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Immune cell found in connective tissue
A mast cell (also known as a mastocyte or a labrocyte) is a resident cell that develops and lives in connective or mucosal tissue and contains many small
Mast_cell
Immunological condition
Mast cell activation syndrome (MCAS) is one type of mast cell activation disorder (MCAD). MCAS is an immunological condition in which mast cells, a type
Mast_cell_activation_syndrome
Category of pharmaceutical drugs
Mast cell stabilizers are medications used to prevent or treat certain allergic disorders. They block degranulation of mast cells, stabilizing it and
Mast_cell_stabilizer
Subtype of blood cell cancer
Mast cell leukemia is an extremely aggressive subtype of acute myeloid leukemia that usually occurs de novo but can, rarely, evolve from transformation
Mast_cell_leukemia
Small tumor composed of mast cells
A mastocytoma or mast cell tumor is a type of round-cell tumor consisting of mast cells. It is found in humans and many animal species; the term also can
Mastocytoma
Communications equipment location
placed on a raised structure (typically on a radio mast, or tower) to create a cell, or adjacent cells, in a cellular network. The base station structure
Cell_site
Skin disease characterized by red, raised, and itchy bumps
release of inflammatory mediators, including histamine from cutaneous mast cells, results in fluid leakage from superficial blood vessels. Hives may be
Hives
Immune disorder caused by proliferation of mast cells
type of mast cell disease, is a rare disorder affecting both children and adults caused by the accumulation of functionally defective mast cells (also called
Mastocytosis
Skin disorder
Symptoms are thought to be the result of histamine being released by mast cells on the surface of the skin. Despite the lack of antigens, histamine causes
Dermatographic_urticaria
Cancer tumor in dogs
A mastocytoma in dogs (or mast cell tumor in dogs) is a neoplasm (neoplasia) originating from mast cells in the domestic dog, which occurs mainly in the
Mastocytoma_in_dogs
Tumor composed of mast cells
Mast cell sarcoma is an extremely aggressive form of sarcoma made up of neoplastic mast cells. A sarcoma is a tumor made of cells from connective tissue
Mast_cell_sarcoma
Class of enzymes
granule-derived serine proteinase contained in mast cells and has been used as a marker for mast cell activation. Club cells contain tryptase, which is believed
Tryptase
Medical condition
seen in CSU is thought to be linked to the degranulation of skin mast cells. Mast cells release proteases, histamine, cytokines, and arachidonic acid metabolites
Chronic_spontaneous_urticaria
Medical condition
symptoms are due to the release of histamine and other active substances by mast cells, which stimulate dilation of blood vessels, irritate nerve endings, and
Allergic_conjunctivitis
Organic compound involved in immune responses
basophils and by mast cells found in nearby connective tissues. Histamine increases the permeability of the capillaries to white blood cells and some proteins
Histamine
Process by which cells lose secretory granules
some cells. It is used by several different cells involved in the immune system, including granulocytes (neutrophils, basophils, eosinophils, and mast cells)
Degranulation
Medical condition
Eosinophilic bronchitis (EB) is a type of airway inflammation due to excessive mast cell recruitment and activation in the superficial airways as opposed to the
Eosinophilic_bronchitis
Drug that blocks histamine or histamine agonists
H2-antihistamines. H1-antihistamines work by binding to histamine H1 receptors in mast cells, smooth muscle, and endothelium in the body as well as in the tuberomammillary
Antihistamine
Overreaction of the immune system to an antigen
it binds primarily to mast cells via the high-affinity IgE receptor (FcεRI) expressed on mast cells and basophils. Mast cells reside in the tissues (the
Hypersensitivity
Medical condition
Coombs classification in that the effector cell is also mast cell. In pseudoallergic reaction, the mast cell is directly activated, rather than through
Pseudoallergy
Physical effects resulting from activation of the immune system
immune cells already present in the involved tissue, mainly resident macrophages, dendritic cells, histiocytes, Kupffer cells and mast cells. These cells possess
Inflammation
Life-threatening allergic reaction
occur without an obvious reason. The mast cell disease mastocytosis, along with the mast cell disorder mast cell activation syndrome are both capable
Anaphylaxis
Category of white blood cells
polymorphonuclear granulocytes): Basophils Eosinophils Neutrophils Mast cells Except for the mast cells, their names are derived from their staining characteristics;
Granulocyte
Type of white blood cell
blood clotting, although there are less than that found in mast cell granules. Mast cells were once thought to be basophils that migrated from the blood
Basophil
Rare type of blood cancer
a group of cancers in which there is activation and growth of mutated cells in the bone marrow. This is most often associated with a somatic mutation
Primary_myelofibrosis
Drug used to treat asthma
methylxanthines/phosphodiesterase inhibitors, leukotriene receptor antagonists, mast cell stabilizers, and certain types of monoclonal antibodies. The Global Initiative
Anti-asthmatic_agent
American professional wrestler (born 1991)
November 4. In January 2024, Rodriguez revealed that she was diagnosed with mast cell activation syndrome, resulting in her absence from WWE programming. After
Raquel_Rodriguez_(wrestler)
Cells that ingest harmful matter within the body
dendritic cells, and mast cells. Their name comes from the Greek phagein, "to eat" or "devour", and "-cyte", the suffix in biology denoting "cell", from
Phagocyte
Functional gastrointestinal disorder
and mast cell stabilizers have shown efficacy in reducing pain associated with visceral hypersensitivity in IBS. There is a link between mast cell activity
Irritable_bowel_syndrome
Tumors that affect the blood, bone marrow, lymph, and lymphatic system
erythrocytes, thrombocytes, macrophages and mast cells; the lymphoid cell line produces B, T, NK and plasma cells. Lymphomas, lymphocytic leukemias, and myeloma
Tumors of the hematopoietic and lymphoid tissues
Tumors_of_the_hematopoietic_and_lymphoid_tissues
Mammalian protein found in Homo sapiens
production of mast cells, having less than 1% of the normal levels of mast cells. Conversely, the injection of SCF increases mast cell numbers near the
Stem_cell_factor
Type of allergic reaction
antibodies bind to FcεRI receptors on the surface of tissue mast cells and blood basophils. Mast cells and basophils coated by IgE antibodies are "sensitized"
Type_I_hypersensitivity
Protein-coding gene in the species Homo sapiens
cells). Genetic and pharmacological inactivation of p110δ has revealed that this enzyme is important for the function of T cells, B cell, mast cells and
P110δ
Greek-American physician-scientist and immunologist
1950) is a Greek-American physician-scientist whose research focuses on mast cell biology, neuroimmune interactions, and neuroinflammation. He is a professor
Theoharis_C._Theoharides
Antihistamine medication
Ketotifen is an antihistamine medication and a mast cell stabilizer used to treat allergic conditions such as conjunctivitis (pink eye), asthma, and hives
Ketotifen
Mammalian protein and protein-coding gene
tyrosine-protein kinase KIT, CD117 (cluster of differentiation 117) or mast/stem cell growth factor receptor (SCFR). Multiple transcript variants encoding
KIT_gene
German physician and scientist (1854–1915)
nourishment, and accordingly named these cells mast cells, (from the German word for an animal-fattening feed, Mast). This focus on chemistry was unusual
Paul_Ehrlich
Immunoglobulin E (IgE) Antibody
group 2-innate lymphoid cells (ILC2 or natural helper cells). Basophils share a common haemopoietic progenitor with mast cells; upon the cross-linking
Immunoglobulin_E
Redness of the face due to physiological conditions
reaction (caused by antibiotics) keratosis pilaris rubra faceii Kratom mast cell activation syndrome (MCAS) mastocytosis medullary thyroid cancer mixing
Flushing_(physiology)
Cancer of the myeloid line of blood cells
blood cells, characterized by the rapid growth of abnormal cells that build up in the bone marrow and blood and interfere with normal blood cell production
Acute_myeloid_leukemia
Type of blood cancer
cancer of the white blood cells. It is a form of leukemia characterized by the increased and unregulated growth of myeloid cells in the bone marrow and the
Chronic_myelogenous_leukemia
Surface protein important to the immune system
macrophages, neutrophils, eosinophils, basophils, human platelets, and mast cells – that contribute to the protective functions of the immune system. Its
Fc_receptor
Swiss breed of dog
Bellamy, E.; Berlato, D. (2022). "Canine cutaneous and subcutaneous mast cell tumours: a narrative review". Journal of Small Animal Practice. 63 (7):
Bernese_Mountain_Dog
Krystel-Whittemore M, Dileepan KN, Wood JG (2016). "Mast Cell: A Multi-Functional Master Cell". Frontiers in Immunology. 6: 620. doi:10.3389/fimmu.2015
List_of_immune_cells
Most common form of cutaneous mastocytosis
mast cells in the skin that produce hives or lesions on the skin when irritated. Urticaria pigmentosa is characterized by excessive amounts of mast cells
Urticaria_pigmentosa
Abnormally high heart rate after a postural change
(14%) Vasovagal syncope (13-25%) Inappropriate sinus tachycardia (11%) Mast cell activation disorder (9%) There are some overlaps between POTS and myalgic
Postural orthostatic tachycardia syndrome
Postural_orthostatic_tachycardia_syndrome
Medication used to treat allergic reactions
antihistamines, decongestants, corticosteroids, leukotriene pathway modifiers and mast cell stabilizers. Antihistamines and decongestants are generally the first-line
Anti-allergic_agent
Any cell which responds to stimuli and effects some change
marrow transplant Fibroblast, a cell that is most commonly found within connective tissue Mast cell, the primary effector cell involved in the development
Effector_cell
Loose or liquid bowel movements
Radiation enteropathy following treatment for pelvic and abdominal cancers. Mast cell activation syndrome (MCAS) Drug withdrawal side effect. Over 700 medications
Diarrhea
Cognitive disorder with an excessive, irrational dread of everyday situations
October 2023). "Neuropsychiatric Manifestations of Mast Cell Activation Syndrome and Response to Mast-Cell-Directed Treatment: A Case Series". J Pers Med
Anxiety_disorder
Medication that reduces stomach acid
can reduce the activation of mast cells and the subsequent release of inflammatory mediators, therefore acting as a mast cell stabilizer. However, while
Famotidine
Dog breed
including: Hip dysplasia is very rare but possible. Canine epilepsy Cancer (mast cell tumors, hemangiosarcoma, lymphoma) Sebaceous adenitis Responsible breeders
Vizsla
Tall structures designed to support antennas
(radio) Cell on wheels Cell site Folded unipole antenna (a newer type of mast antenna) Lattice tower (also lists radio towers built of wood) Mast radiator
Radio_masts_and_towers
Immune system response to a substance that most people tolerate well
immunoglobulin E antibodies (IgE) binding to an allergen and then to a receptor on mast cells or basophils, where they trigger the release of inflammatory chemicals
Allergy
Genus of eusocial wasp
induce histamine increase in victim tissue – because it does not cause mast cell degranulation – and is not immunogenic. Hornets, like many social wasps
Hornet
mast cell granule proteins by a process called degranulation, as well as the production of leukotrienes, prostaglandins and cytokines, by mast cells following
Allergic_inflammation
Chemical compound
cromoglycate (former BAN), or cromoglicate—is traditionally described as a mast cell stabilizer, and is commonly marketed as the sodium salt sodium cromoglicate
Cromoglicic_acid
Chemical compound
Nedocromil sodium is a medication considered a mast cell stabilizer which acts to prevent wheezing, shortness of breath, and other breathing problems
Nedocromil
Human biomolecule
disulfide bridges on mast cells and basophils. It lacks the beta subunit on other cells. It is constitutively expressed on mast cells and basophils and is
FCER1
Flow of stomach contents into the esophagus
attributable to changes in body mass index. GERD can be a symptom of mast cell activation syndrome (MCAS). Factors that have been linked with GERD, but
Gastroesophageal reflux disease
Gastroesophageal_reflux_disease
Redness of the skin or mucous membranes
massage, electrical treatment, acne medication, allergies, psoriasis, mast cell activation syndrome (MCAS), exercise, solar radiation (sunburn), photosensitization
Erythema
Class of enzymes
Chymases (EC 3.4.21.39, mast cell protease 1, skeletal muscle protease, skin chymotryptic proteinase, mast cell serine proteinase, skeletal muscle protease)
Chymase
Inflammation of the eye
should be treated. Allergic cases can be treated with antihistamines or mast cell inhibitor drops. Between three and six million people get acute conjunctivitis
Conjunctivitis
Perceived cardiac abnormality in which one's heartbeat can be felt
Brugada syndrome, and sinus tachycardia). Palpitations can be a symptom of mast cell activation syndrome (MCAS). Palpitation can be attributed to one of five
Palpitations
Medical symptom or condition
withdrawal Other Post-operative vomiting Nociception Altitude sickness Mast cell activation syndrome Drugs Chemotherapy Antibiotics Antiarrhythmics Digoxin
Nausea
Presumed set of adverse reactions
outside of cells after granule-to-granule and/or granule-to-plasma membrane fusions (Figures 1 and 2). Figure 1: Mediator release from mast cells Archived
Histamine_intolerance
Antibody isotype
anaphylaxis in mice through classic pathway by cross-linking IgE bound to the mast cell receptor FcεRI, stimulating the release of both histamine and platelet
Immunoglobulin_G
Protein-coding gene in the species Homo sapiens
proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix
CMA1
Abnormally low blood pressure
been used to treat high blood pressure. Hypotension can be a symptom of mast cell activation syndrome (MCAS). Orthostatic hypotension, also called postural
Hypotension
Spanish-American allergist
is a Spanish-American allergist who focuses on mast cell diseases, including mastocytosis, mast cell activation syndrome and hereditary alpha tryptasimia
Mariana_Castells
Medical condition
suspected of being commonly overlooked and therefore much more prevalent. Mast cell activation and release of inflammatory cytokines as well as other inflammatory
Kounis_syndrome
Monoclonal antibody medication
mast cells. An increasing series of papers have shown that IgE potentiates the activities of mast cells, while omalizumab can function as a mast cell-stabilizing
Omalizumab
22-amino acid residue peptide
Mast cell degranulating (MCD) peptide is a cationic 22-amino acid residue peptide, which is a component of the venom of the bumblebee (Megabombus pennsylvanicus)
MCD_peptide
Uncomfortable skin sensation
Uraemia – the itching sensation this causes is known as uremic pruritus mast cell activation syndrome (MCAS). fibromyalgia Drugs (such as opioids) that
Itch
Type of organic compounds
bites or allergens. It is released in granular form by mast cells, a type of white blood cell in connective tissues close to the site of interaction.
Histamine_liberators
Feeling of difficulty breathing
a result of vocal cord dysfunction (VCD). Dyspnea can be a symptom of mast cell activation syndrome (MCAS). Sarcoidosis is an inflammatory disease of
Shortness_of_breath
Group of genetic connective tissues disorders
aggregation failure (platelets do not clump together properly) Mast cell disorders (including mast cell activation syndrome and mastocytosis) Pregnancy complications:
Ehlers–Danlos_syndrome
Type of cells of the immunological system
include neutrophils, eosinophils, mast cells, basophils, and monocytes. Monocytes are further subdivided into dendritic cells and macrophages. Monocytes, macrophages
White_blood_cell
Kinase that plays a role in B cell development
successful immunoglobulin heavy chain rearrangement. It also has a role in mast cell activation through the high-affinity IgE receptor. BTK contains a PH domain
Bruton's_tyrosine_kinase
State of tiredness, exhaustion or loss of energy
or liver diseases, e.g., hepatitis; Low blood pressure; Lyme disease; mast cell activation syndrome; neurological disorders such as narcolepsy, Parkinson's
Fatigue
Biological system protecting an organism against disease
The other cells involved in the innate response include innate lymphoid cells, mast cells, eosinophils, basophils, and natural killer cells. Phagocytosis
Immune_system
Medical condition of the bladder and pelvic floor
counts of mast cells than healthy bladder walls. Mast cells, which contain histamine granules, respond to allergic stimuli. In this theory, Mast cells are activated
Interstitial_cystitis
Nasal inflammation due to allergens in the air
result in the release of inflammatory chemicals such as histamine from mast cells. It causes mucous membranes in the nose, eyes and throat to become inflamed
Allergic_rhinitis
Japanese manga series by Akane Shimizu
Killer T Cells do. He also has an antagonistic relationship with Mast Cell, as their combined functions only cause grave disasters for the other cells. Basophil
Cells_at_Work!
Tricyclic antidepressant
supposed to have effect on reducing mast cell degranulation, thus reducing pain and the symptoms associated with mast cell activation, such as IBS pain; people
Amitriptyline
Dog breed
gastrointestinal (6.9%) related issues. The breed is particularly predisposed to mast cell tumours, a cancer of the immune system. Median lifespan was 10.25 years
Boxer_(dog_breed)
Protein(s) forming a major part of an organism's immune system
particular cell triggers an effector function of that cell; phagocytes will phagocytose, mast cells and neutrophils will degranulate, natural killer cells will
Antibody
Development of hives after contact with water
formed by this interaction, the absorption of which causes perifollicular mast cell degranulation with release of histamine. Another proposed theory is of
Aquagenic_urticaria
Visible symptom of mastocytosis
red. This is a result of compression of mast cells, which are hyperactive in these diseases. These mast cells release inflammatory granules which contain
Darier's_sign
Autoimmune disease causing hives and itching
autoantibodies in the patient's immune system that target the body's own mast cells, leading to episodes of hives (urticaria). This immunologically distinct
Autoimmune_urticaria
Immunity strategy in living beings
initiated by cells already present in all tissues, mainly resident macrophages, dendritic cells, histiocytes, Kupffer cells, and mast cells. These cells present
Innate_immune_system
Small bright red dome-shaped bump on the skin
bromides, and cyclosporine. A significant increase in the density of mast cells has been seen in cherry hemangiomas compared with normal skin. The diagnosis
Cherry_angioma
Multipotent adult stem cells present in multiple tissues
PD-L2. MSCs have an effect on macrophages, neutrophils, NK cells, mast cells and dendritic cells in innate immunity. MSCs are able to migrate to the site
Mesenchymal_stem_cell
Protein-coding gene in the species Homo sapiens
of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal
RASGRP4
Enzyme found in humans
Carboxypeptidase A3 (mast cell carboxypeptidase A), also known as CPA3, is an enzyme which in humans is encoded by the CPA3 gene. The "CPA3" gene expression
CPA3
Formation of blood cellular components
Granulopoiesis (or granulocytopoiesis) is haematopoiesis of granulocytes, except mast cells which are granulocytes but with an extramedullar maturation. Thrombopoiesis
Haematopoiesis
Topics referred to by the same term
Look up MAST, Mast, mast, mast-, or masts in Wiktionary, the free dictionary. Mast, MAST or MASt may refer to: Mast (sailing), a vertical spar on a sailing
Mast
Skeletal disorder
mastocytosis, hemophilia, sickle-cell disease and thalassemia. Immune disorders: Osteoporosis can be a symptom of mast cell activation syndrome. Several inherited
Osteoporosis
Protein-coding gene in the species Homo sapiens
eosinophils, mast cells, and, to a lesser extent, basophils. It has thus garnered attention as a molecule that is uniquely expressed by immune effector cells involved
SIGLEC8
Anticoagulant
during pregnancy and breastfeeding. Heparin is produced by basophils and mast cells in all mammals. The discovery of heparin was announced in 1916. It is
Heparin
MAST CELL
MAST CELL
Female
Egyptian
, Child of Bast.
Male
Hebrew
(מַשָׂ×) Variant spelling of Hebrew Massa, MASA means "burden." Compare with another form of Masa.
Boy/Male
Muslim
Gul - flowers
Female
Egyptian
, The Good Maut.
Male
English
Short form of English Matthew, MATT means "gift of God."
Boy/Male
Indian
Gul - flowers
Female
Japanese
(1-æ£, 2-é›…, 3-昌, 4-真, 5-政, 6-å°†) Unisex short form of Japanese names beginning with Masa-, MASA means 1) "correct, just," 2) "elegant," 3) "flourishing, prosperous" 4) "genuine, true," 5) "governing, political," 6) "military." Compare with strictly masculine Masa.
Surname or Lastname
English
English : from an early Middle English personal name, Mert or Mart, or perhaps a nickname from Old English mearð ‘(pine) marten’.German (Alsace-Lorraine) : from a short form of Martin.
Girl/Female
Muslim
Zar - gold, Masta - excited
Surname or Lastname
English
English : from a short form of the personal name Matthew.German : from a short form of the personal name Matthias or Matthäus (see Matthew).German and Dutch : variant of Matte ‘meadow’.
Male
Italian
Short form of Italian Tommaso, MASO means "twin."
Male
Japanese
(1-æ£, 2-é›…, 3-昌, 4-真, 5-政, 6-å°†) Unisex short form of Japanese names beginning with Masa-, MASA means 1) "correct, just," 2) "elegant, splendid" 3) "flourishing, prosperous" 4) "genuine, true," 5) "governing, political," 6) "military." Compare with another form of Masa.
Surname or Lastname
English (East Anglia)
English (East Anglia) : metonymic occupational name for a cobbler, or perhaps a metonymic occupational name for a maker of cobblers’ lasts (see Laster).German and Jewish (Ashkenazic) : metonymic occupational name for a porter, from Middle High German last; German Last or Yiddish last ‘burden’, ‘load’.Dutch : metonymic occupational name as in 2, from Middle Dutch last ‘load’, ‘burden’; or a nickname for an awkward character, from Dutch last ‘trouble’, ‘nuisance’.French : habitational name from a place so named in Puy-de-Dôme.
Surname or Lastname
German
German : probably a habitational name from Haste near Wunstorf or Osnabrück.Dutch : nickname from Middle Dutch haest ‘hasty’.Swedish : soldier’s name, from hast ‘haste’, ‘hurry’.English (Lancashire and Yorkshire) : reduced form of Hayhurst.
Male
Swedish
Norwegian and Swedish form of Greek Mattathias, MATS means "gift of God."
Boy/Male
Arabic, Muslim, Pashtun
Gul - Flowers; Mast - Excitement
Female
Egyptian
, Follower of Maut.
Girl/Female
Arabic, Muslim, Pashtun
Zar - Gold; Masta - Excited
Male
English
Variant spelling of English Matt, MAT means "gift of God."
Surname or Lastname
English
English : topographic name for someone who lived in the eastern part of a town or settlement, or outside it to the east, or a regional name for someone who had migrated from the east of a place. As an American family name, this surname has absorbed various other European names with similar meaning.
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