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Phospholipid antimicrobial drug
Miltefosine, sold under the trade name Impavido among others, is a medication mainly used to treat leishmaniasis and infectious diseases caused by Naegleria
Miltefosine
Rare and usually fatal brain infection by a protist
United States utilized the medication miltefosine. In one of the cases, a 12-year-old girl was given miltefosine and targeted temperature management to
Primary amoebic meningoencephalitis
Primary_amoebic_meningoencephalitis
Type of skin lesion
necrosing portions. There is weak evidence, from one study, that 6% miltefosine solution applied topically on superficial fungating breast lesions of
Fungating_lesion
Rare and usually fatal brain infection by certain amoebae
seizures, coma, risk of death Causes Acanthamoeba spp., Balamuthia mandrillaris, and Sappinia pedata Medication Nitroxoline, miltefosine, azole antifungals
Granulomatous amoebic encephalitis
Granulomatous_amoebic_encephalitis
Human disease caused by protist parasites
Diseases initiative (DNDi) in 2010. Miltefosine is the first oral treatment for this disease. The cure rate of miltefosine in Phase III clinical trials is
Visceral_leishmaniasis
Pharmaceutical fungicide or fungistatic used to treat and prevent mycosis
discontinued due to the emergence of antifungals with fewer side effects Miltefosine works by damaging fungal cell membranes Nikkomycin – blocks formation
Antifungal
Disease caused by parasites of the Leishmania type
paromomycin is recommended. These, however, can have significant side effects. Miltefosine, an oral medication, is effective against both visceral and cutaneous
Leishmaniasis
"Treatment of Granulomatous Amoebic Encephalitis with Voriconazole and Miltefosine in an Immunocompetent Soldier". The American Journal of Tropical Medicine
List of human disease case fatality rates
List_of_human_disease_case_fatality_rates
Species of protozoa
fatality rate is greater than 97%. New treatments are being sought. Miltefosine, an antiparasitic drug that inhibits the pathogen via disrupting its
Naegleria_fowleri
Complication of leishmaniasis
control remain unsolved and deserve urgent attention.[citation needed] Miltefosine is the only available oral medication available for VL and PKDL. While
Post-kala-azar dermal leishmaniasis
Post-kala-azar_dermal_leishmaniasis
Species of intracellular parasite
and its chronic effect is nephrotoxicity. In 1999, an anticancer drug miltefosine was demonstrated to be highly effective (95% cure rate) among Indian
Leishmania_donovani
Pharmaceutical drug
leishmaniasis of the cutaneous, visceral, and mucosal types. Some combination of miltefosine, paromomycin and liposomal amphotericin B, however, may be recommended
Sodium_stibogluconate
Class of medications
Trichomonas) Tinidazole (for intestinal infections caused by Giardia lamblia) Miltefosine (for the treatment of visceral and cutaneous leishmaniasis, currently
Antiparasitic
Antiretroviral vaginal ring
(EGCG) Foscarnet Fosdevirine† Griffithsin Hydroxycarbamide KP-1461† Miltefosine North-methanocarbathymidine Portmanteau inhibitors Scytovirin Seliciclib†
Dapivirine_Ring
Chemical compound
residual leukemic cells from bone marrow transplants. It is an analog of miltefosine and perifosine. Edelfosine apoptosis-inducing abilities were studied
Edelfosine
Medical measurement formula
amphotericin B (5/7), azoles (6/7), rifampin (6/7), azithromycin (4/7), miltefosine (4/7), and dexamethasone (5/7). The median time from symptom onset to
Case_fatality_rate
14th Chief Election Commissioner of Bangladesh
of the Ministry of Health and Family Welfare. He stopped the usage of Miltefosine in Bangladesh. He introduced Hib vaccine in Bangladesh. Uddin retired
AMM_Nasir_Uddin
Brazil's federal drug control statute
61-01-8 , CID 18847 from PubChem) Methoxyflurane Mianserin Milnacipran Miltefosine Minaprine Mirtazapine Misoprostol - Hospital authorization only. Moclobemide
Brazilian Controlled Drugs and Substances Act
Brazilian_Controlled_Drugs_and_Substances_Act
Species of fluke
other commonly used anthelmintics such as albendazole, artesunate, and miltefosine are found to be effective on the cercariae but not on the metacercariae
Opisthorchis_viverrini
Class of prescription drugs in India
MICONAZOLE 324. MIDAZOLAM 325. MIFEPRISTONE 326. MILRINONE LACTATE 327. MILTEFOSINE 328. MINOCYCLINE 329. MINOXIDIL 330. MIRTAZAPINE 331. MISOPROSTOL 332
Schedule_H
Formulary by the World Health Organization
Ribavirin Diloxanide Metronidazole Amphotericin B Meglumine antimoniate Miltefosine Paromomycin Sodium stibogluconate Artemether Artemether/lumefantrine
WHO Model List of Essential Medicines
WHO_Model_List_of_Essential_Medicines
fowleri Primary amoebic meningoencephalitis (PAM) flagellation test Miltefosine, fluconazole, amphotericin B, posaconazole, voriconazole, targeted temperature
List_of_infectious_diseases
Class of chemical compounds
selective, sparing healthy cells. Several examples including edelfosine, miltefosine, and perifosine are under development as drugs against cancer and other
Alkyl-lysophospholipids
Antibiotic chemical compound
pentamidine, sulfadiazine, azithromycin, fluconazole, flucytosine, and miltefosine but progressed negatively. Therefore the regimen was complemented with
Nitroxoline
Chemical compound
when caused by the amoeba Balamuthia mandrillaris, in combination with miltefosine and fluconazole Arthropods Crusted scabies, when combined with topical
Albendazole
Diverse group of tropical infectious diseases which are common in developing countries
Coartem (by Novartis, for malaria); bedaquiline (by Janssen, for TB); and miltefosine (by Knight, for leishmaniasis). However, the success of the PRV system
Neglected_tropical_diseases
Chemical compound
cancer indications. It is an alkyl-phospholipid structurally related to miltefosine. Perifosine interrupts the PI3K/AKT/mTOR pathway by acting as an allosteric
Perifosine
Drug for treatment of leishmaniasis
widespread resistance to antimony has meant that liposomal amphotericin or miltefosine are now used in preference. Cardiotoxicity, reversible kidney failure
Pentavalent_antimonial
Indian academic
(Foxp3) regulatory T cells in human visceral leishmaniasis Trial of oral miltefosine for visceral leishmaniasis Determinants of survival in adult HIV patients
Shyam_Sundar
alternative therapy and other drugs are effective.[citation needed] Miltefosine is the only available oral medication available for VL and PKDL. While
Kala_azar_in_India
Co-packaged antiretroviral medication
(EGCG) Foscarnet Fosdevirine† Griffithsin Hydroxycarbamide KP-1461† Miltefosine North-methanocarbathymidine Portmanteau inhibitors Scytovirin Seliciclib†
Cabotegravir/rilpivirine
Pharmaceutical drug classification
Pentamidine isethionate P01CX02 Suramin sodium P01CX03 Eflornithine P01CX04 Miltefosine "ATC (Anatomical Therapeutic Chemical Classification System) – Synopsis"
ATC_code_P01
Non-profit organization
paromomycin and miltefosine as a second option at all levels; a policy also reflected in Bangladesh and Nepal. This removal of miltefosine monotherapy is
Drugs for Neglected Diseases Initiative
Drugs_for_Neglected_Diseases_Initiative
Veterinary medical products classification subgroup
QP51DX04 Isometamidium QP51DX05 Quinapyramine QP51DX06 Domperidone QP51DX07 Miltefosine QP51EX01 Imidocarb QP51EX02 Parvaquone QP51EX03 Buparvaquone Empty group
ATCvet_code_QP51
Set of three serine threonine-specific protein kinases
In 2010 Perifosine reached phase II. but it failed phase III in 2012. Miltefosine is approved for leishmaniasis and under investigation for other indications
Protein_kinase_B
Class of compounds
analogues are metabolically stable, and several ALPs such as edelfosine, miltefosine and perifosine are under research and development as drugs against cancer
Lysophosphatidylcholine
Class of chemical compounds
as protein kinase C and phospholipase C. A toxic ether lipid analogue miltefosine has recently been introduced as an oral treatment for the tropical disease
Ether_lipid
Species of fungus
to this treatment. Drugs that might also be of help are posaconazole, miltefosine and albaconazole. Albaconazole is in phase III clinical trials. Osteomyelitis
Lomentospora_prolificans
Medical condition
Calmette-Guerin vaccine. For L. panamensis, oral ketoconazole, oral miltefosine, and topical paromomycin + 12% methylbenzethonium chloride were shown
Cutaneous_leishmaniasis
randomised trial of two treatments involving liposomal amphotericin B and miltefosine for post-kala-azar dermal leishmaniasis in India and Bangladesh". PLOS
Randomised non-comparative trial
Randomised_non-comparative_trial
Parasitic disease caused by a protozoan
Only FDA approved for visceral leishmaniasis is amphotericin B and oral miltefosine for cutaneous and mucosal leishmaniasis diagnosis- tissue specimen, bone
Protozoan_infection
Topics referred to by the same term
Impavido or Impávido may refer to: Impavido, a brand name for the drug miltefosine Impávido, the Spanish title for the Spanish film Poker Face (2012 film)
Impavido
Weed control herbicide
sublimation. Analogues have been tried, and some show greater efficacy than miltefosine; all trifluralin analogues have the benefits of being non-hemolytic and
Trifluralin
Formulary
section. Diloxanide Metronidazole Amphotericin B Meglumine antimoniate Miltefosine Paromomycin Sodium stibogluconate Artemether Artemether/lumefantrine
WHO Model List of Essential Medicines for Children
WHO_Model_List_of_Essential_Medicines_for_Children
Species of Kinetoplastea
each time. When resistance is suspected an alternative treatment is miltefosine, some times associated with liposomal amphotericin. Leishmania braziliensis
Leishmania_braziliensis
Class of chemical compounds
phase or M phase in addition possessing the ability to induce apoptosis. Miltefosine Unger C, Sindermann H, Peukert M, Hilgard P, Engel J, Eibl H (1992).
Alkylphosphocholine
Milophene miloxacin (INN) Milprem milrinone (INN) milsaperidone (USAN, INN) miltefosine (INN) Miltown milverine (INN) milveterol hydrochloride (USAN) mimbane
List_of_drugs:_Meu–Mi
Colombian physician, epidemiologist and infectious disease specialist
in clinical trials evaluating the use of meglumine antimoniate versus miltefosine for the treatment of cutaneous leishmaniasis in adults and children.
Lyda_Osorio
Disease affecting dogs
antimony resistant L. infantum Amphotericin B Meglumine antimoniate Miltefosine Allopurinol Domperidone In the United States, research examining the
Canine_leishmaniasis
Parasitic disease in cats
used to treat CanL can be used in cats, particularly those containing miltefosine (Milteforan®), which contains propylene glycol as an excipient. In cats
Feline_leishmaniosis
Experimental antibody for HIV treatment
(EGCG) Foscarnet Fosdevirine† Griffithsin Hydroxycarbamide KP-1461† Miltefosine North-methanocarbathymidine Portmanteau inhibitors Scytovirin Seliciclib†
Semzuvolimab
Essink, DR; Ritmeijer, K (February 2019). "The safety and efficacy of miltefosine in the long-term treatment of post-kala-azar dermal leishmaniasis in
Neglected tropical diseases in India
Neglected_tropical_diseases_in_India
Indian molecular biologist
proteins, as a drug target to combat infection with Leishmania donovani, a Miltefosine-resistant type of trypanosome causing leishmaniasis. His work on myogenesis
Chinmoy_Sankar_Dey
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