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PNV 001

  • PNV-001

    • Pharmaceutical compound

    PNV-001, also known as deuterated basmisanil, is a highly selective α5 subunit-containing GABAA receptor negative allosteric modulator which is under

    PNV-001

    PNV-001

  • Ciprofloxacin

    • Fluoroquinolone antibiotic

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Ciprofloxacin

    Ciprofloxacin

    Ciprofloxacin

  • GABAA receptor negative allosteric modulator

    • Drug class

    Additional selective α5 subunit-containing GABAA receptor NAMs include PNV-001, PWZ-029, Ro4938581, and TB-21007. Certain drugs show weak GABAA receptor

    GABAA receptor negative allosteric modulator

    GABAA_receptor_negative_allosteric_modulator

  • Basmisanil

    • Chemical compound

    GABAA receptor negative allosteric modulator GABAA receptor § Ligands PNV-001 Froestl W, Muhs A, Pfeifer A (2012). "Cognitive enhancers (nootropics)

    Basmisanil

    Basmisanil

    Basmisanil

  • Valiloxybate

    • Pharmaceutical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Valiloxybate

    Valiloxybate

    Valiloxybate

  • RDX

    • Explosive chemical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    RDX

    RDX

    RDX

  • Flumazenil

    • GABA receptor antagonist drug and benzodiazepine antidote

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Flumazenil

    Flumazenil

    Flumazenil

  • Furosemide

    • Loop diuretic medication

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Furosemide

    Furosemide

    Furosemide

  • Valeric acid

    • Carboxylic acid – CH3(CH2)3COOH

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Valeric acid

    Valeric acid

    Valeric_acid

  • 1,4-Butanediol

    • One of four stable isomers of butanediol

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    1,4-Butanediol

    1,4-Butanediol

    1,4-Butanediol

  • Nicardipine

    • Antihypertensive drug of the calcium channel blocker class

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Nicardipine

    Nicardipine

    Nicardipine

  • Picamilon

    • Chemical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Picamilon

    Picamilon

    Picamilon

  • Penicillin

    • Group of antibiotics derived from fungi

    Biotechnology Advances. 31 (2): 287–311. doi:10.1016/j.biotechadv.2012.12.001. hdl:11511/46869. PMID 23228980. Díez B, Gutiérrez S, Barredo JL, van Solingen

    Penicillin

    Penicillin

    Penicillin

  • Γ-Hydroxybutyric acid

    • Chemical compound

    Hospital Psychiatry. 31 (4): 394–96. doi:10.1016/j.genhosppsych.2008.11.001. PMID 19555805. Allen L, Alsalim W (April 2006). "Best evidence topic report

    Γ-Hydroxybutyric acid

    Γ-Hydroxybutyric acid

    Γ-Hydroxybutyric_acid

  • Γ-Butyrolactone

    • Chemical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Γ-Butyrolactone

    Γ-Butyrolactone

    Γ-Butyrolactone

  • GABA receptor agonist

    • Category of drug

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    GABA receptor agonist

    GABA receptor agonist

    GABA_receptor_agonist

  • Γ-Valerolactone

    • Chemical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Γ-Valerolactone

    Γ-Valerolactone

    Γ-Valerolactone

  • Baclofen

    • Muscle relaxant medication

    Options". Sexual Medicine. 5 (4): e237–e243. doi:10.1016/j.esxm.2017.09.001. PMC 5693397. PMID 29066083. Raad S, Wilkerson M, Jones KR, Orr WC (August

    Baclofen

    Baclofen

    Baclofen

  • Levofloxacin

    • Antibiotic

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Levofloxacin

    Levofloxacin

    Levofloxacin

  • Fipronil

    • Chemical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Fipronil

    Fipronil

    Fipronil

  • Anisatin

    • Chemical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Anisatin

    Anisatin

    Anisatin

  • Dihydromuscimol

    • Pharmaceutical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Dihydromuscimol

    Dihydromuscimol

    Dihydromuscimol

  • Chlorophenylsilatrane

    • Chemical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Chlorophenylsilatrane

    Chlorophenylsilatrane

  • Methylglyoxal

    • Chemical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Methylglyoxal

    Methylglyoxal

    Methylglyoxal

  • Desflurane

    • Inhalational anesthesia medication

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Desflurane

    Desflurane

    Desflurane

  • GABA analogue

    • Class of drugs

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    GABA analogue

    GABA analogue

    GABA_analogue

  • Imipenem

    • Carbapenem antibiotic

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Imipenem

    Imipenem

    Imipenem

  • Pentylenetetrazol

    • Chemical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Pentylenetetrazol

    Pentylenetetrazol

    Pentylenetetrazol

  • Monastrol

    • Chemical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Monastrol

    Monastrol

    Monastrol

  • Xywav

    • Combination drug

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Xywav

    Xywav

  • Piperidine-4-sulfonic acid

    • Pharmaceutical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Piperidine-4-sulfonic acid

    Piperidine-4-sulfonic acid

    Piperidine-4-sulfonic_acid

  • 4-AHP

    • Pharmaceutical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    4-AHP

    4-AHP

    4-AHP

  • Clarithromycin

    • Antibiotic medication

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Clarithromycin

    Clarithromycin

    Clarithromycin

  • Suritozole

    • Chemical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Suritozole

    Suritozole

    Suritozole

  • Tolgabide

    • Chemical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Tolgabide

    Tolgabide

    Tolgabide

  • Bicyclic phosphate

    • Class of chemical compounds

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Bicyclic phosphate

    Bicyclic_phosphate

  • Phenibut

    • CNS depressant medication

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Phenibut

    Phenibut

    Phenibut

  • ASP-8062

    • Pharmaceutical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    ASP-8062

    ASP-8062

    ASP-8062

  • Gabamide

    • Pharmaceutical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Gabamide

    Gabamide

    Gabamide

  • Nefiracetam

    • Chemical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Nefiracetam

    Nefiracetam

    Nefiracetam

  • Hopantenic acid

    • Chemical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Hopantenic acid

    Hopantenic acid

    Hopantenic_acid

  • L-655,708

    • Chemical compound

    GABAA receptor negative allosteric modulator GABAA receptor § Ligands PNV-001 Quirk K, Blurton P, Fletcher S, Leeson P, Tang F, Mellilo D, et al. (1996)

    L-655,708

    L-655,708

    L-655,708

  • GABA

    • Main inhibitory neurotransmitter in the mammalian brain

    & Biological Psychiatry. 29 (2): 169–92. doi:10.1016/j.pnpbp.2004.11.001. PMID 15694225. S2CID 36197603. Mellon SH, Griffin LD (2002). "Neurosteroids:

    GABA

    GABA

    GABA

  • Dihydropicrotoxinin

    • Chemical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Dihydropicrotoxinin

    Dihydropicrotoxinin

    Dihydropicrotoxinin

  • Bamaluzole

    • Chemical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Bamaluzole

    Bamaluzole

    Bamaluzole

  • Glutamine

    • Amino acid

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Glutamine

    Glutamine

    Glutamine

  • Cicutoxin

    • Chemical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Cicutoxin

    Cicutoxin

    Cicutoxin

  • Imidazoleacetic acid

    • Pharmaceutical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Imidazoleacetic acid

    Imidazoleacetic acid

    Imidazoleacetic_acid

  • GABAergic

    • Affecting GABA systems in the brain

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    GABAergic

    GABAergic

  • N-Benzoyl-GABA

    • Pharmaceutical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    N-Benzoyl-GABA

    N-Benzoyl-GABA

    N-Benzoyl-GABA

  • 4-Fluorophenibut

    • GABAB receptor agonist and phenibut analogue

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    4-Fluorophenibut

    4-Fluorophenibut

    4-Fluorophenibut

  • PWZ-029

    • Chemical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    PWZ-029

    PWZ-029

    PWZ-029

  • Tetramethylenedisulfotetramine

    • Chemical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Tetramethylenedisulfotetramine

    Tetramethylenedisulfotetramine

    Tetramethylenedisulfotetramine

  • Semicarbazide

    • Chemical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Semicarbazide

    Semicarbazide

    Semicarbazide

  • Γ-Amino-β-hydroxybutyric acid

    • Anticonvulsant drug

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Γ-Amino-β-hydroxybutyric acid

    Γ-Amino-β-hydroxybutyric acid

    Γ-Amino-β-hydroxybutyric_acid

  • EBOB

    • Chemical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    EBOB

    EBOB

    EBOB

  • MRK-016

    • Chemical compound

    receptor negative allosteric modulator GABAA receptor § Ligands L-655,708 and PNV-001 Atack JR, Maubach KA, Wafford KA, O'Connor D, Rodrigues AD, Evans DC, et al

    MRK-016

    MRK-016

    MRK-016

  • Oroxylin A

    • Chemical compound

    through the brain-derived neurotrophic factor in mice". Brain Res. Bull. 108: 67–73. doi:10.1016/j.brainresbull.2014.09.001. PMID 25218897. S2CID 21456826.

    Oroxylin A

    Oroxylin A

    Oroxylin_A

  • Levorphanol

    • Opioid analgesic drug

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Levorphanol

    Levorphanol

    Levorphanol

  • GABA receptor antagonist

    • Drug Class

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    GABA receptor antagonist

    GABA_receptor_antagonist

  • Sodium oxybate

    • Medication to treat symptoms of narcolepsy

    trials". Sleep Medicine Reviews. 16 (5): 431–443. doi:10.1016/j.smrv.2011.09.001. PMID 22055895. Keating GM (January 2014). "Sodium oxybate: a review of its

    Sodium oxybate

    Sodium oxybate

    Sodium_oxybate

  • Isovaline

    • Chemical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Isovaline

    Isovaline

    Isovaline

  • Picrotoxin

    • Chemical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Picrotoxin

    Picrotoxin

    Picrotoxin

  • Isopregnanolone

    • Chemical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Isopregnanolone

    Isopregnanolone

    Isopregnanolone

  • ADX-71441

    • Chemical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    ADX-71441

    ADX-71441

    ADX-71441

  • GABAA-rho receptor

    • Class of transport proteins

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    GABAA-rho receptor

    GABAA-rho_receptor

  • Bicuculline

    • Chemical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Bicuculline

    Bicuculline

    Bicuculline

  • Γ-Hydroxyvaleric acid

    • Chemical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Γ-Hydroxyvaleric acid

    Γ-Hydroxyvaleric acid

    Γ-Hydroxyvaleric_acid

  • Bemegride

    • Chemical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Bemegride

    Bemegride

    Bemegride

  • 4-PIOL

    • Pharmaceutical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    4-PIOL

    4-PIOL

    4-PIOL

  • Isoflavonoid

    • Class of chemical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Isoflavonoid

    Isoflavonoid

    Isoflavonoid

  • Ethyl acetoxy butanoate

    • Chemical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Ethyl acetoxy butanoate

    Ethyl acetoxy butanoate

    Ethyl_acetoxy_butanoate

  • Phenytoin

    • Anti-seizure medication

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Phenytoin

    Phenytoin

    Phenytoin

  • Oenanthotoxin

    • Chemical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Oenanthotoxin

    Oenanthotoxin

    Oenanthotoxin

  • (Z)-4-Amino-2-butenoic acid

    • Chemical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    (Z)-4-Amino-2-butenoic acid

    (Z)-4-Amino-2-butenoic acid

    (Z)-4-Amino-2-butenoic_acid

  • GABAA receptor agonist

    • Hallucinogenic drug

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    GABAA receptor agonist

    GABAA receptor agonist

    GABAA_receptor_agonist

  • TBPS

    • Chemical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    TBPS

    TBPS

    TBPS

  • Enzalutamide

    • Antiandrogen medication used in treatment of prostate cancer

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Enzalutamide

    Enzalutamide

    Enzalutamide

  • Levomethorphan

    • Opioid analgesic

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Levomethorphan

    Levomethorphan

    Levomethorphan

  • GABAA receptor

    • Ionotropic receptor and ligand-gated ion channel

    & Biological Psychiatry. 29 (2): 169–192. doi:10.1016/j.pnpbp.2004.11.001. PMID 15694225. S2CID 36197603. (h) Mellon SH, Griffin LD (2002). "Neurosteroids:

    GABAA receptor

    GABAA receptor

    GABAA_receptor

  • Dieldrin

    • Chemical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Dieldrin

    Dieldrin

    Dieldrin

  • Coriamyrtin

    • Convulsant toxin

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Coriamyrtin

    Coriamyrtin

    Coriamyrtin

  • INDV-1000

    • Pharmaceutical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    INDV-1000

    INDV-1000

  • BHF-177

    • Chemical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    BHF-177

    BHF-177

    BHF-177

  • Ro15-4513

    • Chemical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Ro15-4513

    Ro15-4513

    Ro15-4513

  • Sevoflurane

    • Inhalational anaesthetic

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Sevoflurane

    Sevoflurane

    Sevoflurane

  • N-Acetylputrescine

    • Endogenous GABA precursor

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    N-Acetylputrescine

    N-Acetylputrescine

    N-Acetylputrescine

  • Ro4938581

    • Chemical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Ro4938581

    Ro4938581

    Ro4938581

  • Honokiol

    • Chemical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Honokiol

    Honokiol

    Honokiol

  • Α5IA

    • Chemical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Α5IA

    Α5IA

    Α5IA

  • Lindane

    • Organochlorine chemical and an isomer of hexachlorocyclohexane

    Environment International. 34 (6): 737–40. doi:10.1016/j.envint.2007.12.001. PMID 18207242. "CDC - NIOSH Pocket Guide to Chemical Hazards - Lindane"

    Lindane

    Lindane

    Lindane

  • GABRA5

    • Protein found in humans

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    GABRA5

    GABRA5

    GABRA5

  • Gamma-aminobutyric acid receptor subunit alpha-1

    • Protein-coding gene in humans

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Gamma-aminobutyric acid receptor subunit alpha-1

    Gamma-aminobutyric acid receptor subunit alpha-1

    Gamma-aminobutyric_acid_receptor_subunit_alpha-1

  • 2-Hydroxysaclofen

    • Chemical compound, GABA(B) receptor antagonist

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    2-Hydroxysaclofen

    2-Hydroxysaclofen

    2-Hydroxysaclofen

  • Apalutamide

    • Chemical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Apalutamide

    Apalutamide

    Apalutamide

  • (+)-cis-2-Aminomethylcyclopropane carboxylic acid

    • Chemical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    (+)-cis-2-Aminomethylcyclopropane carboxylic acid

    (+)-cis-2-Aminomethylcyclopropane carboxylic acid

    (+)-cis-2-Aminomethylcyclopropane_carboxylic_acid

  • Phenylsilatrane

    • Chemical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Phenylsilatrane

    Phenylsilatrane

    Phenylsilatrane

  • TBPO

    • Chemical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    TBPO

    TBPO

    TBPO

  • 5α-Dihydroprogesterone

    • Chemical compound

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    5α-Dihydroprogesterone

    5α-Dihydroprogesterone

    5α-Dihydroprogesterone

  • Α3IA

    • Chemical compound, anxiogenic

    Phenylsilatrane Picrotoxin (i.e., picrotin, picrotoxinin and dihydropicrotoxinin) PNV-001 Pregnenolone sulfate Propybicyphat PWZ-029 Radequinil Ro 15-4513 Ro 19-4603

    Α3IA

    Α3IA

    Α3IA

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