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Chemical compound
Phosphatidylserine (abbreviated Ptd-L-Ser or PS) is a phospholipid and is a component of the cell membrane. It plays a key role in cell cycle signaling
Phosphatidylserine
Protein family
Phosphatidylserine decarboxylase is an enzyme that in humans is encoded by the PISD gene. Phosphatidylserine decarboxylase (EC 4.1.1.65) catalyzes the
Phosphatidylserine decarboxylase
Phosphatidylserine_decarboxylase
Group of chemical compounds
Phosphatidylserine decarboxylase is the enzyme that is used to decarboxylate phosphatidylserine in the first pathway. The phosphatidylserine decarboxylation
Phosphatidylethanolamine
Protein-coding gene in the species Homo sapiens
Phosphatidylserine synthase 1 is a protein that in humans is encoded by the PTDSS1 gene. The protein encoded by this gene catalyzes the formation of phosphatidylserine
Phosphatidylserine_synthase_1
Class of lipids
Phosphatidylethanolamine (cephalin) (PE) Phosphatidylcholine (lecithin) (PC) Phosphatidylserine (PS) Phosphoinositides: Phosphatidylinositol (PI) Phosphatidylinositol
Phospholipid
Generic term for amphiphilic substances of plant and animal origin
phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, and phosphatidic acid. Lecithin was first isolated in 1845 by the
Lecithin
Class of enzymes
3-sn-phosphatidyltransferase. Other names in common use include phosphatidylserine synthase, CDPdiglyceride-serine O-phosphatidyltransferase, PS synthase
CDP-diacylglycerol—serine O-phosphatidyltransferase
CDP-diacylglycerol—serine_O-phosphatidyltransferase
L-serine-phosphatidylethanolamine phosphatidyltransferase (EC 2.7.8.29, phosphatidylserine synthase 2, serine-exchange enzyme II, PTDSS2 (gene)) is an enzyme
L-serine-phosphatidylethanolamine phosphatidyltransferase
L-serine-phosphatidylethanolamine_phosphatidyltransferase
Protein-coding gene in the species Homo sapiens
serves as a ligand for TIM-1 but also as a receptor for phosphatidylserine. Its phosphatidylserine binding however does not mediate signalling instead it
TIMD4
Euphemism for false advertising
Study Investigating the Efficacy of a Whole Coffee Cherry Extract and Phosphatidylserine Formulation on Cognitive Performance of Healthy Adults with Self-Perceived
Snake_oil
Form of programmed cell death
molecular patterns (ACAMPs), such as phosphatidylserine on the outer leaflet of the cell membrane. Phosphatidylserine is normally found on the inner leaflet
Apoptosis
Chemical compound
Bavituximab (PGN401) is a human-mouse chimeric monoclonal antibody against phosphatidylserine, which is a component of cell membranes that is exposed when a cell
Bavituximab
phagocytose (eat) that cell. Currently known eat-me signals include: phosphatidylserine, oxidized phospholipids, sugar residues (such as galactose), deoxyribonucleic
Eat-me_signals
Protein-coding gene in the species Homo sapiens
Phosphatidylserine lipase ABHD16A is an enzyme that in humans is encoded by the gene ABHD16A (previously BAT5). A cluster of genes, BAT1-BAT5, has been
BAT5
Class of lipids
functions. Phosphatidylserine Phosphatidylserine is important in cell signaling, specifically apoptosis. Cells will use this phosphatidylserine to enter
Glycerophospholipid
Protein
phospholipid phosphatidylserine on their surface and act as catalysts to induce the coagulation cascade. Surface exposure of phosphatidylserine is thought
Phospholipid_scramblase
Medical condition
or other injury that causes bleeding), platelets are activated and phosphatidylserine (PS) in the inner leaflet of the platelet membrane is transported
Scott_syndrome
Lipid that is soluble in nonpolar solvents with their respective range
PC, GPCho or lecithin), phosphatidylethanolamine (PE or GPEtn) and phosphatidylserine (PS or GPSer). In addition to serving as a primary component of cellular
Lipid
Species of flavivirus causing West Nile fever
flavivirus lipid membrane has been found to contain cholesterol and phosphatidylserine, but other elements of the membrane have yet to be identified. The
West_Nile_virus
Cell organelle that processes proteins
"Transport of Phosphatidylserine from the Endoplasmic Reticulum to the Site of Phosphatidylserine Decarboxylase2 in Yeast: Phosphatidylserine Transport to
Endoplasmic_reticulum
Chemical compound
and the response of rhodopsin contained in the synaptic vesicles. Phosphatidylserine (PS) – which contains high DHA content – has roles in neuronal signaling
Docosahexaenoic_acid
Reduced oxygen-carrying ability of the blood due to breakdown of red blood cells
to signal to the reticuloendothelial phagocytes by externalizing phosphatidylserine, it is likely to lyse through uncontrolled means. The distinguishing
Hemolytic_anemia
Protein-coding gene in the species Homo sapiens
commonly used to detect apoptotic cells by its ability to bind to phosphatidylserine, a marker of apoptosis when it is on the outer leaflet of the plasma
Annexin_A5
Assisted reproductive technology procedure
magnetic microbeads coated with annexin V, a protein that binds to phosphatidylserine — an early marker of apoptosis. When passed through a magnetic field
In_vitro_fertilisation
Natural, artificial, or technological alteration of the human body
development. Some examples of these include Citicoline, Huperzine A, Phosphatidylserine, Bacopa monnieri, Acetyl-L-carnitine, Uridine monophosphate, L-theanine
Human_enhancement
Topics referred to by the same term
Persulfate, a class of peroxide sulfate used as a powerful oxidizing agent Phosphatidylserine, a phospholipid Phosphorothioate (or thiophosphate), a family of compounds
PS
Protein-coding gene in the species Homo sapiens
expression data Gene ontology Molecular function protein binding phosphatidylserine binding phosphatidylinositol binding protein homodimerization activity
APPL2
Chemical element with atomic number 33 (As)
rats with a radioactive arsenic-labeled antibody that binds exposed phosphatidylserine". Clinical Cancer Research. 14 (5): 1377–1385. doi:10.1158/1078-0432
Arsenic
Cell membrane engulfing a large particle
intracellular molecules on the cell surface, such as calreticulin, phosphatidylserine (from the inner layer of the plasma membrane), annexin A1, oxidised
Phagocytosis
Skin which is abnormally inelastic and hangs loosely
laxa is Lenz–Majewski syndrome which is due to a mutation in the phosphatidylserine synthase 1 (PTDSS1) gene. [citation needed] In contrast, acquired
Cutis_laxa
Type of microphage
dendritic cells (FDCs). FDCs provide TBMs with MFGE8 protein, which is a phosphatidylserine-binding "eat me" signal for removal of apoptotic germinal center B
Tingible_body_macrophage
Programmed death of red blood cells
by cell shrinkage, membrane blebbing, activation of proteases, and phosphatidylserine exposure at the outer membrane leaflet. Conditions with excessive
Eryptosis
Enclosing or separating membrane in organisms acting as selective semi-permeable barrier
crucial role in blood clotting. In the bilayer of red blood cells is phosphatidylserine. This is usually in the cytoplasmic side of the membrane. However
Biological_membrane
Autoimmune disease in which the immune system attacks healthy tissue
cells express "eat-me" signals, of cell-surface proteins such as phosphatidylserine, that prompt immune cells to engulf them. Apoptotic cells also express
Lupus
on the phagocyte that recognise either phosphatidylserine directly or opsonins bound to the phosphatidylserine or other "eat-me" signals, such as calreticulin
Phagoptosis
Biological membrane structure
(cytoplasmic) leaflet is composed mostly of phosphatidylethanolamine, phosphatidylserine and phosphatidylinositol and its phosphorylated derivatives. By contrast
Lipid_bilayer
Variety of the common bean
several dietary minerals (table). White bean phytochemicals include phosphatidylserine, apigenin, saponins, ferulic acid, and p-coumaric acid. Dried and
Navy_bean
Protein-coding gene in humans
protein is an essential component for the calcium-dependent exposure of phosphatidylserine on the cell surface. The scrambling of phospholipid occurs in various
Anoctamin_6
Protein-coding gene in the species Homo sapiens
angiogenesis could be a way of fighting cancer. MFGE8 contains a phosphatidylserine (PS) binding domain, as well as an arginine-glycine-aspartic acid
MFGE8
Enzyme family
sheddases are instead related to phosphatidylserine exposure. When PSA-3 cells' ability to synthesize phosphatidylserine was repressed, sheddase activity
Sheddase
Protein found in humans
5)-bisphosphate Phosphatidylinositol (3,4,5)-trisphosphate Phosphatidic acid Phosphatidylserine Phosphatidylethanolamine Cardiolipin Pyroptosis Inflammasome GSDMA
GSDMD
Protein-coding gene in the species Homo sapiens
phosphatidylserine (PS) exposed on apoptotic cell surface. TIM genes are also involved in host-virus interaction. As receptors for phosphatidylserine
HAVCR1
haemostasis. Following strong activation, procoagulant platelets express phosphatidylserine on their surface and become highly efficient in sustaining thrombin
Procoagulant_platelets
Biological membrane that separates the interior of a cell from its outside environment
phospholipids and glycolipids: phosphatidylcholine (PtdCho), phosphatidylethanolamine (PtdEtn), phosphatidylinositol (PtdIns), phosphatidylserine (PtdSer).
Cell_membrane
Immune disorder leading to increased risk of blood clots
testing for antibodies specific for individual targets of aPL such as phosphatidylserine is currently under debate.[citation needed] This is tested for by
Antiphospholipid_syndrome
Protein domain
selectivity for the major components of cell membranes, including phosphatidylserine and phosphatidylcholine. This C2 domain is about 116 amino-acid residues
C2_domain
Protein domain named after the epidermal growth factor protein
stabilin-2 recognize and bind apoptotic cells, probably by recognizing phosphatidylserine, an apoptotic cell marker. Calcium-binding EGF-like domains (cbEGF-like
EGF-like_domain
Antibodies from clones of the same blood cell
bavituximab cancer, hepatitis C infection immunotherapy, targets phosphatidylserine chimeric Anti-viral casirivimab/imdevimab SARS-CoV-2 coronavirus causing
Monoclonal_antibody
Protein family
scaffold. Annexin A-V can form 2-dimensional networks when bound to the phosphatidylserine unit of the membrane. Annexin A-V is effective in stabilizing changes
Annexin
Protein family
binding oxysterol binding phosphatidylinositol-4-phosphate binding phosphatidylserine binding phospholipid transporter activity OSBPL6 (ORP6) Oxysterol-binding
Oxysterol-binding_protein
Protein family
of these Gla domains. The Gla domain causes a binding affinity to phosphatidylserine, a membrane phospholipid, in most Gla coagulation proteins. The exceptions
Gla_domain
Medical condition
physiological platelet activation, a fraction of platelets expresses phosphatidylserine on their surface and become highly efficient in sustaining thrombin
COAT_platelet_defect
Substance that lowers surface tension
phosphate anion with an amine or ammonium, such as the phospholipids phosphatidylserine, phosphatidylethanolamine, phosphatidylcholine, and sphingomyelins
Surfactant
Cellular state
pseudoapoptotic events will occur. Apoptotic events such as membrane blebbing, phosphatidylserine flips (exposure to extracellular space), mitochondrial swelling, and
Pseudoapoptosis
Chemical compound
locus contains a putative regulatory gene, crdR. A membrane-bound phosphatidylserine synthase, encoded by pssAG, is also necessary for maximal production
Curdlan
Cells that ingest harmful matter within the body
apoptosis display molecules, such as phosphatidylserine, on their cell surface to attract phagocytes. Phosphatidylserine is normally found on the cytosolic
Phagocyte
Rare genetic disorder
as being the precursor to several essential compounds, including phosphatidylserine, sphingomyelin, glycine, and D-serine. Diagnosis of SPATCCM generally
SPATCCM
Family of enzymes
βII, and γ. These require Ca2+, DAG, and a phospholipid such as phosphatidylserine for activation. Novel (n)PKCs include the δ, ε, η, and θ isoforms
Protein_kinase_C
Class of phospholipids
metabolism Phosphatidate Choline CDP choline Lysophosphatidylcholine Phosphatidylserine Saturated fatty acid Unsaturated fatty acid Jackowski S, Cronan JE
Phosphatidylcholine
Protein-coding gene in the species Homo sapiens
nucleotide binding heat shock protein binding unfolded protein binding phosphatidylserine binding C3HC4-type RING finger domain binding protein binding MHC
HSPA8
Category of enzyme
asymmetry, in particular the appearance of the anionic phospholipid phosphatidylserine on the exoplasmic face, can serve as an early indicator of apoptosis
Flippase
Protein-coding gene in the species Homo sapiens
phosphatidylinositol-3,4-bisphosphate binding oligosaccharide binding phosphatidylserine binding lipid binding Cellular component extracellular region extrinsic
Retinoschisin
Chemical compound
of proadifen was demonstrated to produce time- and dose-dependent phosphatidylserine externalization, caspase-3 activation and PARP cleavage. Intense upregulation
Proadifen
Protein-coding gene in the species Homo sapiens
function calcium-dependent phospholipid binding calcium ion binding phosphatidylserine binding phosphatidylcholine binding phosphatidylglycerol binding Cellular
Annexin_A13
Cellular structure
ER-mitochondria lipid which transform phosphatidic acid (PA) into phosphatidylserine (PS) by phosphatidylserine synthases 1 and 2 (PSS1, PSS2) in the ER and then transfers
Mitochondria associated membranes
Mitochondria_associated_membranes
Organelle in eukaryotic cells responsible for respiration
enzymes involved in lipid biosynthesis, such as phosphatidylserine synthase on the ER face and phosphatidylserine decarboxylase on the mitochondrial face. Because
Mitochondria
Medical condition
overactive phosphatidylserine synthase 1 was the cause of LMS, making it the first known human disease to be caused by disrupted phosphatidylserine metabolism
Lenz–Majewski_syndrome
the fusion process by binding to negatively charged lipids such as phosphatidylserine, phosphatidylglycerol and cardiolipin. One role on these ions in the
Lipid_bilayer_fusion
Molecular markers associated with apoptosis
externalized in the same locations as phosphatidylserine and helps with clustering phagocytic phosphatidylserine receptors around the apoptotic cell. Another
ACAMPs
protein binds to apoptotic cells in a calcium-dependent manner using phosphatidylserine-containing membrane surfaces that are usually present only on the
Annexin_A5_affinity_assay
Chemical compound and essential nutrient
diphosphate-diacylglycerol. Its hydroxyl group reacts with serine to form phosphatidylserine, which decarboxylates to ethanolamine and phosphatidylethanolamine
Choline
Protein-coding gene in the species Homo sapiens
Molecular function phosphatidylinositol-4,5-bisphosphate binding phosphatidylserine binding protein binding phosphatidylinositol binding identical protein
FCHO2
Genus of parasitic flagellate protist
injection of only viable parasites. When the anti-inflammatory signal phosphatidylserine usually found on apoptotic cells, is exposed on the surface of dead
Leishmania
Tolerance of a fetus during pregnancy
of the cell membrane. Studies have shown that antibodies against phosphatidylserine, phosphatidylcholine, phosphatidylglycerol, phosphatidylinositol and
Immune_tolerance_in_pregnancy
Protein-coding gene in the species Homo sapiens
aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another
ATP8B3
Protein-coding gene in the species Homo sapiens
histone demethylases. This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells. Subsequent studies
JMJD6
Fish eaten by humans
species List of seafood dishes Oily fish Maguro bōchō Pescetarianism Phosphatidylserine Seafood Watch "Why is fish not considered as meat?". Seasoned Advice
Fish_as_food
Protein-coding gene in the species Homo sapiens
"Ribophorin II is involved in the tissue factor expression mediated by phosphatidylserine-dependent antiprothrombin antibody on monocytes". Rheumatology. 55
RPN2
receptor that binds to annexin is added to sperm. Inside normal cells, phosphatidylserine molecules are located within the cell membrane towards the cytoplasm
Magnetic-activated cell sorting
Magnetic-activated_cell_sorting
prevention of organ transplant rejections Bavituximab mab chimeric phosphatidylserine cancer, viral infections BCD-100 human PD-1 melanoma Bebtelovimab
List of therapeutic monoclonal antibodies
List_of_therapeutic_monoclonal_antibodies
Protein-coding gene in the species Homo sapiens
phospholipid binding calcium ion binding acetylcholine receptor activity phosphatidylserine binding protein binding phospholipid binding protein homodimerization
Annexin_A9
Type of white blood cell
removed after phagocytosis of pathogens by macrophages. PECAM-1 and phosphatidylserine on the cell surface are involved in this process.[citation needed]
Neutrophil
Lipid molecules on cell membrane
The major membrane lipids PtdCho - Phosphatidylcholine; PtdEtn - Phosphatidylethanolamine; PtdIns - Phosphatidylinositol; PtdSer - Phosphatidylserine.
Membrane_lipid
Protein-coding gene in humans
ontology Molecular function calcium ion binding transporter activity phosphatidylserine binding protein binding calcium-dependent phospholipid binding Cellular
CPNE6
Oxygen-delivering blood cell and the most common type of blood cell
Phosphatidylethanolamine (PE); Phosphoinositol (PI) (small amounts). Phosphatidylserine (PS); This asymmetric phospholipid distribution among the bilayer
Red_blood_cell
Type of tissue in the spleen
apoptotic cells to be taken up by macrophages, it is important that phosphatidylserine is expressed on the outer surface of the apoptotic cells, which is
White_pulp
Protein-coding gene in the species Homo sapiens
function calcium ion binding phosphatase binding clathrin binding phosphatidylserine binding neurexin family protein binding protein binding calcium-dependent
SYTL2
Protein-coding gene in the species Homo sapiens
hydrogen bonds and is a binding site for ligands such as CEACAM-1 and phosphatidylserine. The extracellular portion of the IgV domain may also be glycosylated
HAVCR2
Protein-coding gene in the species Homo sapiens
dendrite cytoplasm Biological process acylglycerol catabolic process phosphatidylserine catabolic process adult walking behavior response to auditory stimulus
ABHD12
Phosphatidylserine is a phospholipid that usually resides on the inner layer of the cell membrane. After sperm cells are primed, phosphatidylserine can
Fusion_mechanism
Protein-coding gene in the species Homo sapiens
aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another
Phospholipid-transporting ATPase VA
Phospholipid-transporting_ATPase_VA
US-based Protein Kinase C expert
and its interaction with specific membrane phospholipids, such as phosphatidylserine She has also made important discoveries in the protein phosphatase
Alexandra_Newton
Cognitive disease affecting older cats
radical damage and beta-amyloid deposits, N-acetyl cysteine (NAC), phosphatidylserine and apoaequorin, vitamins E, C and B complex, melatonin as a sedation
Feline_cognitive_dysfunction
Outermost layer of many types of the infectious agent
are activated by the ligands Gas6 and Protein S. The phospholipid phosphatidylserine may be seen on the membranes of several enveloped viruses, which they
Viral_envelope
Protein-coding gene in the species Homo sapiens
reticulum membrane integral component of membrane Biological process phosphatidylserine metabolic process positive regulation of CDP-diacylglycerol-serine
SERINC1
Neural oscillation in the brain, 12.5–30 Hz
Baumeister J, Barthel T, Geiss KR, Weiss M (2008). "Influence of phosphatidylserine on cognitive performance and cortical activity after induced stress"
Beta_wave
Protein-coding gene in the species Homo sapiens
Molecular function nucleotide binding ATPase activity ATP binding phosphatidylserine floppase activity phosphatidylcholine floppase activity apolipoprotein
ABCA7
Protein-coding gene in the species Homo sapiens
BioGPS More reference expression data Gene ontology Molecular function phosphatidylserine 1-acylhydrolase activity protein binding 1-acyl-2-lysophosphatidylserine
HRASLS3
Type of extracellular vesicle
kinase (MKP)-1. Uptake of endothelial micoparticles is Annexin I/Phosphatidylserine receptor dependant. Microparticles are derived from many other cell
Microvesicle
Common bean plant
United States. White beans are the most abundant plant-based source of phosphatidylserine known. Yellow (Enola type) 'Sinaloa Azufrado', 'Mayocoba', and 'Peruano'
Phaseolus_vulgaris
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