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Molecular Interaction Maps, also known as MIMs, is a graphic notation to depict cellular and molecular interactions. It was created by Kurt W. Kohn in
Molecular_Interaction_Maps
Topics referred to by the same term
Missile such as MIM-3 Nike Ajax Molecular Interaction Maps, a graphic formalism to depict cellular and molecular interactions MIM, IATA airport code for Merimbula
MIM
Complete set of molecular interactions in a biological cell
In molecular biology, an interactome is the whole set of molecular interactions in a particular cell. The term specifically refers to physical interactions
Interactome
Standard graphical representation
describe interactions and relationships of molecules was pioneered by Kurt Kohn at the National Cancer Institute with his Molecular Interaction Maps (MIM)
Systems Biology Graphical Notation
Systems_Biology_Graphical_Notation
Physical interactions and constructions between multiple proteins
steered by interactions that include electrostatic forces, hydrogen bonding and the hydrophobic effect. Many are physical contacts with molecular associations
Protein–protein_interaction
Methods that imitate, replicate or use natural processes
describe such a massive scale interactions, Kohn maps were introduced as a graphical notation to depict molecular interactions in succinct pictures. Other
Natural_computing
Noncovalent molecular interaction
Cation–π interaction is a noncovalent molecular interaction between the face of an electron-rich π system (e.g. benzene, ethylene, acetylene) and an adjacent
Cation–π_interaction
Protein-coding gene in humans
least 31 disease-causing mutations in this gene have been discovered. Interaction of FLNA with the BRCA1 protein is required for efficient regulation of
Filamin-A
Bioinformatics subfield
of overall folds and local motifs, principles of molecular folding, evolution, binding interactions, and structure/function relationships, working both
Structural_bioinformatics
Solid consisting of discrete molecules
dipole–dipole interactions, quadrupole interactions, π–π interactions, hydrogen bonding, halogen bonding, London dispersion forces, and in some molecular solids
Molecular_solid
Method in molecular biology
set of molecular biology methods used to analyze the spatial organization of chromatin in a cell. These methods quantify the number of interactions between
Chromosome conformation capture
Chromosome_conformation_capture
Collection of bioinformatics databases
the cell and the organism. Each pathway map contains a network of molecular interactions and reactions and is designed to link genes in the genome to gene
KEGG
Theory of evolution by changes at the molecular level
The neutral theory of molecular evolution holds that most evolutionary changes occur at the molecular level, and most of the variation within and between
Neutral theory of molecular evolution
Neutral_theory_of_molecular_evolution
Genomic analysis technique
unbiased genome-wide chromatin interaction maps. Then several different methods can be employed to analyze these maps to identify chromosomal structural
Hi-C (genomic analysis technique)
Hi-C_(genomic_analysis_technique)
Dependence of a gene mutation's phenotype on mutations in other genes
the advent of molecular biology, the focus shifted from simple (and complete) masking effects to the complex, quantitative interactions between genes
Epistasis
Molecular biology technique
a molecular biology technique used to discover protein–protein interactions (PPIs) and protein–DNA interactions by testing for physical interactions (such
Two-hybrid_screening
Short chains of 2–50 amino acids
longer, continuous, unbranched peptide chain. Polypeptides that have a molecular mass of 10,000 Da or more are called proteins. Chains of fewer than twenty
Peptide
Net attractive interaction involving one of the chalcogen elements
of the bond donor. In terms of electrostatic interactions, the molecular electrostatic potential (MEP) maps is often invoked to visualize the electron density
Chalcogen_bond
Aspect of quantum chemistry
Localized molecular orbitals are molecular orbitals which are concentrated in a limited spatial region of a molecule, such as a specific bond or lone pair
Localized_molecular_orbitals
Molecular machine that removes intron RNA from the primary transcript
underscores the importance of zinc in the splicing mechanism. The first molecular-resolution reconstruction of U4/U6.U5 triple small nuclear ribonucleoprotein
Spliceosome
Hierarchical outline list of articles related to the physical sciences
of compounds, the interactions of substances through intermolecular forces to give matter its general properties, and the interactions between substances
Outline_of_physical_science
Computing by new or unusual methods
skills, also known as mental calculators. Human–robot interaction, or HRI, is the study of interactions between humans and robots. It involves contributions
Unconventional_computing
Computational quantum mechanical modelling method to investigate electronic structure
approximation Exchange interaction Electronic correlation List of computational materials science software Molecule Molecular design software Molecular modelling Quantum
Density_functional_theory
Magnetic interaction between an electron and a nucleus
Thus, knowledge of the A values allows one to map the singly occupied molecular orbital. The interaction was first derived by Enrico Fermi in 1930. A classical
Fermi_contact_interaction
Method used in molecular biology
sequencing (termed "HITS-CLIP") to generate genome-wide protein-RNA interaction maps for Nova; since then a number of other RNA-binding proteins have been
Cross-linking immunoprecipitation
Cross-linking_immunoprecipitation
Contact maps provide a more reduced representation of a protein structure than its full 3D atomic coordinates. The advantage is that contact maps are invariant
Protein_contact_map
Database of biological information
2026-04-09. "IntAct Portal". www.ebi.ac.uk. Retrieved 2026-04-09. "The Molecular INTeraction Database – An ELIXIR Core Resource". Retrieved 2026-04-09. "InterPro"
Biological_database
Machine learning technique useful for dimensionality reduction
Self-Organizing Maps: applet, University of Leicester, 2011 Ultsch, Alfred; Siemon, H. Peter (1990). "Kohonen's Self Organizing Feature Maps for Exploratory
Self-organizing_map
Biological interrelationship
The host–pathogen interaction is defined as how microbes or viruses sustain themselves within host organisms on a molecular, cellular, organismal or population
Host–pathogen_interaction
American biologist
Singaporean molecular biologist primarily based in the US, computational biologist and entrepreneur. He is a Professor of Cellular and Molecular Medicine
Gene_Yeo
Technique in molecular biology
Chromatin Interaction Analysis by Paired-End Tag Sequencing (ChIA-PET or ChIA-PETS) is a technique in molecular biology that incorporates chromatin immunoprecipitation
ChIA-PET
bioinformatics software and data resources ConsensusPathDB: a molecular functional interaction database, integrating information from 12 others Entrez search
List_of_biological_databases
Study of molecules in the Universe and their reactions
and their interaction with radiation is sometimes called molecular astrophysics. The formation, composition, evolution and fate of molecular clouds is
Astrochemistry
Biological technique to evolve proteins using bacteriophages
Phage display is a laboratory technique for the study of protein interactions that uses bacteriophages (viruses that infect bacteria) to produce and "display"
Phage_display
Designing solid structures with tailored properties
the strongest intermolecular interactions form the molecular layers or columns and the weakest intermolecular interactions form the slip plane. For example
Crystal_engineering
Protein-coding gene in humans
"Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein". Molecular and
Homeobox_protein_SIX1
Graphical models, especially molecular orbitals, electron density, and electrostatic potential maps, are a routine means of molecular visualization in chemistry
Spartan_(chemistry_software)
Type of stable macromolecular complex
bioinformatics of protein–protein interactions and a guide to their principles". Progress in Biophysics and Molecular Biology. 116 (2–3): 141–50. doi:10
Protein_complex
Protein–protein interactions in human cells
Chaurasia G, Herzel H (March 2007). "Comparison of human protein-protein interaction maps". Bioinformatics. 23 (5): 605–11. doi:10.1093/bioinformatics/btl683
Human_interactome
Technology with features near one nanometer
self-assembly based on molecular recognition in exist in biology, most notably Watson–Crick basepairing and enzyme-substrate interactions. Molecular nanotechnology
Nanotechnology
The history of molecular biology begins in the 1930s with the convergence of various, previously distinct biological and physical disciplines: biochemistry
History_of_molecular_biology
Canadian molecular and systems biologist
Nevan J. Krogan is a Canadian molecular and systems biologist. He is a professor and the director of the Quantitative Biosciences Institute (QBI) at the
Nevan_Krogan
Scientific study of life
Darwin, and in the molecular understanding of genes encoded in DNA. The discovery of the structure of DNA and advances in molecular genetics have transformed
Biology
Canadian scientist
protein–protein, protein–DNA and protein–RNA interactions control the activity of RNA polymerase II, the molecular machine that synthesizes all messenger RNA
Benoit_Coulombe
Graduate-level standardized test in the US
Genome replication and regulation Virus assembly Virus-host interactions H. Methods Restriction maps and PCR Nucleic acid blotting and hybridization DNA cloning
GRE Biochemistry, Cell and Molecular Biology Test
GRE_Biochemistry,_Cell_and_Molecular_Biology_Test
Study of health and disease within a population
Villalba [es] in Epidemiología Española. Epidemiologists also study the interaction of diseases in a population, a condition known as a syndemic. The term
Epidemiology
Substance composed of macromolecules with repeating structural units
composed of macromolecules. A macromolecule is a molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition
Polymer
of cellular and molecular biology is a list of definitions of terms and concepts commonly used in the study of cell biology, molecular biology, and related
Glossary of cellular and molecular biology (M–Z)
Glossary_of_cellular_and_molecular_biology_(M–Z)
Greek-American physician, scientist, (b 1960)
the NCI he studied the molecular regulation of transcription of the bacterial galactose operon of E. Coli through the interaction of the galactose repressor
Mihael_Polymeropoulos
"The shape of high molecular weight kininogen. Organization into structural domains, changes with activation, and interactions with prekallikrein, as
High-molecular-weight kininogen
High-molecular-weight_kininogen
Form of 3D computer interaction merging the real world with virtual objects
(AR), also known as mixed reality (MR), is a form of 3D human–computer interaction that overlays real-time 3D-rendered computer graphics into the real world
Augmented_reality
Revised theory in chemical bonding
method. Instead, this is a localization procedure that maps the full configuration interaction Hartree-Fock wavefunction (CASSCF) onto valence bond structures
Modern_valence_bond_theory
Computational analysis of large, complex sets of biological data
in this field. Other interactions encountered in the field include Protein–ligand (including drug) and protein–peptide. Molecular dynamic simulation of
Bioinformatics
represented by the interaction score applied to each pair of genes. E-MAPs exploit an SGA approach in order to analyze genetic interactions in a high-throughput
Epistasis and functional genomics
Epistasis_and_functional_genomics
Part of an organism targeted by a ligand or drug to affect behavior
the biological target. The interaction between the substance and the target may be: noncovalent – A relatively weak interaction between the stimulus and
Biological_target
Protein-coding gene in the species Homo sapiens
1996). "cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta-amyloid precursor
APLP1
and prions. Molecular Design; research includes protein-drug interaction, molecular synthesis, and surface and material science. Molecular Sensing; research
La Trobe Institute for Molecular Science
La_Trobe_Institute_for_Molecular_Science
P38 mitogen-activated protein kinases
"The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network". Molecular Cell. 20 (6): 951–62
Mitogen-activated protein kinase
Mitogen-activated_protein_kinase
Indian theoretical chemist
Indian theoretical chemist, well known for his research in the fields of molecular many body theory, theoretical spectroscopy, finite temperature non-perturbative
Debashis_Mukherjee
Human protein and coding gene
SK (May 2000). "Protein-protein interaction among hnRNPs shuttling between nucleus and cytoplasm". Journal of Molecular Biology. 298 (3): 395–405. doi:10
HNRNPK
mechanics and quantum mechanics. Furiousatoms - a powerful software for molecular modelling and visualization Aionics.io - a powerful platform for nanoscale
List of software for nanostructures modeling
List_of_software_for_nanostructures_modeling
Class of biological intermolecular interactions
} interactions, suggesting a possible reason for its 9-fold prevalence in carbohydrate binding pockets. Overall, the electrostatic potential maps follow
Glycan–protein_interaction
Protein-coding gene in the species Homo sapiens
Hejna J, et al. (February 2001). "Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway". Molecular Cell. 7 (2): 249–262. doi:10
Fanconi anemia group D2 protein
Fanconi_anemia_group_D2_protein
membrane during cytokinesis This interaction permits cleavage furrow ingression. In addition, centralspindlin's interaction with the ESCRT III allows for
Centralspindlin
Protein found in humans
"Evidence for the direct interaction of the insulin-like growth factor I receptor with IRS-1, Shc, and Grb10". Molecular Endocrinology. 10 (6): 631–41
Insulin_receptor_substrate_1
Integrated web resource focused on proteases
Cytoscape Computational genomics Metabolic network modelling Protein–protein interaction prediction Igarashi, Y; Heureux, E; Doctor, KS; Talwar, P; Gramatikova
The_Proteolysis_Map
biology – study of the cell as a complete unit, and the molecular and chemical interactions that occur within a living cell. Histology – study of the
Outline_of_biology
Prediction by observation and computation
Protein–protein interaction prediction is a field combining bioinformatics and structural biology in an attempt to identify and catalog physical interactions between
Protein–protein interaction prediction
Protein–protein_interaction_prediction
as web browsers, email clients, map programs, and others to be routed via the Tor network Organic Maps – offline map and navigation app for Android &
List of free and open-source software packages
List_of_free_and_open-source_software_packages
Science of genes, heredity and variation
ambiguous definition of what is referred to as a gene. Trait inheritance and molecular inheritance mechanisms of genes are still primary principles of genetics
Genetics
Overview of and topical guide to chemistry
particularly, but not necessarily exclusively of, non-molecular solids. Spectroscopy – study of the interaction between matter and radiated energy. Stereochemistry
Outline_of_chemistry
Chemical compound
other (protein-protein interactions or PPI) and with these interactions, affects cellular interactions and pathways. Such interactions; in viral fusion and
L-Photo-methionine
Gene of the species Homo sapiens
Krev interaction trapped protein 1 or Cerebral cavernous malformations 1 protein is a protein that in humans is encoded by the KRIT1 gene. This gene contains
KRIT1
Scientific field of study
geology and archaeology. Atomic, molecular, and optical physics (AMO) is the study of matter—matter and light—matter interactions on the scale of single atoms
Physics
Protein-coding gene in humans
(2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1) 89. doi:10.1038/msb4100134. PMC 1847948
BRCC3
Molecule or surface that has no attraction to water
linked to hydrophobicity via the DIT molecular criterion Ben-Na'im, Aryeh (31 January 1980). Hydrophobic Interaction. New York: Plenum Press. ISBN 0-306-40222-X
Hydrophobe
Order of insects
"rubbed" and πτερά (ptera), meaning "wings". In the 2000s, morphological and molecular phylogenetic evidence has shown that the parasitic lice (Phthiraptera)
Psocoptera
Protein-coding gene in the species Homo sapiens
Grummt F (Mar 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". Journal of Molecular Biology. 327 (1):
DBF4
Protein-coding gene in the species Homo sapiens
Li N, et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur
HSPA8
Protein-coding gene in the species Homo sapiens
protein, or G protein. By binding GTP or GDP, small G proteins act as molecular switches in numerous cell processes and signaling pathways. RRAGC has
RRAGC
Protein-coding gene in humans
(April 1998). "Specific interaction between the XNP/ATR-X gene product and the SET domain of the human EZH2 protein". Human Molecular Genetics. 7 (4): 679–84
ATRX
System of communication
Biosemiotics Molecular cellular cognition Crosstalk (biology) Bacterial outer membrane vesicles Membrane vesicle trafficking Host–pathogen interaction Retinoic
Cell_signaling
Protein found in humans
Campbell KP, De Waard M (January 1998). "A beta 4 isoform-specific interaction site in the carboxyl-terminal region of the voltage-dependent Ca2+ channel
Cav2.1
Continent
often a collective activity performed in large groups, with significant interaction between dancers and onlookers. Fifty-four African countries have football
Africa
Laboratory technique
components of novel cellular structures and for determining protein-protein interaction partners, among other applications. Before the development of proximity
Proximity_labeling
Group of six protein isoforms produced from the MAPT gene
its involvement in chromosome stability, its interaction with the cellular transcriptome, its interaction with other cytoskeletal or synaptic proteins
Tau_protein
V.; Wright, Z.; Chapman, A.; Jayapandian, M. (2009). "Michigan molecular interactions r2: from interacting proteins to pathways". Nucleic Acids Research
National Center for Integrative Biomedical Informatics
National_Center_for_Integrative_Biomedical_Informatics
Bioinformatics software platform
an open source bioinformatics software platform for visualizing molecular interaction networks and integrating with gene expression profiles and other
Cytoscape
South Korean biotechnologist
RAS degradation. Nature Communications. (2019) β-Catenin-RAS interaction serves as molecular switch for RAS degradation via GSK3β. EMBO Reports. (2018)
Kang-Yell_Choi
Three dimensional shape of a protein
chains and the backbone may interact and bond in a number of ways. The interactions and bonds of side chains within a particular protein determine its tertiary
Protein_tertiary_structure
Data models for IR probes
underlying molecular processes requires theoretical modeling. The vibrational frequency shifts observed due to complex intermolecular interactions of small
Vibrational_spectroscopic_map
Void between celestial bodies
of the Sun, which is of interest both for its proximity and for its interaction with the Solar System. This volume nearly coincides with a region of
Outer_space
Complete set of nucleic acid sequences for humans
studies constitute the realm of human molecular genetics. With the advent of the Human Genome and International HapMap Project, it has become feasible to
Human_genome
Localisation of Protein–Protein Interactions in Living Yeast Cells". Molecular and Cell Biology Methods for Fungi. Methods in Molecular Biology. Vol. 638. pp. 303–17
Protein-fragment complementation assay
Protein-fragment_complementation_assay
Scientific projections regarding the far future
J.; Lisenfeld, U.; Duc, P. A.; Brinks, E.; et al. (2004). "Colliding molecular clouds in head-on galaxy collisions". Astronomy and Astrophysics. 418
Timeline_of_the_far_future
Protein found in humans
entry to cytoplasmic stress granules, and selective interaction with a subset of mRNAs". Molecular and Cellular Biology. 27 (6): 2324–42. doi:10.1128/MCB
Caprin-1
Pharmaceutical compound
Mazurek AP, Weinstein H (1987). "Simulation of Molecular Stereoelectronic Mechanism for the Interaction of Hallucinogens and Indole Derivatives at 5-HT
RU-27251
Protein domain
Structural & Molecular Biology. 10 (8): 614–621. doi:10.1038/nsb956. ISSN 1545-9985. Yang, S.-H. (1998-03-16). "Differential targeting of MAP kinases to
D_domain
1987 radioactive contamination incident in Brazil
"Molecular analysis of T-lymphocyte HPRT– mutations in individuals exposed to ionizing radiation in Goiânia, Brazil". Environmental and Molecular Mutagenesis
Goiânia_accident
Computer graphics
Molecular graphics is the discipline and philosophy of studying molecules and their properties through graphical representation. IUPAC limits the definition
Molecular_graphics
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