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Transmembrane receptors involved in cellular adhesion and signalling
Integrins are transmembrane receptors that help cell–cell and cell–extracellular matrix (ECM) adhesion. Upon ligand binding, integrins activate signal
Integrin
Protein-coding gene in the species Homo sapiens
Integrin, alpha E (ITGAE) also known as CD103 (cluster of differentiation 103) is an integrin protein that in human is encoded by the ITGAE gene. CD103
Integrin_alpha_E
Integrin beta-7 is an integrin protein that in humans is encoded by the ITGB7 gene. It can pair with ITGA4 (CD49d) to form the heterodimeric integrin
Integrin_beta_7
Chemical compound
species ranging from Drosophila to humans. Cell adhesion proteins called integrins recognize and bind to this sequence, which is found within many matrix
Arginylglycylaspartic_acid
Mammalian protein found in Homo sapiens
with integrin alpha 1 and integrin alpha 2 to form integrin complexes which function as collagen receptors. It also forms dimers with integrin alpha
Integrin_beta_1
Mammalian protein found in Homo sapiens
Integrin alpha-1 also CD49a is an integrin alpha subunit encoded in humans by the gene ITGA1. It makes up half of the α1β1 integrin duplex. Though CD49a
Integrin_alpha-1
Protein-coding gene in the species Homo sapiens
Integrin beta-6 is a protein that in humans is encoded by the ITGB6 gene. It is the β6 subunit of the integrin αvβ6. Integrins are αβ heterodimeric glycoproteins
Integrin_beta_6
Mammalian protein found in Homo sapiens
CD49b gene. The CD49b protein is an integrin alpha subunit. It makes up half of the α2β1 integrin duplex. Integrins are heterodimeric integral membrane
Integrin_alpha_2
Medication used for the treatment of gastro-intestinal diseases
to integrin α4β7 (LPAM-1, lymphocyte Peyer's patch adhesion molecule 1, a dimer of Integrin alpha-4 and Integrin beta-7), blocking the α4β7 integrin results
Vedolizumab
Alpha-7 integrin is a protein that in humans is encoded by the ITGA7 gene. Alpha-7 integrin is critical for modulating cell-matrix interactions. Alpha-7
Integrin_alpha_7
Protein complex
Integrin α4β7 (Lymphocyte Peyer’s patch adhesion molecule-1) is an integrin heterodimer composed of CD49d (alpha-4) subunit and beta-7 subunit noncovalently
LPAM-1
Mammalian protein found in Homo sapiens
Integrin alpha-6 is a protein that in humans is encoded by the ITGA6 gene. The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are
Integrin_alpha_6
Integrin-like receptors (ILRs) are found in plants and carry unique functional properties similar to true integrin proteins. True homologs of integrins
Integrin-like_receptors
Protein found in humans
Integrin-linked kinase is an enzyme that in humans is encoded by the ILK gene involved with integrin-mediated signal transduction. Mutations in ILK are
Integrin-linked_kinase
Mammalian protein found in Homo sapiens
Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene. ITGA2B, also known as CD41, encodes integrin alpha chain 2b. Integrins are
Integrin_alpha_2b
Mammalian protein found in Homo sapiens
Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), also known as ITGAL, is a protein that in humans
Integrin_alpha_L
Group of proteins
facilitated through the binding of multiple β1 chain integrins. The interplay between invasin and β1 integrins initiates a reconfiguration of the cytoskeleton
Invasin
Mammalian protein found in Homo sapiens
In molecular biology, CD18 (Integrin beta chain-2) is an integrin beta chain protein that is encoded by the ITGB2 gene in humans. Upon binding with one
Integrin_beta_2
antigen (or integrin αMβ2 or macrophage integrin or Mac-1) is a complement receptor ("CR3") consisting of CD11b (integrin αM) and CD18 (integrin β2). The
Macrophage-1_antigen
Protein-coding gene in the species Homo sapiens
Integrin, beta 4 (ITGB4) also known as CD104 (Cluster of Differentiation 104), is a human gene. Integrins are heterodimers composed of alpha and beta
Integrin_beta_4
In cell biology, CD11 is the α (alpha) component of various integrins, especially ones in which the β (beta) component is CD18 (β2) and mediate leukocyte
CD11
Mammalian protein found in Homo sapiens
CD49d is an integrin alpha subunit. It makes up half of the α4β1 lymphocyte homing receptor. The product of this gene belongs to the integrin alpha chain
Integrin_alpha_4
Protein-coding gene in the species Homo sapiens
Integrin alpha-11 is a protein that, in humans, is encoded by the ITGA11 gene. This gene encodes an alpha integrin. Integrins are heterodimeric integral
Integrin_alpha_11
Mammalian protein found in Homo sapiens
also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a gene that encodes for CD11c . CD11c is an integrin alpha X chain
Integrin_alpha_X
Mammalian protein found in Homo sapiens
Integrin beta-3 (β3) or CD61 is a protein that in humans is encoded by the ITGB3 gene. CD61 is a cluster of differentiation found on thrombocytes. The
Integrin_beta_3
Protein
Integrin alpha-5 is a protein that in humans is encoded by the ITGA5 gene. The product of this gene belongs to the integrin alpha chain family. Integrins
Integrin_alpha_5
Protein found in humans
adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4 / beta7), L-selectin, and VLA-4 (alpha4 / beta1) on myeloid
Addressin
Cascade of intracellular and molecular events for transmission/amplification of signals
matrix such as fibronectin and hyaluronan can also bind to such receptors (integrins and CD44, respectively). In addition, some molecules such as steroid hormones
Signal_transduction
Contrast agent for cancer imaging
targets (i.e., binds to) the cell surface receptor αvβ6-integrin and accumulates in αvβ6-integrin-abundant tissues after intravenous (i.v.) application
Ga-68-Trivehexin
Protein-coding gene in the species Homo sapiens
encodes a subunit of integrin that can interact with the integrin alpha v to form the integrin alpha v beta 5 integrin heterodimer. Integrin alpha V beta 5
Integrin_beta_5
Protein family
to membranes where integrins are found. This provides a mechanism by which Rap1 can act directly on integrins and modulate integrin affinity and/or clustering
Rap1
Mammalian protein found in Homo sapiens
Integrin alpha M (ITGAM) is one protein subunit that forms heterodimeric integrin alpha-M beta-2 (αMβ2) molecule, also known as macrophage-1 antigen (Mac-1)
Integrin_alpha_M
Integrin dimer
Integrin α4β1 (very late antigen-4) is an integrin dimer. It is composed of CD49d (alpha 4) and CD29 (beta 1). The alpha 4 subunit is 155 kDa, and the
VLA-4
Protein-coding gene in the species Homo sapiens
Integrin alpha-9 is a protein that in humans is encoded by the ITGA9 gene. Cytogenetic location: 3p22.2 This gene encodes an alpha integrin. Integrins
Integrin_alpha_9
Protein-coding gene in humans
CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene
CD47
Subset of cell adhesion proteins
groups of CAMs: the immunoglobulin superfamily (IgSF CAMs), cadherins, integrins, and the superfamily of C-type of lectin-like domains proteins (CTLDs)
Cell_adhesion_molecule
Mammalian protein found in Homo sapiens
Integrin alpha-V is a protein that in humans is encoded by the ITGAV gene. ITGAV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane
Integrin_alpha_V
Conversion of mechanical stimulus of a cell into electrochemical activity
activity based on physical pressures. Extracellular matrix linked proteins - integrins and focal adhesions can transmit forces from the linked extracellular
Mechanotransduction
Structures connecting keratinocyte cells to the extracellular matrix
contain integrin α6β4 and plectin without the BP antigens. Hemidesmosomes have two membrane-spanning components: Integrin α6β4 and BPAG2. Integrin α6β4 operates
Hemidesmosome
Mammalian protein found in Homo sapiens
Integrin alpha-3 is a protein that in humans is encoded by the ITGA3 gene. ITGA3 is an integrin alpha subunit. Together with beta-1 subunit, it makes
Integrin_alpha_3
Protein-coding gene in the species Homo sapiens
Integrin alpha-8 is a protein that in humans is encoded by the ITGA8 gene. GRCh38: Ensembl release 89: ENSG00000077943 – Ensembl, May 2017 GRCm38: Ensembl
Integrin_alpha_8
Protein-coding gene in the species Homo sapiens
Integrin alpha-D is a protein that in humans is encoded by the ITGAD gene. GRCh38: Ensembl release 89: ENSG00000156886 – Ensembl, May 2017 GRCm38: Ensembl
Integrin_alpha_D
Protein domain
codistributes with concentrations of integrins in the plasma membrane. Furthermore, in vitro binding studies suggest that integrins bind to talin, although with
Talin_(protein)
American immunologist
adhesion molecules of the immune system, the first relationships among integrins—between LFA-1 and Mac-1—and the three-step model for leukocyte emigration
Timothy_A._Springer
Integrin complex found on platelets
medicine, glycoprotein IIb/IIIa (GPIIb/IIIa, also known as integrin αIIbβ3) is an integrin complex found on platelets. It is a transmembrane receptor
Glycoprotein_IIb/IIIa
Structural support for biological cells
known as integrins. Integrins are cell-surface proteins that bind cells to ECM structures, such as fibronectin and laminin, and also to integrin proteins
Extracellular_matrix
Protein-coding gene in the species Homo sapiens
Integrin subunit beta like 1 is a protein that in humans is encoded by the ITGBL1 gene. This gene encodes a beta integrin-related protein that is a member
Integrin_subunit_beta_like_1
Protein-coding gene in the species Homo sapiens
Integrin beta-8 is a protein that in humans is encoded by the ITGB8 gene. This gene is a member of the integrin beta chain family and encodes a single-pass
Integrin_beta_8
Protein-coding gene in the species Homo sapiens
Integrin beta-1-binding protein 1 is a protein that in humans is encoded by the ITGB1BP1 gene. The cytoplasmic domains of integrins are essential for
ITGB1BP1
Cytokine
of integrins participating in latent TGF-β1 activation arose from studies that examined mutations/knockouts of β6 integrin, αV integrin, β8 integrin and
Transforming growth factor beta
Transforming_growth_factor_beta
integrins to participate in latent TGF-β1 activation, arose from studies that examined mutations/knockouts of β6 integrin, αV integrin, β8 integrin and
TGF_beta_Activation
Protein-coding gene in the species Homo sapiens
Integrin-linked kinase-associated serine/threonine phosphatase 2C is an enzyme that in humans is encoded by the ILKAP gene. The protein encoded by this
ILKAP
switching by means of overlapping motifs (e.g. the C-terminal tails of integrin beta subunits), or they can allow high avidity interactions by multiple
Short_linear_motif
Immunologist
major contributions in the field of adhesion molecules, focusing on the integrins expressed by leukocytes. Hogg was elected to the Academy of Medical Sciences
Nancy_Hogg
Protein in the extracellular matrix
fibronectin, and perlecan. The proteins also bind to cell membranes through integrins and other plasma membrane molecules, such as the dystroglycan glycoprotein
Laminin
Topics referred to by the same term
the Power Rangers franchise Integrin alpha-5, a protein encoded by the ITGA5 gen in humans Alpha-5 beta-1 (α5β1), an integrin that binds to matrix macromolecules
Alpha_5
Monoclonal antibody
antibody, which binds to integrin α4β7 (LPAM-1, lymphocyte Peyer's patch adhesion molecule 1, a dimer of Integrin alpha-4 and Integrin beta-7) on T lymphocytes
Cedelizumab
Medication used to treat multiple sclerosis and Crohn's disease
a humanized monoclonal antibody against the cell adhesion molecule α4-integrin. It is given by intravenous infusion. The drug is believed to work by reducing
Natalizumab
Surface glycoproteins involved in hemostasis
the binding site for von Willebrand factor (vWF), α-thrombin, leukocyte integrin αMβ2 and P-selectin. The binding between GPIbα and vWF mediates the capture
Platelet membrane glycoprotein
Platelet_membrane_glycoprotein
Protein-coding gene in the species Homo sapiens
mediate cell-cell adhesion via the linkage of integrins to the actin cytoskeleton and in the activation of integrins. Altered expression of talin-1 has been
TLN1
Cell surface receptors
noncovalently bound. Collagen binding is primarily provided by integrins α1β1, α2β1, α10β1 and α11β1. Integrin α1β1 binds to collagen via the MIDAS motif in the α
Collagen_receptor
Monoclonal antibody
Intetumumab is a human monoclonal antibody targeting integrins that was being studied for the treatment of solid tumors. Intetumumab was developed by
Intetumumab
Structures which transmit force and signals between a cell and the extracellular matrix
direct numerous signaling proteins at sites of integrin binding and clustering. Focal adhesions are integrin-containing, multi-protein structures that form
Focal_adhesion
Substance that forms a complex with a biomolecule
MAPK/ERK Notch JAK-STAT Akt/PKB Fas apoptosis Hippo PI3K/AKT/mTOR pathway Integrin receptors Agents Receptor ligands Hormones Neurotransmitters/Neuropeptides/Neurohormones
Ligand_(biochemistry)
migration. Alpha-7 integrin pericytes (AIPs) express several types of integrin chains which generate heterodimers. Integrin chains allow integrin pericytes to
Lymph_node_stromal_cell
Protein-coding gene in the species Homo sapiens
differentiation, apoptosis, and senescence through interaction with cell surface integrin receptors and heparan sulfate proteoglycans. During embryonic development
CCN_family_member_1
Pharmaceutical compound
Vitaxin (MEDI-523) is a humanized monoclonal antibody against the vascular integrin alpha-v beta-3. It is shown to be a promising angiogenesis inhibitor used
Vitaxin
Protein-coding gene in humans
regulates the reorganization of the actin cytoskeleton by interacting with integrins, transmembrane receptor complexes, and secondary messengers. At least
Filamin-A
Protein involved in cell adhesion, cell growth, cell migration and differentiation
extracellular matrix that binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as
Fibronectin
Protein found in humans
matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin". EMBO J. 17 (6): 1606–13. doi:10.1093/emboj/17
Collagen,_type_V,_alpha_1
Protein-coding gene in the species Homo sapiens
expression data BioGPS n/a Gene ontology Molecular function calcium ion binding integrin binding extracellular matrix structural constituent Cellular component
Nephronectin
Protein-coding gene in the species Homo sapiens
are responsible for cell to cell crosstalk via cell-cell contacts and integrin mediated cell adhesion through focal adhesion proteins and as specialised
FERMT3
αVβ3 is a type of integrin that is a receptor for vitronectin. It consists of two components, integrin alpha V and integrin beta 3 (CD61), and is expressed
Alpha-v_beta-3
Dog breed
"Canine Chondrodysplasia Caused by a Truncating Mutation in Collagen-Binding Integrin Alpha Subunit 10". PLoS ONE. 8 (9) e75621. Public Library of Science (PLoS)
Karelian_Bear_Dog
Lebanese physician
nephrologist best known for seminal discoveries in the biology and structure of integrin receptors. He is Professor of Medicine at Harvard Medical School and Physician
M._Amin_Arnaout
Protein-coding gene in the species Homo sapiens
Integrin alpha-10 also known as ITGA10 is a protein that in humans is encoded by the ITGA10 gene. Integrins are integral membrane proteins composed of
Integrin_alpha_10
Protein-coding gene in humans
phosphorylated in response to integrin engagement, growth factor stimulation, and the action of mitogenic neuropeptides. Integrin receptors are heterodimeric
PTK2
Species of bacterium
used to silence the genes integrin α2 and integrin β1, reducing the expression of the integrin subunits. Blocking integrin α2/β1 stopped S. moorei's cancer-promoting
Solobacterium_moorei
Protein-coding gene in the species Homo sapiens
to detect substrate stiffness and modulate behavior through the calpain-integrin-E-cadherin pathway. Beginning with the activation of calpain, a protease
PIEZO1
Material or tissue between a eukaryotic organism's cells
bind to cell surface receptor proteins called integrins that are built into the plasma membrane. Integrins span the membrane and bind on the cytoplasmic
Matrix_(biology)
Medical treatment
ulcerative colitis. The other main categories of biologics that treat IBD are integrin receptor antagonists such as vedolizumab and natalizumab and interleukin
Biological therapy for inflammatory bowel disease
Biological_therapy_for_inflammatory_bowel_disease
increased stiffness substrates. Growth cones utilize integrin migratory machinery such as integrins, but are not a class of cell migration. Thy-1 (or CD90
Role of cell adhesions in neural development
Role_of_cell_adhesions_in_neural_development
Integrin found on lymphocytes
Lymphocyte function-associated antigen 1 (LFA-1) is an integrin found on lymphocytes and other leukocytes. LFA-1 plays a key role in emigration, which
Lymphocyte function-associated antigen 1
Lymphocyte_function-associated_antigen_1
Movement of white blood cells out of blood vessels and towards the inflamed site
juxtacrine activation of integrins by chemokines and soluble factors released by endothelial cells. In the activated state, integrins bind tightly to complementary
Leukocyte_extravasation
Protein
and bone. In humans it is encoded by the VTN gene. Vitronectin binds to integrin alpha-V beta-3 and thus promotes cell adhesion and spreading. It also inhibits
Vitronectin
Finnish cancer researcher
aims to find novel regulators for integrin activity, understanding the integrin traffic, and link between integrin activity regulation and mechanosensing
Johanna_Ivaska
Monoclonal antibody
solid tumors. It binds to and inhibits the functional activity of α5β1 integrin. It is thought to reduce metastases. Early results show potential in renal
Volociximab
Antiplatelet drug
of the protein-protein interaction between fibrinogen and the platelet integrin receptor GP IIb/IIIa and is the first drug candidate whose origins can
Tirofiban
Protein-coding gene in the species Homo sapiens
shape change. A major task of kindlins is to regulate the activation of integrins. FERMT2 has been shown to interact with FBLIM1. Loss of kindlin-2 in mice
FERMT2
Protein-coding gene in humans
Calcium and integrin-binding protein 1 is a protein that in humans is encoded by the CIB1 gene and is located in chromosome 15. The protein encoded by
CIB1
Direct extension and penetration by cancer cells into neighboring tissues
Cdc42 with rapid involvement of integrins of the β1 family; 2) occurrence of focal adhesion with the involvement of integrins β1 and β3 at the contact site
Invasion_(cancer)
Protein domain
may function as an integrin ligand in the brain. ADAM23 This gene is highly expressed in the brain and may function as an integrin ligand in the brain
ADAM_(protein)
Protein-coding gene in the species Homo sapiens
affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits". J. Cell Biol. 156 (2). United States: 361–76. doi:10
Filamin-B
Protein-coding gene in humans
gamma) functions as an adhesion molecule by binding the alpha(v)beta(5) integrin". Biochem. Biophys. Res. Commun. 280 (2): 574–80. doi:10.1006/bbrc.2000
ADAM9
Protein-coding gene in the species Homo sapiens
"Discoidin domain receptors promote α1β1- and α2β1-integrin mediated cell adhesion to collagen by enhancing integrin activation". PLOS ONE. 7 (12) e52209. Bibcode:2012PLoSO
Discoidin domain-containing receptor 2
Discoidin_domain-containing_receptor_2
Chemical compound
carotegrast, by the enzyme carboxylesterase 1 in the liver. Carotegrast is an α4-integrin antagonist which prevents the chronic inflammation affecting the gastrointestinal
Carotegrast_methyl
Medical condition
is associated with abnormal integrin αIIbβ3, formerly known as glycoprotein IIb/IIIa (GpIIb/IIIa), which is an integrin aggregation receptor on platelets
Glanzmann's_thrombasthenia
Proteins from viper venom inhibiting platelets aggregation
venoms that function as potent inhibitors of both platelet aggregation and integrin-dependent cell adhesion. Disintegrins work by countering the blood clotting
Disintegrin
Protein
Increased levels of laminin-111 triggered an increase in the expression of α7-integrin receptor and this prevented onset of the disease. Additionally, the presence
Laminin_111
Protein found in humans
various cell surface receptors in a context-dependent manner, including integrin receptors, cell surface heparan sulfate proteoglycans (HSPGs), LRPs, and
CCN_family_member_2
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