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RAD21

  • RAD21
  • Protein-coding gene in humans

    Double-strand-break repair protein rad21 homolog is a protein that in humans is encoded by the RAD21 gene. RAD21 (also known as Mcd1, Scc1, KIAA0078,

    RAD21

    RAD21

    RAD21

  • WAPAL
  • Protein-coding gene in the species Homo sapiens

    homologous recombination and DNA looping. Cohesin is formed of SMC3, SMC1, RAD21 and either SA1 or SA2. Cohesin has a ring-like arrangement and it is thought

    WAPAL

    WAPAL

    WAPAL

  • SMC3
  • Protein-coding gene in humans

    homologous recombination and DNA looping. Cohesin is formed of SMC3, SMC1, RAD21 and either SA1 or SA2. In humans, SMC3 is present in all cohesin complexes

    SMC3

    SMC3

    SMC3

  • Sclerocornea
  • Medical condition

    mutation/deletion in the RAD21 gene. A 2019 study suggest that beyond its known role in cell division and chromosome organization, RAD21 may also contribute

    Sclerocornea

    Sclerocornea

    Sclerocornea

  • Cornelia de Lange syndrome
  • Medical condition

    mutated. Since then, additional genes have been found (SMC1A, SMC3 and HDAC8, RAD21) that cause CdLS when changed. In July 2012, the fourth "CdLS gene"—HDAC8—was

    Cornelia de Lange syndrome

    Cornelia de Lange syndrome

    Cornelia_de_Lange_syndrome

  • SMC1A
  • Protein-coding gene in humans

    recombination and DNA looping. In somatic cells, cohesin is formed of SMC1A, SMC3, RAD21 and either SA1 or SA2 whereas in meiosis, cohesin is formed of SMC3, SMC1B

    SMC1A

    SMC1A

    SMC1A

  • Cohesin
  • Protein complex that regulates the separation of sister chromatids during cell division

    1997. Cohesin is a multi-subunit protein complex, made up of SMC1, SMC3, RAD21 and SCC3 (SA1 or SA2). SMC1 and SMC3 are members of the Structural Maintenance

    Cohesin

    Cohesin

    Cohesin

  • Transient myeloproliferative disease
  • Medical condition

    HLCS, RUNX1, MIR125B2 (which is the gene for microRNA MiR125B2CTCF, STAG2, RAD21, SMC3, SMC1A, NIPBL, SUZ12, PRC2, JAK1, JAK2, JAK3, MPL, KRAS, NRAS, and

    Transient myeloproliferative disease

    Transient_myeloproliferative_disease

  • STAG2
  • Protein-coding gene in humans

    recombination and DNA looping. In somatic cells cohesin is formed of SMC3, SMC1, RAD21 and either SA1 or SA2 whereas in meiosis, cohesin is formed of SMC3, SMC1B

    STAG2

    STAG2

    STAG2

  • STAG1
  • Protein-coding gene in the species Homo sapiens

    recombination and DNA looping. In somatic cells cohesin is formed of SMC3, SMC1, RAD21 and either SA1 or SA2 whereas in meiosis, cohesin is formed of SMC3, SMC1B

    STAG1

    STAG1

    STAG1

  • PDS5B
  • Protein-coding gene in the species Homo sapiens

    recombination and DNA looping. The core cohesin complex is formed of SMC3, SMC1, RAD21 and either SA1 or SA2. PDS5 associates with WAPL to stimulate the release

    PDS5B

    PDS5B

    PDS5B

  • Stress granule
  • Cytoplasmic biomolecular condensates of proteins and RNA occurring in cells under stress

    1 RACK1 RACK1 Receptor For Activated C Kinase 1 RAD21 RAD21 Double-strand-break repair protein rad21 homolog RAE1 RAE1 Ribonucleic Acid Export 1 RAN RAN

    Stress granule

    Stress granule

    Stress_granule

  • List of genetic disorders
  • recessive Cornelia de Lange syndrome (CDLS) HDAC8, SMC1A, NIPBL, SMA3, RAD21 1:10,000-30,000 Cowden syndrome PTEN 1:200,000 CPO deficiency (coproporphyria)

    List of genetic disorders

    List_of_genetic_disorders

  • Separase
  • Mammalian protein found in Homo sapiens

    complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21) by separase, which initiates the final separation of sister chromatids

    Separase

    Separase

    Separase

  • SMC protein
  • SMC2 SMC5 SMC MukB JetC κ-SMC SMC1 SMC4 SMC4 SMC6 SMC MukB JetC kleisin RAD21 CAP-H CAP-H2 Nse4 ScpA MukF JetA HEAT-A NIPBL/Pds5 CAP-D2 CAP-D3 - - - -

    SMC protein

    SMC_protein

  • WASHC5
  • Protein-coding gene in the species Homo sapiens

    S2CID 23783563. Porkka KP, Tammela TL, Vessella RL, Visakorpi T (2004). "RAD21 and KIAA0196 at 8q24 are amplified and overexpressed in prostate cancer"

    WASHC5

    WASHC5

    WASHC5

  • Acute megakaryoblastic leukemia
  • Blood marrow cancer originating in megakaryoblast cells

    HLCS, RUNX1, MIR125B2 (which is the gene for microRNA MiR125B2CTCF, STAG2, RAD21, SMC3, SMC1A, NIPBL, SUZ12, PRC2, JAK1, JAK2, JAK3, MPL, KRAS, NRAS, and

    Acute megakaryoblastic leukemia

    Acute megakaryoblastic leukemia

    Acute_megakaryoblastic_leukemia

  • Establishment of sister chromatid cohesion
  • to as cohesinopathies. Genetic alterations in genes NIPBL, SMC1A, SMC3, RAD21 and HDAC8 are associated with Cornelia de Lange Syndrome. The proteins encoded

    Establishment of sister chromatid cohesion

    Establishment_of_sister_chromatid_cohesion

  • GATA1
  • Protein-coding gene in humans

    genes including: TP53, RUNX1, FLT3, ERG, DYRK1A, CHAF1B, HLCS, CTCF, STAG2, RAD21, SMC3, SMC1A, NIPBL, SUZ12, PRC2, JAK1, JAK2, JAK3, MPL, KRAS, NRAS, SH2B3

    GATA1

    GATA1

    GATA1

  • SMC1B
  • Protein-coding gene in the species Homo sapiens

    capable of. Additionally, in somatic cells SMC1B associates with SMC3 and RAD21 in a mitotic cohesin complex which had been thought to only include SMC1α

    SMC1B

    SMC1B

    SMC1B

  • Chromomere
  • Definition of scientific term

    Aggregates of chromomeres are known as chromonemata. Cohesive proteins SMC3 and hRAD21(plays a role in sister chromatid cohesion) are found within chromomeres

    Chromomere

    Chromomere

    Chromomere

  • STAG3
  • Protein-coding gene in the species Homo sapiens

    Gomez L, Fernandez R, Martinez-A C, Barbero JL (June 2002). "STAG2 and Rad21 mammalian mitotic cohesins are implicated in meiosis". EMBO Reports. 3 (6):

    STAG3

    STAG3

    STAG3

  • Shugoshin N terminal protein domain
  • Protein family

    Shugoshin protein is thought to act by protecting two proteins, named Rec8 and Rad21 at the centromeres from protein degradation by the enzyme separase. This

    Shugoshin N terminal protein domain

    Shugoshin_N_terminal_protein_domain

  • SMARCA5
  • Protein-coding gene in the species Homo sapiens

    ISWI chromatin remodeling protein. SMARCA5 has been shown to interact with RAD21, Histone deacetylase 2, POLE3, SATB1 and BAZ1A. GRCh38: Ensembl release

    SMARCA5

    SMARCA5

    SMARCA5

  • List of human protein-coding genes 6
  • Q6WBX8 13352 RAD17 HGNC:9807; O75943 13353 RAD18 HGNC:18278; Q9NS91 13354 RAD21 HGNC:9811; O60216 13355 RAD21L1 HGNC:16271; Q9H4I0 13356 RAD23A HGNC:9812;

    List of human protein-coding genes 6

    List_of_human_protein-coding_genes_6

  • Spindle checkpoint
  • Cell cycle checkpoint

    form an heterodimer (Smc1p/Smc3p). Scc1p is the homolog in S.cerevisiae of Rad21, first identified as a protein involved in DNA repair in S. pombe. These

    Spindle checkpoint

    Spindle checkpoint

    Spindle_checkpoint

  • Aurora kinase B
  • Protein

    Matsusaka T, Morrison C, Vagnarelli P, Hoshi O, Ushiki T, et al. (2001). "Scc1/Rad21/Mcd1 is required for sister chromatid cohesion and kinetochore function

    Aurora kinase B

    Aurora kinase B

    Aurora_kinase_B

  • Telomeric repeat–containing RNA
  • Long non-coding RNA transcribed from telomeres

    chromatin organization factors CTCF (CCCTC-Binding Factor), Cohesin, and Rad21 - which are known to aid in the recruitment of RNAPII - have also been shown

    Telomeric repeat–containing RNA

    Telomeric repeat–containing RNA

    Telomeric_repeat–containing_RNA

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