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Set of cytochrome P450 enzymes
Epoxygenases are a set of membrane-bound, heme-containing cytochrome P450 (CYP450 or just CYP) enzymes that metabolize polyunsaturated fatty acids (PUFAs)
Epoxygenase
Enzyme protein
metabolizes important endogenous compounds such as serotonin and, owing to its epoxygenase activity, various polyunsaturated fatty acids, converting these fatty
CYP2C9
Gene-coded protein involved in metabolism of xenobiotics
metabolism of xenobiotics in the body. Cytochrome P4502C8 also possesses epoxygenase activity, i.e. it metabolizes long-chain polyunsaturated fatty acids
CYP2C8
Gene of the species Homo sapiens
humans (see epoxyeicosatrienoic acid, epoxydocosapentaenoic acid, and epoxygenase pages). Vernolic and coronaric acids are potentially toxic, causing multiple
CYP2J2
Class of fatty acids
a specific subset of cytochrome P450 enzymes, termed cytochrome P450 epoxygenases. They are nonclassic eicosanoids. EETs are generally short-lived, being
Epoxyeicosatrienoic_acid
Mammalian protein found in humans
cytochrome P450 genes on chromosome no.10 arm q24. CYP2C19 also possesses epoxygenase activity: it is one of the principal enzymes responsible for attacking
CYP2C19
Enzyme in the human body
acid (19-HETE) (see 20-Hydroxyeicosatetraenoic acid) but also has epoxygenase activity in that it metabolizes docosahexaenoic acid to epoxides, primarily
CYP1A2
Chemical compound
eicosapentaenoic acid (EPA), with certain cytochrome P450 epoxygenases. These epoxygenases can metabolize EPA to as many as 10 epoxides that differ in
Epoxyeicosatetraenoic_acid
Group of chemical compounds
docosahexaenoic acid (DHA). Cell types that express certain cytochrome P450 (CYP) epoxygenases metabolize polyunsaturated fatty acids (PUFAs) by converting one of their
Epoxydocosapentaenoic_acid
Protein-coding gene in humans
acid (19-HETE) (see 20-Hydroxyeicosatetraenoic acid) but also has epoxygenase activity in that it metabolizes docosahexaenoic acid to epoxides, primarily
CYP1A1
Enzyme found in humans
(19-HETE) (see 20-Hydroxyeicosatetraenoic acid). However, it also acts as an epoxygenase activity to metabolize docosahexaenoic acid to epoxides, primarily 19R
CYP2E1
Fatty acid used metabolically in many organisms
hydroxyeicosatetraenoic acids (HETEs) and epoxyeicosatrienoic acids (EETs) by epoxygenase. The production of these derivatives and their actions in the body are
Arachidonic_acid
Chilean-American biochemist
20-hydroxyeicosatetraenoic acids (19- and 20-HETE) as products of the epoxygenase and ω-hydroxylase branches of P450 AA monooxygenase, respectively. Characterization
Jorge_H._Capdevila
Chemical compound
vernolic acid is made by the metabolism of linoleic acid by cytochrome P450 epoxygenase enzymes; under these circumstances it is termed leukotoxin because of
Vernolic_acid
Protein-coding gene in the species Homo sapiens
primary tumor tissues of ovarian cancer. CYP2S1 has recently been assigned epoxygenase activity. It metabolizes 1) arachidonic acid to its various epoxides
CYP2S1
Chemical compound
species through the metabolism of linoleic acid by cytochrome P450 (CYP) epoxygenase enzymes. These CYPs (CYP2C9 and probably other CYPs that metabolize polyunsaturated
Coronaric_acid
Protein-coding gene in the species Homo sapiens
artefact based on a chimera of CYP2C18 and CYP2C19. CYP2C18 also possesses epoxygenase activity: it can attack various long-chain polyunsaturated fatty acids
CYP2C18
Class of compounds
conditions. ALOXE3 preferentially metabolizes arachidonic acid to hepoxilins. Epoxygenases: these are cytochrome P450 enzymes which generate nonclassic eicosanoid
Eicosanoid
Enzyme that metabolizes substances by oxidation
their toxic forms (see table below for examples). CYP3A4 also possesses epoxygenase activity in that it metabolizes arachidonic acid to epoxyeicosatrienoic
CYP3A4
Class of enzymes
alkene,NADH:oxygen oxidoreductase. This enzyme is also called alkene epoxygenase. It contains a Rieske type of ferredoxin. The enzyme from a Xanthobacter
Alkene_monooxygenase
Protein-coding gene in the species Homo sapiens
PMC 3285496. PMID 21942677. Imig JD (September 2005). "Epoxide hydrolase and epoxygenase metabolites as therapeutic targets for renal diseases". American Journal
Epoxide_hydrolase_2
Protein-coding gene in the species Homo sapiens
humans. In addition to its role in omega oxidation, CYP4A11 exhibits epoxygenase activity, converting docosahexaenoic acid to epoxydocosapentaenoic acids
CYP4A11
Enzyme involved in prostaglandin synthesis
(January 2013). "Cytochrome P4502S1: a novel monocyte/macrophage fatty acid epoxygenase in human atherosclerotic plaques". Basic Research in Cardiology. 108
Cyclooxygenase-1
Protein-coding gene in the species Homo sapiens
In addition to monooxygenase activity, CYP4F12 also functions as an epoxygenase. It metabolizes docosahexaenoic acid (DHA) and eicosapentaenoic acid
CYP4F12
Protein-coding gene in humans
n/a Gene ontology Molecular function iron ion binding arachidonic acid epoxygenase activity oxidoreductase activity, acting on paired donors, with incorporation
CYP2B6
double bonds of the arachidonic acid carbon backbone by cytochrome P450 epoxygenase enzymes. In addition, in some cases hydrogen peroxide has been suggested
Endothelium-derived hyperpolarizing factor
Endothelium-derived_hyperpolarizing_factor
Protein found in humans
n/a Gene ontology Molecular function iron ion binding arachidonic acid epoxygenase activity oxidoreductase activity, acting on paired donors, with incorporation
CYP2A6
Protein-coding gene in the species Homo sapiens
ion binding oxidoreductase activity oxygen binding arachidonic acid epoxygenase activity steroid hydroxylase activity Cellular component membrane intracellular
CYP2A7
Polyunsaturated omega-6 fatty acid
9-oxo-octadecdienoic acid. Certain cytochrome P450 enzymes, the CYP epoxygenases, catalyze oxidation of LA to epoxide products viz., its 12,13-epoxide
Linoleic_acid
Chemical compound
neoxanthin. The C15 end of the molecule is then cleaved by an epoxycarotenoid epoxygenase to form xanthoxin, an aldehyde. Xanthoxin is reduced at the epoxy group
Phaseic_acid
British author, adventurer, and biologist
Wei S., Friedberg T., Waterman M.R. (1998). A keratinocyte-specific epoxygenase, CYP2B12, metabolizes arachidonic acid with unusual selectivity producing
Colin_Skinner
Human enzyme
activity alpha-tocopherol omega-hydroxylase activity arachidonic acid epoxygenase activity tocotrienol omega-hydroxylase activity tocopherol omega-hydroxylase
CYP4F2
American organic chemist
acids (19- and 20-HETEs), and characterized them as products of the epoxygenase and ω/ω-1 hydroxylase branches of the P450 AA Monooxygenase, respectively
John_R._Falck
Protein-coding gene in the species Homo sapiens
molecular oxygen metal ion binding monooxygenase activity arachidonic acid epoxygenase activity steroid hydroxylase activity oxidoreductase activity, acting
CYP2W1
Chemical compound
the case of the sheep enzyme, 18-HETE; human CYP2J2, however, is an epoxygenase, metabolizing arachidonic acid to epoxide products. Many agents stimulate
20-Hydroxyeicosatetraenoic acid
20-Hydroxyeicosatetraenoic_acid
Protein-coding gene in the species Homo sapiens
development in camera-type eye cellular response to organic cyclic compound epoxygenase P450 pathway endothelial cell-cell adhesion omega-hydroxylase P450 pathway
CYP1B1
Chemical compound
(also PGH synthase pathway), isoprostane pathway, and cytochrome P450 epoxygenases pathway following the arachidonic acid metabolism, but is the only pathway
Leukotriene_A4
Protein-coding gene in the species Homo sapiens
19 of arachidonic acid and Dihomo-γ-linolenic acid, CYP458 possesses epoxygenase activity in that it metabolizes the omega-3 fatty acids, docosahexaenoic
CYP4F8
Protein-coding gene in the species Homo sapiens
binding oxidoreductase activity aromatase activity arachidonic acid epoxygenase activity oxidoreductase activity, acting on paired donors, with incorporation
CYP2A13
Group of cytochrome P450 enzymes
November 2014). "CYP-13A12 of the nematode Caenorhabditis elegans is a PUFA-epoxygenase involved in behavioural response to reoxygenation" (PDF). The Biochemical
CYP13_family
List of Cytochrome P450 enzymes
products. These CYPs possess cytochrome P450 omega hydroxylase and/or epoxygenase enzyme activity. CYP1A1, CYP1A2, and CYP2E1 metabolize endogenous PUFAs
Cytochrome P450 (individual enzymes)
Cytochrome_P450_(individual_enzymes)
Chemical compound
polyunsaturated fatty acids that are made by various cytochrome P450 epoxygenases. EETs, EDPs, and EEQs have various effects in animals including vasodilation
Regorafenib
Chemical compound
(2013). "Cytochrome P4502S1: A novel monocyte/macrophage fatty acid epoxygenase in human atherosclerotic plaques". Basic Research in Cardiology. 108
12-Hydroxyheptadecatrienoic acid
12-Hydroxyheptadecatrienoic_acid
Protein-coding gene in the species Homo sapiens
Molecular function iron ion binding oxygen binding arachidonic acid epoxygenase activity oxidoreductase activity, acting on paired donors, with incorporation
CYP2F1
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