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Protein family
Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain is a protein domain that contains post-translational modifications of many glutamate
Gla_domain
Chemical compound
γ-carboxyglutamate residues are present in the γ-carboxyglutamic acid-rich ("GLA") domain. This GLA domain is known to be found in over a dozen known proteins, including
Carboxyglutamic_acid
Topics referred to by the same term
a glycoside hydrolase enzyme GLA (gene), an encoding of the enzyme alpha-galactosidase A Gla domain, a protein domain Gamma-Linolenic acid, a fatty acid
GLA
Fat-soluble vitamers
gamma-carboxyglutamate (Gla) residues. The modified residues are often (but not always) situated within specific protein domains called Gla domains. Gla residues are
Vitamin_K
Protein involved in coagulation
a common domain architecture. The factor IX protein is composed of four protein domains: the Gla domain, two tandem copies of the EGF domain and a C-terminal
Factor_IX
protein is a Gla domain, and such a protein is informally called a Gla protein. Some Gla proteins have "Gla" in their name, for example Matrix Gla protein
Vitamin_K-dependent_protein
Group of vitamins and bacterial metabolites
carboxylation of the gla domain in "gla proteins" (i.e., in conversion of peptide-bound glutamic acid (glu) to γ-carboxyglutamic acid (Gla) in these proteins)
Vitamin_K2
Complex formed by blood clotting factors X and V
vitamin K-dependent procoagulant factors dock to this surface through their Gla domain with Ca2+ bridges. Undas, A.; Brummel-Ziedins, K. E.; Mann, K. G. (29
Tenase
Protein-coding gene in the species Homo sapiens
to support adhesion and migration of epithelial cells. Periostin is a gla domain vitamin K dependent factor. Periostin is a secreted extracellular matrix
Periostin
Vitamin K-dependent plasma glycoprotein synthesized in the liver
S has a peptide between the Gla domain and the EGF-like domain, that is cleaved by thrombin. The Gla and EGF-like domains stay connected after the cleavage
Protein_S
Mammalian protein found in Homo sapiens
protease domain (212–450). The light chain contains the Gla- and EGF-like domains and the aromatic segment. The heavy chain contains the protease domain and
Protein_C
Autonomous protein domains
Kringle domains are autonomous protein domains that fold into large loops stabilized by three disulfide linkages. These are important in protein–protein
Kringle_domain
Mammalian protein found in Homo sapiens
first identified as a calcium-binding protein. Because osteocalcin has gla domains, its synthesis is vitamin K2-dependent. In humans, osteocalcin is encoded
Osteocalcin
Enzyme involved in blood coagulation in humans
is composed of four domains; an N-terminal Gla domain, two kringle domains and a C-terminal trypsin-like serine protease domain. Factor Xa with factor
Thrombin
LD, Robinson RC (2013). "The expanding superfamily of gelsolin homology domain proteins". Cytoskeleton. 70 (11): 775–95. doi:10.1002/cm.21149. PMID 24155256
Intracellular calcium-sensing proteins
Intracellular_calcium-sensing_proteins
Mammalian protein involved in blood clotting
functions to inhibit blood coagulation by binding to an inhibitor. It is a GLA domain protein and thus Vitamin K-dependent, and its functionality is therefore
Protein_Z
Enzyme
Galactosidase alpha is an enzyme that in humans is encoded by the GLA gene. Pathogenic mutations in the GLA gene impair the synthesis, folding, or stability of lysosomal
GLA_(gene)
Intracellular communication process
sialophosphoprotein Osteopontin Secreted hormones Osteocalcin Calcium-binding domains C2 domain Cadherin C-type lectin EF hand EGF-like domain Gla domain
Calcium_signaling
Membrane proteins that adhere temporarily to membranes with which they are associated
acidic protein residues and phosphate groups of lipids, as in annexins or GLA domains. These peripheral proteins function as carriers of non-polar compounds
Peripheral_membrane_protein
Chemical compound
sialophosphoprotein Osteopontin Secreted hormones Osteocalcin Calcium-binding domains C2 domain Cadherin C-type lectin EF hand EGF-like domain Gla domain
Inositol_trisphosphate
Protein family
residues. Gamma-carboxyglutamate residues are more commonly associated with GLA domains, where they occur through post-translational modification catalysed by
Fasciclin_domain
Enzyme
A (GLA). Human α‑galactosidases encoded by GLA and MYORG genes share a conserved modular architecture built around a TIM barrel catalytic domain with
Α-Galactosidase
Protein
the CALB1 gene. Calbindin contains 4 active calcium-binding domains, and 2 modified domains that have lost their calcium-binding capacity. Calbindin acts
Calbindin
Complex that catalyzes conversion of prothrombin to thrombin
contains an N-terminal γ-carboxyglutamic acid domain (Gla domain) and two epidermal growth factor-like domains (EGF1 and EGF2). The heavy chain consists of
Prothrombinase
Medication
native FXa due to the removal of a 34 residue fragment that contains the Gla domain. This modification reduces andexanet alfa's anticoagulant potential. Additionally
Andexanet_alfa
Biological process
sialophosphoprotein Osteopontin Secreted hormones Osteocalcin Calcium-binding domains C2 domain Cadherin C-type lectin EF hand EGF-like domain Gla domain
Calcium-induced calcium release
Calcium-induced_calcium_release
Messenger protein
kDa). The protein has two approximately symmetrical globular domains (the N- and C- domains) each containing a pair of EF hand motifs separated by a flexible
Calmodulin
Enzyme
the function of the encoded enzyme is essential for hemostasis. Most gla domain-containing proteins depend on this carboxylation reaction for posttranslational
Gamma-glutamyl_carboxylase
Protein involved in coagulation
in the signaling function of TF. Note that one of factor VIIa's domains, GLA domain, binds in the presence of calcium to negatively charged phospholipids
Tissue_factor
Protein domain named after the epidermal growth factor protein
"The relative orientation of Gla and EGF domains in coagulation factor X is altered by Ca2+ binding to the first EGF domain. A combined NMR-small angle
EGF-like_domain
Protein-coding gene in the species Homo sapiens
neuronal), controlling nitric oxide production. Proline rich Gla, PRRG2, has a Gla domain which binds hyaluronan and is associated with proteins present
Proline-rich_12
Serum protein related to amyloid diseases
brains of patients with schizophrenia. Transthyretin is known to contain a Gla domain, and thus be dependent for production on post-translational modification
Transthyretin
Human gene coding for the GAS6 protein
by growth arrested fibroblasts. Gas6 is a gamma-carboxyglutamic acid (Gla) domain-containing protein thought to be involved in the stimulation of cell
GAS6
Protein-coding gene in the species Homo sapiens
DD (January 1996). "Calcium-dependent binding of S100C to the N-terminal domain of annexin I". The Journal of Biological Chemistry. 271 (2): 719–725. doi:10
Annexin_A1
Class of intracellular transport proteins
receptors, approximately 80% of the mass, are present in the cytosolic domain, which accounts for the many regulatory interactions. The cytosolic portion
Ryanodine_receptor
Protein-coding gene in the species Homo sapiens
binding protein C and APC. Through their gamma-carboxyglutamic acid (Gla) domain, both protein C and APC interact with EPCR. Occupied by a phospholipid
Endothelial protein C receptor
Endothelial_protein_C_receptor
Family of vertebrate proteins involved in cell division and inflammation
Chin (2014-08-01). "Structural Insights into Calcium-Bound S100P and the V Domain of the RAGE Complex". PLOS ONE. 9 (8) e103947. Bibcode:2014PLoSO...9j3947P
S100_protein
Protein family
consist of annexin with other domains like gelsolin. The basic structure of an annexin is composed of two major domains. The first is located at the COOH-terminal
Annexin
Protease enzyme present in mammals and other organisms
sialophosphoprotein Osteopontin Secreted hormones Osteocalcin Calcium-binding domains C2 domain Cadherin C-type lectin EF hand EGF-like domain Gla domain
Calpain
Protein-coding gene in the species Homo sapiens
that in humans is encoded by the ITIH2 gene. It is known to contain a Gla domain, and thus be dependent for production on post translational modification
ITIH2
Biomedical academic
intercellular communication in cancer biology, and the development of Gla-domain proteins that bind phosphatidylserine on cell surfaces and are internalized
Christopher_H._Contag
role in many cellular processes. Calcium-binding proteins have specific domains that bind to calcium and are known to be heterogeneous. One of the functions
Calcium-binding_protein
Protein family
two C-terminal C2 domains - C2A and C2B. There are 17 isoforms in the mammalian synaptotagmin family. There are several C2-domain containing protein
Synaptotagmin
Chemical compound
two domains (an N-terminus LSm domain and a C-terminus anticodon-binding [AD] domain), LSm12 mediates NAADP activation of TPCs via its LSm domain. This
Nicotinic acid adenine dinucleotide phosphate
Nicotinic_acid_adenine_dinucleotide_phosphate
Protein-coding gene in the species Homo sapiens
sialophosphoprotein Osteopontin Secreted hormones Osteocalcin Calcium-binding domains C2 domain Cadherin C-type lectin EF hand EGF-like domain Gla domain
Recoverin
Danish businessperson
Accumulation of the Recombinant Factor VIIa in Rat Bone: Importance of the Gla‐Domain and Relevance to Factor IX, another Vitamin K‐Dependent Clotting Factor
Mads_Krogsgaard_Thomsen
Chemical compound
one between the two phosphate groups, was reported. SARM1 and other TIR domain-containing proteins also catalyze the formation of cADPR from NAD+. Variants
Cyclic_ADP-ribose
Calcium-binding protein
sialophosphoprotein Osteopontin Secreted hormones Osteocalcin Calcium-binding domains C2 domain Cadherin C-type lectin EF hand EGF-like domain Gla domain
Calexcitin
Soluble protein
the DNA-binding domain of the superfamily of nuclear receptors. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid
Calreticulin
Protein-coding gene in the species Homo sapiens
catalyzes γ‐carboxylation of specific glutamic acid residues in Gla‐factors/proteins (Gla domain) leading to their activation and participation in blood clotting
NAD(P)H dehydrogenase (quinone 1)
NAD(P)H_dehydrogenase_(quinone_1)
Protein domain
they participate in diverse supramolecular structures. The amino-terminal domain I of fibulin consists of three anaphylatoxin-like (AT) modules, each approximately
Fibulin
Calcium-binding protein
for its high-capacity to bind Ca2+. In addition, the hydrophobic core of domain II appears to be necessary for CASQ2's function, because a single amino
Calsequestrin
Mammalian protein found in Homo sapiens
repeats are related in structure (but barely in sequence) to the ADF-H domain, forming a superfamily (InterPro: IPR029006). The family appears to have
Gelsolin
Mammalian protein found in humans
(ER). It consists of a large (50 kDa) N-terminal calcium-binding lumenal domain, a single transmembrane helix and a short (90 residues), acidic cytoplasmic
Calnexin
Mammalian protein found in Homo sapiens
broken into 4 domains: 1) a Ca2+ binding domain near the glutamic acid-rich region at the amino terminus (domain I), 2) a cysteine-rich domain (II), 3) a
Osteonectin
Protein-coding gene in the species Homo sapiens
sialophosphoprotein Osteopontin Secreted hormones Osteocalcin Calcium-binding domains C2 domain Cadherin C-type lectin EF hand EGF-like domain Gla domain
Hippocalcin
Protein-coding gene in the species Homo sapiens
(November 2000). "Structural and functional analysis of the recombinant G domain of the laminin alpha4 chain and its proteolytic processing in tissues".
FBLN2
Protein-coding gene in the species Homo sapiens
WW domain-containing transcription regulator protein 1 (WWTR1), also known as Transcriptional coactivator with PDZ-binding motif (TAZ), is a protein that
WWTR1
Protein found in humans
troponin C superfamily. Members of this protein family have six EF-hand domains which bind calcium. This protein plays a role in diverse cellular functions
Calretinin
Protein
sialophosphoprotein Osteopontin Secreted hormones Osteocalcin Calcium-binding domains C2 domain Cadherin C-type lectin EF hand EGF-like domain Gla domain
Calgranulin
Protein complex involved in the complement system
The interaction with apoptotic and necrotic cells is mediated by the Gla domain of protein S and does not affect the ability of C4BP to inhibit complement
C4b-binding_protein
sialophosphoprotein Osteopontin Secreted hormones Osteocalcin Calcium-binding domains C2 domain Cadherin C-type lectin EF hand EGF-like domain Gla domain
Neuronal_calcium_sensor
Protein-coding gene in the species Homo sapiens
fluorescence microscope. Annexin A5 has been shown to interact with Kinase insert domain receptor and Integrin, beta 5. GRCh38: Ensembl release 89: ENSG00000164111
Annexin_A5
Drug discovery
catalytic domain and is also linked to a 142 amino acid light chain. The chain contains both GLA domain and two epidermal growth factor domains (EGF like
Discovery and development of direct Xa inhibitors
Discovery_and_development_of_direct_Xa_inhibitors
Mammalian protein found in Homo sapiens
NM, Kurzydlowski K, Tada M, MacLennan DH (August 2001). "Phospholamban domain IB forms an interaction site with the loop between transmembrane helices
Phospholamban
Protein-coding gene in the species Homo sapiens
protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins
FBLN5
Protein found in humans
help organize exocytosis of intracellular proteins to the extracellular domain. Annexin II is a pleiotropic protein meaning that its function is dependent
Annexin_A2
Protein-coding gene in the species Homo sapiens
Ca2+-related proteins as it does not contain an EF-hand motif of Ca2+-binding domain. It may regulate the effect of Ca2+ on liver cell functions. From many investigations
Regucalcin
Protein-coding gene in the species Homo sapiens
sialophosphoprotein Osteopontin Secreted hormones Osteocalcin Calcium-binding domains C2 domain Cadherin C-type lectin EF hand EGF-like domain Gla domain
S100G
Mammalian protein found in Mus musculus
(52%). It has a 40-residue N-terminal domain with an inactive calcium binding site and a 70-residue EF-hand domain with one low affinity Ca2+ and Mg2+ binding
Oncomodulin
Protein-coding gene in the species Homo sapiens
sialophosphoprotein Osteopontin Secreted hormones Osteocalcin Calcium-binding domains C2 domain Cadherin C-type lectin EF hand EGF-like domain Gla domain
Sarcalumenin
Mammalian protein found in Homo sapiens
sialophosphoprotein Osteopontin Secreted hormones Osteocalcin Calcium-binding domains C2 domain Cadherin C-type lectin EF hand EGF-like domain Gla domain
Neurocalcin
Protein-coding gene in the species Homo sapiens
a blood protein capable of binding to fibrinogen. Fibulin-1 has modular domain structure and includes a series of nine epidermal growth factor-like modules
FBLN1
Scottish theologian (1695–1773)
John Glas (5 October 1695 – 2 November 1773) was a Scottish clergyman who started the Glasite church movement. He was born at Auchtermuchty, Fife, where
John_Glas
Protein family
and a C lobe. The C lobe serves a structural purpose and binds to the N domain of troponin I (TnI). The C lobe can bind either Ca2+ or Mg2+. The N lobe
Troponin_C
Bolognese–Florentine army under Muzio Attendolo. Glyndŵr rebellion Battle of Bryn Glas 22 June English army routed in mid-Wales; Owain Glyndŵr's revolt spreads
List_of_battles_1301–1600
George Glas (1725 – 30 November 1765) was a Scottish seaman and merchant adventurer in West Africa. The son of John Glas, the divine, Glas was born at
George_Glas
Proposed hydroelectric power station in Scotland
Coire Glas power station is a proposed 1.3 GW pumped storage hydroelectric power station in the Scottish Highlands. If built, it will double the UK's ability
Coire_Glas_power_station
Tubercle of the lower extremity of the femur where the adductor magnus muscle inserts
2011.07.015. ISSN 0749-8063. PMID 22001735. Anatomy photo:12:os-0206 at the SUNY Downstate Medical Center Diagram at gla.ac.uk Portal: Anatomy v t e
Adductor_tubercle_of_femur
Ligament of the foot
20th edition of Gray's Anatomy (1918) lljoints at The Anatomy Lesson by Wesley Norman (Georgetown University) Image at gla.ac.uk Portal: Anatomy v t e
Plantar calcaneocuboid ligament
Plantar_calcaneocuboid_ligament
Ligament that connects the calcaneus and cuboid bones in the human foot
retrieved 2021-02-20 lljoints at The Anatomy Lesson by Wesley Norman (Georgetown University) (soleoffootligaments) Image at gla.ac.uk Portal: Anatomy v t e
Long_plantar_ligament
InterPro Domain
DNA photolyase, N-terminal is an evolutionary conserved protein domain. This domain binds a light harvesting chromophore that enhanced the spectrum of
DNA photolyase N-terminal domain
DNA_photolyase_N-terminal_domain
Enchantress-goddess in Greek mythology
"Alciato at Glasgow: Emblem: Cavendum à meretricibus". www.emblems.arts.gla.ac.uk. "Whitney 82". www.mun.ca. The text is at Online Literature. French
Circe
Town of ancient Boeotia
Magoula Balomenou. Alternately, Arne may be linked to the ancient citadel of Gla, whose Mycenaean name has been lost, though this is by no means uncontested
Arne_(Boeotia)
American fraudster
millions owed after the theft of a tangled web domain". CNNMoney.com. /Fortune/News/Technology. [1]. (GLA) Glasner, Joanna. August 14, 2002, 2:00 AM. "Sex
Stephen_M._Cohen
first film to win the Academy Award for Best Picture, entered the public domain this year. A large number of the year's films significantly underperformed
2023_in_film
Video game
featured three unique factions: European Union (EU), Global Liberation Army (GLA) and Asia-Pacific Alliance (APA). A downloadable campaign was planned to
Command & Conquer (cancelled video game)
Command_&_Conquer_(cancelled_video_game)
development and participation, arranged national congresses and used Zhenski glas as its organ. However, they had limited success. In 1937 married women received
Women's_suffrage_by_country
NASA satellite to observe ice sheets, clouds, and land (2003–2010)
System (GLAS), a space-based lidar. GLAS combined a precision surface lidar with a sensitive dual-wavelength cloud and aerosol lidar. The GLAS lasers emit
ICESat
Capital of England and the United Kingdom
coordinated by the Greater London Authority (GLA), and a local tier with 33 local administrations. The GLA consists of the mayor of London, who has executive
London
Real-time text-to-speech AI tool
new voice line from GLaDOS' voice actor". Taiwanese newspaper United Daily News also highlighted 15.ai's ability to recreate GLaDOS's mechanical voice
15.ai
1991–95 war during the Yugoslav Wars
45,703 persons formerly serving with Croatian military]. Glas Slavonije (in Croatian). Glas Slavonije d.d. Archived from the original on July 19, 2011
Croatian_War_of_Independence
Realistic artificially generated media
September 2022. Zwiezen, Zack (18 January 2021). "Website Lets You Make GLaDOS Say Whatever You Want". Kotaku. Archived from the original on 17 January
Deepfake
German physicist (1845–1923)
age of 80. In 1866, they met in Zurich at Anna's father's café, Zum Grünen Glas. They became engaged in 1869 and wed in Apeldoorn, Netherlands, on 7 July
Wilhelm_Röntgen
Altimeter System Integration and Test Plan"[dead link], NASA GSFC GLAS CMO, document GLAS-568-PLAN-001, 22 March 1999, acronym list p. 1, PDF p. 81. Retrieved
Spacecraft_command_language
Collection of fables credited to Aesop
Retrieved 22 March 2012. "A modernised version is available here". Arts.gla.ac.uk. Archived from the original on 14 May 2011. Retrieved 22 March 2012
Aesop's_Fables
Village on the Isle of Anglesey, Wales
the 2002 Guinness Book of Records as the world's longest valid Internet domain name Ball, John. "Origins and meaning of Llanfairpwllgwyngyllgogeryc
Llanfairpwllgwyngyll
City in the West Bank, Palestine
Frenkel, 2011, p. 28–29 Forbes 1965, p. 155, citing Anton Kisa et al., Das Glas im Altertum, 1908. Gil 1997, pp. 205 Al-Muqaddasi 2001, pp. 156–57. For an
Hebron
Shopping mall in Queensland, Australia
Floor area 81,000 m2 (870,000 sq ft) (Hyperdome GLA Retail) 22,756 m2 (244,940 sq ft) (Home Centre GLA Retail) Parking Approx 4200 Website hyperdomeshopping
Logan_Hyperdome
Country in Southeastern Africa
April 2019. Retrieved 16 April 2019. kig, Antony; a (2 February 2017). "GLA Energy to construct 250MW gas powered plant in Mozambique". Construction
Mozambique
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