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Autonomous protein domains
Kringle domains are autonomous protein domains that fold into large loops stabilized by three disulfide linkages. These are important in protein–protein
Kringle_domain
Type of pretzel
Kringle is a Northern European pastry or bread, a variety of pretzel that may be sweet, salty or filled, in a characteristic pretzel-like twisted shape
Kringle
Protein family
that shows high affinity for the lysine binding site (LBS) of the kringle-2 (K2) domain of human (h)Pg. Plasminogen (Pg) is an important mediator of angiostatin
VEK-30_protein_domain
Protein family
native plasminogen the PAN domain is associated with five kringle domains. The interactions between the PAN domain and the kringles play a critical role in
PAN_domain
Self-stable region of a protein's chain that folds independently from the rest
widespread protein modules are the following domains: SH2, immunoglobulin, fibronectin type 3 and the kringle. Molecular evolution gives rise to families
Protein_domain
Enzyme in human blood that degrades clots and other proteins
Kringle domains (KR1-5). The Pan-Apple domain contains important determinants for maintaining plasminogen in the closed form, and the kringle domains
Plasmin
Human protein
three domains: the serine protease domain (consisting of residues 159–411), the kringle domain (consisting of residues 50-131), and the EGF-like domain (consisting
Urokinase
Type of protein found in jellyfish
Rhizostomeae. These proteins are composed of a Kringle domain inserted within a cysteine-rich Frizzled domain, first identified in 2004 as the blue pigment
Rhizostomins
is stabilized by interactions between inter-kringle peptides and kringles, although the kringle domains do not directly interact with each other. Angiostatin
Angiostatin
Mammalian protein involved in blood clotting
chain contains two fibronectin-type domains (type I and II), two epidermal growth factor-like domains, a kringle domain, and a proline-rich region, while
Factor_XII
Protein-coding gene in humans
Genome Browser. Wewer UM, Albrechtsen R (1992). "Tetranectin, a plasminogen kringle 4-binding protein. Cloning and gene expression pattern in human colon cancer"
CLEC3B
Substance that inhibits the growth of new blood vessels
cell migration of endothelial cells, downregulate bFGF prothrombin (kringle domain-2), antithrombin III fragment inhibit cell proliferation of endothelial
Angiogenesis_inhibitor
Enzyme involved in blood coagulation in humans
is composed of four domains; an N-terminal Gla domain, two kringle domains and a C-terminal trypsin-like serine protease domain. Factor Xa with factor
Thrombin
Protein found in humans
single transmembrane domain with its C-terminus on the cytoplasmic side of lipid membranes) with a large extracellular/lumenal domain and a relatively short
Insulin-like growth factor 2 receptor
Insulin-like_growth_factor_2_receptor
American biochemist
properties of plasminogen and its role in fibrinolysis, especially Kringle 2 domain; developed gene knockout and mutant mice models in hemostasis studies;
Francis_J._Castellino
Protein-coding gene in the species Homo sapiens
expression is upregulated by plasminogen kringle domains 1-4 (also known as angiostatin) and the kringle 5 (K5) domain. Hypoxia, or low oxygen conditions,
PEDF
Pharmaceutical drug
glutamine, both within the kringle 1 domain, and a tetra-alanine substitution at amino acids 296–299 in the protease domain. Tenecteplase was approved
Tenecteplase
plasmin extremely hard without additional interactions. Plasminogen has kringle domains that are classic exosite-binding regions that allow it to bind to cofactors
Exosite
Protein-coding gene in the species Homo sapiens
library for angiostatin-binding peptides, using a construct encoding the kringle domains 1-4 of angiostatin. AMOT gene is located on human chromosome X:112
Angiomotin
with angiogenesis inhibitor activity. Angiostatin fragments contain kringle domains which exert their inhibitory activity at several different levels;
Proteases_in_angiogenesis
Mammalian protein found in Homo sapiens
antagonist. NK4 is a molecule bearing the N-terminal hairpin and the four kringle domains of HGF. Moreover, NK4 is structurally similar to angiostatins, which
Hepatocyte growth factor receptor
Hepatocyte_growth_factor_receptor
Low-density lipoprotein containing apolipoprotein(a)
resulting in apo(a) proteins with 10 to more than 50 kringle IV repeats (each of the variable kringle IV consists of 114 amino acids). These variable apo(a)
Lipoprotein(a)
Protein involved in the breakdown of blood clots
of novel tPA- and plasminogen-binding sites within fibrin(ogen) alpha C-domains". Biochemistry. 40 (3): 801–8. doi:10.1021/bi001789t. PMID 11170397. Ichinose
Tissue-type plasminogen activator
Tissue-type_plasminogen_activator
Protein-coding gene in the species Homo sapiens
locus on human chromosome 3: identification of a gene coding for four kringle domains with homology to hepatocyte growth factor". Biochemistry. 30 (40):
STK4
Protein-coding gene in the species Homo sapiens
receptor-related protein 6 (LRP6). It contains extracellular Kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct
KREMEN1
Protein-coding gene in the species Homo sapiens
locus on human chromosome 3: identification of a gene coding for four kringle domains with homology to hepatocyte growth factor". Biochemistry. 30 (40):
MST1
American production company
involved young Kris Kringle, voiced by Mickey Rooney, and the villainous Burgermeister Meisterburger, voiced by Paul Frees. Kringle later marries the town's
Rankin/Bass Animated Entertainment
Rankin/Bass_Animated_Entertainment
Protein-coding gene in the species Homo sapiens
interaction with plasminogen. Evidence for binding to a specific region of the kringle structure of plasminogen". Blood. 73 (4): 976–982. doi:10.1182/blood.V73
Thrombospondin_1
1944 American film
disguising himself as Santa Claus. Wally is so excited at the prospect of Kris Kringle arriving that he quickly adorns the lodge with Christmas decorations. It
Ski_for_Two
Disorder resulting in severe swelling
kringle 3 domain of plasminogen, resulting in a novel type of dysplasminogenemia. The mutation creates a new lysine-binding site within the kringle 3
Hereditary_angioedema
Independent agency of the U.S. federal government
postal". In the film Miracle on 34th Street (1947), the identity of Kris Kringle (played by Edmund Gwenn) as the one and only "Santa Claus" was validated
United_States_Postal_Service
American musical group
of Bethlehem" "Leaping and Dancing" "Sherbourne" "Gower Wassail" "Kris Kringle" "Winter/Spring" "Flower Carol" "Green Grow'th the Holly" "Morris and Sword
Nowell_Sing_We_Clear
Web-episode released by The White House
Retrieved September 2, 2011. "West Wing Week: 07/02/10 or "Home of the Kringle"". The Whithouse, YouTube Channel. The Whithouse. Retrieved September 2
West_Wing_Week
American poet
States as a child. She was the author of three volumes, entitled Karan Kringle's Journal, A Willful Heiress, and Poems. Booth composed numerous songs and
Emma_Scarr_Booth
American early science fiction and fantasy writer (1826/8–1862)
Monthly Magazine, Sep. 1858). "Three of a Trade; or, Red Little Kriss Kringle" (Saturday Press, Dec. 25, 1858). "What Was It? A Mystery" (Harper's New
Fitz-James_O'Brien
Fields O&H Danish Bakery Orwasher's bakery Pillsbury Company Racine Danish Kringles Round Rock Donuts Schmidt Baking Company Semifreddi's Bakery Sprinkles
List_of_food_companies
Class of 33 human protein receptors
including Kringle, Somatomedin B (Pfam PF01033), SRCR (Pfam PF00530) may be contained with the extracellular region. Since many of these domains have been
Adhesion G protein-coupled receptor
Adhesion_G_protein-coupled_receptor
Protein-coding gene in the species Homo sapiens
extracellular matrix protein DANCE with apolipoprotein(a) mediated by the kringle IV-type 2 domain". Molecular Genetics and Genomics. 267 (4): 440–6. doi:10.1007/s00438-002-0673-6
FBLN5
1994 film and television awards
Lieutenant Dan Taylor Richard Attenborough – Miracle on 34th Street as Kris Kringle Robert De Niro – Mary Shelley's Frankenstein as Creature Raul Julia – Street
21st_Saturn_Awards
709.610.380 – hmg-box domains MeSH G06.184.603.790.709.610.480 – kringles MeSH G06.184.603.790.709.610.800 – src homology domains MeSH G06.184.603.790
List_of_MeSH_codes_(G06)
Doom Patrol?" Joshua Quagmire Critters #50 (March 1990): "X-Mass Blitz-Kringle" Joe Quinones Howard the Duck #10 (October 2016): "...Hell If I Know..
List of comics creators appearing in comics
List_of_comics_creators_appearing_in_comics
Protein-coding gene in the species Homo sapiens
(EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with
Neuregulin_1
Mammalian protein found in Homo sapiens
hyaluronan-binding protein (PHBP) from human plasma: it has three EGF, a kringle and a serine protease domain, similar to hepatocyte growth factor activator". J Biochem
HABP2
Protein-coding gene in Homo sapiens
Neuron Derived Factor; SMDF because it lacks Ig-like as well as Kringle-like domains that are attributed to many NRG1 isomers. Hydropathy profile studies
Neuregulin_3
Medication
contain the plasmin-sensitive cleavage site and the lysine-binding Kringle 2 domain. As a result, desmoteplase, in comparison to rt-PA, has high fibrin
Desmoteplase
Village in South Lanarkshire, Scotland
the train, a visit to Santa down the lead mine and a story read by "Mrs Kringle" in the Museum of Lead Mining, Wanlockhead. The Elvanfoot railway station
Leadhills
American biochemist (born c. 1955)
University of Cincinnati, Degen led a team towards the discovery of a novel kringle-containing protein in mice which they called hepatocyte growth factor-like
Sandra_J._F._Degen
Enzyme involved in breakdown of extracellular matrix
MMP-12, cleaves human apolipoprotein(a) in the linker region between kringles IV-4 and IV-5. Potential relevance to lipoprotein(a) biology". J. Biol
Matrix_metallopeptidase_12
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