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Mammalian protein found in Homo sapiens
Hepatocyte growth factor (HGF) or scatter factor (SF) is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells
Hepatocyte_growth_factor
Mammalian protein found in Homo sapiens
Hepatocyte growth factor receptor (HGF receptor) is a protein that in humans is encoded by the MET gene. The protein possesses tyrosine kinase activity
Hepatocyte growth factor receptor
Hepatocyte_growth_factor_receptor
Protein or other substance that stimulates cellular proliferation
Fibroblast growth factor (FGF) Foetal Bovine Somatotrophin (FBS) GDNF family of ligands Growth differentiation factor-9 (GDF9) Hepatocyte growth factor (HGF)
Growth_factor
Chemical compound
drug derived from angiotensin IV that binds with high affinity to hepatocyte growth factor (HGF) and potentiates its activity at its receptor, c-Met. The
Dihexa
of the heart and ameliorating heart dysfunction post-MI. Human hepatocyte growth factor (HGF) is an 80kD pleiotropic protein that is endogenously produced
Human_HGF_plasmid_DNA_therapy
American biochemist (born c. 1955)
underlying blood coagulation, growth factors, and growth control. Her lab discovered a novel growth factor called hepatocyte growth factor-like protein. Degen is
Sandra_J._F._Degen
Formation of blood vessels
growth factor, insulin-like growth factor, hepatocyte growth factor, and platelet-derived endothelial growth factor. It may occur through angiogenesis
Vascularisation
Measurable indicators of diabetes
Omentin Endothelin-1 Nesfatin-1 Irisin Betatrophin Hepatocyte growth factor (HGF) Fibroblast growth factor -Biomarkers with insulin-sensitizing properties
Biomarkers_of_diabetes
Greek-American pathologist
liver regeneration, with a specific focus on the significance of hepatocyte growth factor (HGF) and its receptor (MET), as well as the role of the extracellular
George_Michalopoulos
Cell line
same year, the "scatter factor" was shown to be a previously described protein secreted by fibroblasts, hepatocyte growth factor (HGF). This work solved
Madin-Darby canine kidney cells
Madin-Darby_canine_kidney_cells
Protein-coding gene in the species Homo sapiens
Macrophage-stimulating protein (MSP), also known as hepatocyte growth factor-like protein (HLP, HGFL, or HGFLP), is a protein that in humans is encoded
MST1
ALK inhibitor for treatment of non-small-cell lung cancer
non-small cell lung carcinoma (NSCLC). Crizotinib inhibits the c-Met/Hepatocyte growth factor receptor (HGFR) tyrosine kinase, which is involved in the oncogenesis
Crizotinib
Protein-coding gene in the species Homo sapiens
Hepatocyte growth factor-regulated tyrosine kinase substrate is an enzyme that in humans is encoded by the HGS gene. HGS has been shown to interact with:
HGS_(gene)
Protein found in humans
Insulin-like growth factor 1 (IGF1), also called somatomedin C, is a hormone similar in molecular structure to insulin which plays an important role in
Insulin-like_growth_factor_1
Protein involved in blood vessel growth
Vascular endothelial growth factor (VEGF, /vɛdʒˈɛf/), originally known as vascular permeability factor (VPF), is a signal protein produced by many cells
Vascular endothelial growth factor
Vascular_endothelial_growth_factor
Protein found in humans
growth factors, which are related to the canonical nerve growth factor (NGF), a family which also includes NT-3 and NT-4/NT-5. Neurotrophic factors are found
Brain-derived neurotrophic factor
Brain-derived_neurotrophic_factor
Mammalian protein found in humans
Nerve growth factor (NGF) is a neurotrophic factor and neuropeptide primarily involved in the regulation of growth, maintenance, proliferation, and survival
Nerve_growth_factor
Protein-coding gene in the species Homo sapiens
Placental growth factor (PlGF) is a protein that in humans is encoded by the PGF gene. Placental growth factor is a member of the VEGF (vascular endothelial
Placental_growth_factor
Chemical compound
pro-drug of the active metabolite dihexa. Dihexa in turn binds to the hepatocyte growth factor (HGF) and potentiates its activity at its receptor, c-Met. "Fosgonimeton
Fosgonimeton
Family of proteins that bind to fibroblast growth factors
The fibroblast growth factor receptors (FGFR) are, as their name implies, receptors that bind to members of the fibroblast growth factor (FGF) family of
Fibroblast growth factor receptor
Fibroblast_growth_factor_receptor
Medication
contains amivantamab, a bispecific epidermal growth factor receptor (EGFR)-directed and hepatocyte growth factor receptor (MET)-directed antibody; and hyaluronidase
Amivantamab/hyaluronidase
Protein-coding gene in mammals
Fibroblast growth factor 21 (FGF-21) is a protein found in humans and other mammals that is encoded by the FGF21 gene. This protein is a member of the
Fibroblast_growth_factor_21
Pharmaceutical drug
MET exon 14 skipping mutation. Gumarontinib is a selective MET—hepatocyte growth factor receptor—inhibitor. "NMPA conditionally approves gumarontinib for
Gumarontinib
Transmembrane protein
epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family
Epidermal growth factor receptor
Epidermal_growth_factor_receptor
Signaling glycoprotein regulating cell proliferation
Platelet-derived growth factor (PDGF) is one among numerous growth factors that regulate cell growth and division. In particular, PDGF plays a significant
Platelet-derived growth factor
Platelet-derived_growth_factor
Biological process in primates
autocrine and paracrine growth factors, including IGF-1, IGF-2, amphiregulin, EGF, FGF, hepatocyte growth factor (HGF), tumor necrosis factor α (TNF-α), tumor
Breast_development
Biomarker indicative of breast cancer patients' prognosis
Transforming growth factor ([attribution needed], or TGF) is used to describe two classes of polypeptide growth factors, TGFα and TGFβ. The name transforming
Transforming_growth_factor
South Korean biotechnology company
plasmid DNA designed to simultaneously express two isoforms of hepatocyte growth factor (HGF), HGF 728 and HGF 723. In addition to DPN, Engensis is also
Helixmith
Human protein-coding gene
low-affinity nerve growth factor receptor (LNGFR) before discovery that p75NTR bound other neurotrophins equally well as nerve growth factor. p75NTR is a neurotrophic
Low-affinity nerve growth factor receptor
Low-affinity_nerve_growth_factor_receptor
Family of biomolecules
Neurotrophic factors (NTFs) are a family of biomolecules – nearly all of which are peptides or small proteins – that support the growth, survival, and
Neurotrophic_factors
Cell surface receptors
Platelet-derived growth factor receptors (PDGF-R) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF) family
Platelet-derived growth factor receptor
Platelet-derived_growth_factor_receptor
Protein-coding gene in the species Homo sapiens
Teratocarcinoma-derived growth factor 1 is a protein that in humans is encoded by the CRIPTO gene (previously TDGF1). The protein is an extracellular
Teratocarcinoma-derived growth factor 1
Teratocarcinoma-derived_growth_factor_1
Protein-coding gene in the species Homo sapiens
this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by
SNX15
Protein hormone
Insulin-like growth factor 2 (IGF-2) is one of three protein hormones that share structural similarity with insulin. The MeSH definition reads: "A well-characterized
Insulin-like_growth_factor_2
Protein-coding gene in humans
Hepatocyte growth factor activator is a protein that in humans is encoded by the HGFAC gene. The protein encoded by this gene, belongs to peptidase family
HGFAC
Protein that stimulates cell division and differentiation
Epidermal growth factor (EGF) is a protein that stimulates cell growth and differentiation by binding to its receptor, EGFR. Human EGF is 6-kDa and has
Epidermal_growth_factor
Protein found in humans
Fibroblast growth factor 23 (FGF-23) is a protein and member of the fibroblast growth factor (FGF) family which participates in the regulation of phosphate
Fibroblast_growth_factor_23
Medication which blocks growth of blood vessels
endothelial growth factor therapy, also known as anti-VEGF (/vɛdʒˈɛf/) therapy or medication, is the use of medications that block vascular endothelial growth factor
Anti-VEGF
InterPro family
The keratinocyte growth factor (KGF), also known as FGF7, is a growth factor present in the epithelialization-phase of wound healing. In this phase, keratinocytes
Keratinocyte_growth_factor
Gene involved in the most common form of dwarfism
Fibroblast growth factor receptor 3 (FGFR-3) is a protein that in humans is encoded by the FGFR3 gene. FGFR3 has also been designated as CD333 (cluster
Fibroblast growth factor receptor 3
Fibroblast_growth_factor_receptor_3
Mammalian protein found in Homo sapiens
Fibroblast growth factor 18 (FGF-18) is a protein that is encoded by the FGF18 gene in humans. The protein was first discovered in 1998, when two newly-identified
Fibroblast_growth_factor_18
Topics referred to by the same term
scientific organisation in Germany Hepatocyte growth factor, a paracrine cellular growth, motility and morphogenic factor Hereditary gingival fibromatosis
HGF
Class of compounds
activity of the c-Met tyrosine kinase, the receptor of hepatocyte growth factor/scatter factor (HGF/SF). These inhibitors may have therapeutic application
C-Met_inhibitor
Primary male sex hormone
antagonist of the TrkA and p75NTR, receptors for the neurotrophin nerve growth factor (NGF), with high affinity (around 5 nM). In contrast to testosterone
Testosterone
proteolytic function. Hepsin cleaves and activates pro-hepatocyte growth factor (pro-HGF) and coagulation factor VII, suggesting roles in both signaling pathways
Hepsin
Protein capable of worsening malignant diseases
Hepatoma-derived growth factor (HDGF) also known as high mobility group protein 1-like 2 (HMG-1L2) is a protein that in humans is encoded by the HDGF
Hepatoma-derived growth factor
Hepatoma-derived_growth_factor
Topics referred to by the same term
Lokhit Party, a political party; see Haryana Legislative Assembly Hepatocyte growth factor-like protein Houston Lighting & Power, HL&P, former Texas, US utility
HLP
Cell receptor protein found in humans
The insulin-like growth factor 1 (IGF-1) receptor is a protein found on the surface of human cells. It is a transmembrane receptor that is activated by
Insulin-like growth factor 1 receptor
Insulin-like_growth_factor_1_receptor
Protein
Transforming growth factor alpha (TGF-α) is a protein that in humans is encoded by the TGFA gene. As a member of the epidermal growth factor (EGF) family
TGF_alpha
Protein-coding gene in the species Homo sapiens
of toll-like receptor 4 signaling pathway cellular response to hepatocyte growth factor stimulus glucose homeostasis regulation of innate immune response
APPL2
Protein-coding gene in the species Homo sapiens
EGF-like growth factor (HB-EGF) is a member of the EGF family of proteins that in humans is encoded by the HBEGF gene. HB-EGF-like growth factor is synthesized
Heparin-binding EGF-like growth factor
Heparin-binding_EGF-like_growth_factor
Cytokine
Transforming growth factor beta (TGF-β) is a multifunctional cytokine belonging to the transforming growth factor superfamily that includes three different
Transforming growth factor beta
Transforming_growth_factor_beta
Exocrine gland in humans and other mammals
beta (TGF-β), amphiregulin, fibroblast growth factor (FGF), and hepatocyte growth factor (HGF) are involved in breast development as mediators downstream
Mammary_gland
Series of events that restore integrity to damaged tissue after an injury
cytokines and growth factors. Growth factors stimulate cells to speed their rate of division. Platelets release other proinflammatory factors like serotonin
Wound_healing
Monoclonal antibody
of cancers. It is a humanized monoclonal antibody that binds to hepatocyte growth factor, thus inhibiting the c-MET receptor signaling cascade. Ficlatuzumab
Ficlatuzumab
Protein involved in blood vessel growth
Vascular endothelial growth factor A (VEGF-A) is a protein that in humans is encoded by the VEGFA gene. The chemical formula is C3914H6252N1212O1278S52
Vascular endothelial growth factor A
Vascular_endothelial_growth_factor_A
Corticosteroid medication
thinning Cushing's syndrome Edema Esophageal ulcer Facial plethora Glaucoma Growth stunting (in children) Herpes zoster Hypernatremia Hypertriglyceridemia
Dexamethasone
Protein family
VEGF receptors (VEGFRs) are receptors for vascular endothelial growth factor (VEGF). There are three main subtypes of VEGFR, numbered 1, 2 and 3. Depending
VEGF_receptor
Protein-coding gene in the species Homo sapiens
inhibiting HGF activator which prevents the formation of active hepatocyte growth factor. Mutations in SPINT2 could result in congenital sodium diarrhea
SPINT2
Protein found in humans
Fibroblast growth factor receptor 1 (FGFR-1), also known as basic fibroblast growth factor receptor 1, fms-related tyrosine kinase-2 / Pfeiffer syndrome
Fibroblast growth factor receptor 1
Fibroblast_growth_factor_receptor_1
Family of proteins involved in anatomical development
Fibroblast growth factors (FGF) are a family of cell signalling proteins produced by the macrophages. They are involved in a wide variety of processes
Fibroblast_growth_factor
Targeted cancer drug
reactivating the normal BRAF survival pathway. Stromal cell secretion of hepatocyte growth factor (HGF). At the maximum tolerated dose (MTD) of 960 mg twice a day
Vemurafenib
Transport protein for insulin-like growth factor 1
The insulin-like growth factor-binding protein (IGFBP) serves as a transport protein for insulin-like growth factor 1 (IGF-1). Approximately 98% of IGF-1
Insulin-like growth factor–binding protein
Insulin-like_growth_factor–binding_protein
Protein receptor active in neurons
Growth Factor (EGF), Fibroblast Growth Factor (FGF), Hepatocyte Growth Factor (HGF), Insulin-like Growth Factor (IGF), Platelet Derived Growth Factor
Neuropilin
Protein-coding gene in the species Homo sapiens
Crepaldi T (Dec 2001). "Ligand-regulated binding of FAP68 to the hepatocyte growth factor receptor". J. Biol. Chem. 276 (49). United States: 46632–8. doi:10
GLMN
Proteins similar to insulin that stimulate cell proliferation
The insulin-like growth factors (IGFs) are proteins with high sequence similarity to insulin. IGFs are part of a complex system that cells use to communicate
Insulin-like_growth_factor
Natural regrowth of damaged liver tissue
communication between β-catenin (inside the hepatocyte) and the growth factors EGFR and HGFR or c-Met (outside the hepatocyte). The presence of these two proteins
Liver_regeneration
Protein-coding gene in the species Homo sapiens
Fibroblast growth factor receptor 2 (FGFR-2) also known as CD332 (cluster of differentiation 332) is a protein that in humans is encoded by the FGFR2
Fibroblast growth factor receptor 2
Fibroblast_growth_factor_receptor_2
of inflammation, such as prostaglandins, as well as growth factors such as hepatocyte growth factor. It is thus indicated to contribute to processes like
Nemosis
High blood sugar levels during pregnancy
receptor tyrosine kinase (RTK) that is activated by its ligand, hepatocyte growth factor (HGF), and is involved in the activation of several cellular processes
Gestational_diabetes
Class of proteins
Hemopoietic growth factors regulate the differentiation and proliferation of particular progenitor cells. Made available through recombinant DNA technology
Hemopoietic_growth_factor
Growth factor and signaling protein otherwise known as FGF2
Fibroblast growth factor 2 (FGF-2), also known as basic fibroblast growth factor (bFGF) and FGF-β, is a growth factor and signaling protein encoded by
Fibroblast_growth_factor_2
Protein-coding gene in the species Homo sapiens
coreceptor to a tyrosine kinase receptor for both vascular endothelial growth factor (for example, VEGFA) and semaphorin (for example, SEMA3A) family members
Neuropilin_1
Protein-coding gene in the species Homo sapiens
Fibroblast growth factor 8 (FGF-8) is a protein that in humans is encoded by the FGF8 gene. The protein encoded by this gene belongs to the fibroblast growth factor
Fibroblast_growth_factor_8
Class of enzymes
(RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. Of the 90 unique tyrosine kinase genes identified
Receptor_tyrosine_kinase
Blood product used in transfusion medicine
interleukin 8 keratinocyte growth factor connective tissue growth factor hepatocyte growth factor stromal cell-derived factor 1 endostatin PRP is prepared
Platelet-rich_plasma
Protein-coding gene in the species Homo sapiens
Fibroblast growth factor 1 (FGF-1) also known as acidic fibroblast growth factor (aFGF), is a growth factor and signaling protein encoded by the FGF1 gene
Fibroblast_growth_factor_1
Protein that stimulates red blood cell production
Erythropoietin is the primary erythropoietic factor that cooperates with various other growth factors (e.g., IL-3, IL-6, glucocorticoids, and SCF) involved
Erythropoietin
Monoclonal antibody
treat non-small cell lung cancer. Amivantamab is a bispecific epidermal growth factor (EGF) receptor-directed and MET receptor-directed antibody. It is the
Amivantamab
Topics referred to by the same term
London, UK Mesenchymal–epithelial transition MET (gene), encoding hepatocyte growth factor receptor Met, hypermethioninemia Microbial electrochemical technologies
Met
Cancer of the colon or rectum
has been isolated. It is a transcriptional factor that influences the expression of hepatocyte growth factor. This gene is associated with the proliferation
Colorectal_cancer
Drug typically used in cancer treatment
description of compounds inhibiting the catalytic activity of the epidermal growth factor receptor (EGFR). The 1988 study was the first demonstration of a systematic
Tyrosine_kinase_inhibitor
Protein-coding gene in the species Homo sapiens
endothelial growth factor B also known as VEGF-B is a protein that, in humans, is encoded by the VEGF-B gene. VEGF-B is a growth factor that belongs
Vascular endothelial growth factor B
Vascular_endothelial_growth_factor_B
Rare human disease
and prolactin) and/or growth factors (e.g., hepatocyte growth factor, insulin-like growth factor 1, and epidermal growth factor) in the breasts. Macromastic
Breast_hypertrophy
Protein-coding gene in the species Homo sapiens
osteogenesis and bone resorption, regulation of the insulin and hepatocyte growth factor receptors, and response to systemic inflammation. This protein
Fetuin-B
Growth factor protein found in humans
endothelial growth factor C (VEGF-C) is a protein that is a member of the platelet-derived growth factor / vascular endothelial growth factor (PDGF/VEGF)
Vascular endothelial growth factor C
Vascular_endothelial_growth_factor_C
Group of protein families
Neurotrophic factor receptors or neurotrophin receptors are a group of growth factor receptors which specifically bind to neurotrophins (neurotrophic factors). Two
Neurotrophic_factor_receptor
Protein found in humans
CCN family member 2, also known as Connective tissue growth factor (CTGF), is a protein encoded by the CCN2 gene in humans. CTGF is a matricellular protein
CCN_family_member_2
Human protein-coding gene
Platelet-derived growth factor receptor A, also termed CD140a, is a receptor located on the surface of a wide range of cell types. The protein is encoded
Platelet-derived growth factor receptor A
Platelet-derived_growth_factor_receptor_A
Protein family
members of the plasminogen/hepatocyte growth factor family, the apple domains of the plasma prekallikrein/coagulation factor XI family, and domains of
PAN_domain
Family of four EGF proteins
differentiation factor; acetylcholine receptor synthesis stimulator; glial growth factor; and sensory and motor-neuron derived factor. Multiple family
Neuregulin
Medication for treatment of non-small-cell lung cancer
Approximately 20% of drug resistance is caused by amplification of the hepatocyte growth factor receptor, which drives ERBB3 dependent activation of PI3K. Rash
Erlotinib
Form of biological cell death
1038/430973a. PMID 15329701. Zeng Q, Chen S, You Z, et al. (July 2002). "Hepatocyte growth factor inhibits anoikis in head and neck squamous cell carcinoma cells
Anoikis
Behaviour of substances
receptor. Epinephrine induces platelet aggregation, and so does hepatocyte growth factor (HGF). Thus, they are physiological agonists to each other. There
Physiological agonism and antagonism
Physiological_agonism_and_antagonism
Protein-coding gene in the species Homo sapiens
M, Birchmeier W, Feller SM (April 2000). "Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein
GRB2-associated-binding protein 1
GRB2-associated-binding_protein_1
Protein-coding gene in the species Homo sapiens
Hepatocyte nuclear factor 4 alpha (HNF4A) also known as NR2A1 (nuclear receptor subfamily 2, group A, member 1) is a nuclear receptor that in humans is
Hepatocyte nuclear factor 4 alpha
Hepatocyte_nuclear_factor_4_alpha
Protein-coding gene in the species Homo sapiens
Chwang EL, He YG (Jul 1993). "Hepatocyte growth factor, keratinocyte growth factor, their receptors, fibroblast growth factor receptor-2, and the cells of
FGF7
Protein domain
receptor; 72 Kd and 92 Kd type IV collagenase (EC 3.4.24.24); and hepatocyte growth factor activator. Fibronectin type II domain is part of the extracellular
Fibronectin_type_II_domain
Protein-coding gene in the species Homo sapiens
Insulin-like growth factor-binding protein 3, also known as IGFBP-3, is a protein that in humans is encoded by the IGFBP3 gene. IGFBP-3 is one of six
IGFBP3
Pharmaceutical drug
Oxervate, also known as recombinant human nerve growth factor, is a recombinant form of human nerve growth factor. Cenegermin is a peripherally selective agonist
Cenegermin
HEPATOCYTE GROWTH-FACTOR
HEPATOCYTE GROWTH-FACTOR
HEPATOCYTE GROWTH-FACTOR
HEPATOCYTE GROWTH-FACTOR
HEPATOCYTE GROWTH-FACTOR
HEPATOCYTE GROWTH-FACTOR
HEPATOCYTE GROWTH-FACTOR
HEPATOCYTE GROWTH-FACTOR
HEPATOCYTE GROWTH-FACTOR