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Protein family
Protocadherins (Pcdhs) are the largest mammalian subgroup of the cadherin superfamily of homophilic cell-adhesion proteins. They were discovered by Shintaro
Protocadherin
Protein
Protocadherin 19 is a protein belonging to the protocadherin family, which is part of the large cadherin superfamily of cell-adhesion proteins. The PCDH19
Protocadherin_19
Protein-coding gene in the species Homo sapiens
Protocadherin-7 is a protein that in humans is encoded by the PCDH7 gene. This gene belongs to the protocadherin gene family, a subfamily of the cadherin
PCDH7
Protein-coding gene in the species Homo sapiens
Protocadherin alpha-1 is a protein that in humans is encoded by the PCDHA1 gene. This gene is a member of the protocadherin alpha gene cluster, one of
Protocadherin_alpha_1
Protein-coding gene in the species Homo sapiens
Protocadherin 11 X-linked, also known as PCDH11X, is a protein which in humans is encoded by the PCDH11X gene. This gene belongs to the protocadherin
PCDH11X
Protein-coding gene in the species Homo sapiens
Protocadherin alpha-9 is a protein that in humans is encoded by the PCDHA9 gene. This gene is a member of the protocadherin alpha gene cluster, one of
PCDHA9
Class of mollusks
first gene family was identified as the protocadherins which are attributed to neuron development. Protocadherins function as cell adhesion molecules, essential
Cephalopod
Soft-bodied eight-limbed order of molluscs
unremarkably bilaterian except for large developments of two gene families: protocadherins, which regulate the development of neurons; and the C2H2 zinc-finger
Octopus
Recessive genetic disorder causing deafblindness
a cohort of Usher patients shows the importance of cadherin 23 and protocadherin 15 genes and establishes a detection rate of above 90%". J Med Genet
Usher_syndrome
Protein-coding gene in the species Homo sapiens
Protocadherin beta-15 is a protein that in humans is encoded by the PCDHB15 gene. This gene is a member of the protocadherin beta gene cluster, one of
PCDHB15
Protein-coding gene in the species Homo sapiens
PCDH11Y is a Y-linked gene in the genus Homo that encodes protocadherin 11Y, a protein that guides the development of nerve cells. It is the Y-chromosomal
PCDH11Y
Protein-coding gene in the species Homo sapiens
Protocadherin-15 is a protein that in humans is encoded by the PCDH15 gene. This gene is a member of the cadherin superfamily. Family members encode integral
PCDH15
Protein-coding gene in the species Homo sapiens
Protocadherin gamma-A11 is a protein that in humans is encoded by the PCDHGA11 gene. This gene is a member of the protocadherin gamma gene cluster, one
PCDHGA11
Property of neurons
human neural protocadherin cell adhesion genes which formed a gene cluster encoding 58 protocadherins. The members of the protocadherin gene cluster were
Neuronal_self-avoidance
Protein-coding gene in the species Homo sapiens
Protocadherin-8 is a protein that in humans is encoded by the PCDH8 gene. This gene belongs to the protocadherin gene family, a subfamily of the cadherin
PCDH8
Protein-coding gene in the species Homo sapiens
Protocadherin alpha-C2 is a protein that in humans is encoded by the PCDHAC2 gene. This gene is a member of the protocadherin alpha gene cluster, one
PCDHAC2
Protein-coding gene in the species Homo sapiens
Protocadherin FAT1 is a protein that in humans is encoded by the FAT1 gene. This gene is an ortholog of the Drosophila fat gene, which encodes a tumor
FAT1
Protein-coding gene in the species Homo sapiens
Protocadherin beta-5 is a protein that in humans is encoded by the PCDHB5 gene. This gene is a member of the protocadherin beta gene cluster, one of three
PCDHB5
Protein-coding gene in the species Homo sapiens
Protocadherin beta-9 is a protein that in humans is encoded by the PCDHB9 gene. This gene is a member of the protocadherin beta gene cluster, one of three
PCDHB9
Protein-coding gene in the species Homo sapiens
Protocadherin beta-3 is a protein that in humans is encoded by the PCDHB3 gene. This gene is a member of the protocadherin beta gene cluster, one of three
PCDHB3
Protein-coding gene in humans
Protocadherin beta-12 is a protein that in humans is encoded by the PCDHB12 gene. This gene is a member of the protocadherin beta gene cluster, one of
PCDHB12
Genus of viruses
acceleration factors, complement receptors, and, for New World hantaviruses, protocadherin-1 have also been proposed to be involved in attachment. After attachment
Hantavirus
Genetic form of epilepsy
syndrome. - PCDH19: This gene, located on the X chromosome, encodes protocadherin 19, a protein that helps neurons adhere to each other as they migrate
Dravet_syndrome
Protein-coding gene in the species Homo sapiens
Protocadherin alpha-5 is a protein that in humans is encoded by the PCDHA5 gene. This gene is a member of the protocadherin alpha gene cluster, one of
PCDHA5
Protein-coding gene in the species Homo sapiens
Protocadherin-1 is a protein that in humans is encoded by the PCDH1 gene. This gene belongs to the protocadherin subfamily within the cadherin superfamily
PCDH1
Protein-coding gene in the species Homo sapiens
Protocadherin beta-16 is a protein that in humans is encoded by the PCDHB16 gene. This gene is a member of the protocadherin beta gene cluster, one of
PCDHB16
Protein-coding gene in the species Homo sapiens
Protocadherin alpha-4 is a protein that in humans is encoded by the PCDHA4 gene. This gene is a member of the protocadherin alpha gene cluster, one of
PCDHA4
Protein-coding gene in the species Homo sapiens
Protocadherin gamma-C3 is a protein that in humans is encoded by the PCDHGC3 gene. This gene is a member of the protocadherin gamma gene cluster, one
PCDHGC3
Protein-coding gene in the species Homo sapiens
Protocadherin alpha-12 is a protein that in humans is encoded by the PCDHA12 gene. This gene is a member of the protocadherin alpha gene cluster, one
PCDHA12
Protein-coding gene in the species Homo sapiens
Protocadherin alpha-2 is a protein that in humans is encoded by the PCDHA2 gene. This gene is a member of the protocadherin alpha gene cluster, one of
PCDHA2
American cell biologist and professor
govern artery remodeling to set vessel diameter , and identification of protocadherin gamma A9 as a key molecule that promotes vascular inflammation and potential
Martin_A._Schwartz
Protein-coding gene in the species Homo sapiens
Protocadherin-10 is a protein that in humans is encoded by the PCDH10 gene. This gene belongs to the protocadherin gene family, a subfamily of the cadherin
PCDH10
Kidney disease
causes progressive disease and it can recur in kidney transplants. Protocadherin 7 (PCDH7) in 2020. It is generally described in older patients, who
Membranous_glomerulonephritis
Protein-coding gene in the species Homo sapiens
Protocadherin-20 is a protein that in humans is encoded by the PCDH20 gene. This gene belongs to the protocadherin gene family, a subfamily of the cadherin
PCDH20
Protein-coding gene in the species Homo sapiens
Protocadherin beta-14 is a protein that in humans is encoded by the PCDHB14 gene. This gene is a member of the protocadherin beta gene cluster, one of
PCDHB14
Protein-coding gene in the species Homo sapiens
Protocadherin gamma-A12 is a protein that in humans is encoded by the PCDHGA12 gene. This gene is a member of the protocadherin gamma gene cluster, one
PCDHGA12
Protein-coding gene in the species Homo sapiens
Protocadherin-18 is a protein that in humans is encoded by the PCDH18 gene. This gene belongs to the protocadherin gene family, a subfamily of the cadherin
PCDH18
Protein-coding gene in the species Homo sapiens
Protocadherin beta-4 is a protein that in humans is encoded by the PCDHB4 gene. This gene is a member of the protocadherin beta gene cluster, one of three
PCDHB4
Protein-coding gene in the species Homo sapiens
Protocadherin-17 is a protein that in humans is encoded by the PCDH17 gene. This gene belongs to the protocadherin gene family, a subfamily of the cadherin
PCDH17
Protein-coding gene in the species Homo sapiens
National Library of Medicine. Suzuki ST (Dec 2000). "Recent progress in protocadherin research". Exp Cell Res. 261 (1): 13–8. doi:10.1006/excr.2000.5039.
PCLKC
Type of kidney cell
A, Allen ND, ffrench-Constant C (May 2003). "Mice lacking the giant protocadherin mFAT1 exhibit renal slit junction abnormalities and a partially penetrant
Podocyte
Protein-coding gene in the species Homo sapiens
Protocadherin beta-11 is a protein that in humans is encoded by the PCDHB11 gene. This gene is a member of the protocadherin beta gene cluster, one of
PCDHB11
Protein-coding gene in the species Homo sapiens
Protocadherin-12 is a protein that in humans is encoded by the PCDH12 gene. This gene belongs to the protocadherin gene family, a subfamily of the cadherin
PCDH12
Protein-coding gene in the species Homo sapiens
Protein dachsous homolog 2, also known as protocadherin-23 (PCDH23) or cadherin-27 (CDH27), is a protein that in humans is encoded by the DCHS2 gene.
DCHS2
Calcium-dependent cell adhesion molecule
cytoskeletal complexes. The cadherin superfamily includes cadherins, protocadherins, desmogleins, desmocollins, and more. In structure, they share cadherin
Cadherin
tip links. Tip links are protein complexes of cadherin 23 (CDH23) and protocadherin 15 (PCDH15). Harmonin binds to proteins that are involved in connecting
USH1C
Protein-coding gene in the species Homo sapiens
Protein dachsous homolog 1, also known as protocadherin-16 (PCDH16) or cadherin-19 (CDH19) or cadherin-25 (CDH25) or fibroblast cadherin-1 (FIB1), is
DCHS1
Effort to determine the DNA sequence of the chimpanzee genome
chromosome 4 may contain elements regulating the expression of a nearby protocadherin gene that may be important for brain development and function. Although
Chimpanzee_genome_project
Protein-coding gene in the species Homo sapiens
Protocadherin Fat 4, also known as cadherin family member 14 (CDHF14) or FAT tumor suppressor homolog 4 (FAT4), is a protein that in humans is encoded
FAT4
Protein-coding gene in the species Homo sapiens
Protocadherin beta-10 is a protein that in humans is encoded by the PCDHB10 gene. This gene is a member of the protocadherin beta gene cluster, one of
PCDHB10
hyperpolarization occurs. The tip link is made of two different cadherin molecules, protocadherin 15 and cadherin 23. It has been found that the tip links are relatively
Tip_link
Surface expression is also regulated via protocadherin-mediated adhesion. Protocadherin-alpha and protocadherin-gamma interact to form a protein complex
Cadherin–catenin complex in learning and memory
Cadherin–catenin_complex_in_learning_and_memory
Mechanism of nuclear organization
consistent with those predicted by loop extrusion. Protocadherin promoter choice: Protocadherins are mammalian proteins involved in cell adhesion of
Loop_extrusion
Protein-coding gene in the species Homo sapiens
Protocadherin beta-7 is a protein that in humans is encoded by the PCDHB7 gene. This gene is a member of the protocadherin beta gene cluster, one of three
PCDHB7
Protein-coding gene in the species Homo sapiens
Protocadherin alpha-3 is a protein that in humans is encoded by the PCDHA3 gene. This gene is a member of the protocadherin alpha gene cluster, one of
PCDHA3
Protein-coding gene in the species Homo sapiens
Protocadherin beta-2 is a protein that in humans is encoded by the PCDHB2 gene. This gene is a member of the protocadherin beta gene cluster, one of three
PCDHB2
Medical condition
cause the protocadherin 19 protein to be malformed, reduced in function or not produced at all. This abnormal expression of protocadherin 19 causes deficits
Epilepsy-intellectual disability in females
Epilepsy-intellectual_disability_in_females
Sensory system used for hearing
the hair cell. Recently it has been shown that cadherin-23 CDH23 and protocadherin-15 PCDH15 are the adhesion molecules associated with these tip links
Auditory_system
Topics referred to by the same term
overweight or having obesity FAT (gene), which encodes the protein protocadherin FAT1 Female athlete triad, now known as relative energy deficiency in
Fat_(disambiguation)
type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 Protocadherin alpha 1 Pulmonary surfactant-associated protein A1 Pyruvate dehydrogenase
List of A1 genes, proteins or receptors
List_of_A1_genes,_proteins_or_receptors
Protein-coding gene in the species Homo sapiens
Ahmed ZM, Riazuddin S, Bernstein SL, et al. (2001). "Mutations of the protocadherin gene PCDH15 cause Usher syndrome type 1F". Am. J. Hum. Genet. 69 (1):
USH1G
Protein-coding gene in the species Homo sapiens
intronless gene for this transcription coactivator is located between the protocadherin beta and gamma gene clusters on chromosome 5. The protein encoded by
TAF7
Protein-coding gene in the species Homo sapiens
Protocadherin gamma-B7 is a protein that in humans is encoded by the PCDHGB7 gene. This gene is a member of the protocadherin gamma gene cluster, one
PCDHGB7
proteins Heat shock factor Ion channels Membrane-spanning 4A Peroxin Protocadherin gene family Roundabout family SNARE family Protein family Housekeeping
List_of_gene_families
Species of cephalopod
sequencing, has provided new information on the large amounts of clustered protocadherins (PCDH) in O. bimaculoides. The octopus was found to have 168 PCDH genes
California_two-spot_octopus
Viral pulmonary disease of humans
acceleration factors, complement receptors, and, for New World hantaviruses, protocadherin-1 have also been proposed to be involved in attachment. After attachment
Hantavirus_pulmonary_syndrome
Protein-coding gene in the species Homo sapiens
Protocadherin alpha-6 is a protein that in humans is encoded by the PCDHA6 gene. This gene is a member of the protocadherin alpha gene cluster, one of
PCDHA6
Protein and coding gene in humans
Müller K, Hofer HW (Oct 2006). "The intracellular domain of the human protocadherin hFat1 interacts with Homer signalling scaffolding proteins". FEBS Letters
HOMER3
Protein-coding gene in the species Homo sapiens
Peshkovsky C, Shifteh A, Al-Awqati Q (Sep 2000). "mu-Protocadherin, a novel developmentally regulated protocadherin with mucin-like domains". J Biol Chem. 275 (32):
MUPCDH
Enzyme
PMID 10504266. Yoshida K, Watanabe M, Kato H, Dutta A, Sugano S (1999). "BH-protocadherin-c, a member of the cadherin superfamily, interacts with protein phosphatase
PPP1CA
Human chromosome
synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) PCDH15: protocadherin 15 PI4K2A: phosphatidylinositol 4-kinase 2-alpha PIP4K2A: phosphatidylinositol
Chromosome_10
Protein-coding gene in the species Homo sapiens
exons encoding multiple ectodomains are a characteristic feature of protocadherin genes". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124–9. doi:10.1073/pnas
CELSR2
Protein-coding gene in humans
exons encoding multiple ectodomains are a characteristic feature of protocadherin genes". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124–9. doi:10.1073/pnas
CELSR1
Communications in cell biology
can also be neurons or other cell types (i.e. muscle or gland cells). Protocadherins, a member of the cadherin family, mediate the adhesion of neurons to
Cell–cell_interaction
Protein-coding gene in the species Homo sapiens
However, new research suggests that TMC1 interacts with Tip link proteins protocadherin 15 and cadherin 23 indicating that TMC1, along with TMC2, are necessary
TMC1
Protein-coding gene in the species Homo sapiens
PMID 15308666. Okazaki N, Takahashi N, Kojima S, Masuho Y, Koga H (July 2002). "Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers
MAST2
American biologist
- RNA transcription, splicing and stochastic promoter choice in the Protocadherin α gene cluster". library.cshl.edu. Retrieved 2021-06-21. "Thomas Maniatis"
Tom_Maniatis
Influence of a single gene on multiple phenotypic traits
development and has been shown to impact the expression of several protocadherin genes. These genes have been linked to schizophrenia and major depressive
Pleiotropy
Protein-coding gene in humans
hair bundle formation. Specifically, it is thought to interact with protocadherin 15 to form tip-link filaments. The gene is located in a region containing
CDH23
Large secreted extracellular matrix glycoprotein involved in neuronal migration
binds to the alpha-3-beta-1 integrin receptor. The proposal that the protocadherin CNR1 behaves as a Reelin receptor has been disproven. As members of
Reelin
Protein-coding gene in the species Homo sapiens
"Comparative genomics and diversifying selection of the clustered vertebrate protocadherin genes". Genetics. 169 (4): 2179–88. doi:10.1534/genetics.104.037606
FAT_atypical_cadherin_3
Protein-coding gene in the species Homo sapiens
exons encoding multiple ectodomains are a characteristic feature of protocadherin genes". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124–9. doi:10.1073/pnas
CELSR3
Risk factors related to schizophrenia
also play a role in schizophrenia, with the expression of Protocadherin 11 X-linked/Protocadherin 11 Y-linked playing a possible role in schizophrenia. A
Risk_factors_of_schizophrenia
South American orthohantavirus species
endothelial cells. It enters these cells by binding to β3-integrins and protocadherin-1 receptors with its glycoproteins. Virions are then taken into a cell
Andes_virus
Indian psychiatrist and clinician
Venkatasubramanian G (March 2009). "Evidence for positive selection on Protocadherin Y gene in Homo sapiens: implications for schizophrenia". Schizophrenia
Ganesan_Venkatasubramanian
American neuroscience academic (1945–2025)
(2019). "Bartsch TF & Hudspeth AJ. et al (2019) Elasticity of individual protocadherin 15 molecules implicates tip links as the gating springs for hearing
A._James_Hudspeth
Cluster of signs and symptoms that define a unique epileptic condition
intellectual disability. The condition is caused by mutations in PCDH19 (protocadherin 19).[citation needed] See Febrile infection-related epilepsy syndrome
Epilepsy_syndromes
Protein family
of E-cadherin, possibly through interaction with the cytoskeleton. Protocadherin, a different, unrelated cytoplasmic region Yap AS, Niessen CM, Gumbiner
Cadherin_cytoplasmic_region
injury repair genes, like tnfrsfs, chemokines, chemokine receptors, and protocadherins, are highly expressed in the appendages, suggesting that these genes
Genome evolution in seadragons
Genome_evolution_in_seadragons
Protein-coding gene in the species Homo sapiens
Protocadherin beta-13 is a protein that in humans is encoded by the PCDHB13 gene. This gene is a member of the protocadherin beta gene cluster, one of
PCDHB13
Transduction of mechanical stimuli into neural signals
known that the tip link is made of two different cadherin molecules, protocadherin 15 and cadherin 23. When an event occurs which causes the bundle of
Mechanosensation
Protein
Tissir F, Bar I, Jossin Y, De Backer O, Goffinet AM (April 2005). "Protocadherin Celsr3 is crucial in axonal tract development". Nat. Neurosci. 8 (4):
Flamingo_(protein)
Oommen, Oommen V.; Kumar, Pradeep G. (24 October 2017). "Expression of protocadherin 11Yb (PCDH11Yb) in seminal germ cells is correlated with fertility status
G._Pradeep_Kumar
Protein-coding gene in humans
(December 2012). "CTCF/cohesin-mediated DNA looping is required for protocadherin α promoter choice". Proceedings of the National Academy of Sciences
RAD21
Lebanese-Swiss biochemist
N-terminal domains Krahn MP, Rizk S, Alfalah M, Behrendt M, Naim HY Protocadherin of the liver, kidney and colon associates with detergent-resistant membranes
Hassan_Naim
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