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Academic journal
Aging Cell is a peer-reviewed open access scientific journal and an official journal of the Anatomical Society. It is published on their behalf by John
Aging_Cell
Deterioration of function with age
senescence and thus age-related diseases. Rare human mutations can cause accelerated aging diseases. Environmental factors may affect aging – for example,
Senescence
Theory of aging
The stem cell theory of aging postulates that the aging process is the result of the inability of various types of stem cells to continue to replenish
Stem_cell_theory_of_aging
Australian geneticist (born 1969)
epigenetic information as a cause of mammalian aging, Cell 2021, The economic value of targeting aging, Nature Aging 2020, Reprogramming to recover youthful
David_A._Sinclair
Types of irreversible biochemical changes
death. The hallmarks of aging are the types of biochemical changes that occur in all organisms that experience biological aging and lead to a progressive
Hallmarks_of_aging
Social movement devoted to eliminating or reversing aging, or reducing its effects
The anti-aging movement is a social movement devoted to eliminating or reversing aging, or reducing the effects of it. A substantial portion of the attention
Anti-aging_movement
Phenomenon characterized by the cessation of cell division
repair. Senescent cells contribute to the aging phenotype, including frailty syndrome, sarcopenia, and aging-associated diseases. Senescent astrocytes
Cellular_senescence
Biological process of getting older
conditions. However, evidence has been reported that aging leading to death occurs in the single-cell bacterium Escherichia coli, an organism that reproduces
Ageing
Medical discipline focused on the practical reversal of the aging process
reversal of the aging process. Rejuvenation is distinct from life extension. Life extension strategies often study the causes of aging and try to oppose
Rejuvenation
Biochemical test for age
lipid elongation enzyme ELOVL2 is a molecular regulator of aging in the retina". Aging Cell. 19 (2) e13100. doi:10.1111/acel.13100. ISSN 1474-9718. PMC 6996962
Epigenetic_clock
Branch of biology that studies cells
physiology and biochemistry of cells (e.g., metabolic studies, aging), the effects of drugs and toxic compounds on the cells, and mutagenesis and carcinogenesis
Cell_biology
Region of repetitive nucleotide sequences on chromosomes
Martínez P, Blasco MA (October 2010). "Role of shelterin in cancer and aging". Aging Cell. 9 (5): 653–66. doi:10.1111/j.1474-9726.2010.00596.x. PMID 20569239
Telomere
Longer than typical lifespan, especially of humans
"Hallmarks of aging: An expanding universe". Cell. 186 (2): 243–278. doi:10.1016/j.cell.2022.11.001. López-Otín C, Kroemer G. Hallmarks of aging: an expanding
Longevity
research into senescence or biological aging, including the research and development of life extension methods, brain aging delay methods and rejuvenation. People
Timeline_of_aging_research
Concept of extending human lifespan
(January 2012). "Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock". Cell. 148 (1–2): 46–57. doi:10.1016/j.cell.2012.01.003. PMC 3336960
Life_extension
Hypothesis that aging is caused by accumulated DNA damage
The DNA damage theory of aging proposes that aging is a consequence of unrepaired accumulation of naturally occurring DNA damage. Damage in this context
DNA_damage_theory_of_aging
Medical condition
premature aging. Werner syndrome is named after the German scientist Otto Werner. He identified the syndrome in four siblings observed with premature aging, which
Werner_syndrome
Genetic disorder that causes early aging
play a role in normal human aging, since its production is activated in typical senescent cells. Unlike other "accelerated aging diseases", such as Werner
Progeria
Immune system deterioration brought on by aging
Removal of senescent cells with senolytics has been proposed as a means to enhance immunity during aging. Immune system aging in mice can be partially
Immunosenescence
Type of biomarkers
aging are biomarkers that could predict functional capacity at some later age better than chronological age. Stated another way, biomarkers of aging would
Biomarkers_of_aging
Type of cellular stress response
Murshid A, Prince T (2009). "The shock of aging: molecular chaperones and the heat shock response in longevity and aging--a mini-review". Gerontology. 55 (5):
Heat_shock_response
Sub-field of gerontology
errors, and this leads to deformed cells and increases the risk of cancer. Genetic theories of aging propose that aging is programmed within each individual's
Biogerontology
Model of aging as a trade-off between growth, reproduction, and DNA maintenance
evolutionary trade-off between growth and aging has been well established, the relationship between reproduction and aging is still without scientific consensus
Disposable soma theory of aging
Disposable_soma_theory_of_aging
2007 book by Aubrey de Grey and Michael Rae
Ending Aging: The Rejuvenation Breakthroughs that Could Reverse Human Aging in Our Lifetime is a 2007 book written by biogerontologist Aubrey de Grey,
Ending_Aging
German–American aging researcher, geneticist and biostatistician
He is known for developing the Horvath aging clock, which is a highly accurate molecular biomarker of aging, and for developing weighted correlation
Steve_Horvath
Study of the evolutionary development of ageing processes
the actual rate of aging can be an adaptation the aging itself is inevitable. In other words, evolution can change the speed of aging but some ageing no
Evolution_of_ageing
Increasing remaining life expectancy faster than time passes
themselves nor that all non-aging-related causes of death will be eradicted. Life extension Post-aging society Pro-aging trance Technological utopianism
Longevity_escape_velocity
State in which the rate of mortality from senescence is stable or decreasing
Reliability theory of aging and longevity Rejuvenation (aging) Strategies for engineered negligible senescence (SENS) Telomerase in cancer cell Timeline of senescence
Biological_immortality
Medical condition
an aging phenotype, such as cystic fibrosis and sickle cell anemia. It is further argued that segmental aging phenotype is a natural part of aging insofar
DNA repair-deficiency disorder
DNA_repair-deficiency_disorder
Proposed regenerative medical therapies
subsequent categorization systems of the biology of aging, such as the highly influential Hallmarks of Aging published in 2013. While some biogerontologists
Strategies for engineered negligible senescence
Strategies_for_engineered_negligible_senescence
down or reversing the processes of aging to extend both the maximum and average lifespan. Also known as anti-aging medicine, experimental gerontology
Outline_of_life_extension
US biomedical research institute
Research on Aging is an independent nonprofit biomedical research institute located in Novato, California, that researches aging and age-related disease
Buck Institute for Research on Aging
Buck_Institute_for_Research_on_Aging
society organises scientific meetings, publishes the Journal of Anatomy and Aging Cell and makes annual awards of PhD studentships, grants and prizes. The society
Anatomical_Society
American biotechnology company
Manuel; Kroemer, Guido (June 2013). "The Hallmarks of Aging". Cell. 153 (6): 1194–1217. doi:10.1016/j.cell.2013.05.039. PMC 3836174. PMID 23746838. López-Otín
BioViva
American nonprofit organization
American Academy of Anti-Aging Medicine (A4M) is a United States 501(c)(3) nonprofit organization, that promotes the field of anti-aging medicine, and the organization
American Academy of Anti-Aging Medicine
American_Academy_of_Anti-Aging_Medicine
Important Biological tissue that allows movement
the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging". Cell Metab. 25 (5): 1135–46.e7. doi:10.1016/j.cmet.2017.04.008. PMC 5485859
Muscle
Range of genetic disorders which cause a person to appear to grow older faster
cellular processes which repair DNA. The DNA damage theory of aging proposes that aging is a consequence of the accumulation of naturally occurring DNA
Progeroid_syndromes
Limit to divisions of a normal human cell
Alexis Carrel that normal cells are immortal. Hayflick interpreted his discovery to be aging at the cellular level. The aging of cell populations appears to
Hayflick_limit
Type of molecule that may be able to induce death of senescent cells
diseases. Removal of senescent cells with senolytics has been proposed as a method of enhancing immunity during aging. A related concept is "senostatic"
Senolytic
Portuguese microbiologist
Genomics of Aging and Rejuvenation Lab there. He helps maintain several databases on aging - among them - GenAge, AnAge, DrugAge, CellAge, GenDR, the
João_Pedro_de_Magalhães
Aging in cats is the process by which cats change over the course of their natural lifespans. The normal lifespan of domestic cats is in the range of
Aging_in_cats
American biotechnology company
extension therapies based on induced pluripotent stem cells that can halt or reverse the human aging process. Russian-born technology businessman Yuri Milner
Altos_Labs
Specific location in the body containing stem cells
process that contributes to tissue degradation and aging. Therefore, the population size of the stem cell niche represents an evolutionary trade-off between
Stem-cell_niche
Rare metabolic genetic disorder resulting in leukoencephalopathy
extends lifespan, and attenuates polyglutamine toxicity in Drosophila". Aging Cell. 11 (1): 93–103. doi:10.1111/j.1474-9726.2011.00762.x. ISSN 1474-9718
Ribose-5-phosphate isomerase deficiency
Ribose-5-phosphate_isomerase_deficiency
2019 non-fiction book by David Sinclair and Matthew LaPlante
proteostasis; exhaustion of stem cells; and the production of inflammatory molecules. "Address one of these, and you can slow down aging," the authors argue. "Address
Lifespan: Why We Age – and Why We Don't Have To
Lifespan:_Why_We_Age_–_and_Why_We_Don't_Have_To
Stem cells that give rise to other blood cells
mechanism for the aging of hematopoietic stem cells: aging changes the clonal composition of the stem cell compartment but not individual stem cells". Blood. 111
Hematopoietic_stem_cell
Cell that differentiates into one or a few cell types
the natural process of aging, which makes them a target for aging therapy research. This field of regenerative medicine and aging research is still currently
Progenitor_cell
Israeli geneticist
for Aging Research, the Nathan Shock Center of Excellence in the Basic Biology of Aging and the Paul F. Glenn Center for the Biology of Human Aging Research
Nir_Barzilai
Chemical compound
irradiation-induced premature aging of the hematopoietic system and rejuvenated the aged hematopoietic stem cells and muscle stem cells in normally aged mice. On September
Navitoclax
Biological theory of cellular aging
critical roles in cellular aging and cancer. An important facet to how telomeres function in these roles is their involvement in cell cycle regulation. Because
Telomeres_in_the_cell_cycle
Hypothetical hydrolase enzyme
accumulation that can be induced in young mice by senescent cells". Aging. 8 (7): 1294–1315. doi:10.18632/aging.100991. PMC 4993332. PMID 27391570. Hall BM, Balan
Senescence-associated beta-galactosidase
Senescence-associated_beta-galactosidase
Genetics in relation to aging and lifespans
Genetics of aging is generally concerned with genetic effects involved in biological mechanisms of normal aging, as well as life extension associated
Genetics_of_aging
co-Editor-in-Chief of the journal Aging Cell, and is chair of the 2015 Gordon Research Conference on the Biology of Aging. Sedivy, J. M., & Joyner, A. L
John_M._Sedivy
Experimental therapy
perspective and methodological considerations for studies of aging and longevity". Aging Cell. 12 (3): 525–530. doi:10.1111/acel.12065. PMC 4072458. PMID 23489470
Young_blood_transfusion
Physical immortality free of ageing
Edda. An individual's DNA plays a role in the aging process. Aging begins even before birth, as soon as cells start to die and need to be replaced. On the
Eternal_youth
Medical condition
Sickle cell disease (SCD), also simply called sickle cell, is a group of inherited hemoglobin-related blood disorders. Sickle cell disease is caused by
Sickle_cell_disease
Canadian researcher and exercise physiologist
"Mitochondrial function and apoptotic susceptibility in aging skeletal muscle". Aging Cell. 7 (1): 2–12. doi:10.1111/j.1474-9726.2007.00347.x. PMID 18028258
David_A._Hood
Cell Technology Corporation Aerobic exercise Age-adjusted life expectancy Age-Related Eye Disease Study Age-Related Macular Degeneration Aging Aging and
Index of topics related to life extension
Index_of_topics_related_to_life_extension
Liver cell type
responses to DNA damage determine ageing differences between organs". Aging Cell. 21 (4) e13562. doi:10.1111/acel.13562. PMC 9009128. PMID 35246937. Lecluyse
Hepatocyte
Observed ability of muscles
epigenetics in nutritional programming, metabolic disease, aging and exercise". Aging Cell. 15 (4): 603–616. doi:10.1111/acel.12486. ISSN 1474-9726. PMC 4933662
Muscle memory (strength training)
Muscle_memory_(strength_training)
Chinese scientist
张维绮; pinyin: Zhāng Wéiqǐ) is a Chinese scientist specializing in aging and stem cell biology. She is a Principal Investigator at the Beijing Institute
Weiqi_Zhang
American biochemist
Helen Blau is a cell biologist and stem cell researcher known for her work on muscle diseases, regeneration and aging. She is the Donald E. and Delia
Helen_Blau
Pharmaceutical compound
alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice". Aging. 12 (2): 1272–1284. doi:10.18632/aging.102682
FOXO4-DRI
DNA repair mechanism
multi-system premature aging degenerative phenotype that appears to strengthen the link between DNA damage and aging.(see DNA damage theory of aging). Cockayne syndrome
Nucleotide_excision_repair
Theory of ageing
Lobachev A.N.Role of mitochondrial processes in the development and aging of organism. Aging and cancer (PDF), Chemical abstracts. 1979 v. 91 N 25 91:208561v
Mitochondrial theory of ageing
Mitochondrial_theory_of_ageing
Hypothetical anti-aging dietary supplement or drug candidate
Lane, Ingram, Roth of the National Institute on Aging in a seminal 1998 paper in the Journal of Anti-Aging Medicine, the forerunner of Rejuvenation Research
Caloric_restriction_mimetic
Genus of unicellular ciliates
for clonal aging. Other experiments by Smith-Sonneborn, Holmes and Holmes, and Gilley and Blackburn demonstrated that, during clonal aging, DNA damage
Paramecium
Aging in dogs varies from breed to breed, and affects the dog's health and physical ability. As with humans, advanced years often bring changes in a dog's
Aging_in_dogs
Biogerontologist
"Interventions to Slow Aging in Humans: Are We Ready?" Longo, Valter D.; Antebi, Adam; Bartke, Andrzej; et al. Aging Cell, 2015. "Age-related somatic mutations
Jan_Vijg
Organisms that do not exhibit evidence of biological aging
successive cell divisions undergo aging. The old pole cells can be regarded as an aging parent repeatedly reproducing rejuventated offspring. Aging in the
Negligible_senescence
Family of lipids
inducing a cellular senescence-like phenotype in dopaminergic neurons". Aging Cell. 23 (4) e14077. doi:10.1111/acel.14077. ISSN 1474-9726. PMC 11019121.
Glucocerebroside
Organelle in eukaryotic cells responsible for respiration
between aging and oxidative stress are not new and were proposed in 1956, which was later refined into the mitochondrial free radical theory of aging. A vicious
Mitochondria
Involution (shrinking) of the thymus after the neonatal period
Zhaoqi; Zhang, Qian; Zhao, Yong (2022). "Age-related thymic involution: Mechanisms and functional impact". Aging Cell. 21 (8) e13671. doi:10.1111/acel.13671
Thymic_involution
Phenotype of senescent cells which secrete certain substances
and molecular biology of skin aging"". Arch Dermatol. Booth LN, Brunet A (June 2016). "The Aging Epigenome". Molecular Cell. 62 (5): 728–744. doi:10.1016/j
Senescence-associated secretory phenotype
Senescence-associated_secretory_phenotype
Reactive oxygen species produced by mitochondria
"Accelerated aging phenotype in mice with conditional deficiency for mitochondrial superoxide dismutase in the connective tissue". Aging Cell. 10 (2): 239–54
Mitochondrial_ROS
Chemical compound which is reduced and oxidized
NAD+ levels decline during aging. The decline in cellular concentrations of NAD+ during aging likely contributes to the aging process and to the pathogenesis
Nicotinamide adenine dinucleotide
Nicotinamide_adenine_dinucleotide
American anatomist (1928–2024)
have vehemently condemned "anti-aging medicine" and criticized organizations such as the American Academy of Anti-Aging Medicine. Hayflick has written
Leonard_Hayflick
Type of immune cell involved in germinal center formation and maintenance
Haynes L (2012). "The aged microenvironment contributes to the age-related functional defects of CD4 T cells in mice". Aging Cell. 11 (5): 732–40. doi:10
Follicular_B_helper_T_cells
Mammal reproductive system cell
ovarian aging. Granulosa cell tumour Ovulation Membrana granulosa List of human cell types derived from the germ layers List of distinct cell types in
Granulosa_cell
American cancer researcher (born 1966)
(2009). "Expression of p16INK4a in peripheral blood T-cells is a biomarker of human aging". Aging Cell. 8 (4): 439–448. doi:10.1111/j.1474-9726.2009.00489
Norman_Sharpless
Accumulation of lipofuscin Aging brain Calorie restriction Cross-link Crosslinking of DNA Degenerative disease DNA damage theory of aging Exposure to ultraviolet
List_of_aging_processes
Power generation technology
consumes electricity. They are a leading candidate to replace the aging alkaline fuel-cell technology, which was used in the Space Shuttle. PEMFCs are built
Proton-exchange membrane fuel cell
Proton-exchange_membrane_fuel_cell
Early onset muscle loss due to ageing or immobility
lysosomal homeostasis mitigates inflammation and muscle atrophy during aging". Aging Cell. 21 (4) e13583. doi:10.1111/acel.13583. PMC 9009131. PMID 35263007
Sarcopenia
Mammalian protein found in humans
other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs". Aging. 9 (6): 1477–1536. doi:10.18632/aging.101250. PMC 5509453. PMID 28611316
MTOR
Telomere-restoring protein active in the most rapidly dividing cells
(December 2002). "Regenerative potential of human skeletal muscle during aging". Aging Cell. 1 (2): 132–9. doi:10.1046/j.1474-9728.2002.00017.x. PMID 12882343
Telomerase
Chemical compound
has done testing on the anti-aging aspect of TA-65;[unreliable source?], as well as Maria Blasco in the journal Aging Cell, finding no increase in murine
Cycloastragenol
foundation, or institution. npj 2D Materials and Applications npj Aging (formerly npj Aging and Mechanisms of Disease) npj Biodiversity npj Biofilms and Microbiomes
List of Nature Research journals
List_of_Nature_Research_journals
Russian immunologist (1845–1916)
healthier. The issues of aging occupied a significant place in Metchnikoff's works. Metchnikoff developed a theory that aging is caused by toxic bacteria
Élie_Metchnikoff
Natural stoppage of cell cycle during cell division
Cell cycle withdrawal refers to the natural stoppage of cell cycle during cell division. When cells divide, there are many internal or external factors
Cell_cycle_withdrawal
Relationship between getting older and ability to reproduce among females
rapamycin treatment increases ovarian lifespan in young and middle-aged female mice". Aging Cell. 16 (4): 825–836. doi:10.1111/acel.12617. ISSN 1474-9726. PMC 5506398
Age_and_female_fertility
American non-profit organization
York City in the summer. It is focused on biomarkers of aging, fundamental studies on aging, the development of rejuvenation therapies for humans, and
Lifespan_Research_Institute
Death of a cell mediated by intracellular program, often as part of development
Programmed cell death (PCD), sometimes referred to as cell suicide or cellular suicide, is the death of a cell as a result of events inside of a cell, such
Programmed_cell_death
American biogerontologist
restriction slows aging by activation of sirtuins. The Kenyon and Guarente labs came to lead the field studying the genetics of aging. In 1995 the Guarente
Leonard_P._Guarente
Group of identical cells that share a common ancestry
clonal aging in P. tetraurelia. This aging process has similarities to the aging process in multicellular eukaryotes (See DNA damage theory of aging). Clone
Clone_(cell_biology)
Therapy in which cellular material is injected into a patient
an attempt to stop the effects of aging. In 1931 Paul Niehans (1882–1971) – who has been called the inventor of cell therapy – attempted to cure a patient
Cell_therapy
Chemical compound
male-specific improvements in glucose tolerance and mTORC 2 signaling". Aging Cell. 16 (6): 1256–1266. doi:10.1111/acel.12656. ISSN 1474-9718. PMC 5676051
17α-Estradiol
Type of disease
An aging-associated disease (commonly termed age-related disease, ARD) is a disease that is most often seen with increasing frequency with increasing
Aging-associated_diseases
Chemical compound
"N-homocysteinylation of DJ-1 promotes neurodegeneration in Parkinson's disease". Aging Cell. 23 (5) e14124. doi:10.1111/acel.14124. PMC 11113254. PMID 38380563.
Homocysteine_thiolactone
American biochemist, nutritionist and gerontologist
perspective and methodological considerations for studies of aging and longevity". Aging Cell. 12 (3): 525–530. doi:10.1111/acel.12065. PMC 4072458. PMID 23489470
Clive_McCay
Biological tissue housed in bone
Lustgarten J, Scrable H, et al. (October 2010). "Fat tissue, aging, and cellular senescence". Aging Cell. 9 (5): 667–684. doi:10.1111/j.1474-9726.2010.00608.x
Bone_marrow_adipose_tissue
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