pruritus_ani
Chemical compound
Homocapsaicin is a capsaicinoid and analog and congener of capsaicin in chili peppers (Capsicum). Like capsaicin it is an irritant. Homocapsaicin accounts for about
Homocapsaicin
Species of plant
in ancient medicine. It contains resiniferatoxin, an extremely potent capsaicin analog tested as an analgesic since 1997. It is a shrub growing to 61
Euphorbia_resinifera
Class of chemical compounds naturally occurring in chili peppers
naturally present in chili peppers. Although they are structurally similar to capsaicin, the substance that causes pungency in hot peppers, they largely lack
Capsinoid
How an organism receives and responds to painful stimuli
appropriate defensive response. In nociception, intense chemical (e.g., capsaicin present in chili pepper or cayenne pepper), mechanical (e.g., cutting
Nociception
Chemical compound
much milder than capsicum oleoresin, often containing relatively little capsaicin. Extraction is performed by percolation with a variety of solvents, primarily
Paprika_oleoresin
American pharmacist (1865–1942)
Parke-Davis pharmaceutical company to measure pungency, "spiciness" or "capsaicin concentration" of various chili peppers. Scoville was born in Bridgeport
Wilbur_Scoville
Chemical compounds containing a vanillyl group
vanillylmandelic acid, homovanillic acid, capsaicin, etc. Isomers are the isovanilloids. A number of vanilloids, most notably capsaicin, bind to the transient receptor
Vanilloid
American sauce manufacturer
around 1993 and was one of the first sauces to be made directly from capsaicin extract, allowing it to be hotter than the hottest habanero-pepper sauces
Dave's_Gourmet
Chemical compound
capsaicin. It is used as a biochemical tool in the study of TRPV ion channels. Capsazepine blocks the painful sensation of heat caused by capsaicin (the
Capsazepine
Chemical compound
Homodihydrocapsaicin is a capsaicinoid and analog and congener of capsaicin in chili peppers (Capsicum). Like capsaicin it is an irritant. Homodihydrocapsaicin accounts
Homodihydrocapsaicin
Informal pepper competition
microscopy, found that super-hots not only have more capsaicin than other peppers, but also store their capsaicin differently. While for most peppers removing
Hottest_chili_pepper
German chemist
pharmaceutical chemist who is credited with the isolation of the oleoresin capsaicin in a crude form from chilli peppers using solvent extraction in 1816.
Christian_Friedrich_Bucholz
Medical condition
limited number of treatment options exist, including regular application of capsaicin cream, and prolonged relief may be provided by botulinum toxin treatment
Chromhidrosis
American physiologist and Nobel laureate 2021
including the characterization of the TRPV1 and TRPM8 receptors that detect capsaicin, menthol, and temperature. He is a professor at the University of California
David_Julius
Sensation and perception of temperature
sensitive proteins in thermoreceptors may also be activated by menthol or capsaicin, hence why these molecules evoke cooling and burning sensations, respectively
Thermoception
Ointment-like medicated topical preparation
chemical compounds, such as methyl salicylate, benzoin resin, menthol, and capsaicin. They produce a feeling of warmth within the muscle of the area they are
Liniment
United States snack company
500 to 5,000 Scoville units). It contains only capsaicin crystals, and is the hottest possible capsaicin-based sauce. Only 999 bottles of "Blair's 16 Million
Blair's_Sauces_and_Snacks
Chemical compound
traditional home remedy Piperine, the piquant chemical in black pepper Capsaicin, the piquant chemical in chili peppers Allicin, the piquant flavor chemical
Allyl_isothiocyanate
Chemical compound
Phenylacetylrinvanil (IDN-5890) is a synthetic analogue of capsaicin which acts as a potent and selective agonist for the TRPV1 receptor, with slightly
Phenylacetylrinvanil
Protein-coding gene in humans
potential channel (TRP) superfamily, which includes the menthol (TRPM8) and capsaicin receptors (TRPV1), serve a variety of functions in the peripheral and
TRPM8
Drug discovery
needed] Capsaicin, the active ingredient in chili pepper, was first isolated over a century ago. In 1919 the exact chemical structure of capsaicin was determined
Discovery and development of TRPV1 antagonists
Discovery_and_development_of_TRPV1_antagonists
Spicy fermented Korean condiment
gas chromatography and the high-performance liquid chromatography of capsaicin and dihydrocapsaicin concentrations. Gochujang products are assigned to
Gochujang
Incapacitant spray similar to pepper spray
(PAVA), also called nonivamide, a synthetic capsaicinoid (analogue of capsaicin), in a solvent of aqueous ethanol. The propellant is nitrogen. This solution
PAVA_spray
Hot chili pepper used to flavor dishes
It is also used as a herbal supplement, due to its active compound, capsaicin. They are also nutritious and they are especially rich in provitamin A
Cayenne_pepper
South Korean food company
the Danish Veterinary and Food Administration assessed the levels of capsaicin in a single packet to be high enough to pose a risk of the consumer developing
Samyang_Foods
Exceptionally hot cultivar of C. chinense pepper plant
Carolina Reaper derives from the density of capsaicinoids, particularly capsaicin, which relates directly to the intensity of chili pepper heat and Scoville
Carolina_Reaper
Pain affecting the somatosensory nervous system
of capsaicin are followed by a prolonged period of reduced skin sensibility, referred to as desensitization or nociceptor inactivation. Capsaicin causes
Neuropathic_pain
Strain of chili (Capsicum)
vegetative growth but the same number of fruit, with lower concentrations of capsaicin, as compared to plants which are watered only when dry (every seven days)
Habanero
East Asian variety of pepper
agricultural testing center at Kishigawa, Wakayama stated in 2005 that capsaicin forms more easily in hot and dry conditions in the summer, and even experts
Shishito
Iberian culinary style
antimicrobial properties due to the capsaicin content). Paprika gives a reddish color to adobos, and the capsaicins in paprika dissolve in fats, allowing
Adobo
Medications that inhibit itching
main chemical that causes heat in chili pepper, the main side effect of capsaicin is a burning sensation that usually persists for several days. A topical
Antipruritic
Chemical compound
capsaicin as both are fatty acid amides, but the mechanism of action by which it induces nerve sensations has been a matter of debate. Like capsaicin
Hydroxy-α-sanshool
Family of proteins found in milk
used to make emulsions in foods. Casein is also believed to neutralize capsaicin, the active spicy ingredient of chili peppers such as jalapeños, and habaneros
Casein
Nervous system disease affecting nerves beyond the brain and spinal cord
application of topical capsaicin. Capsaicin is the factor that causes heat in chili peppers. However, the evidence suggesting that capsaicin applied to the skin
Peripheral_neuropathy
Triglyceride found in butter
Butyric acid (butyrate) Sodium butyrate Tributyrin (glyceryl tributyrate) Capsaicin Citarinostat CKD-506 CN133 CN147 Crebinostat Curcumin Dacinostat Diallyl
Tributyrin
Organism that eats mostly fruit
carbon-based phenolics. Capsaicin is a carbon-based phenolic compound only found in plant genus Capsicum (chili and bell peppers). Capsaicin is responsible for
Frugivore
One of three classes of nerve fiber in the nervous system
information. Damage or injury to nerve fibers causes neuropathic pain. Capsaicin activates C fibre vanilloid receptors, providing the burning sensation
Group_C_nerve_fiber
Mild chili pepper originating in Puebla, Mexico
Mark A.; Tominaga, Makoto; Rosen, Tobias A.; Levine, Jon D. (1997). "The capsaicin receptor: a heat-activated ion channel in the pain pathway". Nature. 389
Poblano
Sensory neuron that detects pain
spices. The one that sees the most response and is very widely tested is capsaicin. Other chemical stimulants are environmental irritants like acrolein,
Nociceptor
Type of inflammation
are the principal detectors of noxious environmental stimuli. The heat/capsaicin receptor TRPV1 and the wasabi receptor TRPA1. TRPA1 channels stimulated
Neurogenic_inflammation
Mild irritant used to lessen pain
non-analgesic, non-anesthetic substances or treatments used to treat pain. Capsaicin, menthol (mint oil), methyl salicylate, and camphor are examples of counterirritants
Counterirritant
Measures taken against unlawful or violent crowds of people
for domestic law enforcement. The active ingredient in pepper-spray is capsaicin, which is a chemical derived from the fruit of plants in the Capsicum
Riot_control
important in thermal and pain detection. TRPV1 channels are activated by capsaicin (a chemical which can be extracted from chili peppers), noxious temperature
Infrared sensing in vampire bats
Infrared_sensing_in_vampire_bats
Law enforcement weapon
powder called PAVA (capsaicin II) pepper is often used. PAVA is a capsaicinoid that can be synthesized more cheaply than natural capsaicin from peppers, although
Pepper-spray_projectile
Sudden expulsion of air from the lungs as a reflex to clear irritants
tissues, capsaicin is widely used to determine the cough threshold and as a tussive stimulant in clinical research of cough suppressants. Capsaicin is what
Cough
Group of chilli pepper cultivars
America. Chillies have various colours and flavours because of the level of capsaicin in them. Guntur chillies form an important part of curries and various
Guntur_chilli
Species of plant
basil, camphor basil) Cannabidiol (cannabis) Cannabidivarin (cannabis) Capsaicin (chili pepper) Carvacrol (oregano, thyme, pepperwort, wild bergamot, others)
Rosemary
State of inflammation
Irritants are typically thought of as chemical agents (for example phenol and capsaicin) but mechanical, thermal (heat), and radiative stimuli (for example ultraviolet
Irritation
Organic compound used as flavouring and analgesic
inhaled, eaten, or applied to the skin. In this sense, it is similar to capsaicin, the chemical responsible for the spiciness of hot chilis (which stimulates
Menthol
Class of transport proteins
activated by molecules found in spices like garlic (allicin), chili pepper (capsaicin), wasabi (allyl isothiocyanate); others are activated by menthol, camphor
Transient receptor potential channel
Transient_receptor_potential_channel
Species of flowering plant in the nightshade family
the centre. The anthers are partly purple, partly white. Capsaicinoids (capsaicin) are naturally occurring phytochemicals responsible for the heat in chili
Capsicum_pubescens
Topics referred to by the same term
football Officer candidate Officer commanding, in military use Oleoresin capsaicin or oleoresin capsicum, the active ingredient in pepper spray and OC gas
OC
Ester of salicylic acid
PMID 15033879. Tramer, M. R. (2004). "It's not just about rubbing—topical capsaicin and topical salicylates may be useful as adjuvants to conventional pain
Methyl_salicylate
Spice extracted from Vanilla orchids
basil, camphor basil) Cannabidiol (cannabis) Cannabidivarin (cannabis) Capsaicin (chili pepper) Carvacrol (oregano, thyme, pepperwort, wild bergamot, others)
Vanilla
vanillyl group are called vanilloids, and include vanillin, vanillic acid, capsaicin, vanillylmandelic acid, etc. Lee DW, Kim HN, Lee DS (June 2019). "Introduction
Vanillyl_group
Type of firearm
PAVA has other names: Pelargonylvanillylamide Nonivamide Capsaicin II Synthetic capsaicin Purpose-built launchers are commonly large bore guns, formerly
Riot_gun
Medical condition
can be used for symptomatic treatment. Examples include NSAIDs, topical capsaicin, and lidocaine gel/patches for epidermal hypersensitivity or dysesthesia
Meralgia_paraesthetica
Process of diverting the attention of an individual or group
diversion from the dental surgery process. Topical ointments containing capsaicin, provide a superficial burning sensation that can momentarily distract
Distraction
Substance for topical application that produces redness of the skin
Salicylates, such as methyl salicylate (oil of wintergreen) Nicotinate esters Capsaicin, derived from chili pepper, Capsicum minimum, "incites irritation without
Rubefacient
Alkaloid responsible for the pungency of black pepper
Piperic acid – the carboxylic acid also derived from hydrolysis of piperine Capsaicin – the active piquant chemical in chili peppers Allyl isothiocyanate –
Piperine
Chemical compound
studies. It is suspected that its mechanism of action is similar to that of capsaicin. As such, it has been included in some dietary supplements. Neither its
Evodiamine
Chemical compound
shogaol is moderately more pungent than piperine, but 100 times less than capsaicin. [4]-Shogaol, [8]-shogaol, [10]-shogaol, and [12]-shogaol (all found in
Shogaol
Receptive portion of a sensory neuron
with capsaicin, an active chemical commonly found in chili peppers. When coming in contact with the tongue (or any internal surface), the capsaicin de-polarizes
Thermoreceptor
American fraudster (born c. 1854)
found to contain mineral oil, a fatty compound thought to be from beef, capsaicin from chili peppers, and turpentine. He was fined $20 ($502.60 in 2025)
Clark_Stanley
Class of plant and fungus secondary metabolites
acids Phenylethanoids Tyrosol Hydroxytyrosol Oleocanthal Oleuropein Others Capsaicin Gingerol Alkylresorcinols Misc: Phenolic compounds Phlorotannins)
Flavonoid
PMC 2719146. PMID 19553373. Zhang, Zi-Xin (2016). "Discovery of putative capsaicin biosynthetic genes by RNA-Seq and digital gene expression analysis of
Branched-chain_fatty_acid
Chemical compound
basil, camphor basil) Cannabidiol (cannabis) Cannabidivarin (cannabis) Capsaicin (chili pepper) Carvacrol (oregano, thyme, pepperwort, wild bergamot, others)
Hydrogen_peroxide
Norwegian show jumping competitor
detecting the illegal substance capsaicin in his urine. If the second, or B, test was also found positive for capsaicin, Norway were likely to lose the
Tony_André_Hansen
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