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Type of inflammation
Neurogenic inflammation is inflammation arising from the local release by afferent neurons of inflammatory mediators such as substance P, calcitonin gene-related
Neurogenic_inflammation
Physical effects resulting from activation of the immune system
Inflammatory cytokine Inflammatory reflex Interleukin Lipoxin Neurogenic inflammation Substance P Stress (biology) Endothelial Cell Tropism All these
Inflammation
Medical condition
through IL-31 signaling. Eosinophil-derived neurotoxins exacerbate neurogenic inflammation, creating a vicious itch-scratch cycle. Chronic pruritus in PN
Prurigo_nodularis
Inflammation of the upper rib joints
costochondritis remains unclear. Proposed mechanisms of pain include neurogenic inflammation, muscular imbalances, neuropathy of the intercostal nerves, myofascial
Costochondritis
French culinary dish
Carriere, M.; Duvaux-Ponter, C.; Guy, G.; Roussel, S. (2011). "Neurogenic inflammation in the upper digestive tract of the mule duck: effect of a chemical
Foie_gras
Discomfort in the legs during walking due to nerve impingement
Neurogenic claudication (NC), also known as pseudoclaudication, is the most common symptom of lumbar spinal stenosis (LSS) and describes intermittent leg
Neurogenic_claudication
Chemical compound (polypeptide neurotransmitter)
muscle, and joints. It is proposed that this release is involved in neurogenic inflammation, which is a local inflammatory response to certain types of infection
Substance_P
Drop in blood pressure when standing up or sitting down
sitting down. Primary orthostatic hypotension is also often referred to as neurogenic orthostatic hypotension. The drop in blood pressure may be sudden (vasovagal
Orthostatic_hypotension
Cellular second messenger
involved in activation of trigeminocervical system leading to neurogenic inflammation and causing migraine. Disrupted functioning of cAMP has been noted
Cyclic adenosine monophosphate
Cyclic_adenosine_monophosphate
Compression of nerves or blood vessels between the neck and ribcage
as the thoracic outlet. There are three main types: neurogenic, venous, and arterial. The neurogenic type is the most common and presents with pain, weakness
Thoracic_outlet_syndrome
Chronic multi-symptomatic pain disorder
interleukins such as IL-10 have also been associated with fibromyalgia. Neurogenic inflammation has been proposed as a contributing factor to fibromyalgia. A repeated
Fibromyalgia
Irritation and inflammation of the mucous membrane inside the nose
rhinitis". The pathology of vasomotor rhinitis appears to involve neurogenic inflammation and is as yet not very well understood. The role of transient receptor
Rhinitis
Muscle of the middle ear
tonic contractions) of the tympanic tensor muscle may trigger neurogenic inflammation. Indeed, fibers with substances P and CGRP were found in close
Tensor_tympani_muscle
Type of alkaloid
decrease of inflammation by inhibiting the cytokine release. In addition, it was found that avenanthramides inhibit neurogenic inflammation, which is defined
Avenanthramide
Increased sensitivity to sound and decreased tolerance of noise
Via a cascade of events, the activated pain neurons can cause neurogenic inflammation, which may lead to additional pain. In this way, a "vicious circle"
Hyperacusis
Array of painful conditions in humans
is a multifactorial disorder with clinical features of neurogenic inflammation (inflammation mediated by nerve cells), nociceptive sensitisation (which
Complex regional pain syndrome
Complex_regional_pain_syndrome
Disorder resulting in recurrent moderate–severe headaches
mast cells, vasodilation of cerebral and dural blood vessels, neurogenic inflammation, and the transmission of pain signals via nerves in the meninges
Migraine
Active component of the Australian black rock scorpion's venom
thereby eliciting pain and pain hypersensitivity without the neurogenic inflammation that typically occurs in other animal toxins. This scorpion toxin
Wasabi_receptor_toxin
Sensory neuron that detects pain
gene-related peptide (CGRP), which provides important role in neurogenic inflammation and facilitate nociceptive communication within the spinal cord
Nociceptor
Protein-coding gene in the species Homo sapiens
been identified as a possible pathogenic gene involved in the neurogenic inflammation in rosacea. GRCh38: Ensembl release 89: ENSG00000128594 – Ensembl
LRRC4
Pungent chemical compound in chili peppers
Glinski W, Glinska-Ferenz M, Pierozynska-Dubowska M (1991). "Neurogenic inflammation induced by capsaicin in patients with psoriasis". Acta Dermato-Venereologica
Capsaicin
Chemical compound
more potent than capsaicin for effects on thermoregulation and neurogenic inflammation. For rats, LD50 through oral ingestion is 148.1 mg/kg. It causes
Resiniferatoxin
Medical condition
dysfunction and adrenocortical hormone (endocrine) abnormalities, and neurogenic inflammation. The role of androgens is studied in CP/CPPS, with C 21 11-oxygenated
Chronic prostatitis/chronic pelvic pain syndrome
Chronic_prostatitis/chronic_pelvic_pain_syndrome
Chemical compound
is 40,000 times more potent than sumatriptan as an inhibitor of neurogenic inflammation and plasma protein extravasation, it is only twice as potent as
CP-122288
Class of molecules found in the outer membrane of Gram-negative bacteria
Fajardo O, et al. (20 January 2014). "TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins". Nature Communications
Lipopolysaccharide
Inflammation of inner tissue (pulp) of a tooth
flow of dentinal fluid; (2) odontoblasts; (3) neuropeptides and neurogenic inflammation; (4) innate immune cells, including immature dendritic cells (DCs)
Pulpitis
Protein and coding gene in humans
(mustard oil) as a human surrogate model of pain, hyperalgesia, and neurogenic inflammation" (PDF). Pain. 158 (9): 1723–1732. doi:10.1097/j.pain.0000000000000979
TRPA1
Species of plant
Press. ISBN 978-0-674-01171-7. Miller, Mark (2001). "Inhibition of neurogenic inflammation by the Amazonian herbal medicine sangre de grado". Journal of Investigative
Croton_lechleri
Chemical compound
bronchoconstriction, mucus production in the lungs and process neurogenic inflammation. This release is propagated through the stimulation of e-NANC nerves
Neurokinin_A
American neuroscientist (born 1942)
involvement in migraine pathophysiology and the mechanisms by which neurogenic inflammation influences cerebrovascular disorders. He began researching migraine
Michael_A._Moskowitz
Species of plant
receptor on primary sensory neurons mediating pain (nociception) and neurogenic inflammation. The pain sensing cation channel is TRPV1. Resiniferatoxin has
Euphorbia_resinifera
Substances produced by living organisms
inflation, and topsentin and scytonemin are potent inhibitors of neurogenic inflammation. Pigments may be extracted and used as dyes. Pigments (such as
Biological_pigment
Injury to the main nerve bundle in the back of humans
signs, such as bowel and bladder dysfunction can occur at any level. Neurogenic bladder involves a compromised ability to empty the bladder and is a common
Spinal_cord_injury
Medical condition
common and refer to cardiac or neurogenic tumors. Masses in the posterior portion of the mediastinum tend to be neurogenic in origin, and in adults tend
Mediastinal_tumors
Chemical compounds containing a vanillyl group
acid (20-HETE) is a pivotal endogenous ligand for TRPV1-mediated neurogenic inflammation in the skin". Br J Pharmacol. 179 (7): 1450–1469. doi:10.1111/bph
Vanilloid
Class of pharmaceutical drugs
centrally. 5-HT1D has been found responsible for inhibition of neurogenic inflammation upon administration with sumatriptan and other related compounds
Triptan
Any impairment or discomfort in walking
symptoms. Spinal or neurogenic claudication may be differentiated from arterial claudication based on activity and position. In neurogenic claudication, positional
Claudication
Three membranes protecting the brain
such as CGRP, vasodilation of cerebral and dural blood vessels, neurogenic inflammation, and the transmission of pain signals via nerves in the meninges
Meninges
Professor of Pharmacology at King's College London
(2018). "A historical perspective on the role of sensory nerves in neurogenic inflammation". Seminars in Immunopathology. 40 (3): 229–236. doi:10.1007/s00281-018-0673-1
Susan_Brain
Cerebrospinal fluid lesion in the spinal canal
fluid pressure, filling of congenital cysts with one-way valves, and/or inflammation in response to trauma and disease.[citation needed] They are named after
Tarlov_cyst
Class of transport proteins
Fajardo O, et al. (20 January 2014). "TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins". Nature Communications
Transient receptor potential channel
Transient_receptor_potential_channel
Drooping of the upper eyelid over the eye
eliminating the neurotransmitter. Ptosis may be attributable to a myogenic, neurogenic, aponeurotic, mechanical or traumatic cause, and it usually occurs in
Ptosis_(eyelid)
Sudden expulsion of air from the lungs as a reflex to clear irritants
ipratropium to treat the inflammation, as well as cough suppressants to reduce frequency of the cough until inflammation clears. Inflammation may increase sensitivity
Cough
Muscular disease in which the muscle fibers do not function correctly
defect is within the muscle, as opposed to the nerves ("neuropathies" or "neurogenic" disorders) or elsewhere (e.g., the brain). This muscular defect typically
Myopathy
Group of signaling molecules in the gut
depolarization acetylcholine cotransmitter CGRP peptide non-myelinated sensory neurons vasodilation increase vascular permeability neurogenic inflammation
Non-noradrenergic, non-cholinergic transmitter
Non-noradrenergic,_non-cholinergic_transmitter
Organ in vertebrates that collects and stores urine from the kidneys before disposal
for "bladder" – cystis – appears in associated terms such as cystitis (inflammation of the bladder). In humans, the bladder is a hollow muscular organ situated
Bladder
The following is a partial list of the "C" codes for Medical Subject Headings (MeSH), as defined by the United States National Library of Medicine (NLM)
List_of_MeSH_codes_(C10)
Tube attached to the intestine
in an operation known as the Mitrofanoff procedure, in people with a neurogenic bladder. The appendix can also be used to access the colon in children
Appendix_(anatomy)
Long-term high blood pressure in the arteries
chronically high activity of the autonomic nervous system, an effect known as neurogenic hypertension. Electrical therapies that stimulate the baroreflex are being
Hypertension
Disease of the bony spine that results in narrowing of the spinal canal
progress to paralysis. Pinched nerve, causing numbness. Intermittent neurogenic claudication characterized by lower limb numbness, weakness, diffuse or
Spinal_stenosis
Alternative medical treatment for low back pain
nerve signals that tighten the lower back muscles, and reducing neurogenic inflammation. The metal pieces in the lower back stimulate the release of peptides
Neuroreflexotherapy
Degeneration of a weight-bearing joint due to loss of sensation
extend with continuing load bearing and, hence, progressing reactive inflammation. This process can be halted (while neuropathy continues) by appropriate
Neuropathic_arthropathy
and its crucial role in NSC development has led some to label it as a neurogenic "niche". It is also frequently referred to as a vascular, or angiogenic
Subgranular_zone
Disease that damages the myelin sheaths around nerves
spasticity, while others are little changed. Equipment such as catheters for neurogenic bladder dysfunction or mobility aids can help improve functional status
Multiple_sclerosis
Formation of bone tissue outside of the skeleton
skeleton in muscles and soft tissue. It forms following a traumatic injury, neurogenic injury, or genetic predisposition. The likelihood and severity of HO is
Heterotopic_ossification
Chemical compound
(CGRP) and other neuropeptides (neurokinin A, kassinin), leading to neurogenic inflammation [A19720]. Zucapsaicin is also reported to affect the peptidergic
Zucapsaicin
Chemical compound
duration of isopetasin exposure. The ability of isopetasin to inhibit neurogenic inflammation beyond the trigeminal innervation may explain its effectiveness
Isopetasin
induce a prolonged sensation of severe pain, accompanied with neurogenic inflammation due to enduring TRPV1 activation. However, specific behavioural
Double-knot_toxin
PMC 3414909. PMID 22907990. Kazanis, Ilias (2009). "The subependymal zone neurogenic niche: a beating heart in the centre of the brain". Brain. 132 (11): 2909–2921
Subependymal_zone
Insufficient blood flow due to abnormal distribution in the capillaries
system. According to the cause, there are 4 types of distributive shock: Neurogenic shock: Decreased sympathetic stimulation leading to decreased vessel tone
Distributive_shock
Systemic Brain Function of Human Physiology
Connection: Stress Worsens Dermatitis via Substance P-dependent Neurogenic Inflammation in Mice". Journal of Investigative Dermatology. 128 (2): 434–446
Neural top–down control of physiology
Neural_top–down_control_of_physiology
Inflammation of the kidney
Pyelonephritis is inflammation of the kidney, typically due to a bacterial infection. Symptoms most often include fever and flank tenderness. Other symptoms
Pyelonephritis
Antidepressant pharmacology hypotheses
of alternative hypotheses have been proposed, including the glutamate, neurogenic, epigenetic, cortisol hypersecretion and inflammatory hypotheses. Another
Pharmacology of antidepressants
Pharmacology_of_antidepressants
Medical condition in which spasm of arteries causes episodes of reduced blood flow
Raynaud's phenomenon: reduced blood flow, blood vessel constriction, and neurogenic, inflammatory, and immune responses. It is induced by emotional stress
Raynaud_syndrome
Medical condition
Sheehan's syndrome have been known to cause central diabetes insipidus. Inflammation/Infection - Central diabetes insipidus has been linked to sarcoid, histiocytosis
Central_diabetes_insipidus
One path neural stem cells take to reach the olfactory bulb
In addition, astrocytes derived from the neurogenic hippocampus and SVZ, but not from the non-neurogenic spinal cord, promote proliferation and neuronal
Rostral_migratory_stream
Injury caused by a bullet
Long-term complications can include bowel obstruction, failure to thrive, neurogenic bladder and paralysis, recurrent cardiorespiratory distress and pneumothorax
Gunshot_wound
Chemical compound
pp. 54–55. ISBN 978-1-4557-1220-5. Jancso G (27 November 2008). Neurogenic Inflammation in Health and Disease. Elsevier. pp. 297–. ISBN 978-0-444-53229-9
Nepadutant
Peptide involved in placental development
being delivered before adequate neural development has taken place. The neurogenic effects of PIF are not isolated to the prenatal environment; in fact PIF
Preimplantation_factor
Medical condition
include infection with Toxoplasma gondii, Herpes simplex virus, Rubella, neurogenic causes, and autoimmune pathology. Diagnosis is made by an ophthalmologist
Fuchs heterochromic iridocyclitis
Fuchs_heterochromic_iridocyclitis
British surgeon (born 1950)
professor with his lecture titled "The Investigation and Management of the Neurogenic Bladder", and appointed consultant urologist at St Bartholomew's Hospital
Roger_Kirby
Anti-ageing drug
exploit e.g. use of bacteriophages. Its derivative CAD-31 has enhanced neurogenic activity over J147 in human neural precursor cells. CAD-31 enhances the
J147
Chemical compound
76–. ISBN 978-0-7923-8757-2. Brain S, Moore PK (1999). Pain and Neurogenic Inflammation. Springer Science & Business Media. pp. 28–. ISBN 978-3-7643-5875-4
Endomorphin-1
Pharmaceutical compound
receptors: binding affinities, brain penetration and activity in the neurogenic dural inflammation model of migraine". Life Sciences. 61 (21): 2117–2126. doi:10
LY-344864
Uncomfortable skin sensation
(dermal or neuropathic) or in the central nervous system (neuropathic, neurogenic, or psychogenic). Itch originating in the skin is known as pruritoceptive
Itch
Human protein-coding gene
various tissues during development, disease or injury, and in restricted neurogenic areas of the central nervous system. Tenascin-C is the founding member
Tenascin_C
Chemical compound
ISBN 978-0-7923-8757-2. Susan Brain; P.K. Moore (1999). Pain and Neurogenic Inflammation. Springer Science & Business Media. pp. 28–. ISBN 978-3-7643-5875-4
Endomorphin-2
Fluid accumulation in the tissue and air spaces of the lungs
ruptures capillaries and floods the alveoli with blood Pulmonary embolism Neurogenic causes (seizures, head trauma, strangulation, electrocution). Transfusion
Pulmonary_edema
Release of urine from the urinary bladder
becomes hypertrophied. This type of bladder is sometimes called the spastic neurogenic bladder. The reflex hyperactivity is made worse, and may be caused, by
Urination
Central part of the thoracic cavity
mediastinum: Neurogenic tumors, either from the nerve sheath (mostly benign) or elsewhere (mostly malignant). Mediastinitis is inflammation of the tissues
Mediastinum
Medical condition
catheters, mechanical irritation, chronic bladder outlet obstruction, and neurogenic bladders. Changes in the bladder mucosa caused by diffuse cystitis cystica
Cystitis_cystica
Stomach aches
threatened abortion Abdominal wall muscle strain or trauma muscular infection neurogenic pain: herpes zoster, radiculitis in Lyme disease, abdominal cutaneous
Abdominal_pain
Life-threatening response to infection
pulmonary embolism, thyrotoxicosis, anaphylaxis, adrenal insufficiency, and neurogenic shock. Hyperinflammatory syndromes such as hemophagocytic lymphohistiocytosis
Sepsis
Medical condition
and chronic urinary tract infections, being female, diabetes mellitus, neurogenic bladder, and being in an immunocompromised state. In 50% of cases, patients
Emphysematous_cystitis
Voice disorder
to ASHA, organic dysphonia can be subdivided into structural and neurogenic; neurogenic dysphonia is defined as impaired functioning of the vocal structure
Hoarse_voice
Bacterial infection of the prostate gland
infection of the prostate gland and a form of prostatitis (prostate inflammation). It should be distinguished from other forms of prostatitis such as
Chronic_bacterial_prostatitis
of asthma. These microbial infections result in chronic lower airway inflammation, impaired mucociliary clearance, an increase in mucous production and
Asthma-related_microbes
Abnormally low blood pressure
by increasing vascular tone. Erythropoietin is given to patients with neurogenic orthostatic hypotension, and it works through increasing vascular volume
Hypotension
Medical procedure
doi:10.1016/j.juro.2018.05.048. PMID 29775639. EAU: Management of Non-neurogenic Male LUTS - Summary of Changes 2019 Archived 2022-02-07 at the Wayback
Transurethral needle ablation of the prostate
Transurethral_needle_ablation_of_the_prostate
Pharmaceutical compound
reducing the production of prostaglandins, which mediate inflammation, pain and potentially neurogenic processes. Its proposed application in tinnitus stems
(R)-Ketoprofen
Pain relief by electrical means
and NSAIDs (non-steroidal anti-inflammatory drugs) that help relieve inflammation and stop pain at the source. Electroanalgesia has a lower addictive potential
Electroanalgesia
Precursor cells of neurons and glia during embryonic development
cells from the adult striatal tissue, including the SVZ — one of the neurogenic areas — of adult mice brain tissue. In the same year the team of Constance
Neural_stem_cell
Muscle pain from mild exertion
phenomenon functional vasospasm.[clarification needed] It is distinct from neurogenic claudication, which is associated with lumbar spinal stenosis. It is strongly
Intermittent_claudication
South Korean neuroscientist and neuroimmunologist
motor neuron specification and suppress interneuron specification in the neurogenic phase, Olig1/2 promote oligodendrocyte specification and suppress astroglial
Gloria_Choi
the lateral ventricule (SVZa) in a mouse brain. Originally found in the neurogenic areas of the brain, recent studies indicate that fractones are also present
Fractone
Medical condition
phantom breast pain, cervical radiculopathy, pectoralis minor syndrome/neurogenic thoracic outlet syndrome, scapulothoracic bursitis, glenohumeral joint
Post-mastectomy_pain_syndrome
Medical diagnostic method
addition, EIM can use anisotropy to discriminate between myopathic and neurogenic disease. Different forms of neuromuscular disease have unique anisotropies
Electrical impedance myography
Electrical_impedance_myography
Fluid injection into the large intestine
continence enema adapting a transanal irrigation system in patients with neurogenic bowel dysfunction". Spinal Cord Series and Cases. 7 (1): 34. doi:10
Enema
Human spinal cord disorder
autonomic dysfunction. Autonomic dysfunction includes bladder dysfunction, neurogenic bowel, erectile dysfunction, and orthostatic hypotension. Vibration and
Anterior spinal artery syndrome
Anterior_spinal_artery_syndrome
Intestinal disease due to radiation exposure
radiation injury. The research approach in humans has been reviewed. Neurogenic bowel dysfunction Hauer-Jensen M, Denham JW, Andreyev HJ (August 2014)
Radiation_enteropathy
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