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Type of protist cell
An amastigote is a protist cell that does not have visible external flagella or cilia. The term is used mainly to describe an intracellular phase in the
Amastigote
Group of single-celled parasitic organisms
example, the amastigote (prefix "a-", meaning no flagellum) form is also known as the leishmanial form as all Leishmania have an amastigote life cycle stage
Trypanosomatida
Species of parasitic euglenoids (protozoans)
metacyclic trypomastigotes invade host cells and transform into amastigotes. Amastigotes are intracellular, rounded forms with a short flagellum; they multiply
Trypanosoma_cruzi
Species of intracellular parasite
amastigotes. Granulocytes selectively kill the promastigotes by oxidative mechanism, while amastigotes are resistant. Then the surviving amastigotes undergo
Leishmania_donovani
Human disease caused by protist parasites
called an amastigote, which is round, non-motile, and only 3–7 micrometers in diameter. Inside the stomach of the sandfly, the amastigotes quickly transform
Visceral_leishmaniasis
Name of several types of blood-sucking fly
pancytopenia. It can be diagnosed through microscopic review by visualizing amastigotes in containing macrophages, and is treatable with sodium stibogluconate
Sandfly
microbiology is a culture medium used to grow Leishmania – needed when the amastigotes are not found in sufficient quantities by scraping the growth substrate
Novy–MacNeal–Nicolle_medium
Species of parasitic protist
host. When macrophages phagocytize the parasite, it transitions into its amastigote form, rapidly dividing to break the host cell open and infect other mononuclear
Leishmania_mexicana
Mammal parasitic disease
into a replicative form called an amastigote, which undergoes several rounds of replication. The replicated amastigotes transform back into trypomastigotes
Chagas_disease
Genus of parasitic flagellate protist in the Kinetoplastea class
invertebrate hosts. At different points in its life-cycle, it passes through amastigote, promastigote, and epimastigote phases; the last is particularly characteristic
Crithidia
Disease caused by parasites of the Leishmania type
puncture wound are phagocytized by macrophages, and transform into amastigotes. Amastigotes multiply in infected cells and affect different tissues, depending
Leishmaniasis
Genus of parasitic flagellate protist in the Kinetoplastea class
invertebrate host. Intracellular lifecycle stages are normally found in the amastigote form. The trypomastigote morphology is unique to species in the genus
Trypanosoma
Species of parasitic protist
macrophages. Following engulfment, promastigotes differentiate into amastigotes. Amastigotes are oval or round, and have a diameter between 2 and 3 μm. Additionally
Leishmania_major
Chemical compound
26-Azasterol, a Δ24(25)-Sterol Methyltransferase Inhibitor, on Promastigote and Amastigote Forms of Leishmania amazonensis". Antimicrob Agents Chemother. 46 (2):
5-Dehydroepisterol
Genus of parasitic flagellate protist
stage of their life cycle, they exist in two structural variants, as: The amastigote form is found in the mononuclear phagocytes and circulatory systems of
Leishmania
Genus of flies
similar between all Leishmania species, with the sandfly taking up the amastigote form of the parasite following a bite of an infected host. However, unlike
Lutzomyia
species Leishmaniasis Hematology laboratory by direct visualization of the amastigotes (Leishman–Donovan bodies). For visceral leishmaniasis in India, South
List_of_infectious_diseases
Species of parasitic flagellate protist in the Kinetoplastea class
flagellum for motility, and the attached, immotile, amastigote form in the mosquito gut. Amastigotes excreted in the faeces contaminate the mosquito habitat;
Crithidia_fasciculata
Cells that ingest harmful matter within the body
Leishmania tropica amastigotes (arrows) in a macrophage from skin
Phagocyte
Use of laboratory and field experiments to explore evolutionary dynamics
on the status of the experiments. Bussotti and collaborators isolated amastigotes from Leishmania donovani and cultured them in vitro for 3800 generations
Experimental_evolution
Species of mammal native to Africa
with Leishmania aethiopia. However, there were no visible lesions and no amastigote stage parasites present, thus indicating that the bush hyrax is a reservoir
Yellow-spotted_rock_hyrax
Extinct genus of parasitic flagellate protist in the Kinetoplastea class
2004 by George Poinar Jr. and Robert Poinar in the journal Protist from amastigotes, promastigotes and paramastigotes preserved with a blood engorged female
Paleoleishmania
Medical condition
fine-needle aspiration of the lesion is confirmatory with identification of amastigote form of Leishmania. The gold standard for diagnosis is a polymerase chain
Cutaneous_leishmaniasis
Parasitic disease in cats
vertebrate, it ingests macrophages containing amastigotes. Inside the gut of the fly, the amastigotes transform back into promastigotes, developing their
Feline_leishmaniosis
Species of parasitic protist
Leishmania infantum Several Leishmania infantum amastigotes in a bone marrow smear from a naturally infected dog Scientific classification Domain: Eukaryota
Leishmania_infantum
Functions of nitric oxide in organisms
Hockmeyer JT, Meltzer MS, Nacy CA (December 1990). "Leishmania major amastigotes initiate the L-arginine-dependent killing mechanism in IFN-gamma-stimulated
Biological functions of nitric oxide
Biological_functions_of_nitric_oxide
Cytoplasmic body from the fusion of the phagosome and lysosome
for its synthesis of nucleic acids and proteins. Similarly, when in its amastigote stage, Leishmania obtains all its purine sources, various vitamins, and
Phagolysosome
Species of protozoan parasite
first being the promastigote, which develops inside the vector, and the amastigote which resides within the phagolysosomes of rye host macrophages Animals
Leishmania_amazonensis
Parasitic disease caused by a protozoan
has a quick onset, the trypanosomes enter the bloodstream, they become amastigotes, and replicate. Acute Chagas disease can be treated using benznidazole
Protozoan_infection
Phospholipid antimicrobial drug
primarily acts on Leishmania by affecting the species's promastigote and amastigote stages. Miltefosine exerts its activity by interacting with lipids, inhibiting
Miltefosine
Cyst-like sac growth lacking an epithelial or endothelial cell lining
neurological tissue. Within these pseudocysts the parasites enter their amastigote stage, reproducing asexually, before rupturing from the pseudocyst and
Pseudocyst
Class of neurotransmitters
Hockmeyer JT, Meltzer MS, Nacy CA (December 1990). "Leishmania major amastigotes initiate the L-arginine-dependent killing mechanism in IFN-gamma-stimulated
Gasotransmitter
Genus of parasitic flagellate protist in the Kinetoplastea class
promastigote with some paramastigotes in the phloem and lacticiferous tubes, and amastigote form in the latex. However, most of the species are mainly observed in
Phytomonas
Extinct species of fly
Paleoleishmania neotropicum amastigotes in proboscis of L. adiketis
Lutzomyia_adiketis
Species of fly
host, the infectious promastigotes utilize glucose to phagocytize into amastigotes that will undergo mitosis and infect other host cells. For the host,
Phlebotomus_papatasi
Argentine glycobiologist
glycoconjugates in tissue culture trypomastigotes and intracellular amastigotes of Trypanosoma cruzi". Molecular and Biochemical Parasitology. 21 (1):
Armando_J._Parodi
Species of Kinetoplastea
fluids transforming into amastigotes 6. The amastigotes then begin to reproduce asexually through binary fission 7. amastigotes turn into trypomastigotes
Trypanosoma_melophagium
Protein-coding gene in humans
in the host cell. LdBPK_351030.1 is active in both promastigotes and amastigotes. LmCK1.2 can be inhibited by the CK1-specific inhibitor D4476 and is
CSNK1D
Species of protozoan parasite
Leishmania species alternate between two main life forms: intracellular amastigotes in the sandfly – the vector – and extracellular motile promastigotes
Leishmania_tropica
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