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Chemical compound
Guanidine is the compound with the formula HNC(NH2)2. It is a colourless solid that dissolves in polar solvents. It is a strong base that is used in the
Guanidine
Chemical compound
Guanidine nitrate is the chemical compound with the formula CH5N3·HNO3 (linear formula NH2C(=NH)NH2·HNO3). It is a colorless, water-soluble salt. It is
Guanidine_nitrate
Polymer
Polyhexamethylene guanidine (PHMG) is a guanidine derivative that is used as a biocidal disinfectant, often in the form of its salt polyhexamethylene guanidine phosphate
Polyhexamethylene_guanidine
Chemical compound
Agmatine, also known as 4-aminobutyl-guanidine, was discovered in 1910 by Albrecht Kossel. It is a chemical substance which is naturally created from
Agmatine
Chemical compound
Guanidinium chloride or guanidine hydrochloride, usually abbreviated GdmCl and sometimes GdnHCl or GuHCl, is the hydrochloride salt of guanidine. Guanidinium chloride
Guanidinium_chloride
Chemical compound
Guanidinium carbonate or guanidine carbonate is the carbonate salt of guanidine with the chemical formula [C(NH2)3]2CO3. It is a white solid, forming tetragonal
Guanidinium_carbonate
Chemical compound
GITC may also be recognized as guanidine thiocyanate. This is because guanidinium is the conjugate acid of guanidine and is called the guanidinium cation
Guanidinium_thiocyanate
Chemical compound
2-Cyanoguanidine is a nitrile derived from guanidine. It is a dimer of cyanamide, from which it can be prepared. 2-Cyanoguanidine is produced by treating
2-Cyanoguanidine
Type of chemical substance
category of base rather than a qualitative description. For example, guanidine is a very basic molecule, but it does not meet the definition of a strong
Base_(chemistry)
Basic taste
sweeteners, including the most potent family of sweeteners known to date, the guanidine sweeteners. The most potent of these, lugduname, is about 225,000 times
Sweetness
Pharmaceutical drug classification
ATC code C02 Antihypertensives is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed
ATC_code_C02
Amino acid
proteins. It is encoded by the codons CGU, CGC, CGA, CGG, AGA, and AGG. The guanidine group in arginine is the precursor for the biosynthesis of nitric oxide
Arginine
Chemical compound
4.0]dec-5-ene or TBD) is an organic compound consisting of a bicyclic guanidine. For a charge-neutral compound, it is a relatively strong base that is
Triazabicyclodecene
Chemical compound
potent sweeteners which contain acetic acid functional groups attached to guanidine. Carrelame Sucrononic acid Hürter, T. (2004). "Wie wir schmecken". Technology
Lugduname
Lung disease outbreak in South Korea
South Korean CDC to identify the cause as the chemicals polyhexamethylene guanidine (PHMG), chloromethylchloroisothiazolinone (CMIT), methylisothiazolinone
South Korean humidifier disinfectant case
South_Korean_humidifier_disinfectant_case
Chemical compound
in which the amino group has been converted into a guanidine by guanylation (transfer of a guanidine group from arginine). In vertebrate organism it is
Glycocyamine
Genus of legumes
Argentina. It is threatened by habitat loss and harvesting for timber. Five guanidine alkaloid natural products were isolated from the leaves of Pterogyne nitens:
Pterogyne
Species of flowering plant in the pea family
for its constituents, which include galegine, hydroxygalegine, several guanidine derivatives, such as 4-hydroxygalegine flavones, flavone glycosides, kaempferol
Galega_officinalis
Conserved RNA structure in bacteria
to guanidine and it was renamed Guanidine-I riboswitch. Furthermore, they demonstrated that bacteria are capable of endogenously producing guanidine and
YkkC-yxkD_leader
Chemical reaction which adds a nitro (–NO2) group onto a molecule
used for the production of explosives, for example the conversion of guanidine to nitroguanidine and the conversion of toluene to trinitrotoluene (TNT)
Nitration
Chemical compound
Leonurine (also known as SCM-198 in research) is a substituted guanidine that has been isolated from Leonotis leonurus, Leonotis nepetifolia, Leonurus
Leonurine
Extremely strong base
than proton sponge. Common superbases of this variety feature amidine, guanidine, and phosphazene functional groups. Strong superbases can be designed
Superbase
Medication used to treat diabetes
of two guanidine molecules joined together and designed to be less toxic than the plant-derived parent compound galegine (isoamylene guanidine). Metformin
Metformin
Chemical compound
chemist Derek Barton. Barton and his assistants prepared a series of guanidines with steric hindrance in 1982; in this case five alkyl groups: four methyl
2-tert-Butyl-1,1,3,3-tetramethylguanidine
2-tert-Butyl-1,1,3,3-tetramethylguanidine
pyridine alkylamines, such as methylamine imidazole benzimidazole histidine guanidine phosphazene bases hydroxides of quaternary ammonium cations or some other
Organic_base
Chemical compound
Experimental Identifiers IUPAC name N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine CAS Number 187870-78-6 PubChem CID 9799487 ChemSpider 7975252 UNII QH6B4V5743
Rimeporide
Suffix used in chemistry
subsequently renamed to "morphine". Examples include quinine, morphine and guanidine. The second usage is to denote a hydrocarbon of the second degree of unsaturation
-ine
Chemical compound
(tetrahydro-3-furanyl) methyl] guanidine Other names (RS)-1-methyl-2-nitro-3-[(tetrahydro-3-furanyl) methyl] guanidine; MTI-446 Identifiers CAS Number
Dinotefuran
Medication used for high blood pressure and ADHD
can be prepared from equal parts methyl 2,6-dichlorophenylacetate and guanidine: Guanfacine was first described in the literature by 1974. In 1986, guanfacine
Guanfacine
Chemical reaction
original Barton publication the reaction was optimized by using a strong guanidine base, the inverse addition of the hydrazone to an iodine solution, and
Hydrazone_iodination
Chemical compound
Asymmetric dimethylarginine (ADMA) is a naturally occurring chemical found in blood plasma. It is a metabolic by-product of continual protein modification
Asymmetric_dimethylarginine
Class of enzymes
L-arginine + O2 ⇌ {\displaystyle \rightleftharpoons } succinate + CO2 + guanidine + (S)-1-pyrroline-5-carboxylate + H2O (overall reaction) (1a) 2-oxoglutarate
2-oxoglutarate/L-arginine monooxygenase/decarboxylase (succinate-forming)
2-oxoglutarate/L-arginine_monooxygenase/decarboxylase_(succinate-forming)
Excess urea in the blood due to kidney dysfunction
major histocompatibility complex poorly dialyzed because of large size Guanidines guanidinosuccinic acid arginine increased production in uremia Phenols
Uremia
Pharmaceutical compound
discontinued by 2008. In terms of chemical structure, naminidil is a guanidine derivative and is structurally distinct from minoxidil. List of investigational
Naminidil
Chemical compound
Sulfaguanidine is a sulfonamide. Sulfaguanidine is a guanidine derivative of sulfanilamide used in veterinary medicine. Sulfaguanidine is poorly absorbed
Sulfaguanidine
Chemical compound with formula NH4NO3
once used, in combination with independently explosive "fuels" such as guanidine nitrate, as a cheaper (but less stable) alternative to 5-aminotetrazole
Ammonium_nitrate
Chemical compound
Sucronic acid is a guanidine derivative artificial sweetener. It is one of the most potent sweeteners known, with a sweetness 200,000 times that of sucrose
Sucrononic_acid
Isomers of chemical compounds that interconvert
cyanamide – carbodiimide guanidine – guanidine – guanidine: With a central carbon surrounded by three nitrogens, a guanidine group allows this transform
Tautomer
Chemical compound
Zetekitoxin AB (ZTX AB) is a guanidine alkaloid neurotoxin found in the skin of Panamanian golden frog Atelopus zeteki. It was firstly reported in 1969
Zetekitoxin_AB
Medication that reduces stomach acid
Famotidine, sold under the brand name Pepcid among others, is a histamine H2 receptor antagonist medication that decreases stomach acid production. It
Famotidine
Disinfectant and antiseptic
Retrieved 17 August 2025. Güthner T, Mertschenk B, Schulz B (2007), "Guanidine and Derivatives", Ullman's Encyclopedia of Industrial Chemistry (7th ed
Chlorhexidine
Sodium hydroxide and potassium hydroxide
they often cause scalp irritation. Though no-lye solutions, which use guanidine or lithium hydroxide, produce less scalp irritation, they may cause brittleness
Lye
Chemical compound
(French lilac) was used in diabetes treatment for centuries. In the 1920s, guanidine compounds were discovered in Galega extracts. Animal studies showed that
Biguanide
sensitive and can be converted into imides upon exposure to water. Amidine Guanidines Pinner, A. (January 1883). "Ueber die Umwandlung der Nitrile in Imide
Imidine
Loss of structure in proteins and nucleic acids due to external stress
denaturation process through various chemical agents such as formamide, guanidine, sodium salicylate, dimethyl sulfoxide (DMSO), propylene glycol, and urea
Denaturation_(biochemistry)
Chemical compound
bicyclic strong guanidine base (pKa = 25.43 in CH3CN and pKa = 17.9 in THF). mTBD, like 1,5,7-triazabicyclo[4.4.0]dec-5-ene and other guanidine super bases
7-Methyl-1,5,7-triazabicyclo(4.4.0)dec-5-ene
7-Methyl-1,5,7-triazabicyclo(4.4.0)dec-5-ene
Chemical compound
Zevaquenabant (S-MRI-1867, INV-101, or MRI-1867) is an investigational small-molecule drug, discovered by Dr George Kunos, Dr Resat Cinar, and Dr Malliga
Zevaquenabant
Proteins or lipids chemically altered by sugar exposure
Glycation often entails the modification of the guanidine group of arginine residues with glyoxal (R = H), methylglyoxal (R = Me), and 3-deoxyglucosone
Advanced glycation end-product
Advanced_glycation_end-product
Antidepressant medication
M, Quarum M, McLean S, Pou S, Keana JF (1986). "1,3-Di(2-[5-3H]tolyl)guanidine: a selective ligand that labels sigma-type receptors for psychotomimetic
Nortriptyline
Antihypertensive drug
Prazosin, sold under the brand name Minipress among others, is a medication used to treat high blood pressure, symptoms of an enlarged prostate, and nightmares
Prazosin
Microbiological and biochemical method for identification
acetylmethylcarbinol is oxidized to diacetyl, which then reacts with guanidine compounds commonly found in the peptone medium of the broth. Alpha-naphthol
Voges–Proskauer_test
Chemical compound
Carrelame is an extremely high potency artificial sweetener of the guanidine class, closely related to lugduname. While carrelame is roughly 200,000 times
Carrelame
Attachment of a sugar to a protein or lipid
CH2CH(OH)CH(OH)CH2OH) are typical glycation products. They arise by the condensation of 3-deoxyglucosone with the guanidine group of an arginine residue.
Glycation
Antidepressant
Quarum M, McLean S, Pou S, Keana JF (November 1986). "1,3-Di(2-[5-3H]tolyl)guanidine: a selective ligand that labels sigma-type receptors for psychotomimetic
Imipramine
Aggregates of specific proteins in neurons and tissues
bodies often involves treatment with denaturing agents, such as urea or guanidine chloride at high concentrations, to de-aggregate the collapsed proteins
Inclusion_bodies
Pharmaceutical compound
RF9 is a drug used in scientific research which acts as a potent and selective antagonist for the neuropeptide FF receptors NPFF1 and NPFF2, binding to
RF9_(drug)
Solution used for the colorimetric determination of phenolic compounds
react with some nitrogen-containing compounds such as hydroxylamine and guanidine. The reagent has also been shown to be reactive towards thiols, many vitamins
Folin–Ciocalteu_reagent
Chemical compound
Gabexate is a serine protease inhibitor which is used therapeutically (as gabexate mesilate) in the treatment of pancreatitis, disseminated intravascular
Gabexate
Hair straightening product
weaker alkaline agent, such as potassium hydroxide, lithium hydroxide, or guanidine hydroxide. The last of these is not pre-formulated, but rather is generated
Relaxer
Tricyclic antidepressant
Quarum M, McLean S, Pou S, Keana JF (November 1986). "1,3-Di(2-[5-3H]tolyl)guanidine: a selective ligand that labels sigma-type receptors for psychotomimetic
Amitriptyline
Chemical compound
in 1998 and its eventual sale to CeNeS Pharmaceuticals in 2000. Other guanidine substances that the company had been bowling on was Cns-1145 & CNS1237
Aptiganel
Chemical compound that is an isomer of cytosine
abbreviation rS. It can be synthesized from guanidine and malic acid. Isocytosine can also be obtained by condensing guanidine hydrochloride with 3-oxopropanoic
Isocytosine
Pharmaceutical drug
Vildagliptin/metformin, sold under the brand name Eucreas among others, is a fixed-dose combination anti-diabetic medication for the treatment of type
Vildagliptin/metformin
Chemical compound
Creatine (/ˈkriːətiːn/ or /ˈkriːətɪn/) is an organic compound that facilitates recycling of adenosine triphosphate (ATP) in vertebrates, primarily in their
Creatine
Several medications which disrupt the movement of Na+ ions
5-diamino-6-chloropyrazine-2-carbonyl)-N'-4-[4-(2,3-dihydroxypropoxy)phenyl]butyl-guanidine methanesulfonate (552-02), a novel epithelial sodium channel blocker with
Sodium_channel_blocker
American biochemist and physiologist
gravis and muscular dystrophy. In 1938, she became the first to apply guanidine to treat myasthenia gravis. Other topics of research include protein deficiency
Ann_Stone_Minot
Protein domain
weight was determined to 76kD by gel chromatography in the presence of 6 M guanidine HCl. Protein L does not contain any interchain disulfide loops, nor does
Protein_L
Chemical element with atomic number 85 (At)
Adenocarcinomas 211At-labeled methylene blue Melanomas Meta-[211At]astatobenzyl guanidine Neuroendocrine tumors 5-[211At]astato-2'-deoxyuridine Various 211At-labeled
Astatine
Chemical compound
R.; Colegate, S. M. (1993). "Identification of galegine, an isoprenyl guanidine, as the toxic principle of Schoenus asperocarpus (poison sedge)". Australian
Galegine
Chemical compound
folic acid is assigned to the vitamin B complex; ethyl cyanoacetate and guanidine can be used as starting material in a multi-stage convergent synthesis
Ethyl_cyanoacetate
Chemical compound
Debrisoquine is a derivative of guanidine. It is an antihypertensive drug similar to guanethidine. Debrisoquine is frequently used for phenotyping the
Debrisoquine
Polyamine involved in cellular metabolism
is hydrolysed by agmatine deiminase, releasing ammonia, converting the guanidine group into a urea. The resulting N-carbamoylputrescine is acted on by
Spermine
Chemical property
"Y-Conjugated compounds: the equilibrium geometries and electronic structures of guanidine, guanidinium cation, urea, and 1,1-diaminoethylene". Journal of the American
Aromaticity
Chemical compound
Guanitoxin (GNT), formerly known as anatoxin-a(S) "Salivary", is a naturally occurring cyanotoxin commonly isolated from cyanobacteria (specifically of
Guanitoxin
Breakdown product of creatine phosphate
Creatinine (/kriˈætɪnɪn, -ˌniːn/; from Ancient Greek κρέας (kréas) 'flesh') is a breakdown product of creatine phosphate from muscle and protein metabolism
Creatinine
Functions of nitric oxide in organisms
endothelial nitric oxide synthase (eNOS). eNOS synthesizes NO from the terminal guanidine-nitrogen of L-arginine and oxygen and yields citrulline as a byproduct
Biological functions of nitric oxide
Biological_functions_of_nitric_oxide
Antiviral drug targeting influenza
Peramivir (trade name Rapivab) is an antiviral drug developed by BioCryst Pharmaceuticals for the treatment of influenza. Peramivir is a neuraminidase
Peramivir
Vehicle safety device
relatively inert potassium silicate and sodium silicate. Modern airbags use guanidine nitrate to generate gas through the following reaction: [C(NH2)3]NO3 (s)
Airbag
Active region of an enzyme
ions, COO− will attract positively charged groups such as protonated guanidine side chain of arginine.[citation needed] Hydrogen bond: A hydrogen bond
Active_site
Protein in the Coronavirus genome
The domain can then transfer the monophosphorylated RNA from nsp9 to a Guanidine Diphosphate (GDP) to form the initial cap structure for SARS-CoV-2. Snijder
Nsp12
Autoimmune disorder causing muscular weakness
symptoms, namely pyridostigmine, 3,4-diaminopyridine (amifampridine), and guanidine. They work to improve neuromuscular transmission. Intravenous immunoglobulin
Lambert–Eaton myasthenic syndrome
Lambert–Eaton_myasthenic_syndrome
Chemical compound
a polymethylene chain with a guanidine group at each end. These diguanides were less toxic and more potent than guanidine. In 1926, E. Frank, working in
Synthalin
Chemical compound
an exchange of the amidine function and formation of the corresponding guanidine. The saturated guanidino-amide is obtained by catalytic hydrogenation
Gusperimus
Chemical compound
more manageable guanidine salt is used, e.g. guanidine hydrochloride, the base sodium methanolate is added to liberate free guanidine. Because the aromatic
2,4,6-Triaminopyrimidine
Drug used to reduce frequency of headaches
2013). "Synthesis and structure-activity relationships of new carbonyl guanidine derivatives as novel dual 5-HT2B and 5-HT7 receptor antagonists". Bioorg
Pizotifen
RNA family
The mini-ykkC RNA motif (later renamed Guanidine-II riboswitch) was discovered as a putative RNA structure that is conserved in bacteria. The motif consists
Mini-ykkC_RNA_motif
Human hair texture
1800s and 1900s. These relaxers often contained sodium hydroxide (lye) or guanidine hydroxide which result in hair breakage, thinning of the hair, slowing
Kinky_hair
Medication
5-diamino-6-chloropyrazine-2-carbonyl)-N'-4-[4-(2,3-dihydroxypropoxy)phenyl]butyl-guanidine methanesulfonate, research name "552-02"), with better pharmacokinetic
Amiloride
Chemical compound
Creatinolfosfate (creatinol-O-phosphate, creatinol phosphate, COP) is a cardiac preparation, not to be confused with phosphocreatine. v t e
Creatinolfosfate
Chemical compound
with urea or guanidine resulted in a compound with much less activity (only 5% of the potency of metiamide) however, the NH form (the guanidine analog of
Metiamide
Chemical compound
forming DNA adducts, the primary one being M1G, which is mutagenic. The guanidine group of arginine residues condense with malondialdehyde to give 2-aminopyrimidines
Malondialdehyde
acid 13881-91-9 CH5N3 guanidine 113-00-8 CH5N3O3S thiourea nitrate 55011-91-1 CH5N3S hydrazinecarbothioamide 79-19-6 CH5N4O2 guanidine nitrate 506-93-4 CH5O3P
List of compounds with carbon number 1
List_of_compounds_with_carbon_number_1
Group of atoms giving a molecule characteristic properties
R4C(NR1)(NR2R3) amidino- -amidine acetamidine (acetimidamide) Guanidine Guanidine RNC(NR2)2 Guanidin- -Guanidine Guanidinopropionic acid Amines Primary amine RNH2
Functional_group
Chemical compound
can be synthesized by reacting cyclohex-1-enyl 2-cyanopropanoate with guanidine and sodium methylate. A hexobarbital sodium intermediate is then formed
Hexobarbital
Fixed-dose combination anti-diabetic medication
Canagliflozin/metformin, sold under the brand name Vokanamet among others, is a fixed-dose combination anti-diabetic medication used for the treatment
Canagliflozin/metformin
American rocket engineer (1914–1952)
issue with GALCIT-46, which replaced the former's ammonium nitrate with guanidine nitrate. To avoid the problems seen with ammonium nitrate, he had GALCIT-46
Jack_Parsons
4-15 ×10−4 cGMP 0.6-4.4 ×10−9 Gonadotropin-releasing hormone 1-80 ×10−12 Guanidine 1.8-2.3 ×10−6 Haptoglobin 3-22 ×10−4 Hemoglobin 1.2-1.75 ×10−1 1-4 ×10−5
List of human blood components
List_of_human_blood_components
Aminoglycoside antibiotic
Look up streptomycin in Wiktionary, the free dictionary. Streptomycin is an antibiotic medication used to treat a number of bacterial infections, including
Streptomycin
Chemical compound
with S-methyl isothiourea proceeds first by aromatic cyclisation to the guanidine derivative followed by elimination of methyl mercaptan to yield the 2-aminobenzimidazole
Oxibendazole
Chemical compound
2-[3-[2-[(2S)-butan-2-yl]-6-(1H-indol-3-yl)-3-oxo-7H-imidazo[2, 1-c]pyrazin-8-yl]propyl]guanidine Other names Cypridina luciferin Cypridinid luciferin Vargula luciferin
Vargulin
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