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Type of kidney cell
Podocytes are cells in Bowman's capsule in the kidneys that wrap around capillaries of the glomerulus. Podocytes make up the epithelial lining of Bowman's
Podocyte
Kidney disease
histopathologic finding of scarring (sclerosis) of glomeruli and damage to renal podocytes. This process damages the filtration function of the kidney, resulting
Focal segmental glomerulosclerosis
Focal_segmental_glomerulosclerosis
Microscopic structural and functional unit of the kidney
endothelial cells of the capillary wall, its basement membrane, and between the podocyte foot processes of the lining of the capsule. The tubule has adjacent peritubular
Nephron
Mammalian protein found in Homo sapiens
fenestrated endothelial cells, the glomerular basement membrane, and the podocytes of epithelial cells. Nephrin is a transmembrane protein that is a structural
Nephrin
Kidney disease causing nephrotic syndrome
These are diffuse loss of visceral epithelial cells' foot processes (i.e., podocyte effacement), vacuolation, and growth of microvilli on the visceral epithelial
Minimal_change_disease
Blood-filtering component of the nephron of the kidney
layer, composed of modified simple squamous epithelium, is lined by podocytes, podocyte foot processes (pedicels), that wrap around glomerular capillaries
Renal_corpuscle
Functional unit of nephron
albumin and globulin. The part of the podocyte in contact with the glomerular basement membrane is called a podocyte foot process or pedicle (Fig. 3): there
Glomerulus_(kidney)
Structures projecting from cells
brain. In the kidneys specialised cells called podocytes extend processes that terminate in podocyte foot processes that cover capillaries in the nephron
Cellular_extensions
Part of the filtration apparatus of the kidney
the glomerular basement membrane, and the filtration slits between the podocytes perform the filtration function of the glomerulus, separating the blood
Glomerular_basement_membrane
Medical condition
membrane, and podocyte processes. The resulting fluid is then filtered further throughout the various tubular segments to become urine. Podocytes are a particularly
Glomerulosclerosis
Inflammatory disease of the kidney
Syndrome, and hepatitis B, and some cancers, including multiple myeloma. Podocytes are specialized cells that make up parts of the lining of the glomerulus
Glomerulonephrosis
Kidney structure which performs the first step in blood filtration
just above the thickened glomerular basement membrane and is made of podocytes. Beneath the visceral layer lie the glomerular capillaries.[citation needed]
Bowman's_capsule
Symptoms resulting from kidney damage
to the podocyte within the glomerulus of the kidney. This circulating factor damages the podocyte, which changes its structure. The podocytes are now
Nephrotic_syndrome
Protein modified with sugar molecules including sialic acid
Podocalyxin is another sialoglycoprotein found in the foot processes of the podocyte cells of the glomerulus in kidneys. Podocalyxin is negatively charged and
Sialoglycoprotein
Term for several kidney diseases
blood. Inflammation that affects the cells surrounding the glomerulus, podocytes, increases the permeability to proteins, resulting in an increase in excreted
Glomerulonephritis
refer to cervical effacement. It can also refer to a process occurring in podocytes in nephrotic syndrome. In histopathology, it refers to the near obliteration
Effacement_(histology)
Medical condition
clinicopathologic entity that involves hypertrophy and hyperplasia of podocytes and segmentar or global collapse of the glomerulus. Glomerulocystic kidney
Glomerulopathy
Protein
normal mature kidneys, dendrin is found only in the podocytes near the slit diaphragm. Podocytes are epithelia cells in the kidneys that do not readily
Dendrin
Human sialoglycoprotein
sialoglycoprotein, is thought to be the major constituent of the glycocalyx of podocytes in the glomerulus (Bowman's capsule) in the kidneys. It is a member of
Podocalyxin
Type of blood and immune-system cancer
related to the induction of c-mip in Hodgkin-Reed Sternberg cells and podocytes". Blood. 115 (18): 3756–62. doi:10.1182/blood-2009-11-251132. PMC 2890576
Hodgkin_lymphoma
Smallest type of blood vessel
protein to diffuse. In the renal glomerulus the capillaries are wrapped in podocyte foot processes or pedicels, which have slit pores with a function analogous
Capillary
Chemical compound
calcineurin-mediated dephosphorylation of synaptopodin, a regulator of Rho GTPases in podocytes, thereby preserving the phosphorylation-dependent synaptopodin-14-3-3
Ciclosporin
Genus of viruses
cells and macrophages are the primary cells infected by hantaviruses. Podocytes, tubular cells, dendritic cells, and lymphocytes can also be infected
Hantavirus
Viral pulmonary disease of humans
cells and macrophages are the primary cells infected by hantaviruses. Podocytes, tubular cells, dendritic cells, and lymphocytes can also be infected
Hantavirus_pulmonary_syndrome
Thin fibrous layer between the cells and the adjacent connective tissue in animals
It is faced by a cell layer on either side, the endothelium, and the podocytes, and has a thicker structure of three laminae. It is thicker by the fusion
Basement_membrane
Protein-coding gene in the species Homo sapiens
Aström E, et al. (2003). "A novel protein, densin, expressed by glomerular podocytes". J. Am. Soc. Nephrol. 14 (7): 1731–7. doi:10.1097/01.ASN.0000075553.33781
LRRC7
Podocin is a protein component of the filtration slits of podocytes. Glomerular capillary endothelial cells, the glomerular basement membrane and the
Podocin
Organ of the urinary system
cell types include: Kidney glomerulus parietal cell Kidney glomerulus podocyte Intraglomerular mesangial cell Extraglomerular mesangial cell Juxtaglomerular
Kidney
Protein and coding gene in humans
When podocytes are stretched by glomerular capillary pressure, mechanosensitive TRPC6 channels trigger a surge in Ca2+ influx into podocytes, causing
TRPC6
cell Mesangial cell Parietal epithelial cell Urinary system Barrier cells Podocyte Proximal tubule brush border cell Loop of Henle thin segment cell Kidney
List_of_human_cell_types
Hypertension occurring during pregnancy
later onset remains challenging. 2011 studies have shown that looking for podocytes (specialized cells of the kidney) in the urine has the potential to aid
Pre-eclampsia
Symptoms resulting from kidney inflammation
glomerular basement membrane and the occurrence of small pores in the podocytes of the glomerulus. These pores become large enough to permit both proteins
Nephritic_syndrome
Medical condition
caused by AGEs and the other pathways, causes apoptosis of pericytes and podocytes in the retina and the kidneys respectively leading to capillary wall fragility
Microangiopathy
Medication
mediated immune responses. As a result of the calcineurin inhibition, podocytes (cells within the kidneys) are stabilized while inflammation is reduced
Voclosporin
German nephrologist and internist (born 1971)
Investigation". www.the-asci.org. "Young Investigator Attains Recognition for Podocyte Research - Kidney News". www.kidneynews.org. "Prof. Dr. Tobias B. Huber
Tobias_Huber
Protein-coding gene in the species Homo sapiens
(NPHS2; MIM 604766). NEPH1 is expressed in filtration slits of kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration
KIRREL
Protein-coding gene in the species Homo sapiens
24106 Cybulsky, Papillon. “Ste20-Like Kinase, SLK, a Novel Mediator of Podocyte Integrity.” American Journal of Physiology. Renal Physiology, vol. 315
SLK_(gene)
Phylum of invertebrate animals
known as a nephridiopore. The pouch is occupied by special cells called podocytes, which facilitate ultrafiltration of the blood through the partition between
Onychophora
American biomedical engineer
vitro model glomerulus with differentiation of stem cells into mature podocytes. She was honored for her interdisciplinary work in this project by a Physics
Samira_Musah
Swedish Physician-scientist
between podocytes and endothelial cells in a coculture system, and further highlighted that segmental glomerulosclerosis develops as a result of podocyte-endothelial
Börje_Haraldsson
Hungarian-American nephrologist
2006). "Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy". Diabetes. 55 (1):
Katalin_Susztak
Phylum of marine animals also known as lamp shells
and other dissolved wastes. However, brachiopods have no sign of the podocytes, which perform the first phase of excretion in this process, and brachiopod
Brachiopod
Protein-coding gene in the species Homo sapiens
guanylate kinase protein MAGI-1 binds megalin and is present in glomerular podocytes". Journal of the American Society of Nephrology. 12 (4): 667–77. doi:10
MAGI1
Chemical compound
Basgen, John M; Sinha, Satyesh (2011). "Using stereologic techniques for podocyte counting in the mouse: shifting the paradigm". Am J Nephrol. 33 (Suppl
Toluidine_blue
Thin layer of extracellular matrix upon which epithelial cells reside
glomerular basement membrane is a special case, consisting of a fusion of the podocyte and endothelial basal laminas, and lacking a lamina reticularis. Thus,
Basal_lamina
Protein-coding gene in the species Homo sapiens
T, Oguchi H, et al. (October 2015). "Renin-angiotensin blockade resets podocyte epigenome through Kruppel-like Factor 4 and attenuates proteinuria". Kidney
KLF4
Group of clinically similar illnesses caused by species of hantaviruses
cells and macrophages are the primary cells infected by hantaviruses. Podocytes, tubular cells, dendritic cells, and lymphocytes can also be infected
Hantavirus hemorrhagic fever with renal syndrome
Hantavirus_hemorrhagic_fever_with_renal_syndrome
Paired organ in the urinary system of mammals
composed of four cell types: fenestrated endothelium, mesangial cells, podocytes and parietal epithelial cells of Bowman's capsule. At least 16 different
Mammalian_kidney
Gene editing method
junctional defects between podocytes, the filtering cells affected in that disease. This was traced to the inability of podocytes to form microvilli between
CRISPR_gene_editing
German nephrologist (born 1971)
Galveston and CEO of the UTMB Health System. Reiser's research focuses on podocyte biology and glomerular diseases. His laboratory has been developing therapies
Jochen_Reiser
Protein found in humans
et al. (May 2025). "Melanocortin 5 receptor signaling protects against podocyte injury in proteinuric glomerulopathies". Kidney International. 107 (5):
Melanocortin_5_receptor
Medical condition
Gene therapy has been frequently discussed, but delivering it to the podocytes in the glomerulus that normally produce the type IV collagen in the glomerular
Alport_syndrome
Protein-coding gene in the species Homo sapiens
inhibits bone fracture healing in mice. In the kidney, CCN1 is expressed in podocytes in normal adult and embryonic glomeruli, but expression is decreased in
CCN_family_member_1
Protein found in humans
I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, hyalocytes, and splenic follicular dendritic cells. The Knops blood group
Complement_receptor_1
Non-invasive treatment for incontinence in women
Renal corpuscle Glomerulus Bowman's capsule Glomerular basement membrane Podocyte Filtration slits Mesangium Intraglomerular mesangial cell Renal tubule
Urethral_bulking_injections
Interstitial cell of Cajal Spleen See main article on Intermediate mesoderm. Podocyte Angioblast → Endothelial cell Mesangial cell Intraglomerular Extraglomerular
List of human cell types derived from the germ layers
List_of_human_cell_types_derived_from_the_germ_layers
Paired internal organ in vertebrates
Wesley S. Ercanbrack; Rebecca A. Wingert (20 February 2023). "Modeling Podocyte Ontogeny and Podocytopathies with the Zebrafish". Journal of Developmental
Kidney_(vertebrates)
Medical condition
diffuse mesangial sclerosis. Electron microscopy shows podocyte disruption (loss of podocyte foot processes or slit diaphragm). Genetic analysis and
Congenital_nephrotic_syndrome
Specialised kidney cells
form a glomerular functional unit with glomerular endothelial cells and podocytes through interactions of molecular signalling pathways which are essential
Mesangial_cell
Filtration by a semi-permeable membrane
lead to a separation through a semipermeable membrane (provided by the podocytes). The Bowman's capsule contains a dense capillary network called the glomerulus
Ultrafiltration_(kidney)
Topics referred to by the same term
liver. Pancreatic stellate cell, reside in exocrine areas of the pancreas Podocyte, found in the Bowman's capsule in the kidneys Osteocyte, commonly found
Stellate cell (disambiguation)
Stellate_cell_(disambiguation)
Protein-coding gene in the species Homo sapiens
expression in podocytes was seen in PHN, the rat model of human mGN. This UCH-L1 expression is thought to induce at least in part podocyte hypertrophy.
Ubiquitin carboxy-terminal hydrolase L1
Ubiquitin_carboxy-terminal_hydrolase_L1
Diabetes researcher
Aguillon-Prada R, Jauregui AN, et al. (June 2011). "Rituximab Targets Podocytes in Recurrent Focal Segmental Glomerulosclerosis". Science Translational
Camillo_Ricordi
Protein-coding gene in the species Homo sapiens
CLIC5A is expressed chiefly in the renal glomerulus, specifically in podocytes. Within the cell, CLIC5A is localized to the plasma membrane and the cytosol
CLIC5
Miniaturized and simplified version of an organ
focal segmental glomerulosclerosis developed junctional defects between podocytes, the filtering cells affected in that disease. Importantly, these disease
Organoid
Type of collagen
et al. (March 2011). "Lack of collagen XVIII long isoforms affects kidney podocytes, whereas the short form is needed in the proximal tubular basement membrane"
Type_XVIII_collagen
Chronic loss of kidney function
causing stress on the endothelial cells, the mesangial cells and the podocytes. This exacerbates the dysfunction caused by the metabolic effects of hyperglycemia
Diabetic_nephropathy
Medical condition
glomerular injury, which includes increased urine podocyte excretion in TG and significant podocyte detachment, both of which are linked to progressive
Transplant_glomerulopathy
Chemical compound
S, Lehtonen E, Hyvönen ME, Ristola M, Fogarty CL, et al. (May 2015). "Podocyte apoptosis is prevented by blocking the Toll-like receptor pathway". Cell
VGX-1027
Protein-coding gene in the species Homo sapiens
complications. It is highly expressed in diabetic blood vessels, cardiomyocytes, podocytes, and immune cells, where it co-localizes with ligands such as AGEs, S100
RAGE_(receptor)
Medical condition
Galloway–Mowat syndrome is yet to be discovered. However, mutations in podocyte proteins, such as nephrin, alpha-actinin 4, and podocin, are associated
Galloway–Mowat_syndrome
Mammalian protein found in Homo sapiens
associations with postsynaptic densities and dendritic spines and with renal podocytes (Mundel et al., 1997).[supplied by OMIM] SYNPO has been shown to interact
SYNPO
Nanotechnology simulation of human organ function
cells, composed by the endothelium, basement membrane and the epithelial podocytes. The fluid that is filtered from the capillary blood into Bowman's space
Organ-on-a-chip
Protein family
signal pathway regulates microtubule-based process formation of cultured podocytes--inhibition of ROCK promoted process elongation". Nephron Experimental
Rho-associated_protein_kinase
Protein-coding gene in the species Homo sapiens
differentiation, BASP1 is mostly found within podocytes, which regulate kidney filtration of the blood in the glomerulus. Podocytes also continue to express WT1 in
BASP1
Species of protozoan parasite
required for parasite killing. Within the kidney, ApoL1 is found in the podocytes in the glomeruli, the proximal tubular epithelium and the arteriolar endothelium
Trypanosoma_brucei
Phylum of marine animals
blood's volume in cm3 per gm of body weight is twice that of a human. Podocytes on the walls of the blood vessels perform first-stage filtration of soluble
Phoronid
Protein-coding gene in the species Homo sapiens
component of glomerular podocytes. Inactivation of the encoding gene in mice leads to anuria, omphalocele and perinatal death. Podocytes are highly differentiated
PODXL
actin binding protein synaptopodin (which was originally described in podocytes of the kidney) is an essential component of the SA. Mice that lack the
Spine_apparatus
Protein-coding gene in the species Homo sapiens
"Insight into podocyte differentiation from the study of human genetic disease: nail-patella syndrome and transcriptional regulation in podocytes". Pediatr
LMX1B
American biologist (1928–2019)
junctions. Since then, Farquhar has continued to study junctions in the podocytes. After leaving Rockefeller in 1962, she established her own laboratory
Marilyn_Farquhar
Protein
"Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin". Am. J. Pathol
CD2AP
Protein-coding gene in the species Homo sapiens
PMID 12168954. Liu G, Clement LC, Kanwar YS, et al. (2007). "ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome". J. Biol
ZHX3
Protein-coding gene in humans
"Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin". The American
CDH3_(gene)
Protein-coding gene in the species Homo sapiens
PMID 16952470. Liu G, Clement LC, Kanwar YS, et al. (2007). "ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome". J. Biol
ZHX2
Protein-coding gene in the species Homo sapiens
LB, Wiggins RC (Sep 1994). "GLEPP1, a renal glomerular epithelial cell (podocyte) membrane protein-tyrosine phosphatase. Identification, molecular cloning
PTPRO
Series of techniques in optical microscopy
Gunn-Moore FJ, Prystowsky MB, Dholakia K (February 2016). "Visualization of podocyte substructure with structured illumination microscopy (SIM): a new approach
Super-resolution_microscopy
Protein-coding gene in the species Homo sapiens
; Lescuyer, Pierre; Moll, Solange (2013-04-26). "Proteomic analysis of podocyte exosome-enriched fraction from normal human urine". Journal of Proteomics
FAM151A
Direct extension and penetration by cancer cells into neighboring tissues
transmembrane glycoprotein that is expressed under normal conditions in kidney podocytes, type 1 alveolar cells, skeletal muscle cells, placenta, etc. Podoplanin
Invasion_(cancer)
Protein-coding gene in the species Homo sapiens
lung parenchyma of smokers. Nox2 has been shown to interact directly with podocyte TRPC6 channels. GRCh38: Ensembl release 89: ENSG00000165168 – Ensembl,
NOX2
Type III intermediate filament protein
immunoreactivity of glial fibrillary acidic protein in mesangial cells and podocytes of the glomeruli of rat kidney in vivo and in culture". Biology of the
Glial fibrillary acidic protein
Glial_fibrillary_acidic_protein
Protein-coding gene in the species Homo sapiens
suppression of the TGF-β pathway. Dach1 is highly expressed in the adult podocyte, with transcripts showing an approximate tenfold enrichment compared to
DACH1
Mammalian protein found in Homo sapiens
various tissues including the endothelium, intestinal epithelium, kidney podocytes, and antigen-presenting cells, where it continues to regulate IgG and
Neonatal fragment crystallizable receptor
Neonatal_fragment_crystallizable_receptor
Kidney disease
basement membrane seems to be the cause of the thickening. Also, the podocytes lose their foot processes. As the disease progresses, the deposits will
Membranous_glomerulonephritis
Mammalian protein found in Homo sapiens
(2024-05-01). "C5a-C5aR1 axis controls mitochondrial fission to promote podocyte injury in lupus nephritis". Molecular Therapy. 32 (5): 1540–1560. doi:10
C5a_receptor
Cellular molecules that help resolve inflammation
smooth muscle cells, osteoclasts, osteoblasts, goblet cells, and kidney podocytes as well as activate the heme oxygenase system of cells thereby increasing
Specialized pro-resolving mediators
Specialized_pro-resolving_mediators
Protein-coding gene in the species Homo sapiens
Tryggvason K, Yan K (July 2009). "Amino acid transporter LAT3 is required for podocyte development and function". Journal of the American Society of Nephrology
Y+L_amino_acid_transporter_2
Medical condition
microcystic tubular dilatation that is highly echogenic, and prominent podocytes. The characteristic feature of collapsing glomerulopathy is collapse of
HIV-associated_nephropathy
Protein-coding gene in the species Homo sapiens
tubular basement thickening, mesangial expansion, glomerulosclerosis, podocyte effacement and nephron loss. DKD occurs in 30%-50% of the diabetic patient
USF1
The following is a partial list of the "A" codes for Medical Subject Headings (MeSH), as defined by the United States National Library of Medicine (NLM)
List_of_MeSH_codes_(A11)
PODOCYTE
PODOCYTE
PODOCYTE
PODOCYTE
PODOCYTE
PODOCYTE
PODOCYTE
PODOCYTE
PODOCYTE