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KRINGLE DOMAIN

  • Kringle domain
  • Autonomous protein domains

    Kringle domains are autonomous protein domains that fold into large loops stabilized by three disulfide linkages. These are important in protein–protein

    Kringle domain

    Kringle domain

    Kringle_domain

  • Kringle
  • Type of pretzel

    Kringle is a Northern European pastry or bread, a variety of pretzel that may be sweet, salty or filled, in a characteristic pretzel-like twisted shape

    Kringle

    Kringle

    Kringle

  • VEK-30 protein domain
  • Protein family

    that shows high affinity for the lysine binding site (LBS) of the kringle-2 (K2) domain of human (h)Pg. Plasminogen (Pg) is an important mediator of angiostatin

    VEK-30 protein domain

    VEK-30 protein domain

    VEK-30_protein_domain

  • PAN domain
  • Protein family

    native plasminogen the PAN domain is associated with five kringle domains. The interactions between the PAN domain and the kringles play a critical role in

    PAN domain

    PAN domain

    PAN_domain

  • Protein domain
  • Self-stable region of a protein's chain that folds independently from the rest

    widespread protein modules are the following domains: SH2, immunoglobulin, fibronectin type 3 and the kringle. Molecular evolution gives rise to families

    Protein domain

    Protein domain

    Protein_domain

  • Plasmin
  • Enzyme in human blood that degrades clots and other proteins

    Kringle domains (KR1-5). The Pan-Apple domain contains important determinants for maintaining plasminogen in the closed form, and the kringle domains

    Plasmin

    Plasmin

    Plasmin

  • Urokinase
  • Human protein

    three domains: the serine protease domain (consisting of residues 159–411), the kringle domain (consisting of residues 50-131), and the EGF-like domain (consisting

    Urokinase

    Urokinase

    Urokinase

  • Rhizostomins
  • Type of protein found in jellyfish

    Rhizostomeae. These proteins are composed of a Kringle domain inserted within a cysteine-rich Frizzled domain, first identified in 2004 as the blue pigment

    Rhizostomins

    Rhizostomins

  • Angiostatin
  • is stabilized by interactions between inter-kringle peptides and kringles, although the kringle domains do not directly interact with each other. Angiostatin

    Angiostatin

    Angiostatin

  • Factor XII
  • Mammalian protein involved in blood clotting

    chain contains two fibronectin-type domains (type I and II), two epidermal growth factor-like domains, a kringle domain, and a proline-rich region, while

    Factor XII

    Factor XII

    Factor_XII

  • CLEC3B
  • Protein-coding gene in humans

    Genome Browser. Wewer UM, Albrechtsen R (1992). "Tetranectin, a plasminogen kringle 4-binding protein. Cloning and gene expression pattern in human colon cancer"

    CLEC3B

    CLEC3B

    CLEC3B

  • Angiogenesis inhibitor
  • Substance that inhibits the growth of new blood vessels

    cell migration of endothelial cells, downregulate bFGF prothrombin (kringle domain-2), antithrombin III fragment inhibit cell proliferation of endothelial

    Angiogenesis inhibitor

    Angiogenesis_inhibitor

  • Thrombin
  • Enzyme involved in blood coagulation in humans

    is composed of four domains; an N-terminal Gla domain, two kringle domains and a C-terminal trypsin-like serine protease domain. Factor Xa with factor

    Thrombin

    Thrombin

    Thrombin

  • Insulin-like growth factor 2 receptor
  • Protein found in humans

    single transmembrane domain with its C-terminus on the cytoplasmic side of lipid membranes) with a large extracellular/lumenal domain and a relatively short

    Insulin-like growth factor 2 receptor

    Insulin-like growth factor 2 receptor

    Insulin-like_growth_factor_2_receptor

  • Francis J. Castellino
  • American biochemist

    properties of plasminogen and its role in fibrinolysis, especially Kringle 2 domain; developed gene knockout and mutant mice models in hemostasis studies;

    Francis J. Castellino

    Francis_J._Castellino

  • PEDF
  • Protein-coding gene in the species Homo sapiens

    expression is upregulated by plasminogen kringle domains 1-4 (also known as angiostatin) and the kringle 5 (K5) domain. Hypoxia, or low oxygen conditions,

    PEDF

    PEDF

    PEDF

  • Tenecteplase
  • Pharmaceutical drug

    glutamine, both within the kringle 1 domain, and a tetra-alanine substitution at amino acids 296–299 in the protease domain. Tenecteplase was approved

    Tenecteplase

    Tenecteplase

  • Exosite
  • plasmin extremely hard without additional interactions. Plasminogen has kringle domains that are classic exosite-binding regions that allow it to bind to cofactors

    Exosite

    Exosite

  • Angiomotin
  • Protein-coding gene in the species Homo sapiens

    library for angiostatin-binding peptides, using a construct encoding the kringle domains 1-4 of angiostatin. AMOT gene is located on human chromosome X:112

    Angiomotin

    Angiomotin

    Angiomotin

  • Proteases in angiogenesis
  • with angiogenesis inhibitor activity. Angiostatin fragments contain kringle domains which exert their inhibitory activity at several different levels;

    Proteases in angiogenesis

    Proteases_in_angiogenesis

  • Hepatocyte growth factor receptor
  • Mammalian protein found in Homo sapiens

    antagonist. NK4 is a molecule bearing the N-terminal hairpin and the four kringle domains of HGF. Moreover, NK4 is structurally similar to angiostatins, which

    Hepatocyte growth factor receptor

    Hepatocyte growth factor receptor

    Hepatocyte_growth_factor_receptor

  • Lipoprotein(a)
  • Low-density lipoprotein containing apolipoprotein(a)

    resulting in apo(a) proteins with 10 to more than 50 kringle IV repeats (each of the variable kringle IV consists of 114 amino acids). These variable apo(a)

    Lipoprotein(a)

    Lipoprotein(a)

    Lipoprotein(a)

  • Tissue-type plasminogen activator
  • Protein involved in the breakdown of blood clots

    of novel tPA- and plasminogen-binding sites within fibrin(ogen) alpha C-domains". Biochemistry. 40 (3): 801–8. doi:10.1021/bi001789t. PMID 11170397. Ichinose

    Tissue-type plasminogen activator

    Tissue-type plasminogen activator

    Tissue-type_plasminogen_activator

  • STK4
  • Protein-coding gene in the species Homo sapiens

    locus on human chromosome 3: identification of a gene coding for four kringle domains with homology to hepatocyte growth factor". Biochemistry. 30 (40):

    STK4

    STK4

    STK4

  • KREMEN1
  • Protein-coding gene in the species Homo sapiens

    receptor-related protein 6 (LRP6). It contains extracellular Kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct

    KREMEN1

    KREMEN1

    KREMEN1

  • MST1
  • Protein-coding gene in the species Homo sapiens

    locus on human chromosome 3: identification of a gene coding for four kringle domains with homology to hepatocyte growth factor". Biochemistry. 30 (40):

    MST1

    MST1

    MST1

  • Rankin/Bass Animated Entertainment
  • American production company

    involved young Kris Kringle, voiced by Mickey Rooney, and the villainous Burgermeister Meisterburger, voiced by Paul Frees. Kringle later marries the town's

    Rankin/Bass Animated Entertainment

    Rankin/Bass Animated Entertainment

    Rankin/Bass_Animated_Entertainment

  • Thrombospondin 1
  • Protein-coding gene in the species Homo sapiens

    interaction with plasminogen. Evidence for binding to a specific region of the kringle structure of plasminogen". Blood. 73 (4): 976–982. doi:10.1182/blood.V73

    Thrombospondin 1

    Thrombospondin 1

    Thrombospondin_1

  • Ski for Two
  • 1944 American film

    disguising himself as Santa Claus. Wally is so excited at the prospect of Kris Kringle arriving that he quickly adorns the lodge with Christmas decorations. It

    Ski for Two

    Ski_for_Two

  • Hereditary angioedema
  • Disorder resulting in severe swelling

    kringle 3 domain of plasminogen, resulting in a novel type of dysplasminogenemia. The mutation creates a new lysine-binding site within the kringle 3

    Hereditary angioedema

    Hereditary angioedema

    Hereditary_angioedema

  • United States Postal Service
  • Independent agency of the U.S. federal government

    postal". In the film Miracle on 34th Street (1947), the identity of Kris Kringle (played by Edmund Gwenn) as the one and only "Santa Claus" was validated

    United States Postal Service

    United States Postal Service

    United_States_Postal_Service

  • Nowell Sing We Clear
  • American musical group

    of Bethlehem" "Leaping and Dancing" "Sherbourne" "Gower Wassail" "Kris Kringle" "Winter/Spring" "Flower Carol" "Green Grow'th the Holly" "Morris and Sword

    Nowell Sing We Clear

    Nowell_Sing_We_Clear

  • West Wing Week
  • Web-episode released by The White House

    Retrieved September 2, 2011. "West Wing Week: 07/02/10 or "Home of the Kringle"". The Whithouse, YouTube Channel. The Whithouse. Retrieved September 2

    West Wing Week

    West Wing Week

    West_Wing_Week

  • Emma Scarr Booth
  • American poet

    States as a child. She was the author of three volumes, entitled Karan Kringle's Journal, A Willful Heiress, and Poems. Booth composed numerous songs and

    Emma Scarr Booth

    Emma Scarr Booth

    Emma_Scarr_Booth

  • Fitz-James O'Brien
  • American early science fiction and fantasy writer (1826/8–1862)

    Monthly Magazine, Sep. 1858). "Three of a Trade; or, Red Little Kriss Kringle" (Saturday Press, Dec. 25, 1858). "What Was It? A Mystery" (Harper's New

    Fitz-James O'Brien

    Fitz-James O'Brien

    Fitz-James_O'Brien

  • List of food companies
  • Fields O&H Danish Bakery Orwasher's bakery Pillsbury Company Racine Danish Kringles Round Rock Donuts Schmidt Baking Company Semifreddi's Bakery Sprinkles

    List of food companies

    List_of_food_companies

  • Adhesion G protein-coupled receptor
  • Class of 33 human protein receptors

    including Kringle, Somatomedin B (Pfam PF01033), SRCR (Pfam PF00530) may be contained with the extracellular region. Since many of these domains have been

    Adhesion G protein-coupled receptor

    Adhesion G protein-coupled receptor

    Adhesion_G_protein-coupled_receptor

  • FBLN5
  • Protein-coding gene in the species Homo sapiens

    extracellular matrix protein DANCE with apolipoprotein(a) mediated by the kringle IV-type 2 domain". Molecular Genetics and Genomics. 267 (4): 440–6. doi:10.1007/s00438-002-0673-6

    FBLN5

    FBLN5

    FBLN5

  • 21st Saturn Awards
  • 1994 film and television awards

    Lieutenant Dan Taylor Richard Attenborough – Miracle on 34th Street as Kris Kringle Robert De Niro – Mary Shelley's Frankenstein as Creature Raul Julia – Street

    21st Saturn Awards

    21st_Saturn_Awards

  • List of MeSH codes (G06)
  • 709.610.380 – hmg-box domains MeSH G06.184.603.790.709.610.480 – kringles MeSH G06.184.603.790.709.610.800 – src homology domains MeSH G06.184.603.790

    List of MeSH codes (G06)

    List_of_MeSH_codes_(G06)

  • List of comics creators appearing in comics
  • Doom Patrol?" Joshua Quagmire Critters #50 (March 1990): "X-Mass Blitz-Kringle" Joe Quinones Howard the Duck #10 (October 2016): "...Hell If I Know..

    List of comics creators appearing in comics

    List_of_comics_creators_appearing_in_comics

  • Neuregulin 1
  • Protein-coding gene in the species Homo sapiens

    (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with

    Neuregulin 1

    Neuregulin 1

    Neuregulin_1

  • HABP2
  • Mammalian protein found in Homo sapiens

    hyaluronan-binding protein (PHBP) from human plasma: it has three EGF, a kringle and a serine protease domain, similar to hepatocyte growth factor activator". J Biochem

    HABP2

    HABP2

    HABP2

  • Neuregulin 3
  • Protein-coding gene in Homo sapiens

    Neuron Derived Factor; SMDF because it lacks Ig-like as well as Kringle-like domains that are attributed to many NRG1 isomers. Hydropathy profile studies

    Neuregulin 3

    Neuregulin 3

    Neuregulin_3

  • Desmoteplase
  • Medication

    contain the plasmin-sensitive cleavage site and the lysine-binding Kringle 2 domain. As a result, desmoteplase, in comparison to rt-PA, has high fibrin

    Desmoteplase

    Desmoteplase

    Desmoteplase

  • Leadhills
  • Village in South Lanarkshire, Scotland

    the train, a visit to Santa down the lead mine and a story read by "Mrs Kringle" in the Museum of Lead Mining, Wanlockhead. The Elvanfoot railway station

    Leadhills

    Leadhills

    Leadhills

  • Sandra J. F. Degen
  • American biochemist (born c. 1955)

    University of Cincinnati, Degen led a team towards the discovery of a novel kringle-containing protein in mice which they called hepatocyte growth factor-like

    Sandra J. F. Degen

    Sandra J. F. Degen

    Sandra_J._F._Degen

  • Matrix metallopeptidase 12
  • Enzyme involved in breakdown of extracellular matrix

    MMP-12, cleaves human apolipoprotein(a) in the linker region between kringles IV-4 and IV-5. Potential relevance to lipoprotein(a) biology". J. Biol

    Matrix metallopeptidase 12

    Matrix metallopeptidase 12

    Matrix_metallopeptidase_12

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