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Protein found in humans
Decoy receptor 3 (Dcr3), also known as tumor necrosis factor receptor superfamily member 6B (TNFRSF6B), TR6 and M68, is a soluble protein of the tumor
Decoy_receptor_3
A decoy receptor is a receptor that is able to recognize and bind specific ligands efficiently, but is not able to support its intended function. This
Decoy_receptors
Person, device, or event designed as a distraction
decoy receptors, decoy substrates and decoy RNA. In addition, digital decoys are used in protein folding simulations. Decoy receptors, or sink receptors, are
Decoy
Protein-coding gene in the species Homo sapiens
IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 (death receptor 3) and TNFRSF6B (decoy receptor 3). It can activate both the NF-κB and MAPK
Vascular endothelial growth inhibitor
Vascular_endothelial_growth_inhibitor
Secreted protein of the TNF superfamily
It is recognized by herpesvirus entry mediator (HVEM), as well as decoy receptor 3. LIGHT stands for "homologous to lymphotoxin, exhibits inducible expression
LIGHT_(protein)
Protein-coding gene in the species Homo sapiens
Decoy receptor 1 (DCR1), also known as TRAIL receptor 3 (TRAILR3) and tumor necrosis factor receptor superfamily member 10C (TNFRSF10C), is a human cell
Decoy_receptor_1
Protein superfamily of cytokine receptors
The tumor necrosis factor receptor superfamily (TNFRSF) is a protein superfamily of cytokine receptors characterized by the ability to bind tumor necrosis
TNF_receptor_superfamily
Protein-coding gene in the species Homo sapiens
Decoy receptor 2 (DCR2), also known as TRAIL receptor 4 (TRAILR4) and tumor necrosis factor receptor superfamily member 10D (TNFRSF10D), is a human cell
Decoy_receptor_2
Protein found in humans
and an intracellular death domain. DcR3: Decoy receptor 3 (DcR3) is a recently discovered decoy receptor in the tumor necrosis factor (TNF) superfamily
Fas_ligand
Protein family
functions primarily as a decoy. A third receptor has been discovered (VEGFR-3), however, VEGF-A is not a ligand for this receptor. VEGFR-3 mediates lymphangiogenesis
VEGF_receptor
Mammalian protein found in Homo sapiens
The interleukin-3 receptor (CD123) is a molecule found on cells which helps transmit the signal of interleukin-3, a soluble cytokine important in the immune
Interleukin-3_receptor
Protein-coding gene in the species Homo sapiens
protein encoded by this gene is a decoy receptor for certain cytokines that belongs to the interleukin-1 receptor family. This protein binds interleukin-1α
Interleukin 1 receptor, type II
Interleukin_1_receptor,_type_II
Protein found in humans
G, Gentz R, Dixit VM (Aug 1997). "An antagonist decoy receptor and a death domain-containing receptor for TRAIL". Science. 277 (5327): 815–8. doi:10.1126/science
Death_receptor_5
Interleukin-10 receptor subunit alpha precursor - Homo sapiens (Human)". www.uniprot.org. Retrieved 2015-10-13. "IL10RB - Interleukin-10 receptor subunit beta
List of human clusters of differentiation
List_of_human_clusters_of_differentiation
Mammalian protein found in Homo sapiens
protein (IFNγbp). IFNγbp acts a decoy receptor that sequesters IFN-γ to prevent the activation of the host receptor. The result is diminished interferon
Interferon-gamma_receptor
Signaling pathway involving transforming growth factor beta proteins
the agonists for ligands and R-SMADs, the decoy receptors, and the ubiquitination of R-SMADs and receptors. Both chordin and noggin are antagonists of
TGF_beta_signaling_pathway
Protein found in humans
Death receptor 3 (DR3), also known as tumor necrosis factor receptor superfamily member 25 (TNFRSF25), is a cell surface receptor of the tumor necrosis
Death_receptor_3
Mammalian and avian protein
dimer. Myostatin binds to the activin type II receptor, resulting in a recruitment of either coreceptor Alk-3 or Alk-4. This coreceptor then initiates a
Myostatin
Class of enzymes
VEGFR-2 signaling. Another function of VEGFR-1 may be to act as a dummy/decoy receptor, sequestering VEGF from VEGFR-2 binding (this appears to be particularly
Receptor_tyrosine_kinase
Mammalian protein found in Homo sapiens
and, more importantly, prevents metastasis. Decoy MET refers to a soluble truncated MET receptor. Decoys are able to inhibit MET activation mediated by
Hepatocyte growth factor receptor
Hepatocyte_growth_factor_receptor
Immunoglobulin superfamily
IL-1RII is a surface receptor able to bind IL-1α, IL-1β and IL-1RI. It also forms a soluble form sIL-1RII. It is a decoy receptor – it inhibits activity
Interleukin-1_receptor_family
Protein and coding gene in humans
Tropomyosin receptor kinase B (TrkB), also known as tyrosine receptor kinase B, or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type
Tropomyosin_receptor_kinase_B
Family of proteins that bind to fibroblast growth factors
The fibroblast growth factor receptors (FGFR) are, as their name implies, receptors that bind to members of the fibroblast growth factor (FGF) family of
Fibroblast growth factor receptor
Fibroblast_growth_factor_receptor
Protein-coding gene in the species Homo sapiens
The erythropoietin receptor (EpoR) is a protein that in humans is encoded by the EPOR gene. EpoR is a 52 kDa peptide with a single carbohydrate chain resulting
Erythropoietin_receptor
Transmembrane protein
The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth
Epidermal growth factor receptor
Epidermal_growth_factor_receptor
Cytokine
of the type 1 and type 2 receptor subunits, both of which are serine/threonine kinases. Upon assembly, the type 2 receptor kinase phosphorylates and
Transforming growth factor beta
Transforming_growth_factor_beta
Cell surface receptors for interleukin-13
initially thought not to have any signaling activity, and regarded as “decoy” receptor, that is its function would just consist in competing for IL-13 binding
Interleukin-13_receptor
Protein domain
An Activin receptor is a receptor which binds activin. These proteins are receptor-type kinases of Ser/Thr type, which have a single transmembrane domain
Activin_receptor
Protein-coding gene in the species Homo sapiens
these receptors betaglycan (the TGF-β type III receptor) and InhBP/p120 (a membrane-tethered proteoglycan) were identified as putative inhibin receptors and
INHBB
Protein family
Transforming growth factor beta (TGFβ) receptors are single pass serine/threonine kinase receptors that belong to TGFβ receptor family. They exist in several different
TGF_beta_receptor
Protein found in humans
Receptor tyrosine-protein kinase erbB-3, also known as HER3 (human epidermal growth factor receptor 3), is a membrane bound protein that in humans is
ERBB3
Protein-coding gene in the species Homo sapiens
EPH receptor A3 (ephrin type-A receptor 3) is a protein that in humans is encoded by the EPHA3 gene. This gene belongs to the ephrin receptor subfamily
EPH_receptor_A3
Protein-coding gene in the species Homo sapiens
Colotta F, Re F, Muzio M, et al. (1993). "Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4". Science. 261 (5120): 472–5
IL1RL2
Protein found in humans
intracellular domain and tyrosine kinase activity; it may serve as a decoy receptor by binding with and thereby diluting the action of FGFs. There are 18
Fibroblast growth factor receptor 1
Fibroblast_growth_factor_receptor_1
Protein-coding gene in humans
chemokine receptor-like 2 is a protein that in humans is encoded by the CCRL2 gene. Recently it was found that CCRL2 also acts as a receptor for the chemokine
CCRL2
Mammalian protein
truncated death domain (DcR2). DcR1 functions as a TRAIL-neutralizing decoy-receptor. The cytoplasmic domain of DcR2 is functional and activates NFkappaB
TRAIL
TrkC kinase inhibitor LEVI-04 (p75NTR-Fc) – LNGF receptor (p75NTR) fusion protein and decoy receptor for nerve growth factor NRD135S-E1 – tyrosine kinase
List of investigational analgesics
List_of_investigational_analgesics
Protein-coding gene in the species Homo sapiens
Betaglycan also known as Transforming growth factor beta receptor III (TGFBR3), is a cell-surface chondroitin sulfate / heparan sulfate proteoglycan >300
TGFBR3
Protein family
type 2 receptors belong to a larger TGF-beta receptor family and modulate signals for transforming growth factor beta ligands. These receptors are involved
Activin_type_2_receptors
Human protein-coding gene
a neurotrophic factor receptor. Neurotrophic factor receptors bind Neurotrophins including Nerve growth factor, Neurotrophin-3, Brain-derived neurotrophic
Low-affinity nerve growth factor receptor
Low-affinity_nerve_growth_factor_receptor
regulating the expression of Hox genes, and regulates the number of olfactory receptor neurons occurring in the olfactory epithelium, and numbers of retinal ganglionic
Growth_differentiation_factor
Experiment TNFα inhibitor
necrosis factor receptors (TNF receptors) but instead binds to and forms heterotrimers with TNFα and prevents TNFα from activating the TNF receptors. However
Pegipanermin
Family of proteins involved in a TGF signaling pathway
factor beta (TGFβ) receptors are a family of serine/threonine kinase receptors involved in TGF beta signaling pathway. These receptors bind growth factor
TGF-beta_receptor_family
Enzyme
factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR), stem cell factor receptor, and colony-stimulating factor-1 receptor (Burstein
Tyrosine_kinase
Protein-coding gene in the species Homo sapiens
The activin A receptor also known as ACVR1C or ALK-7 is a protein that in humans is encoded by the ACVR1C gene. ACVR1C is a type I receptor for the TGFB
ACVR1C
Protein-coding gene in humans
glial cell-derived neurotrophic factor family receptor alpha-like (GFRAL) and the recruitment of the receptor tyrosine kinase RET in the hindbrain. In both
GDF15
Protein-coding gene in humans
Macrophage-stimulating protein receptor is a protein that in humans is encoded by the MST1R gene. MST1R is also known as RON (Recepteur d'Origine Nantais)
MST1R
Category of small signaling proteins
cells. They typically function by interacting with specific cytokine receptors on the surface of target cells. Cytokines include chemokines, interferons
Cytokine
Mammalian protein found in humans
Receptor tyrosine-protein kinase erbB-2 is a protein that normally resides in the membranes of cells and is encoded by the ERBB2 gene. ERBB is abbreviated
HER2
Protein-coding gene in humans
encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. ACVR2B has been shown to
ACVR2B
Protein-coding gene in the species Homo sapiens
Transforming growth factor, beta receptor II (70/80kDa) is a TGF beta receptor. TGFBR2 is its human gene. It is a tumor suppressor gene. This gene encodes
TGF_beta_receptor_2
Family of proteins
activate two of the receptor tyrosine kinase neurotrophin receptors (TrkC and TrkB). Mice born without the ability to make NT-3 have loss of proprioceptive
Neurotrophin
Protein-coding gene in the species Homo sapiens
diseases. Soluble RAGE (sRAGE): On the other hand, sRAGE functions as a decoy receptor. It circulates in the bloodstream and binds RAGE ligands, thereby preventing
RAGE_(receptor)
Protein found in humans
neurogenesis. NT-3 is unique in the number of neurons it can potentially stimulate, given its ability to activate two of the receptor tyrosine kinase neurotrophin
Neurotrophin-3
Biomarker indicative of breast cancer patients' prognosis
or genetically related to one another, and they act through different receptor mechanisms. Furthermore, they do not always induce cellular transformation
Transforming_growth_factor
Protein-coding gene in the species Homo sapiens
characterized. Receptor tyrosine-protein kinase erbB-4 is a receptor tyrosine kinase that is a member of the epidermal growth factor receptor family. ERBB4
ERBB4
Gene involved in the most common form of dwarfism
Fibroblast growth factor receptor 3 (FGFR-3) is a protein that in humans is encoded by the FGFR3 gene. FGFR3 has also been designated as CD333 (cluster
Fibroblast growth factor receptor 3
Fibroblast_growth_factor_receptor_3
Protein-coding gene in the species Homo sapiens
Ephrin type-B receptor 2 is a protein that in humans is encoded by the EPHB2 gene. Ephrin receptors and their ligands, the ephrins, mediate numerous developmental
EPH_receptor_B2
Group of protein families
Neurotrophic factor receptors or neurotrophin receptors are a group of growth factor receptors which specifically bind to neurotrophins (neurotrophic factors)
Neurotrophic_factor_receptor
Human protein-coding gene
Platelet-derived growth factor receptor A, also termed CD140a, is a receptor located on the surface of a wide range of cell types. The protein is encoded
Platelet-derived growth factor receptor A
Platelet-derived_growth_factor_receptor_A
Protein found in humans
Yves-Alain Barde and Hans Thoenen. BDNF activates the TrkB tyrosine kinase receptor. BDNF acts on certain neurons of the central nervous system and the peripheral
Brain-derived neurotrophic factor
Brain-derived_neurotrophic_factor
Protein-coding gene in the species Homo sapiens
Ephrin type-B receptor 4 is a protein that in humans is encoded by the EPHB4 gene. Ephrin receptors and their ligands, the ephrins, mediate numerous developmental
EPH_receptor_B4
Monoclonal antibody
3, 5 (BMP14), 6 (BMP13), 7 (BMP12), 9, 11 (BMP11), 15) Myostatin (GDF8) Nodal Radotermin Antagonists: Inhibin (A, B) Lefty (1, 2) Decoy receptors: Sotatercept
Stamulumab
Lymphotoxin beta receptor (LTBR), also known as tumor necrosis factor receptor superfamily member 3 (TNFRSF3), is a cell surface receptor for lymphotoxin
Lymphotoxin_beta_receptor
Protein-coding gene in humans
of muscle growth. GDF11 binds the same ActRIIA/B receptors, initiating phosphorylation of the SMAD2/3 transcription factors. GDF11 belongs to the transforming
GDF11
Protein found in humans
Tropomyosin receptor kinase C (TrkC), also known as NT-3 growth factor receptor, neurotrophic tyrosine kinase receptor type 3, or TrkC tyrosine kinase
Tropomyosin_receptor_kinase_C
Mammalian protein found in humans
follicles. In humans, the AMH gene is located on chromosome 19p13.3, while its receptor is encoded by the AMHR2 gene on chromosome 12. In male embryos,
Anti-Müllerian_hormone
Protein found in humans
(CD135) also known as fms like tyrosine kinase 3 (FLT-3 with fms standing for "feline McDonough sarcoma"), receptor-type tyrosine-protein kinase FLT3, or fetal
CD135
Mammalian protein found in Homo sapiens
in the regulation of bone density and later for its role as a decoy receptor for receptor activator of nuclear factor kappa-B ligand (RANKL). OPG also
Osteoprotegerin
Protein-coding gene in the species Homo sapiens
chemotherapy. A monoclonal antibody targeting AXL (YW327.6S2) and an AXL decoy receptor (GL2I.T) are currently in preclinical development. Additionally, an
AXL_receptor_tyrosine_kinase
Chemical compound
by GlaxoSmithKline (GSK) as an inhibitor of the activin receptor-like kinase (ALK) receptors, ALK5, ALK4 and ALK7. However, it is not an inhibitor of
SB-431542
Cell-surface receptors which bind angiopoietin
The angiopoietin receptors are receptors that bind angiopoietin. TIE-1 and TIE-2 comprise the cell-surface receptors that bind and are activated by the
Angiopoietin_receptor
InterPro Family
including inflammation and activation signaling. Upon binding to the LTβ receptor, LT-αβ transmits signals leading to proliferation, homeostasis and activation
Lymphotoxin
Type of interleukin receptor
Interleukin 1 receptor, type I (IL1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL1R1 also denotes its human
Interleukin 1 receptor, type I
Interleukin_1_receptor,_type_I
Monoclonal antibody
2008). "A cytokine-neutralizing antibody as a structural mimetic of 2 receptor interactions". Proceedings of the National Academy of Sciences of the United
Fresolimumab
Cell surface receptors
Platelet-derived growth factor receptors (PDGF-R) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF)
Platelet-derived growth factor receptor
Platelet-derived_growth_factor_receptor
Protein-coding gene in the species Homo sapiens
almost all of them have specific receptors for this peptide. TGF-β1, TGF-β2, and TGF-β3 all function through the same receptor signaling systems. TGF-β1 was
TGF_beta_1
Group of signal transduction pathways involved in embryonic development
begin with proteins that pass signals into a cell through cell surface receptors. The name Wnt, pronounced "wint", is a portmanteau created from the names
Wnt_signaling_pathway
Protein family
"Mutational analysis of class III receptor tyrosine kinases (C-KIT, C-FMS, FLT3) in idiopathic myelofibrosis". Br. J. Haematol. 120 (3): 464–70. doi:10.1046/j.1365-2141
RTK_class_III
InterPro Family
Trk receptors are a family of tyrosine kinases that regulates synaptic strength and plasticity in the mammalian nervous system. Trk receptors affect neuronal
Trk_receptor
Protein-coding gene in the species Homo sapiens
Ascrinvacumab Kinase inhibitors: K-02288 ML-347 (LDN-193719, VU0469381) Decoy receptors: Dalantercept Other inhibitors: Disitertide ALK2 (ACVR1A) Agonists:
Bone_morphogenetic_protein_8B
Cell surface proteins
Interleukin receptors, Type 1 and Type 2. Type 1 interleukin receptors include: Interleukin-1 receptor Interleukin-2 receptor Interleukin-3 receptor Interleukin-4
Interleukin_receptor
Mammalian protein found in humans
also leads to the activation of PI 3-kinase, ras, and PLC signaling pathways. Alternatively, the p75NTR receptor can form a heterodimer with TrkA, which
Nerve_growth_factor
Protein-coding gene in humans
Ephrin type-A receptor 7 is a protein that in humans is encoded by the EPHA7 gene. This gene belongs to the ephrin receptor subfamily of the protein-tyrosine
EPHA7
Mammalian protein found in humans
Calcitonin receptor-like (CALCRL), also known as the calcitonin receptor-like receptor (CRLR), is a human protein; it is a receptor for calcitonin gene-related
CALCRL
Protein that stimulates red blood cell production
its effects by binding to the erythropoietin receptor (EpoR). EPO binds to the erythropoietin receptor on the red cell progenitor surface and activates
Erythropoietin
Heterodimeric receptor
The interferon-α/β receptor (IFNAR) is a virtually ubiquitous membrane receptor which binds endogenous type I interferon (IFN) cytokines. Endogenous human
Interferon-alpha/beta receptor
Interferon-alpha/beta_receptor
Protein-coding gene in the species Homo sapiens
Fibroblast growth factor receptor 2 (FGFR-2) also known as CD332 (cluster of differentiation 332) is a protein that in humans is encoded by the FGFR2 gene
Fibroblast growth factor receptor 2
Fibroblast_growth_factor_receptor_2
Transmembrane receptors involved in cellular adhesion and signalling
Integrins are transmembrane receptors that help cell–cell and cell–extracellular matrix (ECM) adhesion. Upon ligand binding, integrins activate signal
Integrin
Protein-coding gene in humans
EPH receptor A2 (ephrin type-A receptor 2) is a protein that in humans is encoded by the EPHA2 gene. This gene belongs to the ephrin receptor subfamily
EPH_receptor_A2
Protein-coding gene in the species Homo sapiens
Bone morphogenetic protein receptor type II or BMPR2 is a serine/threonine receptor kinase encoded by the BMPR2 gene. It binds bone morphogenetic proteins
BMPR2
Protein-coding gene in the species Homo sapiens
GDNF family receptor alpha-1 (GFRα1), also known as the GDNF receptor, is a protein that in humans is encoded by the GFRA1 gene. Glial cell line-derived
GFRA1
Protein-coding gene in the species Homo sapiens
EPH receptor A1 (ephrin type-A receptor 1) is a protein that in humans is encoded by the EPHA1 gene. This gene belongs to the ephrin receptor subfamily
EPH_receptor_A1
Protein that binds to a cytokine
Cytokine receptors are receptors that bind to cytokines. The binding of cytokines to receptors allows the cell that houses the receptor to be able to receive
Cytokine_receptor
Mammalian protein found in Homo sapiens
megakaryocytes and platelets, but studies on the removal of the thrombopoietin receptor show that its effects on hematopoiesis are more versatile. Its negative
Thrombopoietin
Erythropoietin receptor agonist
States Adopted Name; developmental code name ARA-290) is an erythropoietin receptor agonist which is under development for the treatment of a variety of different
Cibinetide
Mammalian protein found in Homo sapiens
type I cytokine receptors, to elicit signals from the IL-2 receptor family (e.g. IL-2R, IL-7R, IL-9R and IL-15R), the IL-4 receptor family (e.g. IL-4R
Janus_kinase_1
Protein family
member, TGF-β1, originally described in 1983. They interact with TGF-beta receptors. Many proteins have since been described as members of the TGF-β superfamily
Transforming growth factor beta superfamily
Transforming_growth_factor_beta_superfamily
Protein-coding gene in the species Homo sapiens
in injured skin. Transforming growth factor, beta 3 has been shown to interact with TGF beta receptor 2. After successful phase I/II trials, human recombinant
Transforming growth factor, beta 3
Transforming_growth_factor,_beta_3
Primary male sex hormone
sexual arousal: receptor expression, structure, and function". Fertility and Sterility. 77 (Suppl 4): S11–8. doi:10.1016/s0015-0282(02)02978-3. PMID 12007897
Testosterone
DECOY RECEPTOR-3
DECOY RECEPTOR-3
DECOY RECEPTOR-3
DECOY RECEPTOR-3
DECOY RECEPTOR-3
DECOY RECEPTOR-3
DECOY RECEPTOR-3
DECOY RECEPTOR-3
DECOY RECEPTOR-3