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FRESOLIMUMAB

  • Fresolimumab

    • Monoclonal antibody

    Fresolimumab (GC1008) is a human monoclonal antibody and an immunomodulator. It is intended for the treatment of idiopathic pulmonary fibrosis (IPF), focal

    Fresolimumab

    Fresolimumab

  • Metelimumab

    • Chemical compound

    as scleroderma. It was dropped from further development in favour of fresolimumab, which was being developed by Genzyme as of 2006. Metelimumab was isolated

    Metelimumab

    Metelimumab

  • Osteogenesis imperfecta

    • Group of genetic disorders resulting in fragile bones

    that have been studied are romosozumab (targets sclerostin, by Amgen), fresolimumab (TGF-β, Sanofi), blosozumab (sclerostin, Lilly), and setrusumab (sclerostin

    Osteogenesis imperfecta

    Osteogenesis imperfecta

    Osteogenesis_imperfecta

  • Transforming growth factor beta

    • Cytokine

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    Transforming growth factor beta

    Transforming growth factor beta

    Transforming_growth_factor_beta

  • Cambridge Antibody Technology

    • British biotechnology company (1989–2007)

    ophthalmic uses, were covered by the agreement. The deal resulted in fresolimumab (GC1008), a pan-neutralizing IgG4 human antibody directed against all

    Cambridge Antibody Technology

    Cambridge Antibody Technology

    Cambridge_Antibody_Technology

  • Myostatin

    • Mammalian and avian protein

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    Myostatin

    Myostatin

    Myostatin

  • Anti-Müllerian hormone

    • Mammalian protein found in humans

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    Anti-Müllerian hormone

    Anti-Müllerian hormone

    Anti-Müllerian_hormone

  • Theralizumab

    • Monoclonal antibody

    Camidanlumab tesirine Carlumab Cemiplimab Dupilumab Eldelumab Emapalumab Fresolimumab Garadacimab Golimumab Ianalumab† Lanadelumab Lenzilumab Lerdelimumab

    Theralizumab

    Theralizumab

  • Activin and inhibin

    • Regulators of feedback on FSH-production

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    Activin and inhibin

    Activin and inhibin

    Activin_and_inhibin

  • TGF beta signaling pathway

    • Signaling pathway involving transforming growth factor beta proteins

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    TGF beta signaling pathway

    TGF_beta_signaling_pathway

  • GDF11

    • Protein-coding gene in humans

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    GDF11

    GDF11

    GDF11

  • GDF15

    • Protein-coding gene in humans

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    GDF15

    GDF15

    GDF15

  • Activin receptor

    • Protein domain

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    Activin receptor

    Activin_receptor

  • Bone morphogenetic protein

    • Group of growth factor proteins

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    Bone morphogenetic protein

    Bone_morphogenetic_protein

  • GDF2

    • Protein-coding gene in the species Homo sapiens

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    GDF2

    GDF2

    GDF2

  • List of therapeutic monoclonal antibodies

    • humanized calcitonin gene-related peptide alpha and beta Y migraine Fresolimumab mab human TGF-β idiopathic pulmonary fibrosis, focal segmental glomerulosclerosis

    List of therapeutic monoclonal antibodies

    List of therapeutic monoclonal antibodies

    List_of_therapeutic_monoclonal_antibodies

  • Growth differentiation factor

    • Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    Growth differentiation factor

    Growth differentiation factor

    Growth_differentiation_factor

  • Cerberus (protein)

    • Protein found in humans

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    Cerberus (protein)

    Cerberus (protein)

    Cerberus_(protein)

  • Transforming growth factor

    • Biomarker indicative of breast cancer patients' prognosis

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    Transforming growth factor

    Transforming_growth_factor

  • Nodal signaling pathway

    • Cellular process in embryonic development

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    Nodal signaling pathway

    Nodal_signaling_pathway

  • Follistatin

    • Mammalian protein found in Homo sapiens

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    Follistatin

    Follistatin

    Follistatin

  • Growth differentiation factor 9

    • Protein-coding gene in the species Homo sapiens

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    Growth differentiation factor 9

    Growth differentiation factor 9

    Growth_differentiation_factor_9

  • Endoglin

    • Protein-coding gene in the species Homo sapiens

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    Endoglin

    Endoglin

    Endoglin

  • Lefty (protein)

    • Members of the TGF-beta superfamily of growth factors

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    Lefty (protein)

    Lefty_(protein)

  • TGF beta receptor 2

    • Protein-coding gene in the species Homo sapiens

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    TGF beta receptor 2

    TGF beta receptor 2

    TGF_beta_receptor_2

  • SMAD (protein)

    • Family of proteins

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    SMAD (protein)

    SMAD_(protein)

  • BAMBI

    • Protein-coding gene in the species Homo sapiens

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    BAMBI

    BAMBI

    BAMBI

  • INHA

    • Protein and coding gene in humans

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    INHA

    INHA

    INHA

  • Bone morphogenetic protein 15

    • Protein-coding gene in humans

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    Bone morphogenetic protein 15

    Bone morphogenetic protein 15

    Bone_morphogenetic_protein_15

  • INHBB

    • Protein-coding gene in the species Homo sapiens

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    INHBB

    INHBB

    INHBB

  • GDF5

    • Protein-coding gene in the species Homo sapiens

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    GDF5

    GDF5

    GDF5

  • Stamulumab

    • Monoclonal antibody

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    Stamulumab

    Stamulumab

  • List of drugs: Fm–Ft

    • fradafiban (INN) Fragmin framycetin (INN) Fraven Freamine frentizole (INN) fresolimumab (USAN, INN) fronepidil (INN) Frova frovatriptan (INN) froxiprost (INN)

    List of drugs: Fm–Ft

    List_of_drugs:_Fm–Ft

  • Bone morphogenetic protein 6

    • Protein-coding gene in the species Homo sapiens

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    Bone morphogenetic protein 6

    Bone morphogenetic protein 6

    Bone_morphogenetic_protein_6

  • TGF beta 1

    • Protein-coding gene in the species Homo sapiens

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    TGF beta 1

    TGF beta 1

    TGF_beta_1

  • Gremlin (protein)

    • Inhibitor protein in the TGF beta signaling pathway

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    Gremlin (protein)

    Gremlin_(protein)

  • Transforming growth factor beta superfamily

    • Protein family

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    Transforming growth factor beta superfamily

    Transforming growth factor beta superfamily

    Transforming_growth_factor_beta_superfamily

  • Transforming growth factor, beta 3

    • Protein-coding gene in the species Homo sapiens

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    Transforming growth factor, beta 3

    Transforming growth factor, beta 3

    Transforming_growth_factor,_beta_3

  • LTBP1

    • Protein-coding gene in the species Homo sapiens

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    LTBP1

    LTBP1

    LTBP1

  • INHBA

    • Protein-coding gene in the species Homo sapiens

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    INHBA

    INHBA

    INHBA

  • ACVR2A

    • Protein-coding gene in the species Homo sapiens

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    ACVR2A

    ACVR2A

    ACVR2A

  • BMPR2

    • Protein-coding gene in the species Homo sapiens

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    BMPR2

    BMPR2

    BMPR2

  • GDF1

    • Protein-coding gene in the species Homo sapiens

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    GDF1

    GDF1

    GDF1

  • GDF10

    • Protein-coding gene in the species Homo sapiens

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    GDF10

    GDF10

    GDF10

  • Bone morphogenetic protein 3

    • Protein-coding gene in the species Homo sapiens

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    Bone morphogenetic protein 3

    Bone morphogenetic protein 3

    Bone_morphogenetic_protein_3

  • TGF beta receptor 1

    • Protein-coding gene in the species Homo sapiens

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    TGF beta receptor 1

    TGF beta receptor 1

    TGF_beta_receptor_1

  • TGFBR3

    • Protein-coding gene in the species Homo sapiens

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    TGFBR3

    TGFBR3

    TGFBR3

  • ACVR2B

    • Protein-coding gene in humans

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    ACVR2B

    ACVR2B

    ACVR2B

  • TGF beta receptor

    • Protein family

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    TGF beta receptor

    TGF_beta_receptor

  • Bone morphogenetic protein 8A

    • Protein-coding gene in the species Homo sapiens

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    Bone morphogenetic protein 8A

    Bone morphogenetic protein 8A

    Bone_morphogenetic_protein_8A

  • Chordin

    • InterPro Family

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    Chordin

    Chordin

  • SMAD4

    • Mammalian protein found in Homo sapiens

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    SMAD4

    SMAD4

    SMAD4

  • Bone morphogenetic protein 2

    • Protein found in humans

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    Bone morphogenetic protein 2

    Bone morphogenetic protein 2

    Bone_morphogenetic_protein_2

  • BMPR1B

    • Protein-coding gene in the species Homo sapiens

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    BMPR1B

    BMPR1B

    BMPR1B

  • Bone morphogenetic protein 7

    • Protein-coding gene in the species Homo sapiens

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    Bone morphogenetic protein 7

    Bone morphogenetic protein 7

    Bone_morphogenetic_protein_7

  • SMAD2

    • Protein found in humans

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    SMAD2

    SMAD2

    SMAD2

  • Noggin (protein)

    • Protein-coding gene in the species Homo sapiens

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    Noggin (protein)

    Noggin (protein)

    Noggin_(protein)

  • Bone morphogenetic protein 5

    • Protein-coding gene in the species Homo sapiens

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    Bone morphogenetic protein 5

    Bone morphogenetic protein 5

    Bone_morphogenetic_protein_5

  • BMPR1A

    • Bone morphogenetic protein receptor

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    BMPR1A

    BMPR1A

    BMPR1A

  • SMAD3

    • Protein-coding gene in humans

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    SMAD3

    SMAD3

    SMAD3

  • Activin type 2 receptors

    • Protein family

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    Activin type 2 receptors

    Activin_type_2_receptors

  • Poly(A)-specific ribonuclease

    • Protein-coding gene in the species Homo sapiens

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    Poly(A)-specific ribonuclease

    Poly(A)-specific ribonuclease

    Poly(A)-specific_ribonuclease

  • Left-right determination factor 2

    • Protein-coding gene in humans

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    Left-right determination factor 2

    Left-right determination factor 2

    Left-right_determination_factor_2

  • Bone morphogenetic protein 10

    • Protein-coding gene in the species Homo sapiens

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    Bone morphogenetic protein 10

    Bone morphogenetic protein 10

    Bone_morphogenetic_protein_10

  • Decorin

    • Protein-coding gene in humans

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    Decorin

    Decorin

    Decorin

  • Thrombospondin 1

    • Protein-coding gene in the species Homo sapiens

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    Thrombospondin 1

    Thrombospondin 1

    Thrombospondin_1

  • GDF6

    • Protein-coding gene in the species Homo sapiens

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    GDF6

    GDF6

    GDF6

  • ACVRL1

    • Protein-coding gene in humans

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    ACVRL1

    ACVRL1

    ACVRL1

  • SMAD7

    • Protein-coding gene in the species Homo sapiens

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    SMAD7

    SMAD7

    SMAD7

  • SB-431542

    • Chemical compound

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    SB-431542

    SB-431542

    SB-431542

  • SMAD5

    • Protein-coding gene in the species Homo sapiens

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    SMAD5

    SMAD5

    SMAD5

  • Nodal homolog

    • Mammalian protein found in Homo sapiens

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    Nodal homolog

    Nodal homolog

    Nodal_homolog

  • Bone morphogenetic protein 8B

    • Protein-coding gene in the species Homo sapiens

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    Bone morphogenetic protein 8B

    Bone morphogenetic protein 8B

    Bone_morphogenetic_protein_8B

  • ACVR1B

    • Protein-coding gene in humans

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    ACVR1B

    ACVR1B

    ACVR1B

  • ACVR1

    • Protein-coding gene

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    ACVR1

    ACVR1

    ACVR1

  • SMAD6

    • Protein-coding gene in the species Homo sapiens

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    SMAD6

    SMAD6

    SMAD6

  • SMAD9

    • Homolog protein

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    SMAD9

    SMAD9

  • Lerdelimumab

    • Monoclonal antibody

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    Lerdelimumab

    Lerdelimumab

  • TGF beta 2

    • Protein-coding gene in the species Homo sapiens

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    TGF beta 2

    TGF beta 2

    TGF_beta_2

  • GDF7

    • Protein-coding gene in the species Homo sapiens

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    GDF7

    GDF7

    GDF7

  • GDF3

    • Protein-coding gene in humans

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    GDF3

    GDF3

    GDF3

  • Activin type 1 receptors

    • Human biological material

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    Activin type 1 receptors

    Activin_type_1_receptors

  • TGF-beta receptor family

    • Family of proteins involved in a TGF signaling pathway

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    TGF-beta receptor family

    TGF-beta_receptor_family

  • ACVR1C

    • Protein-coding gene in the species Homo sapiens

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    ACVR1C

    ACVR1C

    ACVR1C

  • R-SMAD

    • Receptor regulated SMAD proteins

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    R-SMAD

    R-SMAD

  • INHBC

    • Protein-coding gene in the species Homo sapiens

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    INHBC

    INHBC

    INHBC

  • Bone morphogenetic protein 4

    • Human protein and coding gene

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    Bone morphogenetic protein 4

    Bone morphogenetic protein 4

    Bone_morphogenetic_protein_4

  • Spartalizumab

    • Monoclonal antibody

    Camidanlumab tesirine Carlumab Cemiplimab Dupilumab Eldelumab Emapalumab Fresolimumab Garadacimab Golimumab Ianalumab† Lanadelumab Lenzilumab Lerdelimumab

    Spartalizumab

    Spartalizumab

  • SMAD1

    • Protein-coding gene in the species Homo sapiens

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    SMAD1

    SMAD1

    SMAD1

  • Bone morphogenetic protein receptor

    • Group of three receptors to bone morphogenetic proteins

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    Bone morphogenetic protein receptor

    Bone_morphogenetic_protein_receptor

  • Transforming growth interacting factor

    • Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    Transforming growth interacting factor

    Transforming_growth_interacting_factor

  • Ascrinvacumab

    • Chemical compound

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    Ascrinvacumab

    Ascrinvacumab

  • I-SMAD

    • Inhibitory SMAD proteins

    Agonists: Avotermin GDF (10 (BMP3B), 11 (BMP11)) TGFβ (1, 2, 3) Antibodies: Fresolimumab Lerdelimumab Metelimumab Kinase inhibitors: A 83-01 D-4476 GW-788388

    I-SMAD

    I-SMAD

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