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Chemical compound
Modafinil acid (code name CRL-40467), also known as modafinilic acid or modafinil carboxylate, is one of the two major metabolites of modafinil – the
Modafinil_acid
Wakefulness-promoting medication
Modafinil, sold under the brand name Provigil among others, is a central nervous system (CNS) stimulant medication used to treat narcolepsy, sleep apnea
Modafinil
compounds similar to modafinil, known as modafinil analogues and derivatives. These are structural analogues and derivatives of modafinil, a drug that affects
List of modafinil analogues and derivatives
List_of_modafinil_analogues_and_derivatives
Chemical compound
metabolites of modafinil, the other being modafinil acid. Modafinil sulfone is also a metabolite of the modafinil prodrug, adrafinil. Modafinil sulfone is
Modafinil_sulfone
Wakefulness-promoting medication
enantiopure (R)-(–)-enantiomer of the racemic mixture modafinil (brand name Provigil). Both enantiomers of modafinil are active as DRIs and wakefulness-promoting
Armodafinil
Wakefulness-promoting drug
agent related to modafinil that was never marketed. It is sold online and used non-medically as a nootropic (cognitive enhancer). Modafinil and its analogues
Fladrafinil
Wakefulness-promoting drug related to modafinil
N-methylbisfluoromodafinil, is a wakefulness-promoting agent related to modafinil that was never marketed. It is sold online and used non-medically as a
Modafiendz
Wakefulness-promoting drug
with prolonged use). In addition to modafinil, adrafinil also produces modafinil acid (CRL-40467) and modafinil sulfone (CRL-41056) as metabolites, which
Adrafinil
Compound intended to improve cognitive function
effects of modafinil were examined, when simple psychometric assessments were considered, modafinil intake enhanced executive function. Modafinil does not
Nootropic
Wakefulness-promoting drug/Dopamine reuptake inhibitor
bisfluoromodafinil and lauflumide, is a wakefulness-promoting agent related to modafinil which has been developed for treatment of a variety of different medical
Flmodafinil
Chemical compound
γ-Hydroxybutyric acid (GHB), also known as 4-hydroxybutanoic acid, is a naturally occurring neurotransmitter and a depressant drug. It is a precursor to
Γ-Hydroxybutyric_acid
Unmarketed enantiomer of modafinil
(also known as (S)-modafinil or (+)-modafinil; developmental code name CRL-40983) is the enantiopure (S)-(+)-enantiomer of modafinil. Unlike armodafinil
Esmodafinil
Psychedelic drug
Lysergic acid diethylamide, commonly known as LSD (from German Lysergsäurediethylamid) and by the nicknames acid and Lucy, is a semisynthetic psychedelic
LSD
243 • Dizocilpine • Etilevodopa • Flibanserin • Ketamine • Melevodopa • Modafinil • Pardoprunox • Phencyclidine • PD-128,907 • PD-168,077 • PF-219,061 •
List_of_dopaminergic_drugs
Atypical dopamine reuptake inhibitor
reuptake inhibitor (DRI) that was derived from modafinil. It is closely related to two other modafinil analogues, (S,S)-CE-158 and (S)-CE-123. (S)-MK-26
(S)-MK-26
Medication used for epilepsy, bipolar disorder and migraine
Valproate (valproic acid, VPA, sodium valproate, and valproate semisodium forms) are medications primarily used to treat epilepsy and as a mood stabilizer
Valproate
Drug that increases alertness
nicotine, cocaine , amphetamine, methamphetamine, methylphenidate, and modafinil. Some stimulants are subject to governmental regulation or prohibition
Stimulant
Investigational narcolepsy and hypersomnia drugs
agonist – narcolepsy [9] Flecainide/modafinil (THN-102) – combination of flecainide (sodium channel blocker) and modafinil (atypical dopamine reuptake inhibitor)
List of investigational narcolepsy and hypersomnia drugs
List_of_investigational_narcolepsy_and_hypersomnia_drugs
Chemical compound
is an atypical dopamine reuptake inhibitor (DRI) that was derived from modafinil. It is often but not always referred to as the enantiopure enantiomer
CE-158
CNS depressant medication
medication is structurally related to the neurotransmitter γ-aminobutyric acid (GABA), and hence is a GABA analogue. Phenibut is thought to act as a GABAB
Phenibut
Drug for wakefulness and alertness
both for modafinil-type drugs and other agents. Eugeroics, in the sense of modafinil-type wakefulness promoting agents, include modafinil itself, armodafinil
Eugeroic
Cocaine-like dopamine reuptake inhibitor derived from modafinil
wakefulness-promoting agent modafinil. It has substantially higher affinity for the dopamine transporter (DAT) than modafinil (Ki = 6.72 nM vs. 2,600 nM;
JJC8-088
Class of drug
transporters) Armodafinil (R-enantiomer of modafinil; somewhat more potent at inhibiting DAT than racemic modafinil, with equally negligible action on NET
Dopamine_reuptake_inhibitor
Catecholamine reuptake inhibitors (e.g., methylphenidate, MDPV, cocaine, modafinil, bupropion, atomoxetine) GABAA receptor antagonists (e.g., pentylenetetrazol)
List_of_psychoactive_drugs
Chemical compound
found to dose-dependently produce wakefulness to a similar degree as modafinil in a phase 1 clinical trial. As of March 2021, danavorexton is under development
Danavorexton
Designer drug, analog of modafinil
CE-123, or as the active enantiomer (S)-CE-123, is an analog of modafinil, the most researched of a series of structurally related heterocyclic derivatives
CE-123
Type of α-amino acid
F) is an α-amino acid with the formula C 9H 11NO 2. It is one of the four aromatic amino acids and the 21 proteinogenic amino acids common to all life
Phenylalanine
Abandoned drug
dopamine reuptake inhibitor (DRI) derived from modafinil. It was an early lead in the development of novel modafinil analogues with improved properties for potential
JJC8-016
Test to presumptively identify alkaloids and other compounds
Sheriff’s Office Criminalistics Laboratory. 2012. Retrieved 2013-07-16. "Modafinil reaction with the Froehde reagent and others". Reagent Tests UK. 13 December
Froehde_reagent
Chemical compound
successor to the eugeroic modafinil reported that the corresponding fluorenol derivative was 39% more effective than modafinil at keeping mice awake over
Fluorenol
Chemical group (>N–C(=O)–O–)
R2NC(O)OR and structure >N−C(=O)−O−, which are formally derived from carbamic acid (NH2COOH). The term includes organic compounds (e.g., the ester ethyl carbamate)
Carbamate
Monoamine neurotransmitter
aldehyde dehydrogenase (ALDH) to 5-hydroxyindoleacetic acid (5-HIAA), the indole acetic-acid derivative. The latter is then excreted by the kidneys.
Serotonin
Pharmaceutical compound
Isoergine, also known as isolysergic acid amide (iso-LSA or iso-LA-819), isolysergamide, or erginine, is a serotonergic psychedelic of the ergoline and
Isoergine
Organic compounds which include diphenylmethane
etc. Amido: dextromoramide Imino: benzodiazepine, GYKI-52895 Sulfinyl: modafinil, adrafinil Pituxate gem-diphenylcyclopropane These species are not strictly
Benzhydryl_compounds
Gamma-aminobutyric acid analog
neurotransmitter glutamate and competitively inhibits branched-chain amino acid aminotransferase (BCAT), slowing down the synthesis of glutamate. In particular
Gabapentin
Mixture for identifying alkaloids
Retrieved 31 March 2024. Morris, Jeremiah (2004). "Analytical Profile of Modafinil" (PDF). Microgram Journal. 3 (1–2): 28. Retrieved 9 October 2013. Lancashire
Marquis_reagent
Chemical compound
chemical formula of C7H7NO. It is the simplest amide derivative of benzoic acid. In powdered form, it appears as a white solid, while in crystalline form
Benzamide
Modafinil Nilutamide Paroxetine Phenylbutazone Probenecid Promethazine Quercetin Sertraline Sulfamethoxazole Sulfaphenazole Teniposide Valproic acid Voriconazole
List of cytochrome P450 modulators
List_of_cytochrome_P450_modulators
Pharmaceutical compound
13-Hydroxy-LSD is a lysergamide and a metabolite of the psychedelic drug lysergic acid diethylamide (LSD). It is a major metabolite of LSD in rats and guinea pigs
13-Hydroxy-LSD
Amino acid
one of the 20 standard amino acids that are used by cells to synthesize proteins. It is a conditionally essential amino acid with a polar side group. The
Tyrosine
Chemical compound
lysergic acid amide (LSA or LAA) as well as LA-111, is a psychoactive compound of the ergoline and lysergamide families related to lysergic acid diethylamide
Ergine
Brazil's federal drug control statute
Meprobamate Mesocarb Methylphenobarbital (prominal) Methyprylon Midazolam Modafinil Nimetazepam Nitrazepam Fencamfamin Nordazepam Oxazepam Oxazolam Pemoline
Brazilian Controlled Drugs and Substances Act
Brazilian_Controlled_Drugs_and_Substances_Act
Central nervous system stimulant prodrug
amphetamines is generally less preferred relative to other stimulants (e.g., modafinil) and is considered a third-line treatment option. Medical reviews indicate
Lisdexamfetamine
Psychiatric medication used to treat mood disorders
omega-3 fatty acids alone. Recent studies suggest that preparations with a higher ratio of eicosapentaenoic acid (EPA) to docosahexaenoic acid (DHA) -types
Mood_stabilizer
SNRI class Prolixin (fluphenazine) – typical antipsychotic Provigil (modafinil) - used to treat excessive sleepiness and narcolepsy Prozac (fluoxetine)
List of psychotropic medications
List_of_psychotropic_medications
Class of chemical compounds
Lysergamides, also known as ergoamides or as lysergic acid amides, are amides of lysergic acid (LA). They are ergolines, with some lysergamides being found
Lysergamides
Chemical stimulant produced by some plants
synthase (QS) to give quinolinic acid. Quinolinic acid then reacts with phosphoribosyl pyrophosphate catalyzed by quinolinic acid phosphoribosyl transferase
Nicotine
Drugs that lower neurotransmission levels, reducing brain activity
3-Chloropropanoic acid (UMB66) 3-phenylpropyloxybutyric acid (UMB72) 4-benzyloxybutyric acid (UMB73) 4-hydroxy-4-napthylbutanoic acid (UMB86) 5-Hydroxypentanoate
Depressant
Vertebrate natural glucocorticoid hormone
Scibona P, Fainstein-Day P (2021). "[Adrenal crisis associated with modafinil use]". Medicina (B Aires) (in Spanish). 81 (5): 846–849. PMID 34633961
Cortisol
Type of medication
An aromatic L-amino acid decarboxylase inhibitor (synonyms: DOPA decarboxylase inhibitor, extracerebral decarboxylase inhibitor, DDCI and AAADI) is a medication
Aromatic L-amino acid decarboxylase inhibitor
Aromatic_L-amino_acid_decarboxylase_inhibitor
effects of modafinil were examined, when simple psychometric assessments were considered, modafinil intake enhanced executive function. Modafinil does not
List_of_designer_drugs
Experimental drug for stimulant use disorder
wakefulness-promoting agent modafinil. It has substantially higher affinity and potency in terms of dopamine transporter (DAT) inhibition than modafinil (Ki = 39.4 nM
RDS03-94
Dopaminergic medication
formulated in combination with a peripherally selective aromatic L-amino acid decarboxylase (AAAD) inhibitor like carbidopa or benserazide. Levodopa is
Levodopa
Class of depressant drugs derived from barbituric acid
a class of depressant drugs that are chemically derived from barbituric acid. They are effective when used medically as anxiolytics, hypnotics, and anticonvulsants
Barbiturate
Chemical compound
Oxolinic acid is a quinolone antibiotic developed in Japan in the 1970s. Dosages 12–20 mg/kg orally administered for five to ten days. The antibiotic works
Oxolinic_acid
Chemical compound
Amfonelic acid (AFA; WIN 25,978) is a research chemical and dopaminergic stimulant with antibiotic properties. Limited clinical trials have been conducted
Amfonelic_acid
Methylephedrine Methylhexaneamine (dimethylamylamine, DMAA) Methylphenidate Modafinil N,alpha-Diethylphenylethylamine (N,a-DEPEA) N-ethyl-1-phenyl-2-butanamine
List of banned substances in Major League Baseball
List_of_banned_substances_in_Major_League_Baseball
Dopamine reuptake inhibitor related to modafinil
JJC8-089 is a dopamine reuptake inhibitor (DRI) that was derived from modafinil and is related to JJC8-016, JJC8-088, and JJC8-091. Its affinity (Ki)
JJC8-089
Chemical compound
other animals that utilize l-DOPA, make it via biosynthesis from the amino acid l-tyrosine. l-DOPA is the precursor to the neurotransmitters dopamine, norepinephrine
L-DOPA
Pharmaceutical compound
Descarboxylysergic acid (DCLA), or 8-descarboxylysergic acid, also known as 9,10-didehydro-6-methylergoline or as 6-methyl-9-ergolene, is a drug of the
Descarboxylysergic_acid
Anticonvulsant medication
Lyrica among others, is an anticonvulsant, analgesic, and anxiolytic amino acid medication used to treat epilepsy, neuropathic pain, fibromyalgia, restless
Pregabalin
Active component of a pharmaceutical drug
is an atypical dopamine reuptake inhibitor (DRI) that was derived from modafinil. It is a lead compound for potential treatment of psychostimulant use
JJC8-091
Form of the drug cocaine
cocaine and carbonic acid (H2CO3) in a reversible acid-base reaction. The heating accelerates the degradation of carbonic acid into carbon dioxide (CO2)
Crack_cocaine
Psychedelic drug
as lysergic acid 2,4-dimethylazetidide or as LA-Azetidide (LA-Az), is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide
LSZ
Dissociative hallucinogenic drug, mostly used recreationally
D2High receptors stimulated by phencyclidines, lysergic acid diethylamide, salvinorin A, and modafinil". Synapse. 63 (8): 698–704. doi:10.1002/syn.20647. PMID 19391150
Phencyclidine
Dance party
emerging dance scene, and spearheaded by acid house music and underground bands such as The Prodigy, many of the "acid house" parties were held in squats during
Rave
Class of medications used to alleviate anxiety
neurotransmitters like norepinephrine, serotonin, dopamine, and gamma-aminobutyric acid (GABA) in the central nervous system. Anti-anxiety medication can be classified
Anxiolytic
Tropane alkaloid and stimulant drug
PMID 8816810. Schmitt KC, Reith ME (2011). "The atypical stimulant and nootropic modafinil interacts with the dopamine transporter in a different manner than classical
Cocaine
Dissociative anesthetic and anti-depressant
D2High receptors stimulated by phencyclidines, lysergic acid diethylamide, salvinorin A, and modafinil". Synapse. 63 (8): 698–704. doi:10.1002/syn.20647. PMID 19391150
Ketamine
Drug increasing motivation in humans
instance dopamine reuptake inhibitors (DRIs) like methylphenidate and modafinil, dopamine releasing agents (DRAs) like amphetamine, and other dopaminergic
Motivation-enhancing_drug
Chemical compound
is an atypical dopamine reuptake inhibitor (DRI) that was derived from modafinil. It shows pro-motivational effects in animals and reverses motivational
CT-005404
Combination medication
foscarbidopa, an aromatic amino acid decarboxylation inhibitor and prodrug for carbidopa; and foslevodopa, an aromatic amino acid and prodrug for levodopa that
Foscarbidopa/foslevodopa
Gamma-aminobutyric acid analogs
chemically derivatives of the inhibitory neurotransmitter gamma-Aminobutyric acid (GABA) (i.e., GABA analogues) which bind selectively to the α2δ protein that
Gabapentinoid
Amiphenazole Amphetamine Amphetaminil Armodafinil (active enantiomer of Modafinil) Benfluorex Benzphetamine Benzylpiperazine Bromantane (Ladasten) Cathine
List of drugs banned by the World Anti-Doping Agency
List_of_drugs_banned_by_the_World_Anti-Doping_Agency
Skin disease
barbiturates, sulfonamides, phenytoin, azithromycin, oxcarbazepine, zonisamide, modafinil, lamotrigine, nevirapine, pyrimethamine, ibuprofen, ethosuximide, carbamazepine
Stevens–Johnson_syndrome
Atypical dopamine reuptake inhibitor
transporter (DAT) in an occluded (closed) conformation, similar to (R)-modafinil. This type of receptor binding to the DAT has been observed to result
JHW-007
Chemical compound
lysergic acid hydroxyethylamide, isolysergic hydroxyethylamide, lysergic acid hydroxymethylethylamide (syn. ergonovine), and isolysergic acid hydroxymethylethylamide
Ergoline
1986 non-fiction book by Martin A. Lee and Bruce Shlain
Acid Dreams: The Complete Social History of LSD: the CIA, the Sixties, and Beyond, originally released as Acid Dreams: The CIA, LSD, and the Sixties Rebellion
Acid_Dreams_(book)
Drug class
dextroamphetamine are used in the treatment of narcolepsy when another CNS stimulant, modafinil is not effective. Early users of amphetamine-type stimulants may report
Norepinephrine–dopamine releasing agent
Norepinephrine–dopamine_releasing_agent
methyl ethyl ketone or MEK) Toluene Hydrochloric acid (including anhydrous hydrogen chloride) Sulfuric acid Methyl isobutyl ketone (MIBK) Sodium permanganate
DEA_list_of_chemicals
Class of chemical compounds
prepared involve the opening of one or more of the rings of the parent lysergic acid system. The compounds with the piperidine ring (ring D) opened [see (I)]
Partial_lysergamide
Drug that reduces excitement without inducing sleep
but the majority of them affect the neurotransmitter gamma-aminobutyric acid (GABA). Most sedatives produce relaxing effects by increasing GABA activity
Sedative
Chemical compound
xanthós 'yellow' for its yellowish-white appearance; archaically xanthic acid; systematic name 3,7-dihydropurine-2,6-dione) is a purine base found in most
Xanthine
phenolic hydroxyl group undergoing ionization at physiological pH. List of modafinil analogues List of cocaine analogues Substituted cathinone Klare H, Neudörfl
List of methylphenidate analogues
List_of_methylphenidate_analogues
Contemporary folklore about drugs
on "bad acid". This legend was made famous at the 1969 Woodstock festival, when concert-goers were warned to stay away from "the brown acid", which was
Urban_legends_about_drugs
Enzyme protein
inhibition and induction of human hepatic cytochrome P450 enzymes by modafinil". Drug Metabolism and Disposition. 28 (6): 664–671. doi:10.1016/S0090-9556(24)15146-X
CYP2C9
CNS stimulant and isomer of amphetamine
amphetamines is generally less preferred relative to other stimulants (e.g., modafinil) and is considered a third-line treatment option. Medical reviews indicate
Dextroamphetamine
Chemical compound
inhibitor (also called SNDRI, or triple reuptake inhibitor). The eugeroic modafinil was used as a lead to fuel this compound's discovery.
JZ-IV-10
Chemical compound
Sunshine", is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD). It is taken orally. The drug acts as a readily converted
ALD-52
Substance related to dopamine functions
methylphenidate (Ritalin), amineptine, nomifensine, cocaine, bupropion, modafinil, armodafinil, phenylpiracetam, mesocarb, and vanoxerine, among others
Dopaminergic
Range of popular music styles and genres
United Kingdom, creating the subgenres of psychedelic folk, psychedelic rock, acid rock, and psychedelic pop before declining in the early 1970s. Numerous spiritual
Psychedelic_music
Class of medications
mechanisms of action but many block sodium channels or enhance γ-aminobutyric acid (GABA) function. Several antiepileptic drugs have multiple or uncertain mechanisms
Anticonvulsant
Sleep disorder of unknown cause
in IH. As such, stimulants are used off-label in the treatment of IH. Modafinil and Armodafinil are non-amphetamine wake-promoting agents often used in
Idiopathic_hypersomnia
One of four stable isomers of butanediol
HOCH2CH2CH2CH2OH. It is a colorless viscous liquid first synthesized in 1890 via acidic hydrolysis of N,N'-dinitro-1,4-butanediamine by Dutch chemist Pieter Johannes
1,4-Butanediol
Dissociative anesthetic designer drug
Rogawski MA (September 1993). "Therapeutic potential of excitatory amino acid antagonists: channel blockers and 2,3-benzodiazepines". Trends in Pharmacological
Diphenidine
Central nervous system stimulant
amphetamines is generally less preferred relative to other stimulants (e.g., modafinil) and is considered a third-line treatment option. Medical reviews indicate
Amphetamine
Pharmaceutical compound
Flibanserin 7-Hydroxyropinirole (SK&F-89124) Ketamine Lu AF28996 Matsupexole Modafinil Naxagolide OSU-6162 Pardoprunox PD-128,907 PD-168,077 PF-219,061 PF-592
Naxagolide
Incapacitating gas used in riot control
Elismetrep Flufenamic acid Meclofenamic acid Mefenamic acid N-(p-Amylcinnamoyl)anthranilic acid Nicotine (tobacco) Niflumic acid Ononetin PF-05105679 RQ-00203078
CR_gas
Combination dopaminergic medication
levodopa (L-DOPA), and carbidopa, a peripherally selective aromatic L-amino acid decarboxylase (AAAD) inhibitor, which is used in the treatment of Parkinson's
Melevodopa/carbidopa
Drug mixture used mainly to treat ADHD and narcolepsy
amphetamines is generally less preferred relative to other stimulants (e.g., modafinil) and is considered a third-line treatment option. Medical reviews indicate
Adderall
MODAFINIL ACID
MODAFINIL ACID
Male
English
 English form of Welsh Kai, KAY means "lord." In Arthurian legend, this is the name of one of the first Knights of the Round Table. He was the son of Sir Ector, the foster brother of King Arthur, and is noted for having an acid tongue and boorish behavior, but mostly for trying to take credit when Arthur pulled the sword from the stone. Compare with another form of Kay.Â
Girl/Female
Latin
Named for Venus.
MODAFINIL ACID
MODAFINIL ACID
MODAFINIL ACID
MODAFINIL ACID
MODAFINIL ACID
MODAFINIL ACID
MODAFINIL ACID