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Transmembrane receptors involved in cellular adhesion and signalling
Integrins are transmembrane receptors that help cell–cell and cell–extracellular matrix (ECM) adhesion. Upon ligand binding, integrins activate signal
Integrin
Mammalian protein found in Homo sapiens
with integrin alpha 1 and integrin alpha 2 to form integrin complexes which function as collagen receptors. It also forms dimers with integrin alpha
Integrin_beta_1
Mammalian protein found in Homo sapiens
Integrin beta-3 (β3) or CD61 is a protein that in humans is encoded by the ITGB3 gene. CD61 is a cluster of differentiation found on thrombocytes. The
Integrin_beta_3
Alpha-7 integrin is a protein that in humans is encoded by the ITGA7 gene. Alpha-7 integrin is critical for modulating cell-matrix interactions. Alpha-7
Integrin_alpha_7
Mammalian protein found in Homo sapiens
Integrin alpha-3 is a protein that in humans is encoded by the ITGA3 gene. ITGA3 is an integrin alpha subunit. Together with beta-1 subunit, it makes
Integrin_alpha_3
Protein-coding gene in the species Homo sapiens
Integrin beta-6 is a protein that in humans is encoded by the ITGB6 gene. It is the β6 subunit of the integrin αvβ6. Integrins are αβ heterodimeric glycoproteins
Integrin_beta_6
Mammalian protein found in Homo sapiens
Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), also known as ITGAL, is a protein that in humans
Integrin_alpha_L
Medication used for the treatment of gastro-intestinal diseases
to integrin α4β7 (LPAM-1, lymphocyte Peyer's patch adhesion molecule 1, a dimer of Integrin alpha-4 and Integrin beta-7), blocking the α4β7 integrin results
Vedolizumab
Cascade of intracellular and molecular events for transmission/amplification of signals
matrix such as fibronectin and hyaluronan can also bind to such receptors (integrins and CD44, respectively). In addition, some molecules such as steroid hormones
Signal_transduction
Protein found in humans
Integrin-linked kinase is an enzyme that in humans is encoded by the ILK gene involved with integrin-mediated signal transduction. Mutations in ILK are
Integrin-linked_kinase
Mammalian protein found in Homo sapiens
Integrin alpha-1 also CD49a is an integrin alpha subunit encoded in humans by the gene ITGA1. It makes up half of the α1β1 integrin duplex. Though CD49a
Integrin_alpha-1
Protein domain
codistributes with concentrations of integrins in the plasma membrane. Furthermore, in vitro binding studies suggest that integrins bind to talin, although with
Talin_(protein)
Mammalian protein found in Homo sapiens
also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a gene that encodes for CD11c . CD11c is an integrin alpha X chain
Integrin_alpha_X
Mammalian protein found in Homo sapiens
Integrin alpha M (ITGAM) is one protein subunit that forms heterodimeric integrin alpha-M beta-2 (αMβ2) molecule, also known as macrophage-1 antigen (Mac-1)
Integrin_alpha_M
Protein-coding gene in the species Homo sapiens
Integrin, alpha E (ITGAE) also known as CD103 (cluster of differentiation 103) is an integrin protein that in human is encoded by the ITGAE gene. CD103
Integrin_alpha_E
Mammalian protein found in Homo sapiens
CD49d is an integrin alpha subunit. It makes up half of the α4β1 lymphocyte homing receptor. The product of this gene belongs to the integrin alpha chain
Integrin_alpha_4
Integrin beta-7 is an integrin protein that in humans is encoded by the ITGB7 gene. It can pair with ITGA4 (CD49d) to form the heterodimeric integrin
Integrin_beta_7
Protein complex
Integrin α4β7 (Lymphocyte Peyer’s patch adhesion molecule-1) is an integrin heterodimer composed of CD49d (alpha-4) subunit and beta-7 subunit noncovalently
LPAM-1
Contrast agent for cancer imaging
targets (i.e., binds to) the cell surface receptor αvβ6-integrin and accumulates in αvβ6-integrin-abundant tissues after intravenous (i.v.) application
Ga-68-Trivehexin
Chemical compound
species ranging from Drosophila to humans. Cell adhesion proteins called integrins recognize and bind to this sequence, which is found within many matrix
Arginylglycylaspartic_acid
Structures connecting keratinocyte cells to the extracellular matrix
contain integrin α6β4 and plectin without the BP antigens. Hemidesmosomes have two membrane-spanning components: Integrin α6β4 and BPAG2. Integrin α6β4 operates
Hemidesmosome
Group of proteins
facilitated through the binding of multiple β1 chain integrins. The interplay between invasin and β1 integrins initiates a reconfiguration of the cytoskeleton
Invasin
Experimental antibody-drug conjugate targeting integrin beta-6 for solid tumors
sigvotatug vedotin is composed of a monoclonal antibody directed against integrin beta-6 (IB6), conjugated to the cytotoxic payload monomethyl auristatin
Sigvotatug_vedotin
In cell biology, CD11 is the α (alpha) component of various integrins, especially ones in which the β (beta) component is CD18 (β2) and mediate leukocyte
CD11
Subset of cell adhesion proteins
groups of CAMs: the immunoglobulin superfamily (IgSF CAMs), cadherins, integrins, and the superfamily of C-type of lectin-like domains proteins (CTLDs)
Cell_adhesion_molecule
Integrin complex found on platelets
medicine, glycoprotein IIb/IIIa (GPIIb/IIIa, also known as integrin αIIbβ3) is an integrin complex found on platelets. It is a transmembrane receptor
Glycoprotein_IIb/IIIa
Protein-coding gene in the species Homo sapiens
Integrin alpha-11 is a protein that, in humans, is encoded by the ITGA11 gene. This gene encodes an alpha integrin. Integrins are heterodimeric integral
Integrin_alpha_11
Mammalian protein found in Homo sapiens
In molecular biology, CD18 (Integrin beta chain-2) is an integrin beta chain protein that is encoded by the ITGB2 gene in humans. Upon binding with one
Integrin_beta_2
Mammalian protein found in Homo sapiens
Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene. ITGA2B, also known as CD41, encodes integrin alpha chain 2b. Integrins are
Integrin_alpha_2b
antigen (or integrin αMβ2 or macrophage integrin or Mac-1) is a complement receptor ("CR3") consisting of CD11b (integrin αM) and CD18 (integrin β2). The
Macrophage-1_antigen
Protein-coding gene in the species Homo sapiens
Integrin alpha-9 is a protein that in humans is encoded by the ITGA9 gene. Cytogenetic location: 3p22.2 This gene encodes an alpha integrin. Integrins
Integrin_alpha_9
Viral pulmonary disease of humans
viral glycoprotein spikes to host cell receptors, particularly β1 and β3 integrins. Decay acceleration factors, complement receptors, and, for New World
Hantavirus_pulmonary_syndrome
Integrin dimer
Integrin α4β1 (very late antigen-4) is an integrin dimer. It is composed of CD49d (alpha 4) and CD29 (beta 1). The alpha 4 subunit is 155 kDa, and the
VLA-4
Protein
Integrin alpha-5 is a protein that in humans is encoded by the ITGA5 gene. The product of this gene belongs to the integrin alpha chain family. Integrins
Integrin_alpha_5
Protein-coding gene in the species Homo sapiens
Integrin, beta 4 (ITGB4) also known as CD104 (Cluster of Differentiation 104), is a human gene. Integrins are heterodimers composed of alpha and beta
Integrin_beta_4
Cytokine
of integrins participating in latent TGF-β1 activation arose from studies that examined mutations/knockouts of β6 integrin, αV integrin, β8 integrin and
Transforming growth factor beta
Transforming_growth_factor_beta
Mammalian protein found in Homo sapiens
CD49b gene. The CD49b protein is an integrin alpha subunit. It makes up half of the α2β1 integrin duplex. Integrins are heterodimeric integral membrane
Integrin_alpha_2
αVβ3 is a type of integrin that is a receptor for vitronectin. It consists of two components, integrin alpha V and integrin beta 3 (CD61), and is expressed
Alpha-v_beta-3
Conversion of mechanical stimulus of a cell into electrochemical activity
activity based on physical pressures. Extracellular matrix linked proteins - integrins and focal adhesions can transmit forces from the linked extracellular
Mechanotransduction
American immunologist
adhesion molecules of the immune system, the first relationships among integrins—between LFA-1 and Mac-1—and the three-step model for leukocyte emigration
Timothy_A._Springer
Structural support for biological cells
known as integrins. Integrins are cell-surface proteins that bind cells to ECM structures, such as fibronectin and laminin, and also to integrin proteins
Extracellular_matrix
Protein-coding gene in the species Homo sapiens
Integrin subunit beta like 1 is a protein that in humans is encoded by the ITGBL1 gene. This gene encodes a beta integrin-related protein that is a member
Integrin_subunit_beta_like_1
Integrin-like receptors (ILRs) are found in plants and carry unique functional properties similar to true integrin proteins. True homologs of integrins
Integrin-like_receptors
Protein-coding gene in the species Homo sapiens
Integrin beta-8 is a protein that in humans is encoded by the ITGB8 gene. This gene is a member of the integrin beta chain family and encodes a single-pass
Integrin_beta_8
Mammalian protein found in Homo sapiens
Integrin alpha-6 is a protein that in humans is encoded by the ITGA6 gene. The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are
Integrin_alpha_6
Lebanese physician
nephrologist best known for seminal discoveries in the biology and structure of integrin receptors. He is Professor of Medicine at Harvard Medical School and Physician
M._Amin_Arnaout
Protein-coding gene in humans
CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene
CD47
switching by means of overlapping motifs (e.g. the C-terminal tails of integrin beta subunits), or they can allow high avidity interactions by multiple
Short_linear_motif
Protein-coding gene in the species Homo sapiens
encodes a subunit of integrin that can interact with the integrin alpha v to form the integrin alpha v beta 5 integrin heterodimer. Integrin alpha V beta 5
Integrin_beta_5
Medication used to treat multiple sclerosis and Crohn's disease
a humanized monoclonal antibody against the cell adhesion molecule α4-integrin. It is given by intravenous infusion. The drug is believed to work by reducing
Natalizumab
Mammalian protein found in Homo sapiens
Integrin alpha-V is a protein that in humans is encoded by the ITGAV gene. ITGAV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane
Integrin_alpha_V
integrins to participate in latent TGF-β1 activation, arose from studies that examined mutations/knockouts of β6 integrin, αV integrin, β8 integrin and
TGF_beta_Activation
Direct extension and penetration by cancer cells into neighboring tissues
Cdc42 with rapid involvement of integrins of the β1 family; 2) occurrence of focal adhesion with the involvement of integrins β1 and β3 at the contact site
Invasion_(cancer)
Protein found in humans
adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4 / beta7), L-selectin, and VLA-4 (alpha4 / beta1) on myeloid
Addressin
Genus of viruses
the viral glycoprotein spikes to host cell receptors, particularly β3 integrins. Decay acceleration factors, complement receptors, and, for New World
Hantavirus
Protein domain
immunoglobulin superfamily (IgSF), the members of which are ligands for integrins. The crystal structure of this domain has been reported; it adopts an
Adhesion molecule (immunoglobulin-like)
Adhesion_molecule_(immunoglobulin-like)
Protein-coding gene in the species Homo sapiens
Integrin alpha-8 is a protein that in humans is encoded by the ITGA8 gene. GRCh38: Ensembl release 89: ENSG00000077943 – Ensembl, May 2017 GRCm38: Ensembl
Integrin_alpha_8
Movement of white blood cells out of blood vessels and towards the inflamed site
juxtacrine activation of integrins by chemokines and soluble factors released by endothelial cells. In the activated state, integrins bind tightly to complementary
Leukocyte_extravasation
Structures which transmit force and signals between a cell and the extracellular matrix
direct numerous signaling proteins at sites of integrin binding and clustering. Focal adhesions are integrin-containing, multi-protein structures that form
Focal_adhesion
Species of bacterium
used to silence the genes integrin α2 and integrin β1, reducing the expression of the integrin subunits. Blocking integrin α2/β1 stopped S. moorei's cancer-promoting
Solobacterium_moorei
Surface glycoproteins involved in hemostasis
the binding site for von Willebrand factor (vWF), α-thrombin, leukocyte integrin αMβ2 and P-selectin. The binding between GPIbα and vWF mediates the capture
Platelet membrane glycoprotein
Platelet_membrane_glycoprotein
Protein in the extracellular matrix
fibronectin, and perlecan. The proteins also bind to cell membranes through integrins and other plasma membrane molecules, such as the dystroglycan glycoprotein
Laminin
Protein-coding gene in the species Homo sapiens
Integrin alpha-D is a protein that in humans is encoded by the ITGAD gene. GRCh38: Ensembl release 89: ENSG00000156886 – Ensembl, May 2017 GRCm38: Ensembl
Integrin_alpha_D
Protein involved in cell adhesion, cell growth, cell migration and differentiation
extracellular matrix that binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as
Fibronectin
Process of cell attachment
Cell adhesion molecules (CAMs) are classified into four major families: integrins, immunoglobulin superfamily, cadherins, and selectins. Cadherins and IgSF
Cell_adhesion
migration. Alpha-7 integrin pericytes (AIPs) express several types of integrin chains which generate heterodimers. Integrin chains allow integrin pericytes to
Lymph_node_stromal_cell
Species of virus
the F protein has been proven by its ability to bind to host cells via integrin αvβ1 using an Arginine-Glycine-Aspartate (RGD) motif, which is speculated
Human_metapneumovirus
Cell surface receptors
noncovalently bound. Collagen binding is primarily provided by integrins α1β1, α2β1, α10β1 and α11β1. Integrin α1β1 binds to collagen via the MIDAS motif in the α
Collagen_receptor
Medical treatment
ulcerative colitis. The other main categories of biologics that treat IBD are integrin receptor antagonists such as vedolizumab and natalizumab and interleukin
Biological therapy for inflammatory bowel disease
Biological_therapy_for_inflammatory_bowel_disease
Protein family
to membranes where integrins are found. This provides a mechanism by which Rap1 can act directly on integrins and modulate integrin affinity and/or clustering
Rap1
Protein-coding gene in the species Homo sapiens
mediate cell-cell adhesion via the linkage of integrins to the actin cytoskeleton and in the activation of integrins. Altered expression of talin-1 has been
TLN1
Type of spreading cancer
Fibronectin-integrin interactions are important in tumor cell migration, invasion, metastasis and cell proliferation by signaling through integrins. Integrin-mediated
Metastatic_breast_cancer
Protein-coding gene in the species Homo sapiens
are responsible for cell to cell crosstalk via cell-cell contacts and integrin mediated cell adhesion through focal adhesion proteins and as specialised
FERMT3
Protein-coding gene in the species Homo sapiens
called bone sialoprotein 2 also known as cell-binding sialoprotein or integrin-binding sialoprotein and is encoded by the IBSP gene. Native BSP has an
Bone_sialoprotein
Monoclonal antibody
antibody, which binds to integrin α4β7 (LPAM-1, lymphocyte Peyer's patch adhesion molecule 1, a dimer of Integrin alpha-4 and Integrin beta-7) on T lymphocytes
Cedelizumab
Protein-coding gene in humans
Calcium and integrin-binding protein 1 is a protein that in humans is encoded by the CIB1 gene and is located in chromosome 15. The protein encoded by
CIB1
Protein-coding gene in humans
phosphorylated in response to integrin engagement, growth factor stimulation, and the action of mitogenic neuropeptides. Integrin receptors are heterodimeric
PTK2
Mammalian protein found in Homo sapiens
expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by rhinovirus
ICAM-1
Proteins from viper venom inhibiting platelets aggregation
venoms that function as potent inhibitors of both platelet aggregation and integrin-dependent cell adhesion. Disintegrins work by countering the blood clotting
Disintegrin
Chemical compound
carotegrast, by the enzyme carboxylesterase 1 in the liver. Carotegrast is an α4-integrin antagonist which prevents the chronic inflammation affecting the gastrointestinal
Carotegrast_methyl
Pharmaceutical compound
Vitaxin (MEDI-523) is a humanized monoclonal antibody against the vascular integrin alpha-v beta-3. It is shown to be a promising angiogenesis inhibitor used
Vitaxin
Contact-based cell-cell signalling
cell communication. Cells use mainly the receptor integrin to interact with ECM proteins. Integrins are a family of receptor proteins that integrate the
Juxtacrine_signalling
Integrin found on lymphocytes
Lymphocyte function-associated antigen 1 (LFA-1) is an integrin found on lymphocytes and other leukocytes. LFA-1 plays a key role in emigration, which
Lymphocyte function-associated antigen 1
Lymphocyte_function-associated_antigen_1
Exocrine gland in humans and other mammals
thicker, with strong adhesion to epithelial cells via binding to integrin and non-integrin receptors. When side branches develop, it is a much more "pushing-forward"
Mammary_gland
Protein-coding gene in the species Homo sapiens
molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1". J. Exp. Med. 196 (5): 679–91. doi:10.1084/jem.20020267. PMC 2194005
JAM3
Cell biologist
called integrins and her findings support that epidermal α3β1 integrin is required for the prevention of blistering diseases and that αvβ3-integrin is required
Kairbaan_Hodivala-Dilke
Medical condition
have an inherited molecular defect that causes a deficiency of the β-2 integrin subunit, also called CD18, which is encoded by the ITGB2 gene found on
Leukocyte_adhesion_deficiency
Material or tissue between a eukaryotic organism's cells
bind to cell surface receptor proteins called integrins that are built into the plasma membrane. Integrins span the membrane and bind on the cytoplasmic
Matrix_(biology)
Moperone Luvatren butyrophenone N05AD04 Oxypertine Equipertine, Forit, Integrin, Lanturil, Lotawin, Opertil phenylpiperazine N05AE01 Oxyprothepine Meclopin
List_of_antipsychotics
Multiprotein complex that forms a point of contact or adhesion in animal cells
cytoplasm, but in contrast to desmosomes, their transmembrane anchors are integrins rather than cadherins. Adherens junctions share the characteristic of
Cell_junction
Protein found in humans
cell type. In total CD40L has three binding partners: CD40, α5β1 integrin and integrin αIIbβ3. CD154 acts as a costimulatory molecule and is particularly
CD154
Protein domain named after the epidermal growth factor protein
structures of 4-disulfide EGF-domains have been solved from the laminin and integrin proteins.[citation needed] The main structure of EGF-like domains is a
EGF-like_domain
Protein
Increased levels of laminin-111 triggered an increase in the expression of α7-integrin receptor and this prevented onset of the disease. Additionally, the presence
Laminin_111
Protein-coding gene in the species Homo sapiens
differentiation, apoptosis, and senescence through interaction with cell surface integrin receptors and heparan sulfate proteoglycans. During embryonic development
CYR61
Fibrosis of lungs due to unknown causes
important activator of TGF-β is αvβ6-integrin, which releases TGF-β from its latent form. Hence, αvβ6-integrin has been recognized earlier as a potential
Idiopathic_pulmonary_fibrosis
Protein-coding gene in the species Homo sapiens
to detect substrate stiffness and modulate behavior through the calpain-integrin-E-cadherin pathway. Beginning with the activation of calpain, a protease
PIEZO1
Component of striated muscle cells
dystrophin-glycoprotein complex (DGC) and the integrin-vinculin-talin complex. The sarcoglycans of the DGC and the integrins of the integrin-vinculin-talin complex attach
Costamere
immune response. This process relies on the key interaction between the integrin α4β7 and the addressin MadCAM-1 on the surfaces of the appropriate cells
Gut-specific_homing
South American orthohantavirus species
macrophages to reach endothelial cells. It enters these cells by binding to β3-integrins and protocadherin-1 receptors with its glycoproteins. Virions are then
Andes_virus
Prototypical agent of hantavirus cardiopulmonary syndrome
infects endothelial cells and macrophages. It enters cells by using β3-integrins as receptors. Virions are taken into a cell via an endosome. Once pH is
Sin_Nombre_virus
INTEGRIN
INTEGRIN
INTEGRIN
INTEGRIN
Boy/Male
Latin
noble.
Boy/Male
Hindu, Indian
Tulasi; Radha
Boy/Male
Armenian, Australian
Good News
Boy/Male
Bengali, Gujarati, Hindu, Indian, Kannada, Malayalam, Marathi, Oriya, Telugu
King of Brahmins; The Moon
Girl/Female
British, Christian, English, Portuguese
Maiden of the Bear-spear; Maiden
Female
Native American
Native American Cheyenne name SHESHEBENS means "small duck."
Boy/Male
Tamil
Musical prelude
Girl/Female
Shakespearean
King Henry IV, Part 2' Doll Tearsheet, a woman at the Boar's Head in East.cheap.
Girl/Female
Indian
Hope
Boy/Male
Hindu
Welfare
INTEGRIN
INTEGRIN
INTEGRIN
INTEGRIN
INTEGRIN