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Protein involved in cell adhesion, cell growth, cell migration and differentiation
Fibronectin is a high-molecular weight (~500-~600 kDa) glycoprotein of the extracellular matrix that binds to membrane-spanning receptor proteins called
Fibronectin
Fibronectin binding protein A (FnBPA) is a Staphylococcus aureus MSCRAMM cell surface-bound protein that binds to both fibronectin and fibrinogen. It is
Fibronectin_binding_protein_A
α5β1, also known as the fibronectin receptor, is an integrin that binds to matrix macromolecules and proteinases and thereby stimulates angiogenesis.
Alpha-5_beta-1
Medical diagnostic method
Fetal fibronectin (fFN) is a fibronectin protein produced by fetal cells. It is found at the interface of the chorion and the decidua (between the fetal
Fetal_fibronectin
Protein-coding gene in the species Homo sapiens
Pikachurin, also known as AGRINL (AGRINL) and EGF-like, fibronectin type-III and laminin G-like domain-containing protein (EGFLAM), is a protein that
Pikachurin
Protein family
Fibronectin, type I repeats are one of the three repeats found in the fibronectin protein. Fibronectin is a plasma protein that binds cell surfaces and
Fibronectin_type_I_domain
Series of events that restore integrity to damaged tissue after an injury
Fibrin and fibronectin cross-link together and form a plug that traps proteins and particles and prevents further blood loss. This fibrin-fibronectin plug is
Wound_healing
Term for several kidney diseases
shown to be fibronectin. This condition is inherited in an autosomal dominant fashion. About 40% of cases are due to mutations in the fibronectin (FN1) gene
Glomerulonephritis
Structural support for biological cells
needed] Fibronectins are glycoproteins that connect cells with collagen fibers in the ECM, allowing cells to move through the ECM. Fibronectins bind collagen
Extracellular_matrix
Family of zinc-dependent metalloendopeptidases
is a zinc-binding motif. The gelatinases, such as MMP-2, incorporate Fibronectin type II modules inserted immediately before in the zinc-binding motif
Matrix_metalloproteinase
Acronym
step to establish infection. Examples include clumping factor A (ClfA), fibronectin binding protein A (FnbpA) from Staphylococcus aureus, SdrG from Staphylococcus
MSCRAMM
Protein domain
The Fibronectin type III domain is an evolutionarily conserved protein domain that is widely found in animal proteins. The fibronectin protein in which
Fibronectin_type_III_domain
Birth at less than a specified gestational age
of preterm labor. In one investigation comparing this test to fetal fibronectin testing and cervical length measurement via transvaginal ultrasound,
Preterm_birth
Protein domain
Fibronectin type II domain is a collagen-binding protein domain. Fibronectin is a multi-domain glycoprotein, found in a soluble form in plasma, and in
Fibronectin_type_II_domain
Synthetic binding proteins
Monobodies are synthetic binding proteins constructed using a fibronectin type III domain (FN3) as a molecular scaffold. Specifically, this class of binding
Monobody
Chemical compound
this sequence, which is found within many matrix proteins, including fibronectin, fibrinogen, vitronectin, osteopontin, and several other adhesive extracellular
Arginylglycylaspartic_acid
Material or tissue between a eukaryotic organism's cells
are attached to the ECM by still other ECM glycoproteins such as fibronectin. Fibronectin and other ECM proteins bind to cell surface receptor proteins called
Matrix_(biology)
Protein-coding gene in the species Homo sapiens
peptide, a propeptide, a catalytic domain with inserted three repeats of fibronectin type II domain followed by a C-terminal hemopexin-like domain. Proteins
MMP9
American scientist and textbook author
in chicken embryos (1990) Receptor functions for the integrin VLA-3: Fibronectin, collagen, and laminin binding are differentially influenced by ARG-GLY-ASP
Lisa_Urry
Transmembrane receptors involved in cellular adhesion and signalling
cell–cell and cell–matrix interaction. Ligands for integrins include fibronectin, vitronectin, collagen and laminin. Integrins are obligate heterodimers
Integrin
Low-density lipoprotein containing apolipoprotein(a)
Apo(a), a distinct feature of the Lp(a) particle, binds to immobilized fibronectin and endows Lp(a) with the serine-proteinase-type proteolytic activity
Lipoprotein(a)
Recombinant protease with activity against fibronectin and laminin
the brand name Jetrea, is a recombinant protease with activity against fibronectin and laminin, components of the vitreoretinal interface. It is used for
Ocriplasmin
Mammalian protein found in Homo sapiens
Fibronectin type III domain-containing protein 5, the precursor of irisin, is a type I transmembrane glycoprotein that is encoded by the FNDC5 gene. Irisin
FNDC5
inhibit the polymerization of fibronectin in a number of cell types including fibroblasts and endothelial cells. Fibronectin is an essential component of
PUR4
Species of bacterium
genes gfba, fnB, fbBA, fnBB, lmb and gapC; all mediating binding to fibronectin. gfba was recently shown contribute to bacterial internalization into
Streptococcus_dysgalactiae
Extracellular matrix glycoprotein family
structure is 14 EGF-like repeats towards the N-terminal end, and 8 or more fibronectin-III domains which vary upon species and variant. Tenascin-C is the most
Tenascin
Gene on human chromosome 5
Fibronectin type III domain–containing protein 9 (FNDC9) is a protein which in humans is encoded by the FNDC9 gene. FNDC9 is a single-pass membrane-associated
FNDC9
Receptors on the surface of cells
signal transduction. The common cytokine-binding domain is related to the Fibronectin type III domain. The signal transducing chains are often shared between
Type_I_cytokine_receptor
Two opposing antiparallel beta sheets that commonly occur in proteins
Staphylococcus aureus Adhesin and in modules that bind fibronectin as found in Tenascin (Third Fibronectin Type III Repeat). The L-type lectin domain is a variation
Beta-sandwich
Largest known protein in human muscles
modules, also referred to as protein domains (244 copies in total): type I fibronectin type III domain (132 copies) and type II immunoglobulin domain (112 copies)
Titin
Group of proteins
forms a robust attachment to the α5β1 integrin, typically employed by fibronectin, exhibiting roughly 100 times greater strength. This heightened binding
Invasin
Mammalian protein found in Homo sapiens
1989). "Assignment of the gene encoding the beta-subunit of the human fibronectin receptor (beta-FNR) to chromosome 10p11.2". Annals of Human Genetics
Integrin_beta_1
Folds of throat tissues that help to create n through vocalization
propria is composed of ground substances such as hyaluronic acid and fibronectin, fibroblasts, elastic fibers, and collagenous fibers. While the fibrous
Vocal_cords
Specialised kidney cells
collagen IV (α1 and α2 chains), collagen V, collagen VI, laminin A, B1, B2, fibronectin, and proteoglycans. It is unclear whether the mesangial cells originate
Mesangial_cell
Blood product prepared from blood plasma
100–150 U Cryoprecipitate also contains fibronectin; however, there are no clear indications for fibronectin replacement. US standards require manufacturers
Cryoprecipitate
Protein-coding gene in the species Homo sapiens
Leucine rich repeat and fibronectin type III domain containing 4 is a protein that in humans is encoded by the LRFN4 gene. Fibronectin type III domain Leucine
Leucine rich repeat and fibronectin type iii domain containing 4
Leucine_rich_repeat_and_fibronectin_type_iii_domain_containing_4
Protein-coding gene in the species Homo sapiens
and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, collagens types V and VII and integrins alpha-V/beta-1. This
Thrombospondin_1
Protein family
growth factor, transforming growth factor-beta, fibronectin and antithrombin-1. Interactions between fibronectin and some syndecans can be modulated by the
Syndecan
Naturally occurring organic poison
thuringiensis toxins Cry6Aa Cry34Ab1 Virulence factor Clumping factor A Fibronectin binding protein A Mycotoxins Aflatoxin Amatoxin (alpha-amanitin, beta-amanitin
Toxin
Pharmaceutical compound
skin. It is claimed to stimulate endogenous biosynthesis of collagens, fibronectin, hyaluronic acid and laminin, and is used in skincare products for its
Palmitoyl_tripeptide-38
Mammalian protein found in Homo sapiens
NCAM consists of five immunoglobulin-like (Ig) domains followed by two fibronectin type III (FNIII) domains. The different domains of NCAM have been shown
Neural_cell_adhesion_molecule
Protein complex
organs like Peyer’s patches endothelial venules. LPAM-1 can also bind to fibronectin in the extracellular matrix through a LDV motif on the CS-1 region. LPAM-1
LPAM-1
measurement via transvaginal ultrasound with a cutoff of 25mm (CL), and fetal fibronectin testing (fFN) via a commercially available, rapid test. Furthermore,
Placental alpha microglobulin-1 (PAMG-1)
Placental_alpha_microglobulin-1_(PAMG-1)
Protein
disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate
Integrin_alpha_5
Protein family
domains (CRDs) closest to the plasma membrane, followed by a single fibronectin type II repeat domain and an N-terminal cysteine-rich domain. The cytoplasmic
Mannose_receptor
Gamete-producing cell
orientation of underlying cells and their secreted molecules such as fibronectin play an important role.[citation needed] Mammals have a migratory path
Germ_cell
Cell adhesion molecules in the immunoglobulin superfamily
domains containing Ig-like domains. The Ig domains are then followed by Fibronectin type III domain repeats and IgSFs are anchored to the membrane by a GPI
IgSF_CAM
Hematological malignancy
unusually large nucleolus for their size Production of little excess fibronectin produced by classic hairy cells to interfere with bone marrow biopsies
Hairy_cell_leukemia
Protein-coding gene in the species Homo sapiens
Usherin that contains laminin EGF motifs, a pentraxin domain, and many fibronectin type III motifs. The encoded basement membrane-associated protein may
USH2A
Human protein-coding gene
in the number and identity of fibronectin type III domain repeats. Tenascin-C has been shown to interact with fibronectin. This interaction is shown to
Tenascin_C
American periodontist and cell and molecular biologist
University of Michigan School of Dentistry Thesis Specific domains of fibronectin modulate proteinase expression, apoptosis and invasion (1997) Website
Yvonne_Hernandez-Kapila
Synthetic material
create a lubricating surface on the cartilage for easier joint mobility. Fibronectin and integrins other glycoproteins present that help in adhesion of chondrocytes
Artificial_cartilage
S (2007). "Monobodies: antibody mimics based on the scaffold of the fibronectin type III domain". Protein Engineering Protocols. Methods Mol. Biol. Vol
Antibody_mimetic
Gelatinous matrix within a sponge
tissues. The mesohyl is composed of the following main elements: collagen, fibronectin-like molecules, galectin, and a minor component, dermatopontin. These
Mesohyl
American immunologist
an RGD motif in fibronectin is sufficient for recognition by its receptor and common to other extracellular proteins, the fibronectin and vitronectin
Timothy_A._Springer
Medical condition
connective tissue, extracellular matrix, including collagen, proteoglycans, fibronectin, and elastic fibers; crystalline cholesterol, cholesteryl esters, and
Cerebral_atherosclerosis
Most abundant structural protein in animals
be attached to cell membranes via several types of protein, including fibronectin, laminin, fibulin, and integrin. A single collagen molecule, tropocollagen
Collagen
Finnish and American cancer researcher
extracellular matrix and its receptors. He was one of the discoverers of fibronectin, an adhesion molecule and component of extracellular matrices, and he
Erkki_Ruoslahti
Antibiotic and antiprotozoal medication
amongst other risk factors including the presence of cervicovaginal fetal fibronectin (fFN). Metronidazole was ineffective in preventing preterm delivery in
Metronidazole
Mass formed in response to injury to the nervous system
surrounding the damaged region by secreting many molecules including laminin, fibronectin, tenascin C, and proteoglycans. These molecules are important modulators
Glial_scar
which are found in connective tissue proteins such as collagen, elastin, fibronectin and laminin, and were originally isolated as products of the enzymatic
Matrikine
Family of amphibians
thuringiensis toxins Cry6Aa Cry34Ab1 Virulence factor Clumping factor A Fibronectin binding protein A Mycotoxins Aflatoxin Amatoxin (alpha-amanitin, beta-amanitin
Poison_dart_frog
α-fetoprotein, the fetal counterpart of serum albumin Soluble plasma fibronectin, forming a blood clot that stops bleeding C-reactive protein, opsonin
Proteins produced and secreted by the liver
Proteins_produced_and_secreted_by_the_liver
Cell type
mesangial cells synthesize and secrete the extracellular matrix. It contains fibronectin, type IV collagen, perlecan, and laminin. Intraglomerular mesangial cells
Intraglomerular mesangial cell
Intraglomerular_mesangial_cell
RP11-479G22.2, CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB β1 integrin fibronectin receptor beta Active 16285956 LGR5 FEX, GPR49, GPR67, GRP49, HG38 Luciene-rich
List of intestinal stem cell marker genes
List_of_intestinal_stem_cell_marker_genes
Non-profit medical research institute
'two-site' ELISA. In the 1980s, the Institute conducted research on fibronectin and other extracellular matrix components, including research into cell
Sanford_Burnham_Prebys
Monoamine neurotransmitter
muscle contractility (⍺-actinin, SERCA2a), extracellular matrix proteins (fibronectin), neural surface proteins, and Ras,as well as histone H3. Serotonylation
Serotonin
Protein-coding gene in the species Homo sapiens
Fibronectin leucine-rich repeat transmembrane protein FLRT2 is a protein that in humans is encoded by the FLRT2 gene. This gene encodes a member of the
FLRT2
Toxin produced by a fungus
thuringiensis toxins Cry6Aa Cry34Ab1 Virulence factor Clumping factor A Fibronectin binding protein A Mycotoxins Aflatoxin Amatoxin (alpha-amanitin, beta-amanitin
Mycotoxin
Protein domain
to interact with numerous extracellular matrix constituents including fibronectin, proteoglycans, laminins and tropoelastin. In blood, fibulin-1 binds
Fibulin
Mammalian protein found in Homo sapiens
extracellular portion is formed of six immunoglobulin domains followed by five fibronectin type III domains which are connected to a small intracellular domain
L1_(protein)
dermal fibroblasts produce the protein molecules including laminin and fibronectin which comprise the extracellular matrix. By creating the extracellular
Dermal_fibroblast
Family of related toxins
thuringiensis toxins Cry6Aa Cry34Ab1 Virulence factor Clumping factor A Fibronectin binding protein A Mycotoxins Aflatoxin Amatoxin (alpha-amanitin, beta-amanitin
Shiga_toxin
Post-translational modifications involving monoamines
H3, small GTPases (RhoA, Rab3a), and extracellular matrix proteins (fibronectin). When intracellular Ca2+ and monoamine concentrations are sufficient
Monoaminylation
Amnion and chorion which surround and protect a developing fetus
birth are short cervical length and a raised cervical-vaginal fetal fibronectin concentration. Pathophysiology of the fetal membranes, such as microfractures
Fetal_membranes
Myosin Binding Protein H (MYBPH)
repair to specific parts of the genome. Fibronectin type III (FN3) domain is an internal repeat found in fibronectin whose tenth repeat contains an Arginyl-Glycyl-Aspartic
MYBPH
Protein
They have also been noted to be similar in structure and function to fibronectin proteins, but they interact with different types of proteins and molecules
Chondronectin
plasma. A characteristic feature of this protein is that it contains two fibronectin type 2 (Fn2) domain. Each domain in this protein binds to lipid head
PDC-109
Swedish biochemist
simple, one-step purification of fibronectin by gelatin affinity chromatography that enabled many advances in fibronectin research. The paper describing
Eva_Engvall
domain 1 of CD2 (D1-CD2), which naturally binds weakly to the receptor. Fibronectin domain 10 contains the RGD motif that αVβ3 recognizes. A high-affinity
Alpha-v_beta-3
Protein found in humans
expression of CD11b and an enhanced adhesion of circulating monocytes to fibronectin". Diabetes. 53 (8): 1979–1986. doi:10.2337/diabetes.53.8.1979. hdl:1765/10354
ABCC11
Protein-coding gene in the species Homo sapiens
repeats of epidermal growth factor (EGF)-like motif, a high number of Fibronectin type III (FNIII) module, and a fibrinogen (FBG)-like globular domain
Tenascin_X
Protein-coding gene in the species Homo sapiens
domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based
EPH_receptor_A5
Type of spreading cancer
sulphate proteoglycans(HSPGs). Several different integrins bind to fibronectin. Fibronectin-integrin interactions are important in tumor cell migration, invasion
Metastatic_breast_cancer
Antigenic substance produced in tumor cells
in colorectal carcinoma CML66 in chronic myeloid leukemia, CDK4 and fibronectin, p53, and ras in multiple cancers. Some cancer cells aberrantly express
Tumor_antigen
Pharmaceutical compound
collagens and elastin. It stimulates endogenous biosynthesis of collagens, fibronectin and hyaluronic acid, and is used in skincare products for its purported
Tetrapeptide-21
Topics referred to by the same term
FNZ may refer to: FNZ (company), financial services company Fibronectin FnZ, Australian record production and songwriting duo also known as Finatik N
FNZ
American molecular biologist (1944–2026)
mechanisms of cancer metastasis. Hynes is regarded as a co-discoverer of fibronectin molecules, a discovery that has been listed by Thomson Scientific ScienceWatch
Richard_Hynes
Medical condition
deposition of extracellular matrix components, especially collagen, fibronectin, elastin, and proteoglycans. Generally, they contain relatively acellular
Keloid
Surface glycoproteins involved in hemostasis
Arginine-Glycine-Aspartate amino acid sequence This complex also binds vWF, fibronectin and vitronectin. In the resting state the contact between the two protein
Platelet membrane glycoprotein
Platelet_membrane_glycoprotein
Cell type with functions of both muscular and fibrous connective tissue
of fibronectin, collagens, and hyaluronic acid during and after their differentiation from fibroblasts. Among these, the EDA isoform of fibronectin (EDA-FN)
Myofibroblast
Protein-coding gene in the species Homo sapiens
its first two introns. In addition, it also regulates the splicing of fibronectin and CD45 genes. Two transcript variants encoding different isoforms have
SFSWAP
In molecular biology, the FasX small RNA (fibronectin/fibrinogen-binding/haemolytic-activity/streptokinase-regulator-X) is a non-coding small RNA (sRNA)
FasX_small_RNA
Dental fibers
It consist of type 3 collagen, associated, at least initially, with fibronectin. Microscopic Photo of Korff fibers[permanent dead link] NCBI Essay on
Korff_fibers
First stage of pregnancy
glycoproteins and peptides secreted by the uterine glands Matrix-associated: Fibronectin Laminin Entactin Type-IV collagen Heparan sulfate Proteoglycan Integrins
Implantation_(embryology)
hairy gene, begin expressing adhesion proteins such as N-cadherin and fibronectin, compact, and bud off forming somites. The somites give rise to the vertebral
Somitomere
Argentine molecular biologist
together, they were successful in cloning the human fibronectin gene. They determined that fibronectin, an important glycoprotein for cell adhesion and tissue
Alberto_Kornblihtt
Highly modified saliva containing zootoxins
thuringiensis toxins Cry6Aa Cry34Ab1 Virulence factor Clumping factor A Fibronectin binding protein A Mycotoxins Aflatoxin Amatoxin (alpha-amanitin, beta-amanitin
Snake_venom
Species of bacterium
gingipains (Kgp) can bind to immobilized matrix proteins fibrinogen and fibronectin and may have a role in host colonization. Gingipains also have the ability
Porphyromonas_gingivalis
Proteins found on the outer membrane of Gram-negative bacteria
an element of the host extracellular matrix, for example, collagen, fibronectin, etc. Most TAAs have a similar protein structure. When observed with
Trimeric autotransporter adhesin
Trimeric_autotransporter_adhesin
FIBRONECTIN
FIBRONECTIN
FIBRONECTIN
FIBRONECTIN
Boy/Male
Gujarati, Indian
Victorious Blue; Sky
Girl/Female
French Latin
Heavenly.
Girl/Female
Greek American
Wholesome, from the verb meaning 'to heal'. Althaia was the Greek name for the marshmallow plant...
Boy/Male
Tamil
Full Moon
Girl/Female
Muslim
Daughter, Queen, Owner, A garland
Boy/Male
Indian
Helpfull
Surname or Lastname
North German
North German : from a short form of the personal name Jesper, a Low German form of Kaspar.South German : from a reduced form of the personal name Johannes (see John).Eastern German (of Slavic origin) : topographic name from Czech jes(en) ‘ash tree’.English : from a short form of Jessup.French : from Old French jaisse ‘chick pea’; probably a metonymic occupational name for a grower of chick peas or a topographic name.
Boy/Male
Tamil
Born after or in addition to
Boy/Male
Indian, Sanskrit
Lord of Reciters
Female
German
German form of Greek Aikaterine, KATARINE means "pure."
FIBRONECTIN
FIBRONECTIN
FIBRONECTIN
FIBRONECTIN
FIBRONECTIN