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Cellular component of platelets
Alpha granules, (α-granules) also known as platelet alpha-granules are a cellular component of platelets. Platelets contain different types of granules
Alpha_granule
Medical condition
platelet alpha-granule deficiency, is a rare congenital autosomal recessive bleeding disorder caused by a reduction or absence of alpha-granules in blood
Gray_platelet_syndrome
are found only in platelets and are smaller than alpha granules. The origin of these dense granules is still unknown, however, it is thought that may
Dense_granule
Protein found in humans
Alpha-synuclein (aSyn) is a protein that in humans is encoded by the SNCA gene. It is a neuronal protein involved in the regulation of synaptic vesicle
Alpha-synuclein
Plasma proteins arranged in a fibrin matrix
PRF release several biologically active proteins including; platelet alpha granules, platelet‑derived growth factor (PDGF), transforming growth factors‑β
Platelet-rich_fibrin
Medical condition
deficient granules in platelets. Individuals with these disorders have too few or abnormally functioning alpha granules, delta granules, or both alpha and delta
Platelet storage pool deficiency
Platelet_storage_pool_deficiency
Mammalian protein found in humans
binding protein binding copper ion binding Cellular component platelet alpha granule extracellular vesicle endoplasmic reticulum lumen membrane plasma membrane
Factor_V
Mammalian protein found in humans
Alpha-1 antitrypsin or α1-antitrypsin (A1AT, α1AT, A1A, or AAT) is a protein belonging to the serpin superfamily. It is encoded in humans by the SERPINA1
Alpha-1_antitrypsin
Small particle, often in plants
Examples of granules include granulocytes, platelet granules, insulin granules, germane granules, starch granules, and stress granules. It is considered
Granule_(cell_biology)
Large plasma protein found in the blood
α2-Macroglobulin (α2M) or alpha-2-macroglobulin is a large (720 KDa) plasma protein found in the blood. It is mainly produced by the liver, and also locally
Alpha-2-Macroglobulin
Mammalian protein involved in blood clotting
VWF in endothelium (in the Weibel–Palade bodies) and megakaryocytes (α-granules of platelets). VWF is synthesized as a prepropeptide comprising 2813 amino
Von_Willebrand_factor
Blood-clotting protein
endoplasmic reticulum-Golgi intermediate compartment membrane platelet alpha granule lumen Golgi membrane extracellular space Biological process hemostasis
Factor_VIII
Mammalian protein found in Homo sapiens
N-terminal sequences (5-20) of thymosin beta 4 binds to monomeric actin in an alpha-helical conformation". Biochemical and Biophysical Research Communications
Thymosin_beta-4
Storage granules of endothelial cells
physiology is the alpha-granule of platelets, which also contains vWF. Weibel–Palade bodies are the main source of vWF, while α-granules probably play a
Weibel–Palade_body
Protein-coding gene in the species Homo sapiens
Serglycin, also known as hematopoietic proteoglycan core protein or secretory granule proteoglycan core protein, is a protein that in humans is encoded by the
Serglycin
Class of enzymes
enzyme class is NDP-glucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase. Other names in common use include granule-bound starch synthase, starch synthase
NDP-glucose—starch glucosyltransferase
NDP-glucose—starch_glucosyltransferase
Protein found in humans
vesicle insulin-like growth factor binding protein complex platelet alpha granule lumen insulin-like growth factor ternary complex alphav-beta3 integrin-IGF-1-IGF1R
Insulin-like_growth_factor_1
Protein found in humans
Alpha 1-antichymotrypsin (symbol α1AC, A1AC, or a1ACT) is an alpha globulin glycoprotein that is a member of the serpin superfamily. In humans, it is encoded
Alpha_1-antichymotrypsin
Protein involved in blood clotting, wound healing and inflammation
chemokine (C-X-C motif) ligand 4 (CXCL4) . This chemokine is released from alpha-granules of activated platelets during platelet aggregation, and promotes blood
Platelet_factor_4
Mammalian protein found in Homo sapiens
Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene. ITGA2B, also known as CD41, encodes integrin alpha chain 2b. Integrins are
Integrin_alpha_2b
Protein found in humans
stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified
Coagulation factor XIII A chain
Coagulation_factor_XIII_A_chain
Human gene coding for the GAS6 protein
component endoplasmic reticulum lumen cytoplasm Golgi lumen platelet alpha granule lumen extracellular exosome extracellular region intracellular anatomical
GAS6
Type of protein
of external side of plasma membrane extracellular exosome platelet alpha granule lumen extracellular space plasma membrane extrinsic component of plasma
Plasminogen_activator
Protein-coding gene in the species Homo sapiens
binding RNA binding phospholipase binding Cellular component platelet alpha granule membrane myelin sheath plasma membrane nucleoplasm terminal bouton mitochondrion
STXBP1
Protein-coding gene in the species Homo sapiens
member of the Sec1/Munc18 protein family, in megakaryocyte and platelet alpha-granule biogenesis". Blood. 106 (13): 4159–66. doi:10.1182/blood-2005-04-1356
VPS33B
Protein-coding gene in the species Homo sapiens
extracellular region basement membrane extracellular exosome platelet alpha granule lumen extracellular space endoplasmic reticulum lumen collagen Biological
TIMP1
Human protein
Fijalkowska I, Walkowiak B, Cierniewski CS (September 2001). "Acute phase protein alpha 1-acid glycoprotein interacts with plasminogen activator inhibitor type
Plasminogen activator inhibitor-1
Plasminogen_activator_inhibitor-1
Mammalian protein found in Homo sapiens
PMID 10567433. Altura BM (Jun 1975). "Pharmacological effects of alpha-methyldopa, alpha-methylnorepinephrine, and octopamine on rat arteriolar, arterial
Osteonectin
Component of blood aiding in coagulation
to maintain a discoid shape Organelle zone — rich in platelet granules. Alpha granules contain clotting mediators such as factor V, factor VIII, fibrinogen
Platelet
Protein-coding gene in the species Homo sapiens
the cytoplasm, plasma membrane, extracellular exosome, and platelet alpha granule lumen. Furthermore, the protein is known to play a role in platelet
ISLR
Protein-coding gene in the species Homo sapiens
member of the cadherin superfamily, interacts with protein phosphatase 1 alpha through its intracellular domain". FEBS Lett. 460 (1): 93–8. doi:10
PCDH7
Protein-coding gene in the species Homo sapiens
chain has been shown to interact with Lipoprotein(a). Fibrin Fibrinogen alpha chain Fibrinogen gamma chain GRCh38: Ensembl release 89: ENSG00000171564
Fibrinogen_beta_chain
Type-1 transmembrane protein
granules called Weibel-Palade bodies. In unactivated platelets P-selectin is stored in α-granules. Other names for P-selectin include CD62P, Granule Membrane
P-selectin
Protein that stimulates cell division and differentiation
extracellular region lysosomal membrane extracellular exosome platelet alpha granule lumen extracellular space clathrin-coated vesicle membrane plasma membrane
Epidermal_growth_factor
Protein involved in cell adhesion, cell growth, cell migration and differentiation
basement membrane apical plasma membrane extracellular exosome platelet alpha granule lumen endoplasmic reticulum-Golgi intermediate compartment extracellular
Fibronectin
Mammalian protein found in humans
fragments. It is commonly cleaved by proteases in the secretase family; alpha secretase and beta secretase both remove nearly the entire extracellular
Amyloid-beta precursor protein
Amyloid-beta_precursor_protein
Protein-coding gene in the species Homo sapiens
alpha granule blood microparticle plasma membrane fibrinogen complex extracellular region cell surface extracellular exosome platelet alpha granule lumen
Fibrinogen_gamma_chain
Protein-coding gene in the species Homo sapiens
fibrinogen, fibronectin, laminin, collagens types V and VII and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation
Thrombospondin_1
Protein-coding gene in humans
PMID 77677. Kaplan KL, Broekman MJ, Chernoff A, et al. (1979). "Platelet alpha-granule proteins: studies on release and subcellular localization". Blood. 53
CXCL7
Enzyme in human blood that degrades clots and other proteins
inflammatory responses. Plasmin has been shown to interact with Thrombospondin 1, Alpha 2-antiplasmin and IGFBP3. Moreover, plasmin induces the generation of bradykinin
Plasmin
Mammalian protein found in humans
platelet alpha granule membrane membrane raft cell junction plasma membrane extracellular exosome membrane extracellular space secretory granule membrane
CD31
Protein-coding gene in the species Homo sapiens
Fibrinogen alpha chain is a protein that in humans is encoded by the FGA gene. The protein encoded by this gene is the alpha component of fibrinogen,
Fibrinogen_alpha_chain
Protein-coding gene in the species Homo sapiens
Alpha-1-B glycoprotein is a 54.3 kDa protein in humans that is encoded by the A1BG gene. The protein encoded by this gene is a plasma glycoprotein of
Alpha-1-B_glycoprotein
Protein-coding gene in the species Homo sapiens
Kininogen-1 (KNG1), also known as alpha-2-thiol proteinase inhibitor, Williams-Fitzgerald-Flaujeac factor or the HMWK-kallikrein factor is a protein that
Kininogen_1
Protein-coding gene in the species Homo sapiens
cell types. TGF-β acts synergistically with transforming growth factor-alpha (TGF-α) in inducing transformation. It also acts as a negative autocrine
TGF_beta_1
Mammalian protein found in humans
CD36 forms part of a non-opsonic receptor (the scavenger receptor CD36/alpha-v beta-3 complex) and is involved in phagocytosis. CD36 has also been implicated
CD36
Protein-coding gene in the species Homo sapiens
structural constituent Cellular component extracellular matrix platelet alpha granule basement membrane extracellular region extracellular space collagen-containing
Thrombospondin-2
Albumin found in human blood
extracellular region endoplasmic reticulum extracellular exosome platelet alpha granule lumen nucleus extracellular space endoplasmic reticulum lumen protein-containing
Human_serum_albumin
Protein-coding gene in the species Homo sapiens
Alpha 2-antiplasmin (or α2-antiplasmin or plasmin inhibitor) is a serine protease inhibitor (serpin) responsible for inactivating plasmin. Plasmin is
Alpha_2-antiplasmin
Protein-coding gene in the species Homo sapiens
(1999). "Novel rabphilin-3-like protein associates with insulin-containing granules in pancreatic beta cells". J. Biol. Chem. 274 (40): 28542–8. doi:10.1074/jbc
SYTL4
Mammalian protein found in humans
(1986). "Molecular cloning of human C1 inhibitor: sequence homologies with alpha 1-antitrypsin and other members of the serpins superfamily". Gene. 42 (3):
C1-inhibitor
Protein found in humans
alpha-2-HS-glycoprotein (AHSG, Alpha-2-Heremans-Schmid Glycoprotein) also known as fetuin-A is a protein that in humans is encoded by the AHSG gene. Fetuin-A
Alpha-2-HS-glycoprotein
Protein-coding gene in the species Homo sapiens
membrane trans-Golgi network azurophil granule membrane Golgi apparatus cell junction platelet alpha granule intracellular membrane-bounded organelle
Vesicle-associated membrane protein 7
Vesicle-associated_membrane_protein_7
Mammalian protein found in Homo sapiens
exosome platelet alpha granule lumen nucleus extracellular space cytosol secretory granule lumen tertiary granule lumen ficolin-1-rich granule lumen sperm
Aldolase_A
Protein-coding gene in the species Homo sapiens
membrane endoplasmic reticulum membrane membrane mitochondrion platelet alpha granule membrane Biological process steroid metabolic process sterol biosynthetic
CYB5R1
Protein-coding gene in the species Homo sapiens
endoplasmic reticulum membrane extracellular region cytosol platelet alpha granule lumen early endosome membrane recycling endosome membrane Biological
VTI1B
Type of white blood cells
eosinophilic or "acid-loving" due to their large acidophilic cytoplasmic granules, which show their affinity for acids by their affinity to coal tar dyes:
Eosinophil
Gene of the species Homo sapiens
endoplasmic reticulum membrane endoplasmic reticulum membrane platelet alpha granule membrane plasma membrane Biological process peptidyl-cysteine oxidation
TMX3
Cytoplasmic biomolecular condensates of proteins and RNA occurring in cells under stress
In cellular biology, stress granules are biomolecular condensates in the cytosol composed of proteins and RNA that assemble into 0.1–2 μm membraneless
Stress_granule
Vitamin K-dependent plasma glycoprotein synthesized in the liver
1990). "Intron-exon organization of the active human protein S gene PS alpha and its pseudogene PS beta: duplication and silencing during primate evolution"
Protein_S
Glycoprotein
plasma membrane extracellular region extracellular exosome platelet alpha granule lumen cell surface collagen-containing extracellular matrix Biological
Histidine-rich_glycoprotein
Protein-coding gene in humans
defect in the secretion of the granule contents in neutrophils. There are other causes for a congenital platelet alpha-granule-deficient bleeding disorder
GATA1
Protein-coding gene in the species Homo sapiens
Horsewood P, Stead RH, Podor TJ, et al. (1993). "Multimerin is found in the alpha-granules of resting platelets and is synthesized by a megakaryocytic cell line"
Multimerin_1
Signaling glycoprotein regulating cell proliferation
functional heterodimers. Though PDGF is synthesized, stored (in the alpha granules of platelets), and released by platelets upon activation, it is also
Platelet-derived growth factor
Platelet-derived_growth_factor
Protein-coding gene in humans
Cellular component extracellular matrix extracellular region platelet alpha granule lumen extracellular space collagen-containing extracellular matrix Biological
Left-right determination factor 2
Left-right_determination_factor_2
Medical condition
syndrome Caused by calpain defect: Montreal platelet syndrome Caused by alpha granules defect: gray platelet syndrome Characterized by abnormal neutrophil
Giant_platelet_disorder
Protein-coding gene in the species Homo sapiens
an alpha-helix that is tightly packed on a triple-stranded beta-sheet. The E2 domain is the largest subdomain of APLP2 and consists of six alpha-helixes
APLP2
Protein-coding gene in the species Homo sapiens
Alpha-1-acid glycoprotein 1 is a protein that in humans is encoded by the ORM1 gene. This gene encodes a key acute phase plasma protein. Because of its
ORM1
Protein-coding gene in the species Homo sapiens
(2005). "A TREM family member, TLT-1, is found exclusively in the alpha-granules of megakaryocytes and platelets". Blood. 104 (4): 1042–7. doi:10
TREML1
Aggregation of platelets formed during early stage of coagulation
the dense granules and alpha granules. From the dense granules, serotonin and adenosine diphosphate are released. From the alpha granules come molecules
Platelet_plug
Protein-coding gene in the species Homo sapiens
vesicle extrinsic component of external side of plasma membrane platelet alpha granule extracellular matrix cytosol neuromuscular junction extracellular region
SERPINE2
Post-translational modification involving the monoamine serotonin
small GTPases is a signal transduction pathway that triggers platelet alpha-granule release. Cell. 115(7):851-62.doi:10.1016/S0092-8674(03)01014-6 PMID 14697203
Serotonylation
Blood product used in transfusion medicine
thrombin or calcium chloride, which induce the release of the factors from alpha granules. The addition of thrombin or calcium chloride is not required as natural
Platelet-rich_plasma
Protein-coding gene in the species Homo sapiens
intracellular membrane-bounded organelle extracellular region platelet alpha granule lumen Biological process platelet degranulation biological process translational
GTP_binding_protein_2
Protein involved in blood vessel growth
cytoplasm membrane extracellular region cell surface secretory granule platelet alpha granule lumen extracellular space extracellular matrix Biological process
Vascular endothelial growth factor A
Vascular_endothelial_growth_factor_A
Process of formation of blood clots
complex), gray platelet syndrome (deficient alpha granules), and delta storage pool deficiency (deficient dense granules). Most are rare. They predispose to hemorrhage
Coagulation
Protein found in humans
mitochondrion endoplasmic reticulum extracellular exosome platelet alpha granule lumen nucleus cytoplasmic vesicle intracellular anatomical structure
Clusterin
Medical condition
platelet alpha-granules and their constituents." The defect in GPS is the failure of megakaryocytes to package secretory proteins into alpha-granules. Patients
Pseudo_gray_platelet_syndrome
Protein-coding gene in the species Homo sapiens
Alpha-actinin-4 is a protein that in humans is encoded by the ACTN4 gene. Alpha actinins belong to the spectrin gene superfamily which represents a diverse
Alpha-actinin-4
Movement of white blood cells out of blood vessels and towards the inflamed site
KL, Marshall-Carlson L, Bainton DF (July 1989). "GMP-140, a platelet alpha-granule membrane protein, is also synthesized by vascular endothelial cells
Leukocyte_extravasation
Human protein-encoding gene
been shown to trigger platelet activation and aggregation. It forms an alphaIIbbeta3-CD9-CD63 complex on the surface of platelets that interacts directly
CD9
Mammalian protein found in Homo sapiens
necrosis factor alpha. In response to stress, TIA1 translocates from the nucleus to the cytoplasm, where it nucleates a type of RNA granule, termed the stress
TIA1
Protein-coding gene in the species Homo sapiens
bridge extracellular region platelet alpha granule lumen extracellular space specific granule lumen tertiary granule lumen endoplasmic reticulum lumen Biological
QSOX1
Protein-coding gene in humans
W, et al. (2002). "Cell surface antigen CD109 is a novel member of the alpha(2) macroglobulin/C3, C4, C5 family of thioester-containing proteins". Blood
CD109
bioactive molecules. Alpha-glucan was used in conjunction with modified starch molecules that contained porous starch granules via hydrolysis with amylotic
Alpha_glucan
Protein-coding gene in the species Homo sapiens
extracellular matrix T-tubule plasma membrane secretory granule cell surface soma platelet alpha granule lumen nucleus extracellular region extracellular space
Transforming growth factor, beta 3
Transforming_growth_factor,_beta_3
Protein-coding gene in the species Homo sapiens
(TGF-beta) to pregnancy zone protein (PZP). Comparison to the TGF-beta-alpha 2-macroglobulin interaction". Eur. J. Biochem. 221 (2): 687–93. doi:10.1111/j
TGF_beta_2
Mammalian protein found in Homo sapiens
chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners
Integrin_beta_3
Protein-coding gene in the species Homo sapiens
membrane intracellular anatomical structure extracellular region platelet alpha granule lumen extracellular space Biological process negative regulation of
Vascular endothelial growth factor B
Vascular_endothelial_growth_factor_B
Protein-coding gene in the species Homo sapiens
component cytoplasm platelet alpha granule cytosol membrane tertiary granule plasma membrane basolateral plasma membrane specific granule apical plasma membrane
Syntaxin_binding_protein_3
Growth factor protein found in humans
receptor binding Cellular component extracellular region membrane platelet alpha granule lumen extracellular space Biological process negative regulation of
Vascular endothelial growth factor C
Vascular_endothelial_growth_factor_C
Protein-coding gene in the species Homo sapiens
component membrane integral component of membrane plasma membrane platelet alpha granule membrane cellular component Biological process platelet degranulation
LHFPL2
Protein
best-characterized platelet-specific proteins. β-TG and PF4 are stored in platelet alpha granules and are released during platelet activation. As a result, they are useful
Β-Thromboglobulin
Mammalian protein found in Homo sapiens
et al. (2002). "Stomatin is a major lipid-raft component of platelet alpha granules". Blood. 100 (3): 897–904. doi:10.1182/blood.V100.3.897. PMID 12130500
Stomatin
Glucose polymer used as energy store in plants
in the form of starch, which is packed into semicrystalline granules called starch granules or amyloplasts. Toward the end of the growing season, starch
Starch
Immune cell found in connective tissue
lives in connective or mucosal tissue and contains many small secretory granules for the storage and release of histamine, heparin and other mediators.
Mast_cell
Protein-coding gene in the species Homo sapiens
exosome membrane nucleus extracellular region cytoplasm cytosol platelet alpha granule lumen Biological process ATP metabolic process platelet degranulation
OLA1
Overview of and topical guide to immunology
Granuloma Acute-phase proteins Amyloid SAP SAA Positive Alpha 1-antichymotrypsin Alpha 1-antitrypsin Alpha 2-macroglobulin C-reactive protein Ceruloplasmin C3
Outline_of_immunology
Protein-coding gene in humans
component membrane extracellular region nucleus nucleolus cytosol platelet alpha granule lumen Biological process platelet degranulation female pregnancy renal
MAGED2
Human protein
introns. The genetic code of protein C inhibitor is similar to alpha 1-antitrypsin and alpha 1-antichymotrypsin. The in vivo half time degradation of protein
Protein_C_inhibitor
ALPHA GRANULE
ALPHA GRANULE
Girl/Female
Greek American
Firstbom.' The first letter of the Greek alphabet.
Girl/Female
English American
Healer.
Girl/Female
Indian
Loving
Boy/Male
Tamil
First letter of the greek alphabet
Girl/Female
Arabic
Respectable
Boy/Male
Hindu
First letter of the greek alphabet
Girl/Female
American, British, English, Greek
Healer; With Healing Power
Girl/Female
Tamil
Little
Girl/Female
Indian
Little
Girl/Female
Gujarati, Hindu, Indian, Jain, Kannada, Malayalam, Marathi, Oriya, Sanskrit, Tamil, Telugu
Little; Collection of Many Small Things
Boy/Male
African, Australian, Chinese, French, Latin, Swedish
First Letter of the Greek Alphabet; Leader
Male
African
(ox); the first letter of the Greek alphabet.
ALPHA GRANULE
ALPHA GRANULE
ALPHA GRANULE
ALPHA GRANULE
ALPHA GRANULE
ALPHA GRANULE
ALPHA GRANULE