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Antibiotic
Daptomycin, sold under the brand name Cubicin among others, is a lipopeptide antibiotic used in the treatment of systemic and life-threatening infections
Daptomycin
methicillin-resistant Staphylococcus aureus (MRSA): Vancomycin Teicoplanin Linezolid Daptomycin Trimethoprim/sulfamethoxazole Doxycycline Ceftobiprole (5th generation)
List_of_antibiotics
Species of Gram-positive bacterium
tolerance to the lipopeptide antibiotic daptomycin and several other classes of antibiotics. Serum-induced daptomycin tolerance is due to two independent
Staphylococcus_aureus
Species of bacterium
whether microbes can become entirely tolerant of alcohol. Linezolid, daptomycin, and the streptogramins (e.g., quinupristin/dalfopristin) can have activity
Enterococcus_faecium
Species of bacterium
case of uncomplicated UTIs), linezolid, quinupristin, tigecycline and daptomycin, although ampicillin is preferred if the bacteria are susceptible.
Enterococcus_faecalis
Combination of two antibiotic drugs
Andes DR, Craig WA, Rybak MJ (June 2008). "Activities of clindamycin, daptomycin, doxycycline, linezolid, trimethoprim-sulfamethoxazole, and vancomycin
Trimethoprim/sulfamethoxazole
Species of bacterium
cause meningitis, although rare and sepsis. The antibiotics linezolid, daptomycin and gentamicin, levofloxacin, and penicillin G are effective against the
Enterococcus_gallinarum
Bacterial strains of Enterococcus that are resistant to the antibiotic vancomycin
agents such as contezolid, delpazolid, and sutezolid. The combination of daptomycin and ampicillin is another option to treat VRE infections, especially for
Vancomycin-resistant Enterococcus
Vancomycin-resistant_Enterococcus
Infection that results in the death of the body's soft tissue
gram-negative, and anaerobic bacteria. Often, a combination of clindamycin, daptomycin, IV vancomycin, and gentamicin is used. Gram-negative coverage may entail
Necrotizing_fasciitis
Pharmaceutical company in Denmark
2019, Xellia partnered with Civica Rx to produce generic Vancomycin and Daptomycin. The partnership's stated aim is to remedy chronic drug shortages that
Xellia
Bacterium responsible for difficult-to-treat infections in humans
potent antimicrobial activity. Linezolid, quinupristin/dalfopristin, daptomycin, ceftaroline, and tigecycline are used to treat more severe infections
Methicillin-resistant Staphylococcus aureus
Methicillin-resistant_Staphylococcus_aureus
Antimicrobial substance active against bacteria
clinical use in the late 2000s and early 2010s: cyclic lipopeptides (such as daptomycin), glycylcyclines (such as tigecycline), oxazolidinones (such as linezolid)
Antibiotic
the first oxazolidinone 2001 – telithromycin, the first ketolide 2003 – daptomycin 2005 – tigecycline, the first glycylcycline 2005 – doripenem 2009 – telavancin
Timeline_of_antibiotics
Genus of bacteria
the most important of these are: Chloramphenicol (from S. venezuelae) Daptomycin (from S. roseosporus) Fosfomycin (from S. fradiae) Lincomycin (from S
Streptomyces
Genus of bacteria
resistance to these last-resort antibiotics, including linezolid and daptomycin, is increasingly being reported, involving complex genetic mechanisms
Enterococcus
Chemical compound
antibiotics, including aminoglycosides, carbapenems, cephalosporins, daptomycin and oritavancin. Enzymes conferring resistance to fosfomycin have also
Fosfomycin
Antibiotic
that have different mechanisms of action, like vancomycin, linezolid, daptomycin, and tigecycline. Ampicillin can be administered by mouth, an intramuscular
Ampicillin
Cave in Eddy County, New Mexico, U.S.
found to be naturally resistant to many modern antibiotics, including daptomycin. The Denver Museum of Nature and Science filmed one of the first documentaries
Lechuguilla_Cave
Compound consisting of a short peptide chain conjugated with an acyl chain
developed as drugs with semaglutide being a prominent example. Bacillomycin Daptomycin Echinocandins (e.g., caspofungin) Iturin A Mycosubtilin Surfactin Hamley
Lipopeptide
Antibiotic resistant bacteria
be susceptible by in vitro testing. The agents that are used include daptomycin, linezolid, telavancin, ceftaroline, and quinupristin–dalfopristin. For
Vancomycin-resistant Staphylococcus aureus
Vancomycin-resistant_Staphylococcus_aureus
American pharmacist
Staphylococcus aureus (MRSA) isolates and evaluated the in vitro activities of daptomycin and vancomycin while monitoring the isolates for the development of resistance
Kerry_LaPlante
Chemical compound
methicillin-resistant Staphylococcus aureus with reduced susceptibility to linezolid, daptomycin or vancomycin. Ceftobiprole has also displayed potent activity against
Ceftobiprole
Peptide chains which contain a circular sequence of bonds
Examples include: Amanitins Bacitracin Colistin Ciclosporin Dactinomycin Daptomycin Gramicidin S Hymenistatin Microcystins Nisin Nodularin Octreotide Polymyxin
Cyclic_peptide
Biochemical assembly for transporting hydrophobic lipid molecules
and Lipopeptides - glycopeptidolipids, surfactin, iturnins, polymyxins, daptomycin". The LipidWeb. Retrieved 21 July 2019. Satyanarayana, U. (2002). Biochemistry
Lipoprotein
Chemical compound
days) or 7 days of once daily daptomycin. finding that a single dose brilacidin was comparable to 7 days of daptomycin. The primary endpoint was clinical
Brilacidin
Microbiology term
"Bactericidal agents in the treatment of MRSA infections--the potential role of daptomycin". Journal of Antimicrobial Chemotherapy. 58 (6): 1107–17. doi:10.1093/jac/dkl393
Minimum bactericidal concentration
Minimum_bactericidal_concentration
Antibiotic
Insert into bacterial cell wall causing perforation and depolarization: Daptomycin Surfactin Other Inhibits PG elongation and crosslinking: Ramoplanin§ Intracellular
Benzathine_benzylpenicillin
Protein covalently bonded to lipids
(Victoza®), and insulin detemir (Levemir®). The other two are the antibiotics daptomycin and polymyxin B. Lipidated peptides also have applications in other areas
Proteolipid
Agent which kills bacteria
monobactams, and carbapenems) and vancomycin. Also bactericidal are daptomycin, fluoroquinolones, metronidazole, nitrofurantoin, co-trimoxazole, telithromycin
Bactericide
Antibiotic medication
newer alternatives to vancomycin exist, such as linezolid (2000) and daptomycin (2003), the widespread use of vancomycin makes resistance to it a significant
Vancomycin
Class of antibacterial drugs, subgroup of quinolones
glycopeptides but remains lower compared to antibiotics such as tetracyclines, daptomycin, and fosfomycin, which demonstrate greater efficacy against biofilms.
Quinolone_antibiotic
Accumulation of eosinophil cells in the lungs
anti-inflammatory drugs (e.g., ibuprofen), nitrofurantoin, phenytoin, L-tryptophan, daptomycin and ampicillin, and drugs of abuse such as inhaled heroin and cocaine
Eosinophilic_pneumonia
Species of prokaryote
is a known human pathogen. For the few cases thus far, vancomycin or daptomycin has been used in tandem with rifampicin for a duration ranging from four
Corynebacterium_amycolatum
Antibiotic medication
a combination of two streptogramins, not active against E. faecalis); daptomycin (Cubicin, a lipopeptide); and ceftobiprole (Zevtera, a 5th-generation
Linezolid
Combination antibiotic medication
Insert into bacterial cell wall causing perforation and depolarization: Daptomycin Surfactin Other Inhibits PG elongation and crosslinking: Ramoplanin§ Intracellular
Aztreonam/avibactam
Pharmaceutical drug classification
Methenamine J01XX06 Mandelic acid J01XX07 Nitroxoline J01XX08 Linezolid J01XX09 Daptomycin J01XX10 Bacitracin J01XX11 Tedizolid J01XX12 Lefamulin J01XX13 Gepotidacin
ATC_code_J01
Class of antibiotic drugs
including, in 2000, linezolid of the oxazolidinone class, and in 2003 daptomycin of the lipopeptide class. Several derivatives of vancomycin are currently
Glycopeptide_antibiotic
Chemical compound
and Sean Brady. The group had been looking into antibiotics related to daptomycin and their calcium-dependent nature, but determined that it would be impractical
Malacidin
Chemical compound
Insert into bacterial cell wall causing perforation and depolarization: Daptomycin Surfactin Other Inhibits PG elongation and crosslinking: Ramoplanin§ Intracellular
Avibactam
Pharmaceutical compound
methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, daptomycin-nonsusceptible, and linezolid-nonsusceptible Staphylococcus aureus". Antimicrobial
Voxvoganan
Combination antibiotic drug
Insert into bacterial cell wall causing perforation and depolarization: Daptomycin Surfactin Other Inhibits PG elongation and crosslinking: Ramoplanin§ Intracellular
Ampicillin/sulbactam
Species of bacterium
Streptomyces filamentosus also produces the novel cyclic lipopeptide antibiotic daptomycin (US trade name: Cubicin). List of Streptomyces species LPSN bacterio.net
Streptomyces_filamentosus
Secondary metabolides
use. Antibiotics Actinomycin Bacitracin Calcium dependent antibiotic Daptomycin Vancomycin Teixobactin Tyrocidine Gramicidin Zwittermicin A Antibiotic
Nonribosomal_peptide
Species of pathogenic bacterium
imipenem, and piperacillin. It is resistant to vancomycin, chloramphenicol, daptomycin, gentamicin, netilmicin, polymyxin B, streptomycin, teicoplanin, tetracycline
Erysipelothrix_rhusiopathiae
Insert into bacterial cell wall causing perforation and depolarization: Daptomycin Surfactin Other Inhibits PG elongation and crosslinking: Ramoplanin§ Intracellular
Side_effects_of_penicillin
Chemical compound or substance produced by a living organism, found in nature
antibacterial and antifungal agents including amphotericin B, chloramphenicol, daptomycin and tetracycline (from Streptomyces spp.), the polymyxins (from Paenibacillus
Natural_product
Defunct American pharmaceutical company
wholly owned subsidiary of Merck & Co. The company developed Cubicin (daptomycin) for injection, the first antibiotic in a class of anti-infectives called
Cubist_Pharmaceuticals
Species of bacterium
Streptomyces-derived antibiotics include: Chloramphenicol (Streptomyces venezuelae) Daptomycin (Streptomyces roseosporus) Fosfomycin (Streptomyces fradiae) Lincomycin
Streptomyces_isolates
Group of chemical compounds
medical drugs and biocontrol agents (examples of such include β-lactams, daptomycin, echinocandins, emodepside, bleomycin, cyclosporine, and bialaphos). Peptaibols
Halovir
(INN)) dapiprazole (INN) dapitant (INN) dapoxetine (INN) dapsone (INN) daptomycin (INN) Daranide darapladib (USAN, INN) daratumumab (INN) Daraprim darbepoetin
List_of_drugs:_D–Dd
Class of peptides that have antimicrobial activity
Hepatitis C (oral, cyclic peptide) Dalbavancin, bacterial infections, IV Daptomycin, bacterial infections, IV Enfuvirtide, HIV, subcutaneous injection Oritavancin
Antimicrobial_peptides
cyclosporine MeSH D04.345.566.252 – dactinomycin MeSH D04.345.566.270 – daptomycin MeSH D04.345.566.297 – depsipeptides MeSH D04.345.566.297.500 – valinomycin
List_of_MeSH_codes_(D04)
Medical condition
abscess). Antibiotics, such as vancomycin, teicoplanin, tigecycline, daptomycin or linezolid are given for a minimum of three weeks to clear the infection
Pyomyositis
Classification of membrane proteins including ion channels
Amphipathic Channel-forming Peptide (l/S-SCP) Family 1.D.15 The Daptomycin (Daptomycin) Family 1.D.16 The Synthetic Amphipathic Pore-forming Heptapeptide
Transporter Classification Database
Transporter_Classification_Database
Pharmaceutical drug
Aboutaleb M, Sakoulas G, Rybak MJ (1 June 2015). "β-Lactam combinations with daptomycin provide synergy against vancomycin-resistant Enterococcus faecalis and
Oritavancin
Membrane proteins that adhere temporarily to membranes with which they are associated
neurotransmitter release. Fungal toxins Cyclic lipopeptide antibiotics Surfactin and daptomycin Peptaibols These peptides are characterized by the presence of an unusual
Peripheral_membrane_protein
Type of bacteria growth
synthesis inhibitors (e.g. bicyclomycin) and membrane disruptors (e.g. daptomycin, polymyxin B) cause filamentation too, but these filaments are much shorter
Filamentation
Antibiotic medication
reported to demonstrate in vitro synergistic activity when combined with daptomycin or ceftobiprole versus methicillin-resistant Staphylococcus aureus, vancomycin-resistant
Plazomicin
abarelix 183552-38-7 C72H100CoN18O17P cobamamide 13870-90-1 C72H101N17O26 daptomycin 103060-53-3 C72H104Na8O48S8 sugammadex 343306-79-6 C72H144 cyclodoheptacontane
List of compounds with carbon numbers 50+
List_of_compounds_with_carbon_numbers_50+
Chemical compound
Modulates Cyclic di-AMP Levels in Response to Cell Membrane Stress in Daptomycin-Resistant Enterococci". Antimicrobial Agents and Chemotherapy. 61 (3):
Cyclic_di-AMP
(2016-08-23). "Antimicrobial Cluster Bombs: Silver Nanoclusters Packed with Daptomycin". ACS Nano. 10 (8): 7934–7942. doi:10.1021/acsnano.6b03862. ISSN 1936-0851
Antibiotic_synergy
Molecular structure formed in DNA transcription
PMC 6392460. PMID 30625384. Vilhena, C.; Bettencourt, A. (1 March 2012). "Daptomycin: A Review of Properties, Clinical Use, Drug Delivery and Resistance".
Transcription_bubble
American biologist
(March 27, 2018). "Genetic Basis of Emerging Vancomycin, Linezolid, and Daptomycin Heteroresistance in a Case of Persistent Enterococcus faecium Bacteremia"
Andrew_Kasarskis
Bacterial infection of the prostate gland
for improved activity, including minocycline, tigecycline, linezolid, daptomycin, clindamycin, and vancomycin, have also been used limitedly off-label
Chronic_bacterial_prostatitis
Chemical compound
Insert into bacterial cell wall causing perforation and depolarization: Daptomycin Surfactin Other Inhibits PG elongation and crosslinking: Ramoplanin§ Intracellular
Carumonam
vitro characterisation of an oral self-emulsifying delivery system for daptomycin". European Journal of Pharmaceutical Sciences. 81: 129–136. doi:10.1016/j
Self-microemulsifying drug delivery system
Self-microemulsifying_drug_delivery_system
Canadian chemist
2006). "Mode of action of the new antibiotic for Gram-positive pathogens daptomycin: comparison with cationic antimicrobial peptides and lipopeptides". Biochimica
Suzana_Straus
Chemical compound
Insert into bacterial cell wall causing perforation and depolarization: Daptomycin Surfactin Other Inhibits PG elongation and crosslinking: Ramoplanin§ Intracellular
Cefozopran
Chemical compound
Insert into bacterial cell wall causing perforation and depolarization: Daptomycin Surfactin Other Inhibits PG elongation and crosslinking: Ramoplanin§ Intracellular
Epicillin
cyclotides MeSH D12.644.641.252 – dactinomycin MeSH D12.644.641.270 – daptomycin MeSH D12.644.641.297 – depsipeptides MeSH D12.644.641.297.500 – valinomycin
List_of_MeSH_codes_(D12.644)
DAPTOMYCIN
DAPTOMYCIN
DAPTOMYCIN
DAPTOMYCIN
Girl/Female
Indian
Handsome woman
Girl/Female
American, British, English, Latin
Crowned with Laurels; The Laurel Tree; Sweet Bay Tree Symbolic of Honor and Victory; The Bay; Laurel
Boy/Male
Gaelic
Wealthy or stubborn.
Boy/Male
Italian Greek
Resurrection.
Girl/Female
Slavic
Beloved.
Surname or Lastname
English
English : variant spelling of Hildebrand.
Surname or Lastname
English
English : from the Middle English vernacular form of the personal name Barnabas, which was borne by the companion of St Paul (Acts 4:36). This is of Aramaic origin, from Barnabia ‘son of Nabia’, a personal name perhaps meaning ‘confession’.English : habitational name from Barnaby in North Yorkshire, named with the Old English personal name Beornwald (composed of the elements beorn ‘young warrior’ + wald ‘rule’) + Old Norse býr ‘settlement’.
Boy/Male
Anglo, Australian, Dutch
Like an Eagle
Girl/Female
Tamil
Amilzha | அமீலà¯à®œà¯à®¹à®¾
Girl/Female
Hindu, Indian
The Epitome of Power; Strength; Courage; Determination; Ultimate Masculinity
DAPTOMYCIN
DAPTOMYCIN
DAPTOMYCIN
DAPTOMYCIN
DAPTOMYCIN